H. Jayaram

发表

From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine.

R. Petrelli, L. Cappellacci, P. Kusumanchi, 2014, Bioorganic & medicinal chemistry letters.

L-asparaginases from Mycobacterium tuberculosis strains H37Rv and H37Ra.

R. Ramakrishnan, H. Jayaram, C. S. Vaidyanathan, 1968, Archives of biochemistry and biophysics.

Influence of Physiologic Folate Deficiency on Human Papillomavirus Type 16 (HPV16)-harboring Human Keratinocytes in Vitro and in Vivo*

A. Antony, P. Kusumanchi, Ying Tang, 2012, The Journal of Biological Chemistry.

Cytotoxicity of a new IMP dehydrogenase inhibitor, benzamide riboside, to human myelogenous leukemia K562 cells.

K D Paull, K. Paull, K. Krohn, 1992, Biochemical and biophysical research communications.

Maintenance of ATP favours apoptosis over necrosis triggered by benzamide riboside

G. Peters, T. Szekeres, C. Leisser, 2002, Cell Death and Differentiation.

Antitumor activity of benzamide riboside and its combination with cisplatin and staurosporine.

T. Szekeres, L. Novotný, I. Dovinová, 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Initial studies on the mechanism of action of a new oncolytic thiazole nucleoside, 2-beta-D-ribofuranosylthiazole-4-carboxamide (NSC 286193).

R. K. Robins, R. Glazer, D. Cooney, 1982, Biochemical pharmacology.

Mechanism of resistance to the oncolytic C-nucleoside 2-beta-D-ribofuranosylthiazole-4-carboxamide (NSC-286193).

R. Glazer, D. Cooney, R. L. Dion, 1982, Biochemical pharmacology.

Studies on the mechanism of action of tiazofurin metabolism to an analog of NAD with potent IMP dehydrogenase-inhibitory activity.

L. Zwelling, R. Glazer, V. Marquez, 1983, Advances in enzyme regulation.

Biochemical mechanisms of resistance to tiazofurin.

H. Jayaram, 1985, Advances in enzyme regulation.

Biochemically directed therapy of leukemia with tiazofurin, a selective blocker of inosine 5'-phosphate dehydrogenase activity.

N. Heerema, G. Tricot, G. Weber, 1989, Cancer research.

Determination of thiazole-4-carboxamide adenine dinucleotide (TAD) levels in mononuclear cells of leukemic patients treated with tiazofurin.

G. Weber, H. Jayaram, W. Zhen, 1991, Biochemical pharmacology.

Clinical pharmacokinetic study of tiazofurin administered as a 1‐hour infusion

G. Tricot, R. Hoffman, H. Jayaram, 1992, International journal of cancer.

Molecular targets of guanine nucleotides in differentiation, proliferation and apoptosis.

H. Jayaram, J. Yalowitz, 2000, Anticancer research.

Studies on the antitumor activity and biochemical actions of cyclopentenyl cytosine against human colon carcinoma HT-29 in vitro and in vivo.

T. Szekeres, M. Fritzer-Szekeres, H. Jayaram, 1998, Life sciences.

Sensitizing human colon carcinoma HT-29 cells to cisplatin by cyclopentenylcytosine, in vitro and in vivo.

Y. Pommier, T. Szekeres, M. Fritzer-Szekeres, 2000, Life sciences.

Regulation of de novo and salvage pathways in chemotherapy.

J. Eble, S. Ichikawa, G. Weber, 1991, Advances in enzyme regulation.

Modulation of the cytotoxicity of 3'-azido-3'-deoxythymidine and methotrexate after transduction of folate receptor cDNA into human cervical carcinoma: identification of a correlation between folate receptor expression and thymidine kinase activity.

A. Antony, X. Sun, H. Jayaram, 1999, Cancer research.

Pteroyl-gamma-glutamate-cysteine synthesis and its application in folate receptor-mediated cancer cell targeting using folate-tethered liposomes.

A. Antony, H. Jayaram, Yonghua Zhang, 2004, Analytical biochemistry.

Expression of folate receptors and heterogeneous nuclear ribonucleoprotein E1 in women with human papillomavirus mediated transformation of cervical tissue to cancer

A. Antony, M. Pillai, P. Jayaprakash, 2003, Journal of clinical pathology.

Apoptotic signaling induced by benzamide riboside: an in vitro study

C. Sharma, Neeta Singh, H. Jayaram, 2009, Molecular and Cellular Biochemistry.

Role of Human Nucleoside Transporters in the Cellular Uptake of Two Inhibitors of IMP Dehydrogenase, Tiazofurin and Benzamide Riboside

C. Cass, A. Ng, V. Damaraju, 2005, Molecular Pharmacology.

Maternal folate deficiency results in selective upregulation of folate receptors and heterogeneous nuclear ribonucleoprotein-E1 associated with multiple subtle aberrations in fetal tissues.

A. Antony, D. Hansen, Ying Tang, 2005, Birth defects research. Part A, Clinical and molecular teratology.

Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate.

V. Natarajan, W. M. Scribner, Joe G. N. Garcia, 1994, American journal of respiratory cell and molecular biology.

Effect of UVB radiation on corneal aldehyde dehydrogenase.

D. Balasubramanian, H. Jayaram, Y. Sharma, 1996, Current eye research.

Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation.

Yan Zeng, D. Crabb, S. Liangpunsakul, 2008, American journal of physiology. Gastrointestinal and liver physiology.

Studies on the mechanism of action of 2-beta-D-ribofuranosylthiazole-4-carboxamide (NSC 286193)--II. Relationship between dose level and biochemical effects in P388 leukemia in vivo.

R. Glazer, D. Cooney, H. Jayaram, 1982, Biochemical pharmacology.

Mechanisms of sensitivity and resistance of murine tumors to 5-fluorouracil.

R. Glazer, P. Schein, J. Macdonald, 1980, Cancer research.

Role of p21 RAS in p210 bcr-abl transformation of murine myeloid cells.

G. Burgess, H. Boswell, T. Tauchi, 1993, Blood.

Clinical and molecular impact of inhibition of IMP dehydrogenase activity by tiazofurin.

G. Tricot, Y. Yamaji, E. Oláh, 1989, Advances in enzyme regulation.

Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives.

A. Lavecchia, T. Szekeres, R. Petrelli, 2008, Journal of medicinal chemistry.

Biochemical and antitumor activity of trimidox, a new inhibitor of ribonucleotide reductase

T. Szekeres, A. Srivastava, M. Fritzer, 2004, Cancer Chemotherapy and Pharmacology.

Evidence Favoring a Positive Feedback Loop for Physiologic Auto Upregulation of hnRNP-E1 during Prolonged Folate Deficiency in Human Placental Cells.

A. Antony, P. Kusumanchi, D. Hansen, 2017, The Journal of nutrition.

Incrimination of Heterogeneous Nuclear Ribonucleoprotein E1 (hnRNP-E1) as a Candidate Sensor of Physiological Folate Deficiency*

A. Antony, D. Hansen, Ying Tang, 2011, The Journal of Biological Chemistry.

Technical aspects of imaging and transfemoral arterial treatment of N1-S1 tumors in rats: an appropriate model to test the biology and therapeutic response to transarterial treatments of liver cancers.

Yun Liang, L. Bonnac, S. Ju, 2009, Journal of vascular and interventional radiology : JVIR.

Synergistic effect of 5-fluorouracil and N-(phosphonacetyl)-L-aspartate on cell growth and ribonucleic acid synthesis in human mammary carcinoma.

R. Glazer, T. Kensler, J. Macdonald, 1981, Biochemical pharmacology.

Methylenebis(sulfonamide) linked nicotinamide adenine dinucleotide analogue as an inosine monophosphate dehydrogenase inhibitor.

L. Bonnac, Daniel J. Wilson, E. Bennett, 2007, Bioorganic & medicinal chemistry letters.

Relationships between the cytotoxicity of tiazofurin and its metabolism by cultured human lung cancer cells.

D. Carney, D. Cooney, H. Jayaram, 1985, The Journal of clinical investigation.

Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.

G. Perra, P. la Colla, L. Cappellacci, 1997, Journal of medicinal chemistry.

Interaction of L-alanosine (NSC 153, 353) with enzymes metabolizing L-aspartic acid, L-glutamic acid and their amides.

J. Montgomery, A. Tyagi, D. Cooney, 1980, Biochemical pharmacology.

Synthesis and Cytotoxic Activity of Selenophenfurin, a New Inhibitor of IMP Dehydrogenase

G. Perra, L. Cappellacci, P. Colla, 1997 .

Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase.

Yan Zeng, D. Crabb, S. Liangpunsakul, 2009, Archives of biochemistry and biophysics.

Conversion of 2-beta-D-ribofuranosylselenazole-4-carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibitory properties.

R. K. Robins, V. Marquez, D. Cooney, 1982, Biochemical pharmacology.

The conversion of 2-beta-D-ribofuranosylthiazole-4-carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibitory properties.

C. R. Betts, V. Marquez, D. Cooney, 1982, Biochemical pharmacology.

Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells.

T. Szekeres, H. Strobl, C. Lhotka, 1994, Blood.

Synthesis and IMP Dehydrogenase (Type I and Type II) Inhibitory Activity of Isosteric NAD Analogs Derived from Thiophenfurin and Furanfurin

F. Collart, E. Huberman, L. Cappellacci, 1997 .

Modulation of IMP dehydrogenase activity and guanylate metabolism by tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide).

J. Liepnieks, E. Oláh, G. Weber, 1984, The Journal of biological chemistry.

Studies on the mechanism of action of benzamide riboside: a novel inhibitor of IMP dehydrogenase.

W. Grünberger, H. Jayaram, K. Gharehbaghi, 2002, Current medicinal chemistry.

Cloning, expression and characterization of mouse (Mus musculus) nicotinamide 5'-mononucleotide adenylyltransferase-2.

A. Antony, E. Long, P. Kusumanchi, 2011, Medicinal chemistry (Shariqah (United Arab Emirates)).

Mechanism of resistance to tiazofurin in hepatoma 3924A.

G. Weber, M. Lui, H. Jayaram, 1986, Biochemical pharmacology.

Characterization of human brain nicotinamide 5'-mononucleotide adenylyltransferase-2 and expression in human pancreas.

O. Cummings, A. Antony, M. Deeg, 2004, The Biochemical journal.

Using Apparent Diffusion Coefficient of Water Predicting Response to Benzamide Riboside Chemotherapy in Hepatocellular Carcinoma

A. Sherry, C. Malloy, Mingsheng Huang, 2015 .

Staurosporine enhanced benzamide riboside-induced apoptosis in human multidrug-resistant promyelocytic leukemia cells (HL-60/VCR) in vitro.

T. Szekeres, L. Novotný, J. Sedlák, 1998, Neoplasma.

Mechanism of resistance of variants of the Lewis lung carcinoma to N-(phosphonacetyl)-L-aspartic acid.

T. Kensler, G. Mutter, R. Johnson, 1981, Cancer research.

Antitumor activity of C-methyl-beta-D-ribofuranosyladenine nucleoside ribonucleotide reductase inhibitors.

T. Szekeres, R. Petrelli, L. Cappellacci, 2005, Journal of medicinal chemistry.

A New Tiazofurin Pronucleotide: Synthesis and Biological Evaluation of CycloSaligenyl-Tiazofurin Monophosphate

C. Martini, L. Cappellacci, P. Franchetti, 2003, Nucleosides, nucleotides & nucleic acids.

Consequences of IMP Dehydrogenase Inhibition, and its Relationship to Cancer and Apoptosis

M. Grusch, G. Krupitza, D. Cooney, 1999, Current Medicinal Chemistry.

Two complementary radiometric methods for the measurement of 5-amino-4-imidazole-N-succinocarboxamide ribonucleotide synthetase (SAICAR synthetase).

A. Tyagi, D. Cooney, H. Jayaram, 1980, Journal of biochemical and biophysical methods.

Inosine monophosphate dehydrogenase inhibitors. Probes for investigations of the functions of guanine nucleotide binding proteins in intact cells.

G. Tricot, R. Hoffman, M. Rizzo, 1990, Cellular signalling.

Synthesis of isosteric analogues of nicotinamide adenine dinucleotide containing C-nucleotide of nicotinamide or picolinamide.

K. Watanabe, J. E. Bell, K. Pankiewicz, 1993, Journal of medicinal chemistry.

A new C-nucleoside analogue of tiazofurin: synthesis and biological evaluation of 2-beta-D-ribofuranosylimidazole-4-carboxamide (imidazofurin).

L. Cappellacci, S. Marchetti, P. Franchetti, 2001, Bioorganic & medicinal chemistry letters.

IMP dehydrogenase: inhibition by the anti-leukemic drug, tiazofurin.

G. Tricot, Y. Yamaji, G. Weber, 1989, Leukemia research.

Hematological and biochemical action of tiazofurin (NSC 286193) in a case of refractory acute myeloid leukemia.

G. Tricot, K. Pennington, G. Weber, 1987, Cancer research.

Selective sensitivity to tiazofurin of human leukemic cells.

G. Weber, R. Hoffman, Craig R. Nichols, 1986, Biochemical pharmacology.

Studies on the mechanism of action of 2-beta-D-ribofuranosylthiazole-4-carboxamide--V. Factors governing the response of murine tumors to tiazofurin.

J. Plowman, D. Cooney, H. Jayaram, 1984, Biochemical pharmacology.

Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target.

L. Stuyver, R. Schinazi, S. Patterson, 2004, Current medicinal chemistry.

Ribavirin, tiazofurin, and selenazofurin: mononucleotides and nicotinamide adenine dinucleotide analogues. Synthesis, structure, and interactions with IMP dehydrogenase.

V. Marquez, D. Cooney, R. L. Dion, 1985, Journal of medicinal chemistry.

Purine and Pyrimidine Nucleoside Analogs of 3'-C-Methyladenosine as Antitumor Agents

R. Petrelli, L. Cappellacci, P. Franchetti, 2006 .

Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.

C. Carrell, L. Cappellacci, A. O'Connor, 1995, Journal of medicinal chemistry.

Metabolites of alanosine, an antitumor antibiotic.

R. Adamson, J. Montgomery, A. Tyagi, 1979, Biochemical pharmacology.

Inhibitors of L-asparagine synthetase, in vitro.

R. Davis, J. Driscoll, D. Cooney, 1976, Cancer treatment reports.

DON, CONV and DONV-II. Inhibition of L-'asparagine synthetase in vivo.

D. Cooney, H. Jayaram, R. Rosenbluth, 1976, Biochemical pharmacology.

A facile enzymatic method for the location of radioactivity associated with the carbons of L-aspartic acid, L-asparagine, and beta-cyano-L-alanine.

D. Cooney, H. Jayaram, 1978, Analytical biochemistry.

Determination of NAD pyrophosphorylase activity in biological samples.

G. Weber, H. Jayaram, E. Paulik, 1991, Analytical biochemistry.

Biochemical consequences of resistance to tiazofurin in human myelogenous leukemic K562 cells.

H. Jayaram, K. Gharehbaghi, W. Zhen, 1993, Cancer research.

A facile enzymatic technique for the estimation of nanomolar concentrations of N-phosphonacetyl-L-aspartic acid in plasma.

T. Kensler, D. Cooney, H. Jayaram, 1980, Journal of biochemical and biophysical methods.

A simple and rapid method for the estimation of L-asparaginase in chromatographic and electrophoretic effluents: comparison with other methods.

D. Cooney, H. Jayaram, L. Rosenblum, 1974, Analytical biochemistry.

Salvage pathways as targets of chemotherapy.

Y. Zhen, G. Weber, Y. Natsumeda, 1987, Advances in enzyme regulation.

Mechanism of Resistance of a Variant of P388 Leukemia to L-(αS,5S)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic Acid (Acivicin)

B. Ardalan, Randall K. Johnson, H. Jayaram, 1985 .

Translational upregulation of folate receptors is mediated by homocysteine via RNA-heterogeneous nuclear ribonucleoprotein E1 interactions.

A. Antony, Xin-Lai Sun, Ying Tang, 2004, The Journal of clinical investigation.

Metabolites of tiazofurin as mediators of its biochemical and pharmacologic effects

D. Cooney, H. Jayaram, G. Ahluwalia, 1987 .

Consequences of IMP dehydrogenase inhibition, and its relationship to cancer and apoptosis.

M. Grusch, G. Krupitza, D. Cooney, 1999, Current medicinal chemistry.

The chemistry of nicotinamide adenine dinucleotide (NAD) analogues containing C-nucleosides related to nicotinamide riboside.

Kyoichi A. Watanabe, K. Pankiewicz, H. Jayaram, 2002, Current medicinal chemistry.

Efficient Synthesis of Benzamide Riboside, a Potential Anticancer Agent

L. Bonnac, S. Patterson, Liqiang Chen, 2007, Nucleosides, nucleotides & nucleic acids.

Tiazofurin: biological effects and clinical uses.

G. Tricot, G. Weber, R. Hoffman, 1990, International journal of cell cloning.

Reverse phase HPLC determination of 5,6-dihydro-5-azacytidine in biological fluids

J. Kelley, P. Huguenin, H. Jayaram, 1984 .

Comparison of biochemical parameters of benzamide riboside, a new inhibitor of IMP dehydrogenase, with tiazofurin and selenazofurin.

K. Paull, T. Szekeres, K. Krohn, 1994, Biochemical pharmacology.

Studies of purine and tiazofurin metabolism in drug sensitive human chronic myelogenous leukemia K 562 cells

G. Weber, H. Jayaram, K. Pillwein, 1988, Blut.

Tiazofurin: A new antitumor agent

S. Marsoni, P. O'dwyer, J. Plowman, 2004, Investigational new drugs.

Schedule-dependent synergistic action of tiazofurin and dipyridamole on hepatoma 3924A cells

K. Murayama, G. Weber, H. Jayaram, 2004, Cancer Chemotherapy and Pharmacology.

Antitumor activity of tiazofurin in human colon carcinoma HT-29.

G. Weber, H. Jayaram, W. Zhen, 1992, Cancer investigation.

Enzyme-pattern-targeted chemotherapy with tiazofurin and allopurinol in human leukemia.

G. Tricot, Y. Yamaji, G. Weber, 1988, Advances in enzyme regulation.

Studies on the mechanism of action of tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide). VI. Biochemical and pharmacological studies on the degradation of thiazole-4-carboxamide adenine dinucleotide (TAD).

V. Marquez, D. Cooney, H. Jayaram, 1986, Biochemical pharmacology.

Effects of acivicin and PALA, singly and in combination, on de novo pyrimidine biosynthesis.

T. Kensler, D. Cooney, H. Jayaram, 1982, Advances in enzyme regulation.

L-[alphaS, 5S]-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (NSC-163501): a new amino acid antibiotic with the properties of an antagonist of L-glutamine.

G. Neil, D. Cooney, R. L. Dion, 1975, Cancer chemotherapy reports.

Characterization of Eleven Important Transplantable Murine Tumors from the Standpoint of Morphology, Pyrimidine Biosynthesis and Responsiveness to Pyrimidine Antimetabolites

T. Kensler, H. Schuller, D. Cooney, 1989 .

Ethacrynic acid--an inhibitor of L-asparagine synthetase.

D. Cooney, E. Cragoe, H. Jayaram, 1975, Biochemical pharmacology.

Mechanisms of sensitivity or resistance of murine tumors to N-(phosphonacetyl)-L-aspartate (PALA).

D. Vistica, R. Johnson, D. Cooney, 1979, Cancer treatment reports.

Collateral Sensitivity to N-(Phosphonacetyl)-l-aspartic Acid in a Line of P388 Leukemia Cells Selected for Resistance to l-(αS,5S)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic Acid (Acivicin)

B. Ardalan, Randall K. Johnson, H. Jayaram, 1983 .

Long-term association of N-(phosphonacetyl)-L-aspartate with bone.

T. Kensler, D. Cooney, B. Ardalan, 1981, Cancer research.

Effect of L-glutamine antagonists on 5-phosphoribosyl 1-pyrophosphate levels in P388 leukemia and in murine colon adenocarcinomas in vivo.

M. Arakawa, D. Cooney, B. Ardalan, 1982, Biochemical pharmacology.

Increased Nucleoside Concentrations in Tumors as Markers of Tiazofurin Action

G. Weber, H. Jayaram, K. Pillwein, 1986 .

Tiazofurin action in leukemia: evidence for down-regulation of oncogenes and synergism with retinoic acid.

Y. Yamaji, G. Weber, Y. Natsumeda, 1990, Advances in enzyme regulation.

Cytotoxicity and cellular differentiation activity of methylenebis(phosphonate) analogs of tiazofurin and mycophenolic acid adenine dinucleotide in human cancer cell lines.

Steven E Patterson, S. Patterson, Joel A Yalowitz, 2002, Cancer letters.

Transduction of folate receptor cDNA into cervical carcinoma cells using recombinant adeno-associated virions delays cell proliferation in vitro and in vivo.

A. Antony, S. Gullapalli, A. Srivastava, 1995, The Journal of clinical investigation.

Effect of ischemia on nucleosides and bases in rat liver and hepatoma 3924A.

G. Weber, H. Jayaram, K. Pillwein, 1987, Cancer research.

Cytotoxicity, differentiating activity and metabolism of tiazofurin in human neuroblastoma cells

T. Szekeres, P. Chiba, S. Szalay, 1993, International journal of cancer.

Regulation of purine and pyrimidine metabolism by insulin and by resistance to tiazofurin.

G. Weber, Y. Natsumeda, M. Reardon, 1985, Advances in enzyme regulation.

Phase I and pharmacokinetic study of tiazofurin (TCAR, NSC 286193) administered by continuous infusion

G. Batist, J. Grygiel, R. Fine, 2004, Investigational New Drugs.

The disposition and metabolism of tiazofurin in rodents, rabbits, and dogs.

G. Harper, D. Cooney, L. Malspeis, 1984, Drug metabolism and disposition: the biological fate of chemicals.

Synthesis of thiazole-4-carboxamide adenine dinucleotide. A powerful inhibitor of IMP dehydrogenase.

V. Marquez, D. Cooney, J. Kelley, 1983, Journal of medicinal chemistry.

Tiazofurin down-regulates expression of c-Ki-ras oncogene in a leukemic patient.

G. Tricot, J. Eble, G. Weber, 1991, Cancer communications.

Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents.

Y. Yen, Bingsen Zhou, R. Petrelli, 2011, European journal of medicinal chemistry.

Peripheral leukocytes as indicators of the enzymatic effects of N-(phosphonacetyl)-L-aspartic acid (PALA) on human L-aspartate transcarbamoylase (ATCase) activity.

C. Erlichman, A. Tyagi, T. Kensler, 1980, Cancer treatment reports.

Oncolytic activity and mechanism of action of a novell-cystine derivative,l-cystine, ethyl ester,S-(N-methylcarbamate) monohydrochloride

W. Elliott, J. Plowman, G. Weber, 2008, Cancer Chemotherapy and Pharmacology.

In vitro and in vivo effect of glutamine-antagonists on prpp metabolism in p388 leukemia and in murine colonic adenocarcinoma. Abstr.

M. Arakawa, B. Ardalan, H. Jayaram, 1981 .

Radiometric enzyme-inhibition technique for measuring acivicin in plasma.

T. Kensler, B. Ardalan, H. Jayaram, 1981, Cancer treatment reports.

Analogs of L-aspartic acid in chemotherapy for cancer.

D. Cooney, H. Jayaram, 1979, Cancer treatment reports.

A facile tritium release assay for mammalian L-dihydroorotate dehydrogenase.

T. Kensler, D. Cooney, H. Jayaram, 1981, Analytical biochemistry.

Variability of apoptosis and response in N1-S1 rodent hepatomas to benzamide riboside and correlation to early changes in water apparent diffusion coefficient and sodium MR imaging.

L. Bonnac, M. Lieber, G. McLennan, 2013, Journal of vascular and interventional radiology : JVIR.

Benzamide riboside induced mitochondrial mediated apoptosis in human lung cancer H520 cells.

Neeta Singh, H. Jayaram, N. Khanna, 2004, Life sciences.

Benzamide riboside induces apoptosis independent of Cdc25A expression in human ovarian carcinoma N.1 cells

Georg Krupitza, T. Szekeres, G. Rosenberger, 1999, Cell Death and Differentiation.

Isolation and Characterization of a Folate Receptor mRNA-binding trans-Factor from Human Placenta

A. Antony, Xin-Lai Sun, D. Hansen, 2001, The Journal of Biological Chemistry.

Inhibitory activity of L-asparaginase from Mycobacterium tuberculosis on Yoshida ascites sarcoma in rats.

T. Ramakrishnan, H. Jayaram, M. Sirsi, 1969, Archives of biochemistry and biophysics.

DON, CONV and DONV-III. Pharmacologic and toxicologic studies.

D. Cooney, H. Jayaram, R. Rosenbluth, 1976, Biochemical pharmacology.

Enzyme Applications, Therapeutic

D. Cooney, H. Jayaram, G. Ahluwalia, 2000 .

Cytotoxicity and characterization of an active metabolite of benzamide riboside, a novel inhibitor of IMP dehydrogenase

A. Monks, K. Krohn, V. Marquez, 1994, International journal of cancer.

Letter to the Editors: Corneal Aldehyde Dehydrogenase Displays Antioxidant Properties

D. Balasubramanian, H. Jayaram, L. Uma, 1996 .

NMNAT expression and its relation to NAD metabolism.

P. Kusumanchi, H. Jayaram, J. Yalowitz, 2011, Current medicinal chemistry.

Mycophenolic acid analogs with a modified metabolic profile.

Daniel J. Wilson, Liqiang Chen, K. Pankiewicz, 2008, Bioorganic & medicinal chemistry.

Apoptotic signaling induced by Tiazofurin-an in vitro study

Neeta Singh, Chandresh Sharma, C. Sharma, 2006 .

Cytotoxicity of tiazofurin and its arabinose and xylose analogues in K562 cells.

V. Marquez, G. Weber, D. Cooney, 1991, Biochemical and biophysical research communications.

P-selectin-mediated attachment of small cell lung carcinoma to endothelial cells.

V. Natarajan, W. M. Scribner, H. Jayaram, 1996, The American journal of physiology.

Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: targeting the pyrophosphate binding sub-domain.

R. Petrelli, P. Kusumanchi, Daniel J. Wilson, 2011, Bioorganic & medicinal chemistry.

Interaction between L-aspartic acid and L-asparaginase from Escherichia coli: binding and inhibition studies.

C. Y. Huang, D. Cooney, H. Jayaram, 1986, Journal of enzyme inhibition.

Predicting response to benzamide riboside chemotherapy in hepatocellular carcinoma using apparent diffusion coefficient of water.

S. Ju, G. McLennan, H. Jayaram, 2011, Anticancer research.

Insulin regulatory effects on purine- and pyrimidine metabolism in alloxan diabetic rat liver.

W. Elliott, W. Sperl, G. Weber, 1988, Padiatrie und Padologie.

Synthesis, conformational analysis, and biological activity of new analogues of thiazole-4-carboxamide adenine dinucleotide (TAD) as IMP dehydrogenase inhibitors.

D. B. Boyd, R. Petrelli, L. Cappellacci, 2005, Bioorganic & medicinal chemistry.

Biochemical consequences of resistance to a recently discovered IMP dehydrogenase inhibitor, benzamide riboside, in human myelogenous leukemia K562 cells.

A. O'Connor, D. Cooney, P. Grieco, 1996, Journal of experimental therapeutics & oncology.

Studies on the mechanism of action of 1-beta-D-arabinofuranosyl-5-azacytosine (fazarabine) in mammalian lymphoblasts.

K. Paull, J. Barchi, D. Cooney, 1996, Journal of experimental therapeutics & oncology.

Long term association of pala with bone. Abstr.

D. Cooney, B. Ardalan, H. Jayaram, 1980 .

Isosteric analogues of nicotinamide adenine dinucleotide derived from furanfurin, thiophenfurin, and selenophenfurin as mammalian inosine monophosphate dehydrogenase (type I and II) inhibitors.

F. Collart, E. Huberman, L. Cappellacci, 1998, Journal of medicinal chemistry.

Isolation and Characterization of a Folate Receptor mRNA-binding trans-Factor from Human Placenta EVIDENCE FAVORING IDENTITY WITH HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN E 1 *

A. Antony, Xin-Lai Sun, D. Hansen, 2001 .

Toxicity and efficacy of benzamide riboside in cancer chemotherapy models.

Joel A Yalowitz, Hiremagalur N Jayaram, J. Greene, 2002, Current medicinal chemistry.

Phase I study of continuous-infusion PALA and 5-FU.

C. Presant, B. Ardalan, H. Jayaram, 1984, Cancer treatment reports.

Studies on the mechanism of resistance of selected murine tumors to L-alanosine.

A. Tyagi, R. Johnson, D. Cooney, 1981, Biochemical pharmacology.

Regulators of the metabolism of L-asparagine: a search for endogenous inhibitors.

D. Cooney, H. Jayaram, H. Milman, 1980, The International journal of biochemistry.

p210 bcr-abl confers overexpression of inosine monophosphate dehydrogenase: an intrinsic pathway to drug resistance mediated by oncogene.

F. Collart, G. Burgess, S. Litz-Jackson, 1994, Leukemia.

Ribose-modified Mizoribine Analogues: Synthesis and Biological Evaluation

R. Petrelli, L. Cappellacci, P. Franchetti, 2005, Nucleosides, nucleotides & nucleic acids.

The metabolism of L-asparagine in Asparagus officinalis.

M. Levine, D. Cooney, H. Jayaram, 1980, The International journal of biochemistry.

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure.

Y. Sham, R. Petrelli, Daniel J. Wilson, 2010, Bioorganic & medicinal chemistry.

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment.

Daniel J. Wilson, Liqiang Chen, K. Pankiewicz, 2007, Journal of Medicinal Chemistry.

Synthesis, conformational analysis, and biological activity of C-thioribonucleosides related to tiazofurin.

L. Cappellacci, J. Imbach, P. Franchetti, 2000, Journal of medicinal chemistry.

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