Christopher M. Tan

发表

Peptidase Type I Antibiotics through Inhibition of Signal-Lactam β Broadening the Spectrum of

Alexandre Caron, Mihai Petcu, Kenneth E. Wilson, 2012 .

Quantitation of wall teichoic acid in Staphylococcus aureus by direct measurement of monomeric units using LC-MS/MS.

D. McLaren, Hao Wang, P. Sheth, 2017, Analytical biochemistry.

Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus.

T. Roemer, S. Koseoglu, Jianping Pan, 2016, Bioorganic & medicinal chemistry letters.

Discovery of potent wall teichoic acid early stage inhibitors.

T. Roemer, S. Koseoglu, C. Garlisi, 2016, Bioorganic & medicinal chemistry letters.

TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci

T. Roemer, Xinwei Sher, S. Koseoglu, 2016, Science Translational Medicine.

Broadening the Spectrum of β-Lactam Antibiotics through Inhibition of Signal Peptidase Type I

J. Phillips, A. Therien, P. Beaulieu, 2012, Antimicrobial Agents and Chemotherapy.

NMR Binding and Functional Assays for Detecting Inhibitors of S. aureus MnaA

M. McCoy, D. Wyss, T. Roemer, 2016, Journal of biomolecular screening.

In Vitro and In Vivo Characterization of the Novel Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase

Akinori Nishimura, Jin Wu, C. Garlisi, 2016, Antimicrobial Agents and Chemotherapy.

Broadening the Spectrum of (cid:1) -Lactam Antibiotics through Inhibition of Signal Peptidase Type I

J. Phillips, A. Therien, P. Beaulieu, 2012 .

Restoring Methicillin-Resistant Staphylococcus aureus Susceptibility to β-Lactam Antibiotics

Eric Langlois, Alexandre Caron, Mihai Petcu, 2012, Science Translational Medicine.

Murgocil is a highly bioactive staphylococcal-specific inhibitor of the peptidoglycan glycosyltransferase enzyme MurG.

P. M. Pereira, F. Monsma, T. Roemer, 2013, ACS chemical biology.

Discovery of wall teichoic acid inhibitors as potential anti-MRSA β-lactam combination agents.

T. Roemer, Timothy C. Meredith, S. Walker, 2013, Chemistry & biology.

Use of Translational Pharmacokinetic/Pharmacodynamic Infection Models To Understand the Impact of Neutropenia on the Efficacy of Tedizolid Phosphate

S. Flanagan, Jin Wu, C. Gill, 2018, Antimicrobial Agents and Chemotherapy.

Effect of Suberoylanilide Hydroxamic Acid (SAHA) Administration on the Residual Virus Pool in a Model of Combination Antiretroviral Therapy-Mediated Suppression in SIVmac239-Infected Indian Rhesus Macaques

Octavio A. Quiñones, D. Hazuda, J. Lifson, 2014, Antimicrobial Agents and Chemotherapy.

Effect of SAHA administration on the residual virus pool in a model of combination

Octavio A. Quiñones, D. Hazuda, J. Lifson, 2014 .

Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase

T. Roemer, Xinwei Sher, G. Scapin, 2017, PloS one.

Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor.

T. Roemer, S. Koseoglu, P. Tawa, 2017, Journal of medicinal chemistry.

Use of translational PKPD infection models to understand impact of neutropenia on efficacy of tedizolid phosphate

Jin Wu, C. Gill, Jianying Xiao, 2017 .

Structure activity relationship of C-2 ether substituted 1,5-naphthyridine analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-5).

Akinori Nishimura, Jin Wu, P. Meinke, 2015, Bioorganic & medicinal chemistry letters.

Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3).

R. Nargund, Akinori Nishimura, Jin Wu, 2015, Bioorganic & medicinal chemistry letters.

Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2).

Leo A. Joyce, E. Sherer, R. Nargund, 2015, Bioorganic & medicinal chemistry letters.

Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents.

Sangita Patel, Jin Wu, P. Meinke, 2014, ACS medicinal chemistry letters.

C1–C2-linker substituted 1,5-naphthyridine analogues of oxabicyclooctane-linked NBTIs as broad-spectrum antibacterial agents (part 7)

Akinori Nishimura, Jin Wu, Xuanjia Peng, 2015 .

Structure activity relationship of pyridoxazinone substituted RHS analogs of oxabicyclooctane-linked 1,5-naphthyridinyl novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-6).

Akinori Nishimura, Jin Wu, Xuanjia Peng, 2015, Bioorganic & medicinal chemistry letters.

Daptomycin for Pediatric Gram-Positive Acute Hematogenous Osteomyelitis

P. Bokesch, J. Bradley, M. Dorr, 2020, The Pediatric infectious disease journal.

Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3).

R. Nargund, Akinori Nishimura, Jin Wu, 2015, Bioorganic & medicinal chemistry letters.

Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents.

Sangita Patel, Jin Wu, P. Meinke, 2014, ACS medicinal chemistry letters.