J. Akakpo

发表

Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice

H. Jaeschke, W. Ding, Hua Sun, 2021, Liver research.

Pleiotropic Role of p53 in Injury and Liver Regeneration after Acetaminophen Overdose.

H. Jaeschke, Prachi Borude, B. Bhushan, 2018, The American journal of pathology.

Environmental Liver Toxins

H. Jaeschke, A. Ramachandran, J. Akakpo, 2019, Encyclopedia of Environmental Health.

Fructose Protects Against Acetaminophen‐Induced Hepatotoxicity Mainly by Activating the Carbohydrate‐Response Element‐Binding Protein α–Fibroblast Growth Factor 21 Axis in Mice

P. Saha, H. Jaeschke, L. Yin, 2021, Hepatology communications.

Novel Therapeutic Approaches against Acetaminophen-induced Liver Injury and Acute Liver Failure.

H. Jaeschke, A. Ramachandran, David S. Umbaugh, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Desorption Electrospray Ionization Mass Spectrometry Imaging Allows Spatial Localization of Changes in Acetaminophen Metabolism in the Liver after Intervention with 4-Methylpyrazole.

H. Jaeschke, A. Ramachandran, A. Artigues, 2022, Journal of the American Society for Mass Spectrometry.

4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes

H. Jaeschke, A. Ramachandran, B. Rumack, 2018, Human & experimental toxicology.

Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease.

M. Maes, M. Vinken, H. Jaeschke, 2018, Biochimica et biophysica acta. Molecular basis of disease.

Delayed Administration of N-Acetylcysteine Blunts Recovery After an Acetaminophen Overdose Unlike 4-Methylpyrazole

H. Jaeschke, A. Ramachandran, B. Rumack, 2021, Archives of Toxicology.

Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose

H. Jaeschke, A. Ramachandran, B. Rumack, 2022, Archives of Toxicology.

The Effect of 4-Methylpyrazole on Oxidative Metabolism of Acetaminophen in Human Volunteers

H. Jaeschke, B. Rumack, R. Gerkin, 2019, Journal of Medical Toxicology.

Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives

H. Jaeschke, A. Ramachandran, J. Akakpo, 2018, Journal of clinical and translational research.

The role of apoptosis in acetaminophen hepatotoxicity.

H. Jaeschke, A. Ramachandran, A. Farhood, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Mice deficient in pyruvate dehydrogenase kinase 4 are protected against acetaminophen-induced hepatotoxicity.

H. Jaeschke, A. Ramachandran, B. Woolbright, 2019, Toxicology and applied pharmacology.

Mitochondrial Protein Adduct and Superoxide Generation are Prerequisites for Early Activation of c-Jun N-terminal Kinase within the Cytosol after an Acetaminophen Overdose in Mice.

H. Jaeschke, A. Ramachandran, Nga T. Nguyen, 2020, Toxicology letters.

Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls

H. Jaeschke, A. Ramachandran, Nga T. Nguyen, 2021, Acta pharmaceutica Sinica. B.

4-methylpyrazole protects against acetaminophen-induced acute kidney injury.

H. Jaeschke, A. Ramachandran, B. Rumack, 2020, Toxicology and applied pharmacology.

Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose

H. Jaeschke, A. Ramachandran, B. Rumack, 2022, Archives of Toxicology.

Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase.

H. Jaeschke, A. Ramachandran, B. Rumack, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity

T. Luedde, J. Rahnenführer, A. Canbay, 2022, Journal of hepatology.

Novel strategies for the treatment of acetaminophen hepatotoxicity

H. Jaeschke, A. Ramachandran, J. Akakpo, 2020, Expert opinion on drug metabolism & toxicology.

Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice

H. Jaeschke, A. Ramachandran, W. Ding, 2021, Archives of Toxicology.

Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives

H. Jaeschke, A. Ramachandran, J. Akakpo, 2018, Journal of clinical and translational research.

Dual roles of p62/SQSTM1 in the injury and recovery phases of acetaminophen-induced liver injury in mice

K. Zatloukal, T. Rülicke, H. Jaeschke, 2021, Acta pharmaceutica Sinica. B.

Role of extracellular vesicles in release of protein adducts after acetaminophen-induced liver injury in mice and humans.

H. Jaeschke, A. Ramachandran, S. Curry, 2019, Toxicology letters.

Pre– and Post–Sexual Maturity Liver-specific ERα Knockout Does Not Impact Hepatic Mitochondrial Function

K. Shankar, J. Thyfault, J. Akakpo, 2023, Journal of the Endocrine Society.

Novel Therapeutic Approaches against Acetaminophen-induced Liver Injury and Acute Liver Failure.

H. Jaeschke, A. Ramachandran, David S. Umbaugh, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Nrf2 as a therapeutic target in acetaminophen hepatotoxicity: A case study with sulforaphane

H. Jaeschke, A. Ramachandran, Y. Etemadi, 2023, Journal of biochemical and molecular toxicology.

Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives.

H. Jaeschke, A. Ramachandran, J. Akakpo, 2018, Journal of Clinical and Translational Research.

High-Dose Acetaminophen with Concurrent CYP2E1 Inhibition Has Profound Anticancer Activity without Liver Toxicity

H. Jaeschke, J. Akakpo, Pavani Pingali, 2023, The Journal of Pharmacology and Experimental Therapeutics.

The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice.

J. Akakpo, A. Ramachandran, H. Jaeschke, 2024, Archives of toxicology.

Lack of Mitochondrial Cyp2E1 Drives Acetaminophen-induced ER Stress-mediated Apoptosis in Mouse and Human Kidneys: Inhibition by 4-Methylpyrazole but not N-Acetylcysteine.

H. Jaeschke, A. Ramachandran, J. Akakpo, 2023, Toxicology.