S. H. Chiu

发表

Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.

T. Baillie, Yong Zhang, Wei Tang, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Extrapolation of Diclofenac Clearance from in Vitro Microsomal Metabolism Data: Role of Acyl Glucuronidation and Sequential Oxidative Metabolism of the Acyl Glucuronide

T. Baillie, K. Samuel, Sanjeev Kumar, 2002, Journal of Pharmacology and Experimental Therapeutics.

N-Glucuronidation of Xenobiotics Symposium SPECIES DIFFERENCES IN N-GLUCURONIDATION

S. Huskey, S. H. Chiu, 1998 .

Mechanism of bioactivation and covalent binding of 2,4,6-trinitrotoluene.

M. Yao, R. Stearns, K. H. Leung, 1995, Chemico-biological interactions.

The use of in vitro metabolism studies in the understanding of new drugs.

S. H. Chiu, 1993, Journal of pharmacological and toxicological methods.

Identification of human cytochrome P450 isozymes responsible for the in vitro oxidative metabolism of finasteride.

R. Miller, D. Dean, S. Huskey, 1995, Drug metabolism and disposition: the biological fate of chemicals.

A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys.

R. Miller, C. Strader, J. Metzger, 1998, The Journal of clinical investigation.

Pharmacokinetics and Interactions of a Novel CCR5 Receptor Antagonist with Ritonavir in Rats and Monkeys: Role of CYP3A and P-glycoprotein

T. Baillie, Jiunn H. Lin, Sanjeev Kumar, 2002 .

Metabolism of a thiazole benzenesulfonamide derivative, a potent and elective agonist of the human beta3-adrenergic receptor, in rats: identification of a novel isethionic acid conjugate.

T. Baillie, A. Weber, Wei Tang, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Substance P receptor antagonist I: conversion of phosphoramidate prodrug after i.v. administration to rats and dogs.

S. Huskey, W. Feeney, S. H. Chiu, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Effects of the immunosuppressant FK-506 and its analog FK-520 on hepatic and renal cytochrome P450 mixed-function oxidase.

S. Vincent, B. Karanam, S. H. Chiu, 1991, Biochemical pharmacology.

L-770,644: a potent and selective human beta3 adrenergic receptor agonist with improved oral bioavailability.

R. Miller, C. Strader, D. Macintyre, 1999, Bioorganic & medicinal chemistry letters.

In vivo covalent binding of [14C]trinitrotoluene to proteins in the rat.

R. Stearns, S. H. Chiu, Y. Y. Liu, 1992, Chemico-biological interactions.

Species and gender differences in the formation of an active metabolite of a substituted 2,4-thiazolidinedione insulin sensitizer

M. Beconi, R. Franklin, N. Yu, 2003, Xenobiotica; the fate of foreign compounds in biological systems.

Disposition and metabolism of finasteride in dogs.

R. Miller, B. Arison, S. H. Chiu, 1997, Drug metabolism and disposition: the biological fate of chemicals.

3-Pyridyloxypropanolamine agonists of the beta 3 adrenergic receptor with improved pharmacokinetic properties.

R. Miller, C. Strader, D. Macintyre, 1998, Bioorganic & medicinal chemistry letters.

The design and synthesis of orally active short duration spiroindane growth hormone secretagogues

Roy G. Smith, A. Patchett, G. Hickey, 1997 .

Pharmacokinetics and disposition of the oxytocin receptor antagonist L-368,899 in rats and dogs.

R. Miller, W. Feeney, M. Wallace, 1997, Drug metabolism and disposition: the biological fate of chemicals.

1-(((7,7-Dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido) bicyclo(2.2.1)heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl) piperazine (L-368,899): An Orally Bioavailable, Non-Peptide Oxytocin Antagonist with Potential Utility for Managing Preterm Labor.

B. E. Evans, M. Bock, R. Freidinger, 1994 .

1-((7,7-Dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo [2.2.1]-heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperaz ine (L-368,899): an orally bioavailable, non-peptide oxytocin antagonist with potential utility for managing preterm labor.

B. E. Evans, M. Bock, P. Anderson, 1994, Journal of medicinal chemistry.

The metabolism of DuP 753, a nonpeptide angiotensin II receptor antagonist, by rat, monkey, and human liver slices.

R. Miller, G. Gatto, P. Chakravarty, 1992, Drug metabolism and disposition: the biological fate of chemicals.

Efrotomycin interaction with soil clay and organic matter fractions

R. Tate, S. H. Chiu, B. Halley, 1989 .

O-Benzylated thioglucoses, intermediates for the synthesis of (1→6)- and (1→4)-linked oligosaccharides: S-benzylation, coupling, and thioglycoside cleavage

S. H. Chiu, L. Anderson, S. A. Holick, 1976 .

Absorption, tissue distribution, and excretion of tritium-labeled ivermectin in cattle, sheep, and rat

T. A. Jacob, S. H. Chiu, A. Rosegay, 1990 .

Phosphorylated morpholine acetal human neurokinin-1 receptor antagonists as water-soluble prodrugs.

J. Metzger, M. Maccoss, D. Macintyre, 2000, Journal of medicinal chemistry.

Synthesis of methyl 2-amino-2,6-dideoxy-α-D-altropyranoside and methyl 3-amino-3,6-dideoxy-α-D-glucopyranoside

S. H. Chiu, H. H. Baer, 1973 .

Orally active inhibitors of human leukocyte elastase. III. Identification and characterization of metabolites of L-694,458 by liquid chromatography-tandem mass spectrometry.

B. Arison, R. Stearns, S. H. Chiu, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Depletion of [14C]-clorsulon in cows' milk

S. H. Chiu, B. Halley, R. M. Bodden, 1989 .

Orally active inhibitors of human leukocyte elastase. II. Disposition of L-694,458 in rats and rhesus monkeys.

G. Doss, B. Karanam, S. H. Chiu, 1997, Drug metabolism and disposition: the biological fate of chemicals.

The metabolic disposition of aprepitant, a substance P receptor antagonist, in rats and dogs.

A. Robichaud, T. Baillie, R. Anari, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Brain penetration of aprepitant, a substance P receptor antagonist, in ferrets.

R. Hargreaves, R. Sanchez, R. Bakhtiar, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Pharmacokinetics and Interactions of a Novel Antagonist of Chemokine Receptor 5 (CCR5) with Ritonavir in Rats and Monkeys: Role of CYP3A and P-Glycoprotein

T. Baillie, Sanjeev Kumar, P. Pearson, 2002, Journal of Pharmacology and Experimental Therapeutics.

The Synthesis of Nitro and Dimeric Nitroso Sugars by Peracid Oxidation of Amino Sugars

S. H. Chiu, H. H. Baer, 1973 .

Species differences in N-glucuronidation.

S. Huskey, S H Chiu, S W Huskey, 1998, Drug metabolism and disposition: the biological fate of chemicals.

N-glucuronidation reactions. III. Regioselectivity of N-glucuronidation of methylbiphenyl tetrazole, methylbiphenyl triazole, and methylbiphenyl imidazole using human and rat recombinant UDP-glucuronosyltransferases stably expressed in V79 cells.

G. Siest, J. Magdalou, S. H. Chiu, 1994, Drug metabolism and disposition: the biological fate of chemicals.

N-glucuronidation reactions. II. Relative N-glucuronidation reactivity of methylbiphenyl tetrazole, methylbiphenyl triazole, and methylbiphenyl imidazole in rat, monkey, and human hepatic microsomes.

R. Miller, G. Doss, S. Huskey, 1994, Drug metabolism and disposition: the biological fate of chemicals.

The Synthesis of Miserotoxin and Structural Analogs

S. H. Chiu, H. H. Baer, D. C. Shields, 1973 .

Comparative in vivo and in vitro metabolism of ivermectin in steers, sheep, swine, and rat.

A. Y. Lu, T. A. Jacob, S. H. Chiu, 1987, Drug metabolism reviews.

Metabolic disposition of ivermectin in tissues of cattle, sheep, and rats.

B. Arison, M. Green, T. A. Jacob, 1986, Drug metabolism and disposition: the biological fate of chemicals.

CYTOCHROME P450 3A4 IS THE MAJOR ENZYME INVOLVED IN THE METABOLISM OF THE SUBSTANCE P RECEPTOR ANTAGONIST APREPITANT

P. Lu, R. Sanchez, D. C. Evans, 2004, Drug Metabolism and Disposition.

In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism.

S. Vincent, B. Karanam, S. H. Chiu, 1992, Archives of biochemistry and biophysics.

Metabolism and Tissue Residues

A. Y. Lu, S. H. Chiu, 1989 .

Disposition of L-732,531, a potent immunosuppressant, in rats and baboons.

R. Miller, B. Karanam, K. Carey, 1998, Drug metabolism and disposition: the biological fate of chemicals.

Development of a unified approach to evaluate the toxicological potential of bound residues.

A. Y. Lu, S. H. Chiu, P. Wislocki, 1990, Drug metabolism reviews.

TISSUE DRUG RESIDUES AND THEIR

A. Y. Lu, G. Miwa, S. H. Chiu, 1987 .

Tissue drug residues and their toxicological significance.

A. Y. Lu, G. Miwa, S. H. Chiu, 1987, Drug metabolism reviews.

The pharmacokinetics of a thiazole benzenesulfonamide beta 3-adrenergic receptor agonist and its analogs in rats, dogs, and monkeys: improving oral bioavailability.

A. Weber, Wei Tang, G. Kwei, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Synthesis and identification of a novel tetrazole metabolite of the angiotensin II receptor antagonist DuP 753.

R. Miller, G. Doss, R. Stearns, 1991, Drug metabolism and disposition: the biological fate of chemicals.

N-glucuronidation reactions. I. Tetrazole N-glucuronidation of selected angiotensin II receptor antagonists in hepatic microsomes from rats, dogs, monkeys, and humans.

R. Miller, S. H. Chiu, S. Huskey, 1993, Drug metabolism and disposition: the biological fate of chemicals.

Biotransformation of losartan to its active carboxylic acid metabolite in human liver microsomes. Role of cytochrome P4502C and 3A subfamily members.

P. Chakravarty, R. Stearns, S. H. Chiu, 1995, Drug metabolism and disposition: the biological fate of chemicals.

Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac.

T. Baillie, W. Tang, R. Stearns, 1999, Chemical research in toxicology.

Napthyridines. IV. Synthesis of benzo[f]-1,7-naphthyridines†

S. H. Chiu, H. Baumgarten, R. Thompson, 1981 .

Determination of ivermectin residue in animal tissues by high-performance liquid chromatography-reverse isotope dilution assay

T. A. Jacob, S. H. Chiu, R. Buhs, 1985 .

1-[2(R)-(2-amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl]- 3-benzylpiperidine-3(S)-carboxylic acid ethyl ester (L-163,540): a potent, orally bioavailable, and short-duration growth hormone secretagogue.

A. Patchett, K. Leung, G. Morriello, 1998, Journal of medicinal chemistry.

FK 506 metabolism in human liver microsomes: investigation of the involvement of cytochrome P450 isozymes other than CYP3A4.

B. Karanam, S. H. Chiu, S. Vincent, 1994, Drug metabolism and disposition: the biological fate of chemicals.

Identification of metabolites of a substance P (neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma.

R. Mortishire-Smith, U. Gerhard, Sanjeev Kumar, 2002, Drug Metabolism And Disposition.

Orally active, non-peptide oxytocin antagonists

B. E. Evans, D. Veber, M. Bock, 1994 .

Application of two-dimensional high-performance liquid chromatography in metabolism studies of ivermectin.

S. H. Chiu, R. Taub, E. Sestokas, 1988, Journal of chromatography.

Use of on-line hydrogen/deuterium exchange to facilitate metabolite identification.

David Q. Liu, M. Beconi, C. Hop, 2001, Rapid communications in mass spectrometry : RCM.