H. Finlay

发表

Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages.

M. Sporn, N. Suh, T. Honda, 2000, Journal of medicinal chemistry.

Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-[(1R)-1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311).

David S. Taylor, Hong Shen, M. Poss, 2015, Journal of medicinal chemistry.

Discovery of hydroxyl 1,2-diphenylethanamine analogs as potent cholesterol ester transfer protein inhibitors.

David S. Taylor, P. Sleph, M. Salvati, 2016, Bioorganic & medicinal chemistry letters.

Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) which Demonstrate HDL-C Increase In Vivo.

David S. Taylor, K. Behnia, E. Liu, 2020, Journal of medicinal chemistry.

PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor.

David S. Taylor, P. Sleph, L. Abell, 2018, ACS medicinal chemistry letters.

Discovery of 5-Phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine as a Potent I Kur Inhibitor.

S. Mandlekar, Abhisek Banerjee, M. Conder, 2016, ACS medicinal chemistry letters.

Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor.

David S. Taylor, P. Sleph, M. Salvati, 2019, ACS medicinal chemistry letters.

Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers.

Huabin Sun, Christine S. Huang, M. Conder, 2010, Bioorganic & medicinal chemistry letters.

Benzopyran sulfonamides as KV1.5 potassium channel blockers.

T. Huynh, Wayne Vaccaro, M. Conder, 2007, Bioorganic & medicinal chemistry letters.

Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors.

David S. Nirschl, David S. Taylor, David S Nirschl, 2014, Bioorganic & medicinal chemistry letters.

Linking (Pyr)1apelin-13 pharmacokinetics to efficacy: Stabilization and measurement of a high clearance peptide in rodents.

Michael C. Myers, Rongan Zhang, P. Gargalovic, 2019, Analytical biochemistry.

New enone derivatives of oleanolic acid and ursolic acid as inhibitors of nitric oxide production in mouse macrophages

M. Sporn, N. Suh, T. Honda, 1997 .

Novel synthetic oleanane and ursane triterpenoids with various enone functionalities in ring A as inhibitors of nitric oxide production in mouse macrophages.

M. Sporn, N. Suh, T. Honda, 2000, Journal of medicinal chemistry.

Synthesis of tertiary carbinamines

M. Poss, M. Salvati, R. Lawrence, 2012 .

Synthesis of Tertiary Carbinamines.

M. Poss, M. Salvati, R. Lawrence, 2012 .

Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) inhibitors.

David S. Nirschl, David S. Taylor, David S Nirschl, 2012, Journal of medicinal chemistry.

The Discovery and Chemical Development of BMS-919373: A Selective I Kur Inhibitor for the Potential Treatment of Atrial Fibrillation

Jason M. Stevens, Miao Yu, S. Wisniewski, 2020 .

Dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur)).

T. Huynh, Wayne Vaccaro, M. Conder, 2008, Bioorganic & medicinal chemistry letters.

Dihydropyrazolopyrimidines containing benzimidazoles as K(V)1.5 potassium channel antagonists.

Huabin Sun, T. Huynh, Wayne Vaccaro, 2009, Bioorganic & medicinal chemistry letters.

Concise, efficient new synthesis of pipercide, an insecticidal unsaturated amide from Piper nigrum, and related compounds

H. Finlay, G. Strunz, 1994 .

Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages.

M. Sporn, C. Nathan, N. Suh, 1998, Cancer research.

Expedient synthesis of unsaturated amide alkaloids from Piper spp: Exploring the scope of recent methodology

H. Finlay, G. Strunz, Heather J. Finlay, 1996 .

Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species.

M. Salvati, Christine S. Huang, M. Hageman, 2018, Journal of pharmaceutical sciences.

Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase.

David S. Taylor, Brandon L. Parkhurst, E. Liu, 2019, Bioorganic & medicinal chemistry letters.

Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors.

David S. Taylor, Michael A. Galella, Hong Shen, 2018, Bioorganic & medicinal chemistry letters.

Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase.

David S. Taylor, Michael A. Galella, L. Abell, 2018, ACS medicinal chemistry letters.

Design, synthesis and evaluation of phenethylaminoheterocycles as K(v)1.5 inhibitors.

Huabin Sun, M. Conder, J. Lloyd, 2014, Bioorganic & medicinal chemistry letters.

Benzothiazole-based compounds as potent endothelial lipase inhibitors.

David S. Taylor, R. Wexler, Xiaohong Yin, 2019, Bioorganic & medicinal chemistry letters.

Selective IKur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide.

S. Mandlekar, A. Mathur, Abhisek Banerjee, 2017, Journal of medicinal chemistry.

Design and preparation of N-linked hydroxypyridine-based APJ agonists.

P. Gargalovic, D. Gordon, R. Wexler, 2022, Bioorganic & medicinal chemistry letters.

Synthesis of novel [3,2-b]indole fused oleanolic acids as potential inhibitors of cell proliferation

T. Honda, G. Gribble, H. Finlay, 2003 .

In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure

P. Gargalovic, M. Bouvier, D. Gordon, 2021, Circulation. Heart failure.

Synthesis of sarmentosine, an amide alkaloid from Piper sarmentosum

H. Finlay, G. Strunz, 1995 .

Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists.

M. Blanar, M. Conder, J. Lloyd, 2013, Bioorganic & medicinal chemistry letters.

Novel A-ring cleaved analogs of oleanolic and ursolic acids which affect growth regulation in NRP.152 prostate cells

M. Sporn, D. Danielpour, N. Suh, 1997 .

Identification of 6-Hydroxypyrimidin-4(1H)-one-3-carboxamides as Potent and Orally Active APJ Receptor Agonists.

P. Gargalovic, D. Gordon, R. Wexler, 2021, ACS medicinal chemistry letters.

Identification of 6-Hydroxy-5-phenylsulfonylpyrimidin-4(1H)-one APJ Receptor Agonists.

Michael A. Galella, P. Gargalovic, R. Wexler, 2021, Bioorganic & Medicinal Chemistry Letters.

Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure.

P. Gargalovic, R. Wexler, Tao Wang, 2021, Journal of medicinal chemistry.

Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate.

Michael A. Galella, P. Gargalovic, Soong-Hoon Kim, 2021, Journal of medicinal chemistry.

Pyrano-[2,3b]-pyridines as potassium channel antagonists.

M. Conder, J. Lloyd, P. Levesque, 2008, Bioorganic & medicinal chemistry letters.