Piro Lito

Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism

Neal Rosen, N. Rosen, P. Lito, 2016, Science.

Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors.

Christof Fellmann, Scott Lowe, Neal Rosen, 2014, Cancer cell.

Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition

Davide Risso, Besnik Qeriqi, L. Mazutis, 2020, Nature.