T. Owen

发表

Expression of connective tissue growth factor in bone: Its role in osteoblast proliferation and differentiation in vitro and bone formation in vivo

Jie Xu, S. Marks, S. Popoff, 2003, Journal of cellular physiology.

Factors that promote progressive development of the osteoblast phenotype in cultured fetal rat calvaria cells

G. Stein, J. Lian, L. Gerstenfeld, 1990, Journal of cellular physiology.

Osteoactivin acts as downstream mediator of BMP‐2 effects on osteoblast function

M. Barbe, S. Popoff, F. Safadi, 2007, Journal of cellular physiology.

Regulation of transcription‐factor activity during growth and differentiation: Involvement of the nuclear matrix in concentration and localization of promoter binding proteins

G. Stein, J. Lian, A. V. van Wijnen, 1991, Journal of cellular biochemistry.

A Nonprostanoid EP4 Receptor Selective Prostaglandin E2 Agonist Restores Bone Mass and Strength in Aged, Ovariectomized Rats

V. Paralkar, D. Scott, W. Jee, 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Cloning and Characterization of a Novel Member of the Transforming Growth Factor-β/Bone Morphogenetic Protein Family*

S. Vukicevic, V. Paralkar, H. Ke, 1998, The Journal of Biological Chemistry.

Molecular Approaches to the Characterization of Cell and Blood/Biomaterial Interactions

G. Stein, J. Lian, K. Dasse, 1992, Journal of cardiac surgery.

Connective tissue growth factor (CTGF) acts as a downstream mediator of TGF‐β1 to induce mesenchymal cell condensation

M. Barbe, M. Rico, S. Popoff, 2007, Journal of cellular physiology.

The onset and progression of osteoblast differentiation is functionally related to cellular proliferation.

G. Stein, J. Lian, V. Shalhoub, 1989, Connective tissue research.

An EP2 receptor-selective prostaglandin E2 agonist induces bone healing

S. Vukicevic, V. Paralkar, F. Borovečki, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The role of connective tissue growth factor (CTGF/CCN2) in skeletogenesis.

Alex G. Lambi, J. A. Arnott, S. Popoff, 2011, Critical reviews in eukaryotic gene expression.

Prostate-derived factor and growth and differentiation factor-8: newly discovered members of the TGF-β superfamily

S. Vukicevic, V. Paralkar, T. Owen, 2002 .

Expression of heat shock genes during differentiation of mammalian osteoblasts and promyelocytic leukemia cells

G. Stein, J. Lian, J. Stein, 1992, Journal of cellular biochemistry.

Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription.

K. Wright, A. V. van Wijnen, V. Shalhoub, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Temporal and spatial expression of osteoactivin during fracture repair

M. Barbe, M. Hadjiargyrou, S. Popoff, 2010, Journal of cellular biochemistry.

Effects of CP-336,156, a New, Nonsteroidal Estrogen Agonist/Antagonist, on Bone, Serum Cholesterol, Uterus, and Body Composition in Rat Models.

V. Paralkar, W. Jee, H. Ke, 1998, Endocrinology.

Estrogen Receptor-α Is Developmentally Regulated during Osteoblast Differentiation and Contributes to Selective Responsiveness of Gene Expression.

B. Komm, G. Stein, J. Lian, 1998, Endocrinology.

Differential expression of the chromosomal high mobility group proteins 14 and 17 during the onset of differentiation in mammalian osteoblasts and promyelocytic leukemia cells

G. Stein, J. Lian, M. Bustin, 1993, Journal of cellular biochemistry.

TGFβ1 Prevents the down‐regulation of type I procollagen, fibronectin, and TGFβ1 gene expression associated with 3T3‐L1 pre‐adipocyte differentiation

G. Stein, J. Stein, R. Bortell, 1994 .

Influence of dexamethasone on the vitamin D–mediated regulation of osteocalcin gene expression

G. Stein, J. Lian, E. Breen, 1991, Journal of cellular biochemistry.

Postproliferative transcription of the rat osteocalcin gene is reflected by vitamin D-responsive developmental modifications in protein-DNA interactions at basal and enhancer promoter elements.

G. Stein, J. Lian, J. Stein, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Evidence that the time of entry into S is determined by events occurring in early G1.

D. Soprano, S. Cosenza, K. Soprano, 1988, The Journal of biological chemistry.

Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats.

V. Paralkar, D. Scott, M. Chu-Moyer, 2006, Bioorganic & medicinal chemistry letters.

Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation.

V. Paralkar, B. Lefker, H. Ke, 2009, Bioorganic & medicinal chemistry letters.

Expression of growth-associated genes in various tissues of the fetal and adult rat

D. Soprano, S. Cosenza, K. Soprano, 1987, Molecular and Cellular Biochemistry.

Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis

V. Paralkar, L. Buckbinder, J. Kath, 2007, Proceedings of the National Academy of Sciences.

Time of c-fos and c-myc expression in human diploid fibroblasts stimulated to proliferate after prolonged periods in quiescence.

D. Soprano, S. Cosenza, K. Soprano, 1987, The Journal of biological chemistry.

1α,25‐Dihydroxyvitamin D3 rapidly increases cytosolic calcium in clonal rat osteosarcoma cells lacking the vitamin D Receptor

G. Stein, J. Lian, V. Shalhoub, 1991 .

Developmental expression and hormonal regulation of the rat matrix GLA protein (MGP) gene in chondrogenesis and osteogenesis

G. Stein, J. Lian, R. Bortell, 1991, Journal of cellular biochemistry.

The rapid nongenomic actions of 1α,25‐dihydroxyvitamin D3 modulate the hormone‐induced increments in osteocalcin gene transcription in osteoblast‐like cells

G. Stein, J. Lian, V. Shalhoub, 1992, Journal of cellular biochemistry.

Identification and characterization of the genes encoding human and mouse osteoactivin.

S. Marks, S. Popoff, F. Safadi, 2003, Critical reviews in eukaryotic gene expression.

Molecular cloning and characterization of the canine prostaglandin E receptor EP2 subtype.

P. Vestergaard, S. Smock, T. Owen, 1999, Prostaglandins & other lipid mediators.

Analysis of the growth factor requirements for stimulation of WI‐38 cells after extended periods of density‐dependent growth arrest

D. Soprano, K. Soprano, T. Owen, 1989, Journal of cellular physiology.

KMN-159, a novel EP4 receptor selective agonist, stimulates osteoblastic differentiation in cultured whole rat bone marrow.

S. Barrett, T. Owen, M. I. Morano, 2020, Gene.

A Novel, Non‐Prostanoid EP2 Receptor‐Selective Prostaglandin E2 Agonist Stimulates Local Bone Formation and Enhances Fracture Healing

V. Paralkar, B. Lefker, H. Ke, 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Osteoactivin, an anabolic factor that regulates osteoblast differentiation and function.

Michael G. Anderson, M. Barbe, M. Rico, 2008, Experimental cell research.

Effects of 1,25(OH)2D3 and vitamin D analogs on developmental control of cell growth and tissue-specific gene expression during osteoblast differentiation

G. Stein, J. Lian, V. Shalhoub, 1993 .

VITAMIN D REGULATION OF THE BONE SPECIFIC OSTEOCALCIN GENE IS FUNCTIONALLY RELATED TO OSTEOBLAST GROWTH AND DIFFERENTIATION

G. Stein, J. Lian, J. Bidwell, 1991 .

Inhibition of induced endochondral bone development in caffeine‐treated rats

G. Stein, J. Lian, R. Bortell, 1993, Journal of cellular biochemistry.

Normalization of multiple RNA samples using an in vitro-synthesized external standard cRNA.

A. Toscani, D. Soprano, S. Cosenza, 1987, Analytical biochemistry.

Transgenic Expression of Osteoactivin/gpnmb Enhances Bone Formation In Vivo and Osteoprogenitor Differentiation Ex Vivo

M. Barbe, S. Popoff, Nagat A Frara, 2016, Journal of cellular physiology.

Expression of c-myc and induction of DNA synthesis by platelet-poor plasma in human diploid fibroblasts.

S. Ferrari, B. Calabretta, R. Baserga, 1988, Experimental cell research.

Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists.

B. Lefker, R. Chesworth, T. Owen, 2004, Bioorganic & medicinal chemistry letters.

Variations in vitamin D receptor transcription factor complexes associated with the osteocalcin gene vitamin D responsive element in osteoblasts and osteosarcoma cells

G. Stein, J. Lian, A. V. van Wijnen, 1994, Journal of cellular biochemistry.

Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E(2) receptor EP2 subtype.

R. J. Mather, S. Smock, T. Owen, 1999, Gene.

Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix

G. Stein, J. Lian, M. Kennedy, 1990, Journal of cellular physiology.

Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands.

Matthew D. Wessel, M. Wessel, B. Lefker, 2005, Bioorganic & medicinal chemistry letters.

Constitutive transcription of the osteocalcin gene in osteosarcoma cells is reflected by altered protein-DNA interactions at promoter regulatory elements.

G. Stein, J. Lian, J. Stein, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Vitamin D-responsive protein-DNA interactions at multiple promoter regulatory elements that contribute to the level of rat osteocalcin gene expression.

P. Gavazzo, G. Stein, J. Lian, 1992, Proceedings of the National Academy of Sciences of the United States of America.

10 – Molecular Mechanisms That Mediate a Functional Relationship between Proliferation and Differentiation

G. Stein, J. Lian, R. Bortell, 1992 .

Relationship of cell growth to the regulation of tissue‐specific gene expression during osteoblast differentiation

G. Stein, J. Lian, T. Owen, 1990, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Identification and characterization of two proximal elements in the rat osteocalcin gene promoter that may confer species‐specific regulation

G. Stein, J. Lian, J. Stein, 1993, Journal of cellular biochemistry.

6 – Gene Expression during Development of the Osteoblast Phenotype: An Integrated Relationship of Cell Growth to Differentiation

G. Stein, J. Lian, V. Shalhoub, 1992 .

Cell Structure and the Regulation of Genes Controlling Proliferation and Differentiation: The Nuclear Matrix and Cytoskeleton

G. Stein, J. Lian, J. Stein, 1991 .

Coordination of protein‐DNA interactions in the promoters of human H4, H3, and H1 histone genes during the cell cycle, tumorigenesis, and development

G. Stein, J. Lian, A. V. van Wijnen, 1991, Journal of cellular physiology.

Transcriptional element H4‐site II of cell cycle regulated human H4 histone genes is a multipartite protein/DNA interaction site for factors HiNF‐D, HiNF‐M, and HiNF‐P: Involvement of phosphorylation

G. Stein, J. Lian, A. V. van Wijnen, 1991, Journal of cellular biochemistry.

Tumor cells exhibit deregulation of the cell cycle histone gene promoter factor HiNF-D.

J. Lian, M. Kennedy, K. Wright, 1990, Science.

Difluoromethylene at the γ-Lactam α-Position Improves 11-Deoxy-8-aza-PGE1 Series EP4 Receptor Binding and Activity: 11-Deoxy-10,10-difluoro-8-aza-PGE1 Analog (KMN-159) as a Potent EP4 Agonist.

S. Barrett, F. Ciske, T. Owen, 2019, Journal of medicinal chemistry.

Modifications of protein-DNA interactions in the proximal promoter of a cell-growth-regulated histone gene during onset and progression of osteoblast differentiation.

G. Stein, J. Lian, A. V. van Wijnen, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Cloning and characterization of osteoactivin, a novel cDNA expressed in osteoblasts

Jie Xu, M. Rico, S. Popoff, 2001, Journal of cellular biochemistry.

Properties of blood‐contacting surfaces of clinically implanted cardiac assist devices: Gene expression, matrix composition, and ultrastructural characterization of cellular linings

G. Stein, J. Lian, S. Pockwinse, 1995, Journal of cellular biochemistry.

Evidence that density‐dependent growth arrest is a two‐stage process in WI‐38 cells

D. Soprano, K. Soprano, T. Owen, 1990, Journal of cellular physiology.

Molecular requirements for induction of CTGF expression by TGF-beta1 in primary osteoblasts.

X. Zhang, A. Sanjay, S. Popoff, 2008, Bone.

Molecular cloning and functional characterization of the canine androgen receptor

S. Smock, T. Owen, B. Lu, 2001, Molecular and Cellular Biochemistry.

Regulation of BMP‐7 expression by retinoic acid and prostaglandin E2

S. Vukicevic, V. Paralkar, F. Borovečki, 2002, Journal of cellular physiology.

Involvement of the cell cycle-regulated nuclear factor HiNF-D in cell growth control of a human H4 histone gene during hepatic development in transgenic mice.

R. Jaenisch, G. Stein, J. Lian, 1991, Proceedings of the National Academy of Sciences of the United States of America.

The role of osteoactivin-derived peptides in osteoblast differentiation.

S. Popoff, F. Safadi, T. Owen, 2007, Medical science monitor : international medical journal of experimental and clinical research.

Anti-osteoactivin antibody inhibits osteoblast differentiation and function in vitro.

S. Popoff, F. Safadi, Samir M. Abdelmagid, 2003, Critical reviews in eukaryotic gene expression.

1 Alpha,25-dihydroxyvitamin D3 rapidly increases cytosolic calcium in clonal rat osteosarcoma cells lacking the vitamin D receptor.

G. Stein, J. Lian, V. Shalhoub, 1991, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Molecular cloning and functional characterization of the canine parathyroid hormone/parathyroid hormone related peptide receptor (PTH1)

S. Smock, T. Owen, B. Lu, 2004, Molecular Biology Reports.

A comparison of the anabolic effects of rat and bovine parathyroid hormone (1-34) in ovariectomized rats.

D. Thompson, H. Ke, T. Owen, 2001, Journal of musculoskeletal & neuronal interactions.

Phenotype suppression: A postulated molecular mechanism for mediating the relationship of proliferation and differentiation by Fos/Jun interactions at AP‐1 sites in steroid responsive promoter elements of tissue‐specific genes

G. Stein, J. Lian, R. Bortell, 1991, Journal of cellular biochemistry.

Cell Structure and Gene Expression: Contributions of the Extracellular Matrix to Regulation of Osteoblast Growth and Differentiation

G. Stein, J. Lian, S. Pockwinse, 1991 .

Bone cell differentiation: a functionally coupled relationship between expression of cell-growth- and tissue-specific genes.

G. Stein, J. Lian, T. Owen, 1990, Current opinion in cell biology.

Molecular cloning and functional characterization of the canine prostaglandin E2 receptor EP4 subtype.

S. Smock, T. Owen, B. Lu, 2001, Prostaglandins & other lipid mediators.