Graham L. Smith

发表

Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant

Huichun Zhu, Benjamin J. Burke, John Charles Kath, 2014 .

4-methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors.

D. Knighton, M. Nambu, K. Liu, 2010, Bioorganic & medicinal chemistry letters.

Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain expos

Wei Liu, Huichun Zhu, Dac Dinh, 2014, Journal of medicinal chemistry.

Highly Selective and Potent Thiophenes as PI3K Inhibitors with Oral Antitumor Activity.

G. Paderes, N. Sach, K. Liu, 2011, ACS medicinal chemistry letters.

Development of Scalable Syntheses of Selective PI3K inhibitors

N. Sach, K. Liu, P. Richardson, 2011 .

Development of a Late-Stage Diversification Strategy for the 4- and 5-Positions of 4,5,6-Trisubstituted Indazoles.

M. Tran-Dube, M. Collins, Fen Wang, 2020, Organic letters.

Acidic triazoles as soluble guanylate cyclase stimulators.

P. A. Bradley, M. Bunnage, Y. M. Fobian, 2011, Bioorganic & medicinal chemistry letters.

Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK.

A. Kuki, S. Butler, Buwen Huang, 2010, Bioorganic & medicinal chemistry letters.

Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib.

N. Sach, Hong Shen, M. McTigue, 2014, Journal of medicinal chemistry.

Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.

N. Sach, M. McTigue, Sergei L Timofeevski, 2023, Journal of medicinal chemistry.

Diastereoselective access to substituted 4-aminopiperidines via a pyridine reduction approach

N. Sach, G. Gallego, Graham L. Smith, 2016 .

Design and synthesis of novel N-hydroxy-dihydronaphthyridinones as potent and orally bioavailable HIV-1 integrase inhibitors.

A. Kuki, S. Butler, Guy A. McClellan, 2011, Journal of medicinal chemistry.

Abstract PR10: Is CNS availability for oncology a no-brainer? Discovery of PF-06463922, a novel small molecule inhibitor of ALK/ROS1 with preclinical brain availability and broad spectrum potency against ALK-resistant mutations.

N. Sach, M. McTigue, H. Zou, 2013 .

Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant

N. Sach, H. Zou, R. Kania, 2014 .