Karen L. Milkiewicz

发表

A selective, orally bioavailable 1,2,4-triazolo[1,5-a]pyridine-based inhibitor of Janus kinase 2 for use in anticancer therapy: discovery of CEP-33779.

Jennifer L. Mason, Pawel Dobrzanski, Bruce D. Dorsey, 2012, Journal of medicinal chemistry.

Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo

D. Parks, Tianbao Lu, J. Marugan, 2006, Molecular Cancer Therapeutics.

Substituted 1,4‐Benzodiazepine‐2,5‐diones as α‐Helix Mimetic Antagonists of the HDM2‐p53 Protein–Protein Interaction

Maxwell D Cummings, D. Parks, Tianbao Lu, 2006, Chemical biology & drug design.

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

Maxwell D Cummings, B. Tomczuk, J. Spurlino, 2005, Journal of medicinal chemistry.

Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases.

Jennifer L. Mason, P. Dobrzanski, K. L. Milkiewicz, 2012, Bioorganic & medicinal chemistry letters.

1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2-p53 interaction: discovery and SAR.

Maxwell D Cummings, D. Parks, Tianbao Lu, 2005, Bioorganic & medicinal chemistry letters.

Inhibitors of anaplastic lymphoma kinase: a patent review

K. L. Milkiewicz, Gregory R Ott, Karen L Milkiewicz, 2010, Expert opinion on therapeutic patents.

Synthesis and structure-activity relationships of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase.

A. Ghose, K. L. Milkiewicz, T. Underiner, 2010, Bioorganic & medicinal chemistry.

7-fluoroindazoles as potent and selective inhibitors of factor Xa.

Mark R Player, D. Parks, Yu-Kai Lee, 2008, Journal of medicinal chemistry.

Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein-protein interaction through structure-based drug design.

Maxwell D Cummings, D. Parks, Tianbao Lu, 2006, Bioorganic & medicinal chemistry letters.

Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group.

K. L. Milkiewicz, S. Miknyoczki, T. Underiner, 2011, Bioorganic & medicinal chemistry.

Synthesis of a novel series of 10-oxa-3-aza-tricyclo[5.2.1.01,5]dec-8-en-4-ones through an intramolecular Diels–Alder reaction

D. Parks, Tianbao Lu, K. L. Milkiewicz, 2003 .

Synthesis of a novel series of tetra-substituted furan[3,2-b]pyrroles

D. Parks, Tianbao Lu, Karen L. Milkiewicz, 2003 .