Y. Lau

发表

Evaluation of a novel in vitro Caco-2 hepatocyte hybrid system for predicting in vivo oral bioavailability.

Tongtong Liu, Yung-Hsiang Chen, Cheng Li, 2004, Drug metabolism and disposition: the biological fate of chemicals.

The Use of in Vitro Metabolic Stability for Rapid Selection of Compounds in Early Discovery Based on Their Expected Hepatic Extraction Ratios

I. Chu, Y. Lau, N. Yumibe, 2002, Pharmaceutical Research.

Automatic mass spectrometry method development for drug discovery: application in metabolic stability assays.

Candace Black-Schaefer, L. Chovan, P. Dandliker, 2004, Rapid communications in mass spectrometry : RCM.

Intracellular Analysis with an Immobilized-Enzyme Glucose Electrode Havine 2-Micrometers Diameter and Subsecond Response Times

A. Ewing, T. Abe, Y. Lau, 1991 .

A high-throughput cell-based reporter gene system for measurement of CYP1A1 induction.

K. Cheng, Ronald E. White, Y. Lau, 2002, Journal of pharmacological and toxicological methods.

Solid phase extraction as a faster alternative to HPLC: application to MS analysis of metabolic stability samples.

L. Chovan, P. Dandliker, Y. Lau, 2007, Journal of pharmaceutical sciences.

Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1.

Steven C. Cullen, P. Hajduk, A. Souers, 2012, Journal of medicinal chemistry.

Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor.

A. Souers, G. Diaz, H. Sham, 2008, Journal of medicinal chemistry.

Determination of Ibuprofen Enantiomers in Human Plasma by Derivatization and High Performance Liquid Chromatography with Fluorescence Detection

Y. Lau, 1996 .

Pharmacokinetic Enhancement of the Hepatitis C Virus Protease Inhibitors VX-950 and SCH 503034 by Co-Dosing with Ritonavir

D. Kempf, J. Randolph, K. Marsh, 2007, Antiviral chemistry & chemotherapy.

955 PRECLINICAL POTENCY, PHARMACOKINETIC AND ADME CHARACTERIZATION OF ABT-333, A NOVEL NON-NUCLEOSIDE HCV POLYMERASE INHIBITOR

A. Molla, D. Beno, C. Flentge, 2009 .

Characterization of glucose microsensors for intracellular measurements.

A. Ewing, T. Abe, Y. Lau, 1992, Analytical chemistry.

4 Pharmacokinetic boosting of VX-950, an inhibitor of HCV protease, by co-dosing with ritonavir

D. Kempf, J. Randolph, K. Marsh, 2006 .

Semi-automated determination of plasma stability of drug discovery compounds using liquid chromatography-tandem mass spectrometry.

Walter A. Korfmacher, K. Ng, Gangfeng Wang, 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Determination of rifabutin in human plasma by high-performance liquid chromatography with ultraviolet detection.

Y. Lau, B. J. Carel, G. Hanson, 1996, Journal of chromatography. B, Biomedical applications.

Development of a novel in vitro model to predict hepatic clearance using fresh, cryopreserved, and sandwich-cultured hepatocytes.

Yau Yi Lau, Elpida Sapidou, Xiaoming Cui, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Semi-automatic high-throughput determination of plasma protein binding using a 96-well plate filtrate assembly and fast liquid chromatography-tandem mass spectrometry.

Yung-Hsiang Chen, Eliza N Fung, Yau Yi Lau, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Determination of pramipexole (U-98,528) in human plasma and urine by high-performance liquid chromatography with electrochemical and ultraviolet detection.

Y. Lau, G. Hanson, N. Ichhpurani, 1996, Journal of chromatography. B, Biomedical applications.

Determination of pramipexole (U-98,528) in human plasma by high-performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry.

R. Talaat, Y. Lau, G. Hanson, 1996, Journal of chromatography. B, Biomedical applications.

Determination of rifampin in human plasma by high-performance liquid chromatography with ultraviolet detection.

Y. Lau, B. J. Carel, G. Hanson, 1996, Journal of chromatography. B, Biomedical applications.

Analytical chemistry in microenvironments: single nerve cells

Andrew G. Ewing, A. Ewing, Timothy G. Strein, 1992 .

Characterization of the voltammetric response at intracellular carbon ring electrodes

A. Ewing, D. Wong, Y. Lau, 1991 .

Pulse Voltammetry in Single Cells Using Platinum Microelectrodes

A. Ewing, D. Wong, Y. Lau, 1992 .

Capillary electrophoresis of single cells: observation of two compartments of neurotransmitter vesicles

Andrew G. Ewing, A. Ewing, Helle K. Kristensen, 1994, Journal of Neuroscience Methods.

Rapid hit to lead evaluation of pyrazolo[3,4-d]pyrimidin-4-one as selective and orally bioavailable mGluR1 antagonists.

J. Brioni, R. Moreland, P. Honore, 2007, Bioorganic & medicinal chemistry letters.

Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport

D. Sulzer, A. Ewing, S. Rayport, 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Voltammetric measurement of oxygen in single neurons using platinized carbon ring electrodes.

A. Ewing, T. Abe, Y. Lau, 1992, Analytical chemistry.