R. van de Straat

发表

Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention.

N. Vermeulen, J. Bessems, N P Vermeulen, 1992, Drug metabolism reviews.

A theoretical study on the metabolic activation of paracetamol by cytochrome P-450: indications for a uniform oxidation mechanism.

J. H. van Lenthe, L. Koymans, N. Vermeulen, 1988, Chemical research in toxicology.

Paracetamol, 3-monoalkyl- and 3,5-dialkyl derivatives. Comparison of their microsomal cytochrome P-450 dependent oxidation and toxicity in freshly isolated hepatocytes.

N. Vermeulen, A. Debets, J. de Vries, 1986, Biochemical pharmacology.

Paracetamol, 3-monoalkyl- and 3,5-dialkyl-substituted derivatives. Antioxidant activity and relationship between lipid peroxidation and cytotoxicity.

N. Vermeulen, G. Bijloo, R. van de Straat, 1988, Biochemical pharmacology.

The mechanism of prevention of paracetamol-induced hepatotoxicity by 3,5-dialkyl substitution. The roles of glutathione depletion and oxidative stress.

N. Vermeulen, A. Debets, J. de Vries, 1987, Biochemical pharmacology.

Cytochrome P-450-mediated oxidation of substrates by electron-transfer; role of oxygen radicals and of 1- and 2-electron oxidation of paracetamol.

N. Vermeulen, J. de Vries, R. van de Straat, 1988, Chemico-biological interactions.

Role of hepatic microsomal and purified cytochrome P-450 in one-electron reduction of two quinone imines and concomitant reduction of molecular oxygen.

N. Vermeulen, J. de Vries, R. van de Straat, 1987, Biochemical pharmacology.

One-electron reduction of mitomycin c by rat liver: role of cytochrome P-450 and NADPH-cytochrome P-450 reductase.

N. Vermeulen, R. van de Straat, R. Vromans, 1990, Xenobiotica; the fate of foreign compounds in biological systems.

Paracetamol, 3-monoalkyl- and 3,5-dialkyl derivatives: comparison of their hepatotoxicity in mice.

N. Vermeulen, J. de Vries, R. van de Straat, 1987, Toxicology and applied pharmacology.

Relationship between paracetamol binding to and its oxidation by two cytochromes P-450 isozymes--a proton nuclear magnetic resonance and spectrophotometric study.

N. Vermeulen, J. D. de Vries, R. van de Straat, 1987, Xenobiotica; the fate of foreign compounds in biological systems.

Simultaneous determination of glutathione, glutathione disulphide, paracetamol and its sulphur containing metabolites using HPLC and electrochemical detection with on-line generated bromine.

R. W. Frei, N. Vermeulen, A. Debets, 1988, Journal of pharmaceutical and biomedical analysis.

Abstract of papers

E. Kroese, L. Bree, F. Zitman, 1987, Pharmaceutisch Weekblad.