D. M. Moccio

发表

Pharmacokinetic basis for differences in methotrexate sensitivity of normal proliferative tissues in the mouse.

F. Sirotnak, D. M. Moccio, 1980, Cancer research.

Improved methotrexate therapy of murine tumors obtained by probenecid-mediated pharmacological modulation at the level of membrane transport.

F. Sirotnak, D. M. Moccio, C. Hancock, 1981, Cancer research.

Stereospecificity at carbon 6 of fomyltetrahydrofolate as a competitive inhibitor of transport and cytotoxicity of methotrexate in vitro.

J. Montgomery, F. Sirotnak, D. M. Moccio, 1979, Biochemical pharmacology.

A novel class of genetic variants of the L1210 cell up-regulated for folate analogue transport inward. Isolation, characterization, and degree of metabolic instability of the system.

F. Sirotnak, C. Yang, D. M. Moccio, 1984, The Journal of biological chemistry.

New folate analogs of the 10-deaza-aminopterin series Basis for structural design and biochemical and pharmacologic properties

F. Sirotnak, D. M. Moccio, L. J. Goutas, 2004, Cancer Chemotherapy and Pharmacology.

Biochemical and pharmacologic properties of a new folate analog, 10-deaza-aminopterin, in mice.

F. Sirotnak, D. M. Moccio, P. Chello, 1982, Cancer treatment reports.

New folate analogs of the 10-deaza-aminopterin series

F. Sirotnak, D. M. Moccio, L. J. Goutas, 2004, Cancer Chemotherapy and Pharmacology.

Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo.

F. Sirotnak, D. M. Moccio, L. J. Goutas, 1981, Cancer research.

Biochemical and pharmacokinetic effects of leucovorin after high-dose methotrexate in a murine leukemia model.

F. Sirotnak, D. M. Moccio, D. M. Dorick, 1976, Cancer research.

Analog specific aberrancies in antifolate inhibition of L1210 cell dihydrofolate reductase.

J. Montgomery, F. Sirotnak, D. M. Moccio, 1980, Biochemical pharmacology.

Optimization of high-dose methotrexate with leucovorin rescue therapy in the L1210 leukemia and sarcoma 180 murine tumor models.

F. Sirotnak, D. M. Moccio, D. M. Dorick, 1978, Cancer research.

Tissue pharmacokinetics, inhibition of DNA synthesis and tumor cell kill after high-dose methotrexate in murine tumor models.

F. Sirotnak, D. M. Moccio, D. M. Dorick, 1976, Cancer research.

Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.

F. Sirotnak, D. M. Moccio, L. L. Samuels, 1985, Cancer research.

Similar characteristics of folate analogue transport in vitro in contrast to varying dihydrofolate reductase levels in epithelial cells at different stages of maturation in mouse small intestine.

F. Sirotnak, C. Yang, D. M. Moccio, 1984, Cancer research.

Antitumor properties of a new folate analog, 10-deaza-aminopterin, in mice.

F. Sirotnak, D. M. Moccio, D. M. Dorick, 1978, Cancer treatment reports.

Schedule-dependent synergism of methotrexate and vincristine against murine L1210 leukemia.

F. Sirotnak, D. M. Moccio, P. Chello, 1979, Cancer treatment reports.

Similar specificity of membrane transport for folate analogues and their metabolites by murine and human tumor cells: a clinically directed laboratory study.

F. Sirotnak, A. Yagoda, D. M. Moccio, 1984, Cancer research.

Biochemical correlates of responsiveness and collateral sensitivity of some methotrexate-resistant murine tumors to the lipophilic antifolate, metoprine.

J. Montgomery, F. Sirotnak, D. M. Moccio, 1982, Cancer research.

Increased accumulation of methotrexate by murine tumor cells in vitro in the presence of probenecid which is mediated by a preferential inhibition of efflux.

F. Sirotnak, D. M. Moccio, C. Young, 1981, Cancer research.

Effects of metabolic deprivation on methotrexate transport in L1210 leukemia cells: Further evidence for separate influx and efflux systems with different energetic requirements

M. Dembo, F. Sirotnak, D. M. Moccio, 2005, The Journal of Membrane Biology.

Experimental chemotherapy with 5-arylpyrimidine antifolates: Further studies on toxicity and the responsiveness of ascitic, solid, and intracranial sarcoma 180 to DDMP and DDMP with citrovorum factor.

F. Sirotnak, D. M. Moccio, D. M. Dorick, 1977, Cancer treatment reports.

Experimental chemotherapy with 5-arylpyrimidine antifolates: preliminary studies on toxicity and responsiveness of sarcoma 180 to DDMP (NSC-19494) and DDMP with citrovorum factor (NSC-3590).

F. Sirotnak, D. M. Moccio, D. M. Dorick, 1976, Cancer treatment reports.

Detection by high-performance liquid chromatography of methotrexate and its metabolites in tumor tissue from osteosarcoma patients treated with high-dose methotrexate/leucovorin rescue.

G. Rosen, F. Sirotnak, D. M. Moccio, 1984, Biochemical pharmacology.