Leonardo Pardo

发表

Identifying human diamine sensors for death related putrescine and cadaverine molecules

Jean-Christophe Nebel, Cristina Izquierdo, José C. Gómez-Tamayo, 2018, PLoS Comput. Biol..

Binding of proteins to the minor groove of DNA: What are the structural and energetic determinants for kinking a basepair step?

Leonardo Pardo, David Bosch, Mercedes Campillo, 2003, J. Comput. Chem..

TMalphaDB and TMbetaDB: web servers to study the structural role of sequence motifs in α-helix and β-barrel domains of membrane proteins

Arnau Cordomí, Leonardo Pardo, Mireia Olivella, 2015, BMC Bioinformatics.

Ligand Binding Determinants for Angiotensin II Type 1 Receptor from Computer Simulations

Arnau Cordomí, Leonardo Pardo, Theodore V. Tselios, 2013, J. Chem. Inf. Model..

Relation between sequence and structure in membrane proteins

Leonardo Pardo, Mireia Olivella, Xavier Deupí, 2013, Bioinform..

Computational Model of the Complex between GR113808 and the 5-HT4 Receptor Guided by Site-Directed Mutagenesis and the Crystal Structure of Rhodopsin

Leonardo Pardo, Marta Murcia, Mireia Olivella, 2001, J. Comput. Aided Mol. Des..

Mechanisms Underlying Allosteric Molecular Switches of Metabotropic Glutamate Receptor 5

Leonardo Pardo, Laura Pérez-Benito, Gary Tresadern, 2019, J. Chem. Inf. Model..

GPCRtm: An amino acid substitution matrix for the transmembrane region of class A G Protein-Coupled Receptors

Gianluigi Caltabiano, Leonardo Pardo, Angel Gonzalez, 2015, BMC Bioinformatics.

A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.

Leonardo Pardo, Bellinda Benhamú, Mercedes Campillo, 2005, Journal of medicinal chemistry.

Ser and Thr Residues Modulate the Conformation of Pro-Kinked Transmembrane α-Helices

Leonardo Pardo, Mercedes Campillo, Xavier Deupi, 2004 .

Membrane Protein Simulations Using AMBER Force Field and Berger Lipid Parameters.

Gianluigi Caltabiano, Arnau Cordomí, Leonardo Pardo, 2012, Journal of chemical theory and computation.

Computational models for proton transfer in biological systems

Leonardo Pardo, Roman Osman, L. Pardo, 1990 .

Serine and Threonine Residues Bend α-Helices in the χ1 = g− Conformation

Leonardo Pardo, Eric E. J. Haaksma, Xavier Deupi, 2000 .

Molecular Basis of Ligand Dissociation in β-Adrenergic Receptors

Leonardo Pardo, Tomas Perez-Acle, Xavier Deupi, 2011, PloS one.

Analysis of the interactions of sulfur‐containing amino acids in membrane proteins

Arnau Cordomí, Leonardo Pardo, Eduardo Mayol, 2016, Protein science : a publication of the Protein Society.

Mechanisms of nucleophilic addition to activated double bonds : 1,2- and 1,4-Michael addition of ammonia

Harel Weinstein, Leonardo Pardo, Roman Osman, 1993 .

Influence of the g- conformation of Ser and Thr on the structure of transmembrane helices.

Leonardo Pardo, Nicole Dölker, Mercedes Campillo, 2010, Journal of structural biology.

A Structural Insight into the Reorientation of Transmembrane Domains 3 and 5 during Family A G Protein-Coupled Receptor Activation

Saskia Nijmeijer, Rob Leurs, Leonardo Pardo, 2011, Molecular Pharmacology.

Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.

Jessica Sallander, Leonardo Pardo, Bellinda Benhamú, 2010, Journal of medicinal chemistry.

Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.

Leonardo Pardo, Bellinda Benhamú, L. Pardo, 2014, Journal of medicinal chemistry.

Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity.

Jessica Sallander, Leonardo Pardo, Bellinda Benhamú, 2009, Journal of medicinal chemistry.

An Activation Switch in the Rhodopsin Family of G Protein-coupled Receptors

Leonardo Pardo, L. Pardo, S. Costagliola, 2005, Journal of Biological Chemistry.

A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer.

Leonardo Pardo, Evi Kostenis, Michael Gütschow, 2012, Nature chemical biology.

Pharmacogenomic and structural analysis of constitutive g protein-coupled receptor activity.

Rob Leurs, Leonardo Pardo, Henk Timmerman, 2007, Annual review of pharmacology and toxicology.

Modeling of G protein-coupled receptors using crystal structures: from monomers to signaling complexes.

Arnau Cordomí, Leonardo Pardo, Julian Zachmann, 2014, Advances in experimental medicine and biology.

Activation of CCR5 by Chemokines Involves an Aromatic Cluster between Transmembrane Helices 2 and 3*

Shoshana J. Wodak, Marc Parmentier, Leonardo Pardo, 2003, The Journal of Biological Chemistry.

The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo.

Gianluigi Caltabiano, Leonardo Pardo, Bellinda Benhamú, 2014, Journal of medicinal chemistry.

Quantum chemical study of the molecular patterns of MAO inhibitors and substrates

Ferran Sanz, Leonardo Pardo, Mercedes Campillo, 1983 .

Impact of Helix Irregularities on Sequence Alignment and Homology Modeling of G Protein‐Coupled Receptors

Gianluigi Caltabiano, Arnau Cordomí, Leonardo Pardo, 2012, Chembiochem : a European journal of chemical biology.

Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 8.1 Computational Simulation of Ligand−Receptor Interaction of 5-HT1AR Agonists with Selectivity over α1-Adrenoceptors

Leonardo Pardo, Mercedes Delgado, Esther Fernández, 2005 .

Ligand chain length drives activation of lipid G protein-coupled receptors

Leonardo Pardo, Julian Zachmann, Inés González-Gil, 2017, Scientific Reports.

Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer

Leonardo Pardo, Xavier Deupi, L. Pardo, 2009, The EMBO journal.

Structural models of class a G protein-coupled receptors as a tool for drug design: insights on transmembrane bundle plasticity.

Leonardo Pardo, Nicole Dölker, Mercedes Campillo, 2007, Current topics in medicinal chemistry.

Molecular Switches of Allosteric Modulation of the Metabotropic Glutamate 2 Receptor.

Arnau Cordomí, Leonardo Pardo, Laura Pérez-Benito, 2017, Structure.

The G-protein coupled receptor family: actors with many faces.

Arnau Cordomí, Leonardo Pardo, George Liapakis, 2012, Current pharmaceutical design.

Influence of the environment in the conformation of alpha-helices studied by protein database search and molecular dynamics simulations.

Leonardo Pardo, Xavier Deupi, Mireia Olivella, 2002, Biophysical journal.

Identification of small-molecule inhibitors of calcineurin-NFATc signaling that mimic the PxIxIT motif of calcineurin binding partners

Minos-Timotheos Matsoukas, Leonardo Pardo, Teresa Lozano, 2015, Science Signaling.

Conformational Toggle Switches Implicated in Basal Constitutive and Agonist-Induced Activated States of 5-Hydroxytryptamine-4 Receptors

Jessica Sallander, Leonardo Pardo, Mercedes Campillo, 2009, Molecular Pharmacology.

Quantum chemical structure–activity relationships on β‐carbolines as natural monoamine oxidase inhibitors

Ferran Sanz, Leonardo Pardo, Mercedes Campillo, 1983 .

The Role of Internal Water Molecules in the Structure and Function of the Rhodopsin Family of G Protein‐Coupled Receptors

Leonardo Pardo, Nicole Dölker, Mercedes Campillo, 2007, Chembiochem : a European journal of chemical biology.