Zhufang Li

发表

Targeting a binding pocket within the trimer-of-hairpins: small-molecule inhibition of viral fusion.

N. Meanwell, D. Langley, C. Cianci, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Maturation Inhibitor with Improved Potency, Anti-viral Spectrum and Gag Polymorphic

N. Meanwell, Zeyu Lin, M. Krystal, 2016 .

Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage

N. Meanwell, Zeyu Lin, M. Krystal, 2016, Antimicrobial Agents and Chemotherapy.

Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.

B. Beno, N. Meanwell, Zeyu Lin, 2016, ACS medicinal chemistry letters.

Biochemical Analysis of HIV-1 Integrase Variants Resistant to Strand Transfer Inhibitors*

Zeyu Lin, M. Krystal, B. Terry, 2008, Journal of Biological Chemistry.

Respiratory syncytial virus fusion inhibitors. Part 6: an examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety.

N. Meanwell, D. Langley, I. Medina, 2007, Bioorganic & medicinal chemistry letters.

Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity.

N. Meanwell, D. Langley, C. Cianci, 2007, Bioorganic & medicinal chemistry letters.

Activity of the HIV-1 Attachment Inhibitor BMS-626529, the Active Component of the Prodrug BMS-663068, against CD4-Independent Viruses and HIV-1 Envelopes Resistant to Other Entry Inhibitors

M. Krystal, N. Ray, G. Hanna, 2013, Antimicrobial Agents and Chemotherapy.

Discovery and Characterization of a Novel CD4-Binding Adnectin with Potent Anti-HIV Activity

D. Fabrizio, M. Krystal, M. Cockett, 2017, Antimicrobial Agents and Chemotherapy.

Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase.

J. Snyder, V. Bond, D. Liotta, 2015, ACS medicinal chemistry letters.

Respiratory syncytial virus fusion inhibitors. Part 4: optimization for oral bioavailability.

A. Marino, N. Meanwell, I. Medina, 2007, Bioorganic & medicinal chemistry letters.

Oral Efficacy of a Respiratory Syncytial Virus Inhibitor in Rodent Models of Infection

N. Meanwell, I. Medina, C. Cianci, 2004, Antimicrobial Agents and Chemotherapy.

Evaluation of HIV-1 inhibition by stereoisomers and analogues of the sesquiterpenoid hydroquinone peyssonol A.

N. Meanwell, M. Krystal, S. Snyder, 2013, Bioorganic & medicinal chemistry letters.

Changes to the HIV Long Terminal Repeat and to HIV Integrase Differentially Impact HIV Integrase Assembly, Activity, and the Binding of Strand Transfer Inhibitors*

D. Langley, M. Krystal, M. A. Walker, 2007, Journal of Biological Chemistry.

Rings and filaments of β protein from bacteriophage λ suggest a superfamily of recombination proteins

E. Egelman, S. Passy, Xiong Yu, 1999 .

Clinical evidence for a lack of cross-resistance between temsavir and ibalizumab or maraviroc

M. Krystal, M. Cockett, R. Rose, 2021, AIDS.

International Congress of Drug Therapy in HIV Infection 23-26 October 2016, Glasgow, UK

Raúl Tabarés Gutiérrez, Samit R. Joshi, H. Jessen, 2016, Journal of the International AIDS Society.

GSK3732394: a Multi-specific Inhibitor of HIV Entry

D. Langley, P. Nef, M. Krystal, 2019, Journal of Virology.

A Novel gp41-Binding Adnectin with Potent Anti-HIV Activity Is Highly Synergistic when Linked to a CD4-Binding Adnectin

D. Fabrizio, M. Krystal, M. Cockett, 2018, Journal of Virology.

The N17 region of gp41 in HIV-1 is the most conserved region in gp160. mRNA selection

D. Fabrizio, M. Krystal, M. Cockett, 2018 .

Resistance Mutations (NRTI) BMS-986001 against Known NRTI Nucleoside Reverse Transcriptase Inhibitor Cross-Resistance Profile of In Vitro

M. Krystal, G. Hanna, Tricia L. Protack, 2014 .

In Vitro Cross-Resistance Profile of Nucleoside Reverse Transcriptase Inhibitor (NRTI) BMS-986001 against Known NRTI Resistance Mutations

M. Krystal, G. Hanna, Tricia L. Protack, 2013, Antimicrobial Agents and Chemotherapy.

Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,1

B. Beno, N. Meanwell, V. Arora, 2018, Journal of medicinal chemistry.

The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.

N. Meanwell, Zeyu Lin, M. Krystal, 2018, Bioorganic & medicinal chemistry letters.

Impact of Integrase Sequences from HIV-1 Subtypes A6/A1 on the In Vitro Potency of Cabotegravir or Rilpivirine

J. van Lunzen, Ping Wang, M. Krystal, 2022, Antimicrobial agents and chemotherapy.

The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation.

A. Mathur, N. Meanwell, Zeyu Lin, 2022, Journal of medicinal chemistry.

Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity.

N. Meanwell, Zeyu Lin, M. Krystal, 2022, Journal of Medicinal Chemistry.

C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.

B. Beno, N. Meanwell, Zeyu Lin, 2016, Bioorganic & medicinal chemistry.

C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.

B. Beno, N. Meanwell, Zeyu Lin, 2016, Bioorganic & medicinal chemistry.