A. Drohat

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E2-mediated Small Ubiquitin-like Modifier (SUMO) Modification of Thymine DNA Glycosylase Is Efficient but Not Selective for the Enzyme-Product Complex*

M. Matunis, Catherine M. Guzzo, Megan E. Fitzgerald, 2014, The Journal of Biological Chemistry.

How a mismatch repair enzyme balances the needs for efficient lesion processing and minimal action on undamaged DNA

E. Pozharski, A. Maiti, A. Drohat, 2012, Cell cycle.

Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues

Kristen M Varney, E. Pozharski, Christopher T. Coey, 2016, Nucleic Acids Research.

Structural Basis for Excision of 5-Formylcytosine by Thymine DNA Glycosylase.

E. Pozharski, M. Greenberg, Christopher T. Coey, 2016, Biochemistry.

Divergent mechanisms for enzymatic excision of 5-formylcytosine and 5-carboxylcytosine from DNA.

A. Maiti, A. Drohat, Jeehiun K. Lee, 2013, Journal of the American Chemical Society.

TET-TDG active DNA demethylation at CpG and non-CpG sites.

R. Kohli, J. DeNizio, A. Drohat, 2021, Journal of molecular biology.

Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase

J. Walter, Magda Budzowska, A. Drohat, 2016, Cell.

Nucleosomes and the three glycosylases: High, medium, and low levels of excision by the uracil DNA glycosylase superfamily.

A. Drohat, S. Delaney, Blaine J Dow, 2018, DNA repair.

Structural Insights into the Mechanism of Base Excision by MBD4.

E. Pozharski, S. David, W. Lin, 2021, Journal of molecular biology.

Excision of 5-carboxylcytosine by Thymine DNA Glycosylase.

Qing Dai, E. Pozharski, A. Drohat, 2019, Journal of the American Chemical Society.

Kinetic Methods for Studying DNA Glycosylases Functioning in Base Excision Repair.

Christopher T. Coey, A. Drohat, 2017, Methods in enzymology.

Characterizing Requirements for Small Ubiquitin-like Modifier (SUMO) Modification and Binding on Base Excision Repair Activity of Thymine-DNA Glycosylase in Vivo*

M. Matunis, Christopher T. Coey, A. Drohat, 2016, The Journal of Biological Chemistry.

In vivo effects of sumoylation on TDG activity 1 Characterizing Requirements for SUMO Modification and Binding on Base Excision Repair Activity of Thymine DNA Glycosylase in Vivo

M. Matunis, Christopher T. Coey, A. Drohat, 2016 .

S100B(ββ) inhibits the protein kinase C‐dependent phosphorylation of a peptide derived from p53 in a Ca2+‐dependent manner

David J Weber, P. Wilder, R. Rustandi, 1998 .

Solution structure of calcium-bound rat S100B(betabeta) as determined by nuclear magnetic resonance spectroscopy,.

David J Weber, D. Baldisseri, R. Rustandi, 1998, Biochemistry.

The role of cysteine residues in S100B dimerization and regulation of target protein activity.

David J Weber, J. Correia, D. Zimmer, 1997, Biochimica et biophysica acta.

Oligomerization state of S100B at nanomolar concentration determined by large‐zone analytical gel filtration chromatography

D. Beckett, A. Drohat, David J. Weber, 1997, Protein science : a publication of the Protein Society.

Solution structure of rat apo-S100B(beta beta) as determined by NMR spectroscopy.

David J Weber, D. Baldisseri, F. Abildgaard, 1996, Biochemistry.

Role of electrophilic and general base catalysis in the mechanism of Escherichia coli uracil DNA glycosylase.

J. Stivers, A. Drohat, J. Jagadeesh, 1999, Biochemistry.

Probing the Limits of Electrostatic Catalysis by Uracil DNA Glycosylase Using Transition State Mimicry and Mutagenesis* 210

J. Stivers, Y. Ichikawa, A. Drohat, 2002, The Journal of Biological Chemistry.

Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: Structure and glycosylase mechanism revisited

G. Gilliland, G. Xiao, J. Stivers, 1999, Proteins.

Role of Base Excision "Repair" Enzymes in Erasing Epigenetic Marks from DNA.

Christopher T. Coey, A. Drohat, 2016, Chemical reviews.

Mechanisms for enzymatic cleavage of the N-glycosidic bond in DNA.

A. Maiti, A. Drohat, 2014, Organic & biomolecular chemistry.

Excision of 5-Halogenated Uracils by Human Thymine DNA Glycosylase

A. Drohat, M. Morgan, Matthew T. Bennett, 2007, Journal of Biological Chemistry.

Specificity of human thymine DNA glycosylase depends on N-glycosidic bond stability.

M. Rodgers, Alexander S. Hebert, A. Drohat, 2006, Journal of the American Chemical Society.

Uracil DNA glycosylase: insights from a master catalyst.

J. Stivers, A. Drohat, 2001, Archives of biochemistry and biophysics.

Dependence of substrate binding and catalysis on pH, ionic strength, and temperature for thymine DNA glycosylase: Insights into recognition and processing of G·T mispairs.

A. Maiti, A. Drohat, 2011, DNA repair.

Coordinating the Initial Steps of Base Excision Repair

Megan E. Fitzgerald, A. Drohat, Megan E Fitzgerald, 2008, Journal of Biological Chemistry.

Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition

E. Pozharski, A. Maiti, A. Drohat, 2008, Proceedings of the National Academy of Sciences.

Escherichia coli uracil DNA glycosylase: NMR characterization of the short hydrogen bond from His187 to uracil O2.

J. Stivers, A. Drohat, 2000, Biochemistry.

NMR Evidence for an Unusually Low N1 pKa for Uracil Bound to Uracil DNA Glycosylase: Implications for Catalysis

J. Stivers, A. Drohat, 2000 .

Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: electrophilic catalysis of uracil expulsion by a neutral histidine 187.

G. Gilliland, G. Xiao, J. Stivers, 1999, Biochemistry.

DNA repair | DNA Glycosylases

A. Drohat, 2021, Encyclopedia of Biological Chemistry III.

Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA

E. Pozharski, Christopher T. Coey, A. Drohat, 2015, Nucleic acids research.

Crystal structure of human methyl-binding domain IV glycosylase bound to abasic DNA.

E. Toth, Matthew C. Begley, A. Maiti, 2012, Journal of molecular biology.

Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA

Alexander D. MacKerell, M. Noon, E. Pozharski, 2012, Proceedings of the National Academy of Sciences.

Solution Structure and Base Perturbation Studies Reveal a Novel Mode of Alkylated Base Recognition by 3-Methyladenine DNA Glycosylase I*

J. Stivers, C. Cao, A. Drohat, 2003, Journal of Biological Chemistry.

Thymine DNA Glycosylase Can Rapidly Excise 5-Formylcytosine and 5-Carboxylcytosine

A. Maiti, A. Drohat, 2011, The Journal of Biological Chemistry.

The Ca2+-Dependent Interaction of S100B(ββ) with a Peptide Derived from p53†

David J Weber, P. Wilder, D. Baldisseri, 1998 .

Defining the Role of Nucleotide Flipping in Enzyme Specificity Using 19F NMR.

A. Drohat, S. Malik, Blaine J Dow, 2019, Journal of the American Chemical Society.

Structure of human apurinic/apyrimidinic endonuclease 1 with the essential Mg2+ cofactor

E. Pozharski, E. Toth, A. Drohat, 2013, Acta crystallographica. Section D, Biological crystallography.

Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites.

A. Bellacosa, A. Drohat, 2015, DNA repair.

Lesion search and recognition by thymine DNA glycosylase revealed by single molecule imaging

I. Tessmer, A. Maiti, A. Drohat, 2015, Nucleic acids research.

Stoichiometry and affinity for thymine DNA glycosylase binding to specific and nonspecific DNA

Megan E. Fitzgerald, A. Maiti, A. Drohat, 2010, Nucleic acids research.

S100B(betabeta) inhibits the protein kinase C-dependent phosphorylation of a peptide derived from p53 in a Ca2+-dependent manner.

David J Weber, P. Wilder, R. Rustandi, 1998, Protein science : a publication of the Protein Society.

Characterizing inhibitors of human AP endonuclease 1

E. Pozharski, A. Drohat, M. E. Cook, 2023, PloS one.

Coordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions.

Weirong Yuan, Wuyuan Lu, A. Lu, 2013, DNA repair.

3-methyladenine DNA glycosylase I is an unexpected helix-hairpin-helix superfamily member

J. Stivers, A. Drohat, K. Kwon, 2002, Nature Structural Biology.

The human checkpoint sensor Rad9–Rad1–Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase

A. Lu, D. Chang, A. Madabushi, 2007, Nucleic acids research.

NMR studies reveal an unexpected binding site for a redox inhibitor of AP endonuclease 1.

A. Drohat, K. Seley‐Radtke, Orrette R Wauchope, 2011, Biochemistry.

Functional Assessment of Population and Tumor-Associated APE1 Protein Variants

J. Illuzzi, A. Drohat, Mengxia Li, 2013, PloS one.

Role of Two Strictly Conserved Residues in Nucleotide Flipping and N-Glycosylic Bond Cleavage by Human Thymine DNA Glycosylase*

A. Maiti, A. Drohat, M. Morgan, 2009, The Journal of Biological Chemistry.

Rapid excision of oxidized adenine by human thymine DNA glycosylase

A. Drohat, L. Pidugu, Matthew E Sherman, 2022, The Journal of biological chemistry.

TDG excision of fC may be a predominant element of pathways for active DNA demethylation

A. Maiti, A. Drohat, Cherece J. Armwood, 2013 .

Raman spectroscopy of uracil DNA glycosylase-DNA complexes: insights into DNA damage recognition and catalysis.

P. Carey, J. Stivers, J. Dong, 2000, Biochemistry.

The Ca(2+)-dependent interaction of S100B(beta beta) with a peptide derived from p53.

David J Weber, P. Wilder, D. Baldisseri, 1998, Biochemistry.

The use of dipolar couplings for determining the solution structure of rat apo‐S100B(ββ)

David J Weber, N. Tjandra, D. Baldisseri, 2008, Protein science : a publication of the Protein Society.

Chemical shift assignments for human apurinic/apyrimidinic endonuclease 1

A. Drohat, Kristen M. Varney, Brittney A. Manvilla, 2010, Biomolecular NMR assignments.

Thymine DNA Glycosylase Can Rapidly Excise 5-Formylcytosine and 5-Carboxylcytosine

A. Maiti, A. Drohat, 2011, The Journal of Biological Chemistry.

Role of Base Excision "Repair" Enzymes in Erasing Epigenetic Marks from DNA.

Christopher T. Coey, A. Drohat, 2016, Chemical reviews.

Biological Crystallography Structure of Human Apurinic/apyrimidinic Endonuclease 1 with the Essential Mg 2+ Cofactor

E. Pozharski, E. Toth, A. Drohat, 2022 .

Mechanisms for enzymatic cleavage of the N-glycosidic bond in DNA.

A. Maiti, A. Drohat, 2014, Organic & biomolecular chemistry.

Defining the impact of sumoylation on substrate binding and catalysis by thymine DNA glycosylase

Christopher T. Coey, A. Drohat, 2018, Nucleic acids research.

Structural changes in the C‐terminus of Ca2+‐bound rat S100B(ββ) upon binding to a peptide derived from the C‐terminal regulatory domain of p53

David J Weber, D. Baldisseri, R. Rustandi, 1999, Protein science : a publication of the Protein Society.

Crystal structure of human methyl-binding domain IV glycosylase bound to abasic DNA.

E. Toth, Matthew C. Begley, A. Maiti, 2012, Journal of molecular biology.

Sumoylation of thymine DNA glycosylase impairs productive binding to substrate sites in DNA

A. Drohat, M. E. Cook, L. Pidugu, 2024, The Journal of biological chemistry.

Single-molecule analysis reveals TDG exhibits multiple modes of linear diffusion to process 5-formylcytosine.

V. Roginskaya, B. V. Houten, M. Schaich, 2023 .

Chemical shift assignments for human apurinic/apyrimidinic endonuclease 1

A. Drohat, Kristen M. Varney, Brittney A. Manvilla, 2010, Biomolecular NMR assignments.