J. McGuire

C. Di Giacomo, V. Sorrenti, I. Toth, 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Comparative genomic analysis reveals a novel mitochondrial isoform of human rTS protein and unusual phylogenetic distribution of the rTS gene

J. Nair, B. Dolnick, P. Liang, 2005, BMC Genomics.

Loss of fatty acid binding protein 3 ameliorates lipopolysaccharide-induced inflammation and endothelial dysfunction

Q. Feng, J. Frisbee, Shweta Singh, 2023, The Journal of biological chemistry.

Attenuated Vasodilator Effectiveness of Protease-Activated Receptor 2 Agonist in Heterozygous par2 Knockout Mice

J. McGuire, J. Hennessey, 2013, PloS one.

Proteinase-activated Receptor 2 (PAR2): a challenging new target for treatment of vascular diseases.

J. McGuire, 2004, Current pharmaceutical design.

Progression of Time-Dependent Changes to the Mechanisms of Vasodilation by Protease-Activated Receptor 2 in Metabolic Syndrome.

S. Kagota, Kana Maruyama, J. McGuire, 2017, Biological & pharmaceutical bulletin.

Effects of chronic in-vivo treatments with protease-activated receptor 2 agonist on endothelium function and blood pressures in mice.

J. Valcour, J. McGuire, E. Wijekoon, 2013, Canadian journal of physiology and pharmacology.

Blood pressures, heart rate and locomotor activity during salt loading and angiotensin II infusion in protease-activated receptor 2 (PAR2) knockout mice

B. V. Van Vliet, J. McGuire, Sarah J. Halfyard, 2008, BMC Physiology.

Intrauterine growth-restricted Yucatan miniature pigs experience early catch-up growth, leading to greater adiposity and impaired lipid metabolism as young adults.

B. V. Van Vliet, S. Myrie, J. McGuire, 2017, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high-dose treatment with this drug.

James T. Lin, E. Mini, T. Mazzei, 1988, Cancer research.

Secretion of gamma-glutamyl hydrolase in vitro.

J. Galivan, J. McGuire, R. Rotundo, 1991, Cancer research.

Role of methotrexate polyglutamates in methotrexate- and sequential methotrexate-5-fluorouracil-mediated cell kill.

J. Bertino, E. Mini, J. McGuire, 1985, Cancer research.

Determinants of the disparate antitumor activities of (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolate and methotrexate toward human lymphoblastic leukemia cells, characterized by severely impaired antifolate membrane transport.

L. Matherly, J. McGuire, S. M. Angeles, 1993, Biochemical pharmacology.

Impact of polyglutamation on sensitivity to raltitrexed and methotrexate in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in CCRF-CEM cell lines.

J. Lunec, D. Newell, G. Aherne, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Folylpolyglutamate synthetase expression in antifolate-sensitive and -resistant human cell lines.

J. McGuire, C. Russell, 1998, Oncology research.

Evolution of drug resistance in CCRF-CEM human leukemia cells selected by intermittent methotrexate exposure.

B. Shane, J. McGuire, C. Russell, 1995, Oncology research.

L-erythro-AND D , L-three-y-FLUOROMETHOTREXATE WITH HUMAN LEUKEMIA CELL DIHYDROFOLATE REDUCTASE

J. Coward, J. McGuire, W. Haile, 2002 .

Interaction of D, L-erythro- and D,L-threo-gamma-fluoromethotrexate with human leukemia cell dihydrofolate reductase.

J. Coward, J. McGuire, W. Haile, 1989, Biochemical pharmacology.

Enzymatic synthesis of polyglutamate derivatives of 7-hydroxymethotrexate.

J. Bertino, J. McGuire, P. Hsieh, 1984, Biochemical pharmacology.

Development of an assay system for the detection and classification of methotrexate resistance in fresh human leukemic cells.

S. Rodenhuis, J. Bertino, R. Narayanan, 1986, Cancer research.

Synthesis of N-[4-[(2-Amino-6-Methyl-3,4-Dihydro-4-Oxo-7H-Pyrrolo[2,3-d]-Pyrimidin-5-Yl)Methyl]Benzoyl]-L-Glutamic Acid as an Antifolate

Yibin Zeng, A. Gangjee, J. McGuire, 2002 .

Studies on the cross resistance of folylpolyglutamate synthetase-deficient, methotrexate-resistant CCRF-CEM human leukemia sublines.

J. McGuire, C. Russell, D. McCloskey, 1993, Advances in experimental medicine and biology.

Inherent resistance of human squamous carcinoma cell lines to methotrexate as a result of decreased polyglutamylation of this drug.

J. Bertino, J. McGuire, G. Pizzorno, 1989, Cancer research.

Efficacy of two new systemic fungicides and ethazole for control of Phytophthora root rot of rhododendron, and spread of Phytophthora cinnamomi in propagation benches.

J. McGuire, J. Merlino, L. Englander, 1980 .

In vitro methotrexate polyglutamate synthesis by rat liver folylpolyglutamate synthetase and inhibition by bromosulfophthalein.

J. Bertino, J. Coward, J. McGuire, 1983, Advances in experimental medicine and biology.

An Interaction of the Pre- and Post-Weaning Diets Rich in Omega-6 Polyunsaturated Fats Alters Plasma Lipids, Hepatic Gene Expression and Aortic Vascular Reactivity in Adult C57Bl/6 Mice

K. Chechi, J. McGuire, S. Cheema, 2010, Nutrition and metabolic insights.

Enhanced Nitric Oxide Synthase Activation via Protease-Activated Receptor 2 Is Involved in the Preserved Vasodilation in Aortas from Metabolic Syndrome Rats

Kazuki Nakamura, N. Yoshikawa, S. Kagota, 2016, Journal of Vascular Research.

2-Furoyl-LIGRLO-amide: A Potent and Selective Proteinase-Activated Receptor 2 Agonist

M. Hollenberg, C. Triggle, M. Saifeddine, 2004, Journal of Pharmacology and Experimental Therapeutics.

Submitochondrial localization of the mitochondrial isoform of folylpolyglutamate synthetase in CCRF-CEM human T-lymphoblastic leukemia cells.

J. Nair, J. McGuire, 2005, Biochimica et Biophysica Acta.

Potent inhibition of human folylpolyglutamate synthetase by a phosphinic acid mimic of the tetrahedral reaction intermediate.

J. Coward, J. McGuire, W. Haile, 2003, Biochemical pharmacology.

Developmental programming of lipid metabolism and aortic vascular function in C57BL/6 mice: a novel study suggesting an involvement of LDL-receptor.

K. Chechi, J. McGuire, S. Cheema, 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

The endothelium in health and disease--a target for therapeutic intervention.

K. Andrews, M. Hollenberg, C. Triggle, 2003, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Endothelium-derived relaxing factors: a focus on endothelium-derived hyperpolarizing factor(s).

C. Triggle, H. Ding, J. McGuire, 2001, Canadian journal of physiology and pharmacology.

ENDOTHELIUM-DEPENDENT IMPAIRMENTS TO CEREBRAL VASCULAR REACTIVITY WITH TYPE II DIABETES MELLITUS IN THE GOTO-KAKIZAKI RAT.

S. Whitehead, R. Wiseman, J. Frisbee, 2019, American journal of physiology. Regulatory, integrative and comparative physiology.

Effects of the flavoprotein inhibitor, diphenyleneiodonium sulfate, on ex vivo organic nitrate tolerance in the rat.

D. Anderson, B. Bennett, J. McGuire, 2000, The Journal of pharmacology and experimental therapeutics.

Inhibition of NADPH-cytochrome P450 reductase and glyceryl trinitrate biotransformation by diphenyleneiodonium sulfate.

D. Anderson, B. Bennett, J. McGuire, 1998, Biochemical pharmacology.

PHENOTYPING THE LEVEL OF BLOOD PRESSURE BY TELEMETRY IN MICE

J. Montani, B. V. Van Vliet, J. McGuire, 2006, Clinical and experimental pharmacology & physiology.

Synthesis and Biological Evaluation of dl-4,4-Difluoroglutamic Acid and dl-γ,γ-Difluoromethotrexate

T. Tsukamoto, J. Coward, T. Kitazume, 1996 .

Design, synthesis, and biological activities of classical N-[4-[2-(2-amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and its 6-methyl derivative as potential dual inhibitors of thymidylate synthase and dihydrofolate reductase and as potential antitumor agents.

A. Gangjee, J. McGuire, R. Kisliuk, 2003, Journal of Medicinal Chemistry.

Secretion of γ-Glutamyl Hydrolase in Vitro

J. Galivan, J. McGuire, R. Rotundo, 1991 .

Glutamylation of methotrexate in hepatoma cells in vitro: regulation and the development of specific inhibitors.

J. Coward, J. Galivan, J. McGuire, 1985, Advances in Enzyme Regulation.

Effects of methotrexate and of the "nonclassical" folate antagonist trimetrexate on human leukemia cells.

S. Rodenhuis, J. Bertino, J. McGuire, 1987, Leukemia.

Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on human head and neck and human leukemia cell lines.

J. McGuire, G. Nagel, J. Canestrari, 1999, International journal of oncology.

Cardiac expression of ryanodine receptor subtype 3; a strategic component in the intracellular Ca2+ release system of Purkinje fibers in large mammalian heart.

K. Haq, V. Sorrentino, M. Miura, 2017, Journal of molecular and cellular cardiology.

Can Myogenic Tone Protect Endothelial Function? Integrating Myogenic Activation and Dilator Reactivity for Cerebral Resistance Arteries in Metabolic Disease

J. Lombard, J. Frisbee, P. Chantler, 2021, Journal of Vascular Research.

Dihydrofolate synthetase and folylpolyglutamate synthetase: direct evidence for intervention of acyl phosphate intermediates.

R. Banerjee, B. Shane, J. Coward, 1988, Biochemistry.

gamma-Fluoromethotrexate: synthesis and biological activity of a potent inhibitor of dihydrofolate reductase with greatly diminished ability to form poly-gamma-glutamates.

James Inglese, J. Coward, J. Galivan, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Cross-resistance studies of folylpolyglutamate synthetase-deficient, methotrexate-resistant CCRF-CEM human leukemia sublines.

J. McGuire, C. Russell, D. McCloskey, 1993, Leukemia.

Synthesis and biological activity of folic acid and methotrexate analogues containing L-threo-(2S,4S)-4-fluoroglutamic acid and DL-3,3-difluoroglutamic acid.

J. Coward, J. McGuire, W. Bolanowska, 1996, Journal of medicinal chemistry.

Blood pressures, heart rate and locomotor activity during salt loading and angiotensin II infusion in protease-activated receptor 2 (PAR2) knockout mice

B. V. Van Vliet, J. McGuire, Sarah J. Halfyard, 2008, BMC Physiology.

Uptake and metabolism of 5,8-dideazaisofolic acid in human colon carcinoma cells.

J. Bertino, A. Sobrero, J. McGuire, 1988, Biochemical pharmacology.

Mechanism of action of 5,8-dideazaisofolic acid and other quinazoline antifols in human colon carcinoma cells.

J. Bertino, A. Sobrero, J. Hynes, 1987, Cancer research.

2-Amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as Nonclassical Antifolate Inhibitors of Thymidylate Synthase.

F. Mavandadi, S. Queener, A. Gangjee, 1997, Journal of medicinal chemistry.

Time-Dependent Differences in the Influence of Perivascular Adipose Tissue on Vasomotor Functions in Metabolic Syndrome.

S. Kagota, Kana Maruyama, K. Shinozuka, 2017, Metabolic syndrome and related disorders.

Potent inhibition of human folylpolyglutamate synthetase by suramin.

J. McGuire, W. H. Haile, 1996, Archives of biochemistry and biophysics.

Synthesis and Biological Evaluation of Nα-(4-Amino-4-deoxy-10- methylpteroyl)-DL-4,4-difluoroornithine.

T. Tsukamoto, J. Coward, J. McGuire, 1996 .