J. Maher

发表

Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor‐E2–related factor‐2 transcriptional pathway

Masayuki Yamamoto, C. Klaassen, J. Chan, 2007, Hepatology.

Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity

Takafumi Suzuki, Masayuki Yamamoto, A. Kobayashi, 2008, Molecular and Cellular Biology.

Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo.

Takafumi Suzuki, Masayuki Yamamoto, J. Maher, 2011, Cancer research.

The rise of antioxidant signaling--the evolution and hormetic actions of Nrf2.

Masayuki Yamamoto, J. Maher, 2010, Toxicology and applied pharmacology.

BRG1 Interacts with Nrf2 To Selectively Mediate HO-1 Induction in Response to Oxidative Stress

K. Itoh, K. Nishikawa, Masayuki Yamamoto, 2006, Molecular and Cellular Biology.

Expression and regulation of the sterol half-transporter genes ABCG5 and ABCG8 in rats.

Xingguo Cheng, C. Klaassen, M. Z. Dieter, 2004, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

The Nrf2 Activator Oltipraz Also Activates the Constitutive Androstane Receptor

Jonathan P. Jackson, D. Moore, C. Klaassen, 2008, Drug Metabolism and Disposition.

Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors.

Jianwen A. Feng, Y. Ran, A. Zarrin, 2019, Journal of medicinal chemistry.

Induction of Hepatic Transporters Multidrug Resistance-Associated Proteins (Mrp) 3 and 4 by Clofibrate Is Regulated by Peroxisome Proliferator-Activated Receptor α

Jeffrey S Moffit, C. Klaassen, G. Scheffer, 2006, Journal of Pharmacology and Experimental Therapeutics.

Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor.

D. Moore, C. Klaassen, A. Slitt, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid.

J. Peters, C. Klaassen, J. Manautou, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2.

C. Klaassen, J. Chan, A. Slitt, 2008, Toxicology and applied pharmacology.

Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes.

A. Fukamizu, K. Itoh, K. Nishikawa, 2007, The Biochemical journal.

Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice.

C. Klaassen, T. Leazer, A. Slitt, 2004, Biochemical and biophysical research communications.

TISSUE DISTRIBUTION AND ONTOGENY OF MOUSE ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPS)

Xingguo Cheng, C. Klaassen, Chuan Chen, 2005, Drug Metabolism and Disposition.

TISSUE DISTRIBUTION AND HEPATIC AND RENAL ONTOGENY OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN (MRP) FAMILY IN MICE

Xingguo Cheng, C. Klaassen, A. Slitt, 2005, Drug Metabolism and Disposition.

INDUCTION OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN FAMILY OF TRANSPORTERS BY CHEMICAL ACTIVATORS OF RECEPTOR-MEDIATED PATHWAYS IN MOUSE LIVER

Curtis D. Klaassen, Xingguo Cheng, Xingguo Cheng, 2005, Drug Metabolism and Disposition.

Identification of a Functional Antioxidant Response Element within the Eighth Intron of the Human ABCC3 Gene

Masayuki Yamamoto, Donna D. Zhang, Tongde Wu, 2015, Drug Metabolism and Disposition.

Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems.

N. Goto, Masayuki Yamamoto, E. Warabi, 2009, Biochemical and biophysical research communications.

Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice.

I. Hyodo, N. Goto, Masayuki Yamamoto, 2008, American journal of physiology. Gastrointestinal and liver physiology.

Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites.

C. Klaassen, A. Slitt, N. Cherrington, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Kupffer Cell-Mediated Downregulation of Hepatic Transporter Expression in Rat Hepatic Ischemia-Reperfusion

C. Klaassen, Chuan Chen, J. Maher, 2006, Transplantation.

Tissue distribution and induction of the rat multidrug resistance-associated proteins 5 and 6.

C. Klaassen, A. Slitt, N. Cherrington, 2006, Life sciences.

Endocrine Regulation of Gender-Divergent Mouse Organic Anion-Transporting Polypeptide (Oatp) Expression

Xingguo Cheng, C. Klaassen, Hong Lu, 2006, Molecular Pharmacology.

Hormonal regulation of renal multidrug resistance-associated proteins 3 and 4 (Mrp3 and Mrp4) in mice.

Y. Tanaka, C. Klaassen, G. Scheffer, 2006, Biochemical pharmacology.

Ischemia-reperfusion of rat livers decreases liver and increases kidney multidrug resistance associated protein 2 (Mrp2).

C. Klaassen, Chuan Chen, J. Maher, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

REGULATION OF MOUSE ORGANIC ANION-TRANSPORTING POLYPEPTIDES (OATPS) IN LIVER BY PROTOTYPICAL MICROSOMAL ENZYME INDUCERS THAT ACTIVATE DISTINCT TRANSCRIPTION FACTOR PATHWAYS

Xingguo Cheng, C. Klaassen, M. Z. Dieter, 2005, Drug Metabolism and Disposition.

Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation.

Satoru Takahashi, K. Itoh, Masayuki Yamamoto, 2012, Free radical biology & medicine.

A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors.

Fei Wang, H. Jayaram, F. A. Romero, 2017, Journal of medicinal chemistry.

Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (Oatps) Department of Pharmacology, Toxicolo

Xingguo Cheng, C. Klaassen, Chuan Chen, 2005 .

Physiological Signiﬁcance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity (cid:1) in assays

Takafumi Suzuki, A. Kobayashi, Junko Wakabayashi, 2008 .

RIP1 kinase activity is critical for skin inflammation but not for viral propagation

Min Xu, J. Webster, Summer Park, 2020, Journal of leukocyte biology.

Predicting Human Infection Risk: Do Rodent Host Resistance Models Add Value?

Yu Zhong, K. Wu, J. Maher, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung.

V. Raman, Takafumi Suzuki, Masayuki Yamamoto, 2010, Carcinogenesis.

Hepatocyte-specific deletion of heme oxygenase-1 disrupts redox homeostasis in basal and oxidative environments.

H. Matsui, I. Hyodo, O. Nakajima, 2008, The Tohoku journal of experimental medicine.

Induction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2

C. Klaassen, L. Lehman-Mckeeman, A. Slitt, 2007, Drug Metabolism and Disposition.

Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.

Karen E Gascoigne, Fei Wang, S. Kharbanda, 2016, Journal of medicinal chemistry.

Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity.

Hoai An Le Thi, Jun Liang, Y. Ran, 2019, ACS medicinal chemistry letters.

Fig . 4 Androgens Kidneys ↑ Oatp 1 a 1 → M > F ↑ Oatp 3 a 1 → M > F Livers ↑ Oatp 1 a 1

Xingguo Cheng, C. Klaassen, J. Maher, 2006 .

Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1

Takafumi Suzuki, Masayuki Yamamoto, H. Motohashi, 2010, Molecular and Cellular Biology.

The Use of Genetically Modified Animals in Discovery Toxicology

D. Diaz, J. Maher, 2016 .

Evaluation of miR-122 as a Serum Biomarker for Hepatotoxicity in Investigative Rat Toxicology Studies

V. Devanarayan, E. Blomme, B. Leroy, 2016, Veterinary pathology.

Circulating microRNA 122 in the methionine and choline‐deficient mouse model of non‐alcoholic steatohepatitis

E. Blomme, April D. Lake, N. Cherrington, 2014, Journal of applied toxicology : JAT.

Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages.

T. Toki, K. Itoh, Masayuki Yamamoto, 2011, Archives of biochemistry and biophysics.

Individual serum bile acid profiling in rats aids in human risk assessment of drug‐induced liver injury due to BSEP inhibition

Y. Ran, L. Salphati, J. Tarrant, 2018, Toxicology and applied pharmacology.

Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain.

D. Sutherlin, Jun Chen, D. Hackos, 2019, Journal of medicinal chemistry.

Hepatic Ischemia-Reperfusion Induces Renal Heme Oxygenase-1 via NF-E2-Related Factor 2 in Rats and Mice

C. Klaassen, Chuan Chen, J. Maher, 2007, Molecular Pharmacology.

Induction of Hepatic Transporters Mrp3 and Mrp4 by Clofibrate is Regulated by PPAR α

C. Klaassen, G. Scheffer, J. Manautou, 2006 .

Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha.

Xingguo Cheng, F. Gonzalez, C. Klaassen, 2006, Biochemical pharmacology.

GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).

Karen E Gascoigne, Y. Ran, G. Hatzivassiliou, 2017, Journal of medicinal chemistry.

Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis.

H. Akaza, K. Itoh, Masayuki Yamamoto, 2007, Carcinogenesis.

Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis

C. Klaassen, J. Chan, A. Slitt, 2006, Cell stress & chaperones.

Atypical presentation and pathogenesis of a macaque lymphocryptoviral-associated B-cell lymphoma in a cynomolgus monkey.

S. Durinck, Niraj Tripathi, W. Halpern, 2020, Veterinary clinical pathology.

Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis.

C. Klaassen, A. Slitt, J. Manautou, 2007, Biochimica et biophysica acta.

Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310.

D. Sutherlin, Jun Chen, D. Hackos, 2021, Journal of medicinal chemistry.

Preclinical Safety Assessment of a Highly Selective and Potent Dual Small-Molecule Inhibitor of CBP/P300 in Rats and Dogs

F. A. Romero, G. Cain, E. Choo, 2020, Toxicologic pathology.

Using Genetically Modified Rodent Models in Drug Development to Explore Target Physiology and Potential Drug Effects

D. Dambach, Yu Zhong, J. Maher, 2018, Veterinary pathology.

INDUCTION OF DRUG-METABOLIZING ENZYMES BY GARLIC AND ALLYL SULFIDE COMPOUNDS VIA ACTIVATION OF CAR AND NRF 2

C. Klaassen, L. Lehman-Mckeeman, A. Slitt, 2007 .

In vitro assessment of farnesoid X receptor antagonism to predict drug-induced liver injury risk

T. Kiyota, C. Khojasteh, L. Norona, 2020, Archives of Toxicology.