C. Blindauer

发表

Evidence for a gem-diol reaction intermediate in bacterial C-C hydrolase enzymes BphD and MhpC from 13C NMR spectroscopy.

T. Bugg, Jian-jun Li, Chen Li, 2006, Biochemistry.

Plasma fatty acid levels may regulate the Zn(2+)-dependent activities of histidine-rich glycoprotein.

P. Sadler, A. Stewart, C. Blindauer, 2009, Biochimie.

Interdomain zinc site on human albumin

P. Sadler, D. Sleep, A. Stewart, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of Folding Cores in the Cyclophilin A-Cyclosporin A Complex

S. Wells, R. Freedman, J. W. Heal, 2014, Biophysical journal.

Characterising the folding core of the cyclophilin A — cyclosporin A complex I : hydrogen exchange data and rigidity analysis

R. Freedman, J. W. Heal, R. A. Romer, 2014, 1407.4436.

Site-specific N-terminus conjugation of poly(mPEG1100) methacrylates to salmon calcitonin: synthesis and preliminary biological evaluation

David J Brayden, G. Mantovani, D. Haddleton, 2009 .

Direct peptide bioconjugation/PEGylation at tyrosine with linear and branched polymeric diazonium salts.

David J Brayden, G. Mantovani, D. Haddleton, 2012, Journal of the American Chemical Society.

Bacterial zinc uptake regulator proteins and their regulons

D. Scanlan, A. Mikhaylina, C. Blindauer, 2018, Biochemical Society transactions.

Identification of major zinc-binding proteins from a marine cyanobacterium: insight into metal uptake in oligotrophic environments.

D. Scanlan, C. Blindauer, James P Barnett, 2014, Metallomics : integrated biometal science.

Changes in Plasma Free Fatty Acids Associated with Type-2 Diabetes.

A. Stewart, C. Blindauer, Amélie I S Sobczak, 2019 .

Prion infection in cells is abolished by a mutated manganese transporter but shows no relation to zinc

David R. Brown, Rachel Pass, C. Blindauer, 2015, Molecular and Cellular Neuroscience.

Bacterial metallothioneins: past, present, and questions for the future

C. Blindauer, Claudia A. Blindauer, 2011, JBIC Journal of Biological Inorganic Chemistry.

The Interplay between Non-Esterified Fatty Acids and Plasma Zinc and Its Influence on Thrombotic Risk in Obesity and Type 2 Diabetes

A. Stewart, Dongmei Wu, C. Blindauer, 2021, International journal of molecular sciences.

Fatty acids may influence insulin dynamics through modulation of albumin‐Zn2+ interactions

A. Stewart, J. Penedo, S. Arya, 2021, BioEssays : news and reviews in molecular, cellular and developmental biology.

Stability Enhancing N-Terminal PEGylation of Oxytocin Exploiting Different Polymer Architectures and Conjugation Approaches.

D. Haddleton, K. Kempe, T. P. Davis, 2016, Biomacromolecules.

Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily.

C. Farquharson, R. Schmid, A. Stewart, 2003, Protein engineering.

Molecular genetic and biochemical characterization of a putative family of zinc metalloproteins in Caenorhabditis elegans † Metallomics

S. Stürzenbaum, Y. Essig, S. Webb, 2018 .

Allosteric inhibition of cobalt binding to albumin by fatty acids: implications for the detection of myocardial ischemia.

P. Sadler, T. Pinheiro, A. Stewart, 2012, Journal of medicinal chemistry.

Zinc transfer from the embryo-specific metallothionein E(C) from wheat: a case study.

C. Blindauer, O. I. Leszczyszyn, Claudia A. Blindauer, 2010, Physical chemistry chemical physics : PCCP.

A single sensor controls large variations in zinc quotas in a marine cyanobacterium

V. Fülöp, D. Scanlan, James P. C. Coverdale, 2022, Nature Chemical Biology.

Plasma non-esterified fatty acids contribute to increased coagulability in type-2 diabetes through altered plasma zinc speciation

Terry K. Smith, A. Stewart, R. Ajjan, 2019, bioRxiv.

Ischemia-modified albumin: Crosstalk between fatty acid and cobalt binding

A. Stewart, James P. C. Coverdale, S. Arya, 2018, Prostaglandins, leukotrienes, and essential fatty acids.

Fatty Acid-Mediated Inhibition of Metal Binding to the Multi-Metal Site on Serum Albumin: Implications for Cardiovascular Disease.

A. Stewart, S. Khazaipoul, C. Blindauer, 2016, Current topics in medicinal chemistry.

Plasma free fatty acid levels influence Zn2+-dependent histidine-rich glycoprotein–heparin interactions via an allosteric switch on serum albumin

O. Kassaar, A. Stewart, C. Blindauer, 2014, Journal of thrombosis and haemostasis : JTH.

Crosstalk between zinc and free fatty acids in plasma

A. Stewart, James P. C. Coverdale, S. Khazaipoul, 2019, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Histidine ligands in bacterial metallothionein enhance cluster stability

P. Sadler, D. Campopiano, C. Blindauer, 2007, JBIC Journal of Biological Inorganic Chemistry.

Albumin Substitution in Decompensated Liver Cirrhosis: Don’t Forget Zinc

D. Reinhold, C. Blindauer, K. Grüngreiff, 2021, Nutrients.

Role of Tyr84 in controlling the reactivity of Cys34 of human albumin

P. Sadler, D. Tooth, D. Sleep, 2005, The FEBS journal.

Strategies for Therapeutic Amelioration of Aberrant Plasma Zn2+ Handling in Thrombotic Disease: Targeting Fatty Acid/Serum Albumin-Mediated Effects

A. Stewart, R. Ajjan, C. Blindauer, 2022, International journal of molecular sciences.

Elemental composition of natural populations of key microbial groups in Atlantic waters.

Adrian P. Martin, D. Scanlan, M. Ostrowski, 2013, Environmental microbiology.

A single sensor controls large variations in zinc quotas in a marine cyanobacterium

V. Fülöp, D. Scanlan, James P. C. Coverdale, 2022, Nature Chemical Biology.

Zinc-Handling in Cyanobacteria: An Update

C. Blindauer, 2009 .

Isostructural replacement of zinc by cadmium in bacterial metallothionein

P. Sadler, N. Robinson, M. Harrison, 2008 .

Extent of Intramolecular π Stacks in Aqueous Solution in Mixed-Ligand Copper(II) Complexes Formed by Heteroaromatic Amines and 1-[2-(Phosphonomethoxy)ethyl]cytosine (PMEC), a Relative of Antivirally Active Acyclic Nucleotide Analogues (Part 72)[1, 2]†

H. Sigel, A. Sigel, A. Holý, 2013 .

Complex Formation of the Antiviral 9‐[2‐(Phosphonomethoxy)Ethyl]Adenine (PMEA) and of Its N 1, N 3, and N 7 Deaza Derivatives with Copper(II) in Aqueous Solution

H. Sigel, E. Sletten, A. Emwas, 1997 .

Fractionation and identification of metalloproteins from a marine cyanobacterium

D. Scanlan, C. Blindauer, James P Barnett, 2012, Analytical and Bioanalytical Chemistry.

Metal Ion-Coordinating Properties in Aqueous Solutions of the Antivirally Active Nucleotide Analogue (S )-9-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine (HPMPA) - Quantification of Complex Isomeric Equilibria

H. Sigel, A. Sigel, A. Holý, 2019, European Journal of Inorganic Chemistry.

Metal-ion binding properties of (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir). A nucleotide analogue with activity against DNA viruses

H. Sigel, A. Sigel, A. Holý, 2017 .

Aspects of the co-ordination chemistry of the antiviral nucleotide analogue, 9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP)

H. Sigel, E. Sletten, A. Holý, 1999 .

Earthworm Lumbricus rubellus MT-2: Metal Binding and Protein Folding of a True Cadmium-MT

S. Stürzenbaum, Gregory R. Kowald, C. Blindauer, 2016, International journal of molecular sciences.

Sediment Metal Contamination in the Kafue River of Zambia and Ecological Risk Assessment

S. Nakayama, J. Yabe, N. Bortey-Sam, 2017, Bulletin of Environmental Contamination and Toxicology.

Speciomics as a concept involving chemical speciation and omics.

J. D. de Jesus, M. Arruda, C. Blindauer, 2022, Journal of proteomics.

Magnesium complexes of the antiviral 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) and of its 1-, 3-, and 7-deaza analogues in aqueous solution

H. Sigel, A. Holý, C. Blindauer, 1998, JBIC Journal of Biological Inorganic Chemistry.

How to hide zinc in a small protein.

P. Sadler, C. Blindauer, Claudia A. Blindauer, 2005, Accounts of chemical research.

Intramolecular π-stacks in mixed-ligand copper(II) complexes formed by heteroaromatic amines and antivirally active acyclic nucleotide analogs carrying a hydroxy-2-(phosphonomethoxy)propyl residue‡

H. Sigel, A. Sigel, A. Holý, 2018, Journal of Coordination Chemistry.

Extent of intramolecular π stacks in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and the anticancer and antivirally active 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG). A comparison with related acyclic nucleotide analogues ☆

H. Sigel, A. Sigel, A. Holý, 2016 .

Extent of Intramolecular π‐Stacks in Aqueous Solution in Mixed‐Ligand Copper(II) Complexes Formed by Heteroaromatic Amines and Several 2‐Aminopurine Derivatives of the Antivirally Active Nucleotide Analog 9‐[2‐(Phosphonomethoxy)ethyl]adenine (PMEA)

H. Sigel, A. Sigel, A. Holý, 2012, Chemistry & biodiversity.

Multiple bacteria encode metallothioneins and SmtA‐like zinc fingers

P. Sadler, N. Robinson, M. Harrison, 2002, Molecular microbiology.

Structure and dynamics of metallomacrocycles: recognition of zinc xylyl-bicyclam by an HIV coreceptor.

Xiangyang Liang, Simon Parsons, Peter J Sadler, 2002, Journal of the American Chemical Society.

Solution properties of antiviral adenine-nucleotide analogues. The acid-base properties of 9-(2-(phosphonomethoxy)ethyl)adenine (PMEA) † and of its N1, N3 and N7 deaza derivatives in aqueous solution

H. Sigel, A. Holý, C. Blindauer, 1997 .

O2‐independent demethylation of trimethylamine N‐oxide by Tdm of Methylocella silvestris

T. Bugg, H. Schäfer, Yin Chen, 2016, The FEBS journal.

Diversity and distribution of plant metallothioneins: a review of structure, properties and functions.

C. Blindauer, Hasan T. Imam, O. I. Leszczyszyn, 2013, Metallomics : integrated biometal science.

A metalloproteomic analysis of interactions between plasma proteins and zinc: elevated fatty acid levels affect zinc distribution.

A. Stewart, James P. C. Coverdale, C. Blindauer, 2019, Metallomics : integrated biometal science.

Metallothioneins with unusual residues: histidines as modulators of zinc affinity and reactivity.

C. Blindauer, Claudia A. Blindauer, 2008, Journal of inorganic biochemistry.

Toward a property/function relationship for metallothioneins: Histidine coordination and unusual cluster composition in a zinc‐metallothionein from plants

R. Schmid, C. Blindauer, O. I. Leszczyszyn, 2007, Proteins.

A metallothionein containing a zinc finger within a four-metal cluster protects a bacterium from zinc toxicity

P. Sadler, N. Robinson, M. Harrison, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Metal complexes of N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN): Variable coordination numbers and geometries

P. Sadler, S. Parsons, C. Blindauer, 2006 .

Facilitation of the copper(II)-promoted dephosphorylation of adenosine 5′-triphosphate (ATP4–) by the antiviral nucleotide analogue, 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA)‡

H. Sigel, A. Holý, C. Blindauer, 1998 .

Unexpected Interactions of the Cyanobacterial Metallothionein SmtA with Uranium.

C. Acharya, C. Blindauer, Claudia A. Blindauer, 2016, Inorganic chemistry.

Lessons on the critical interplay between zinc binding and protein structure and dynamics.

C. Blindauer, Claudia A. Blindauer, 2013, Journal of inorganic biochemistry.

Allosteric modulation of zinc speciation by fatty acids.

P. Sadler, O. Kassaar, A. Stewart, 2013, Biochimica et biophysica acta.

A novel copper site in a cyanobacterial metallochaperone.

P. Sadler, C. Cooper, R. Schmid, 2004, The Biochemical journal.

The type 4 metallothionein from Brassica napus seeds folds in a metal-dependent fashion and favours zinc over other metals.

G. Dąbrowska, C. Blindauer, A. Mierek‐Adamska, 2018, Metallomics : integrated biometal science.

Acid–base properties of an antivirally active acyclic nucleoside phosphonate: (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine (HPMPA)

H. Sigel, A. Sigel, A. Holý, 2022, New Journal of Chemistry.

The potent anti-cancer activity of Dioclea lasiocarpa lectin.

P. Sadler, C. Nagano, B. Cavada, 2017, Journal of inorganic biochemistry.

CHAPTER 21:Metallothioneins

C. Blindauer, 2014 .

A Molecular Mechanism for Modulating Plasma Zn Speciation by Fatty Acids

P. Sadler, D. Sleep, T. Pinheiro, 2012, Journal of the American Chemical Society.

A metallothionein from an open ocean cyanobacterium removes zinc from the sensor protein controlling its transcription.

D. Scanlan, A. Mikhaylina, C. Blindauer, 2022, Journal of inorganic biochemistry.

Differential reactivity of closely related zinc(II)-binding metallothioneins from the plant Arabidopsis thaliana

C. Blindauer, Hasan T. Imam, Claudia A. Blindauer, 2017, JBIC Journal of Biological Inorganic Chemistry.

Cytosolic metal handling in plants: determinants for zinc specificity in metal transporters and metallothioneins.

R. Schmid, C. Blindauer, Claudia A. Blindauer, 2010, Metallomics : integrated biometal science.

Protein fractionation and detection for metalloproteomics: challenges and approaches

D. Scanlan, C. Blindauer, James P Barnett, 2012, Analytical and Bioanalytical Chemistry.

Mining Genomes of Marine Cyanobacteria for Elements of Zinc Homeostasis

D. Scanlan, R. Schmid, A. Millard, 2012, Front. Microbio..

Advances in the molecular understanding of biological zinc transport.

C. Blindauer, Claudia A. Blindauer, 2015, Chemical communications.

Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2.

P. Sadler, C. Farquharson, R. Schmid, 2005, Biochimica et biophysica acta.

Albumin as a zinc carrier: properties of its high-affinity zinc-binding site.

Peter J Sadler, P. Sadler, T. Pinheiro, 2008, Biochemical Society transactions.

Protein Disulfide-Isomerase Interacts with a Substrate Protein at All Stages along Its Folding Pathway

M. Howard, R. Williamson, L. Ruddock, 2014, PloS one.

Metallothioneins: unparalleled diversity in structures and functions for metal ion homeostasis and more.

C. Blindauer, O. I. Leszczyszyn, Claudia A. Blindauer, 2010, Natural product reports.

The isolated Cys2His2 site in EC metallothionein mediates metal-specific protein folding.

C. Blindauer, O. I. Leszczyszyn, Craig Roy J White, 2010, Molecular bioSystems.

Differential reactivity of individual zinc ions in clusters from bacterial metallothioneins

C. Blindauer, C. D. Evans, O. I. Leszczyszyn, 2007 .

C. elegans metallothioneins: response to and defence against ROS toxicity.

S. Stürzenbaum, J. Bundy, F. Geier, 2011, Molecular bioSystems.

The Tat protein export pathway and its role in cyanobacterial metalloprotein biosynthesis.

D. Scanlan, C. Robinson, C. Blindauer, 2011, FEMS microbiology letters.

Tools for metal ion sorting: in vitro evidence for partitioning of zinc and cadmium in C. elegans metallothionein isoforms.

S. Stürzenbaum, C. Blindauer, O. I. Leszczyszyn, 2011, Chemical communications.

Direct determination of free Zn concentration in samples of biological interest.

J. Galceran, J. Puy, E. Companys, 2022, Analytica chimica acta.

Metallothionein from Wild Populations of the African Catfish Clarias gariepinus: From Sequence, Protein Expression and Metal Binding Properties to Transcriptional Biomarker of Metal Pollution

S. Stürzenbaum, J. Yabe, K. Choongo, 2017, International journal of molecular sciences.

Bacterial catabolism of membrane phospholipids links marine biogeochemical cycles

D. Scanlan, M. Quareshy, Yin Chen, 2023, Science advances.

Biophysical characterization of a protein for structure comparison: methods for identifying insulin structural changes

A. Rodger, A. Reason, I. Prokes, 2016 .

Why is the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine in its diphosphorylated form (PMEApp4–) initially a better substrate for polymerases than (2′-deoxy)adenosine 5′-triphosphate (dATP4–/ATP4–)? Considerations on the mechanism of nucleic acid polymerases

H. Sigel, L. Kapinos, C. Blindauer, 1999 .

Zinc‐Handling in Cyanobacteria: An Update

C. Blindauer, Claudia A. Blindauer, 2008, Chemistry & biodiversity.

Albumin-mediated alteration of plasma zinc speciation by fatty acids modulates blood clotting in type-2 diabetes†

Terry K. Smith, A. Stewart, R. Ajjan, 2021, Chemical science.

Native electrospray mass spectrometry approaches to probe the interaction between zinc and an anti-angiogenic peptide from histidine-rich glycoprotein

P. Sadler, A. Stewart, J. Scrivens, 2018, Scientific Reports.

A Canonical EF‐Loop Directs Ca2+‐Sensitivity in Phospholipase C‐η2

R. Schmid, K. Morgan, R. Millar, 2014, Journal of cellular biochemistry.

The two Caenorhabditis elegans metallothioneins (CeMT‐1 and CeMT‐2) discriminate between essential zinc and toxic cadmium

M. Hodson, S. Stürzenbaum, J. Charnock, 2010, The FEBS journal.

Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins

W. Minor, O. Kassaar, M. Chruszcz, 2016, Chemical science.

Structural and biochemical characterisation of Co2+-binding sites on serum albumins and their interplay with fatty acids

W. Minor, A. Stewart, I. Shabalin, 2023, Chemical science.

Structure, Properties, and Engineering of the Major Zinc Binding Site on Human Albumin*

P. Sadler, D. Harrison, D. Sleep, 2009, The Journal of Biological Chemistry.