K. Kunishiro

发表

A novel series of (S)-2,7-substituted-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor α/γ dual agonists with protein-tyrosine phosphatase 1B inhibitory activity.

Kazuya Otake, Satoru Azukizawa, Masaki Fukui, 2011, Chemical & pharmaceutical bulletin.

Synthesis and Biological Evaluation of (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acids: A Novel Series of PPARγ Agonists

Kenji Takahashi, C. Mukai, Satoru Azukizawa, 2008 .

Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam cells.

Tomohiro Miike, K. Kunishiro, H. Shirahase, 2008, Life sciences.

NK1 receptor-mediated endothelium-dependent relaxation and contraction with different sensitivity to post-receptor signaling in pulmonary arteries.

Tomohiro Miike, K. Kunishiro, H. Shirahase, 2009, Vascular pharmacology.

Regional heterogeneity of substance P-induced endothelium-dependent contraction, relaxation, and -independent contraction in rabbit pulmonary arteries.

Tomohiro Miike, K. Kunishiro, H. Shirahase, 2008, Life sciences.

Impairment of endothelium-dependent ACh-induced relaxation in aorta of diabetic db/db mice—possible dysfunction of receptor and/or receptor–G protein coupling

Satoru Azukizawa, Tomohiro Miike, K. Kunishiro, 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

Effects of Rooibos Tea Extra . ct on and Cytokine Generation in VitroAntigen-specific a d in Vivo Antibody Production

A. Tai, K. Kunishiro, 2018 .

Effects of Rooibos Tea Extract on Antigen-specific Antibody Production and Cytokine Generation in Vitro and in Vivo

A. Tai, I. Yamamoto, K. Kunishiro, 2001, Bioscience, biotechnology, and biochemistry.

Synthesis and biological evaluation of (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: a novel series of PPAR gamma agonists.

Kenji Takahashi, C. Mukai, Satoru Azukizawa, 2008, Chemical & pharmaceutical bulletin.

Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical properties and biological activities by introduction of carboxylic acid.

M. Ohta, Kenji Takahashi, K. Kunishiro, 2008, Journal of medicinal chemistry.

Novel prodrugs of meropenem with two lipophilic promoieties: synthesis and pharmacokinetics

K. Kunishiro, M. Kasai, H. Shirahase, 2011, The Journal of Antibiotics.

Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor γ selective agonists with protein-tyrosine phosphatase 1B inhibition.

Mamoru Kanda, Kazuya Otake, Satoru Azukizawa, 2012, Bioorganic & medicinal chemistry.

Computational design and selections for an engineered, thermostable terpene synthase

Jonathan Bronson, Jeffery G Saven, Gregory A Weiss, 2011, Protein science : a publication of the Protein Society.

Synergistic Effect of Nitric Oxide Synthase and Cyclooxygenase Inhibitors on Carrageenan-induced Paw Edema in Rats

Y. Uehara, K. Kunishiro, H. Shirahase, 2006, Arzneimittelforschung.

Effect of combination of nitric oxide synthase and cyclooxygenase inhibitors on carrageenan-induced pleurisy in rats.

Y. Uehara, K. Kunishiro, H. Shirahase, 2006, Life sciences.

Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor γ selective agonists with protein-tyrosine phosphatase 1B inhibition.

Kazuya Otake, Satoru Azukizawa, Masaki Fukui, 2012, Bioorganic & medicinal chemistry.

Novel tetrahydroisoquinoline derivatives with inhibitory activities against acyl-CoA: cholesterol acyltransferase and lipid peroxidation.

Kenji Takahashi, C. Mukai, Tomohiro Miike, 2010, Chemical & pharmaceutical bulletin.

Novel acyl-CoA: cholesterol acyltransferase inhibitor: indoline-based sulfamide derivatives with low lipophilicity and protein binding ratio.

Kenji Takahashi, Tomohiro Miike, K. Kunishiro, 2010, Chemical & pharmaceutical bulletin.

Novel indoline-based acyl-CoA: cholesterol acyltransferase inhibitor: Effects of introducing a methanesulfonamide group on physicochemical properties and biological activities.

Kenji Takahashi, K. Kunishiro, M. Kasai, 2009, Bioorganic & medicinal chemistry.

Relationships between Lipophilicity and Biological Activities in a Series of Indoline-based Anti-oxidative Acyl-CoA:Cholesterol Acyltransferase (ACAT) Inhibitors

Kenji Takahashi, Tomohiro Miike, K. Kunishiro, 2008, Arzneimittel-Forschung (Drug Research).