C. Koble

发表

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

Peter J. Brown, Timothy M. Willson, J. Lehmann, 1997 .

A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.

J. Lehmann, L. Moore, T. Willson, 1999, Journal of medicinal chemistry.

Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.

R. Hamatake, Z. Hong, Shawn P. Williams, 2014, Journal of medicinal chemistry.

Discovery of bioavailable 4,4-disubstituted piperidines as potent ligands of the chemokine receptor 5 and inhibitors of the human immunodeficiency virus-1.

Brian A. Chauder, W. Kazmierski, D. K. Jones-Hertzog, 2008, Journal of medicinal chemistry.

A Scaleable Synthesis of Methyl 3-Amino-5-(4-fluorobenzyl)-2-pyridinecarboxylate

S. A. Burova, M. Sharp, C. Koble, 2007 .

Synthesis of ultra-short-acting neuromuscular blocker GW 0430: a remarkably stereo- and regioselective synthesis of mixed tetrahydroisoquinolinium chlorofumarates.

J. A. Ray, R. Mook, V. Samano, 1999, Organic letters.

1-(Fluorobenzyl)-4-amino-1H-1,2,3-triazolo[4,5-c]pyridines: synthesis and anticonvulsant activity.

B. Cooper, C. Koble, F. Soroko, 1995, Journal of medicinal chemistry.

Synthesis and antiviral activity of 7-benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV integrase inhibitors.

E. Garvey, S. Foster, T. Fujiwara, 2009, Journal of medicinal chemistry.

2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase.

T. Blumenkopf, T. Spector, C. Koble, 1992, Journal of medicinal chemistry.

Isolation and characterization of an ether glucuronide of zidovudine, a major metabolite in monkeys and humans.

R. Crouch, C. Koble, J. L. Rideout, 1990, Drug metabolism and disposition: the biological fate of chemicals.

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma.

J. Lehmann, T. Willson, S. Kliewer, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and HIV-integrase strand transfer inhibition activity of 7-hydroxy[1,3]thiazolo[5,4-b]pyridin-5(4H)-ones.

E. Garvey, C. Koble, W. H. Miller, 2006, Bioorganic & medicinal chemistry letters.

Naphthyridinone (NTD) integrase inhibitors 4. Investigating N1 acetamide substituent effects with C3 amide groups.

E. Garvey, S. Foster, T. Fujiwara, 2014, Bioorganic & medicinal chemistry letters.

Naphthyridinone (NTD) integrase inhibitors: N1 protio and methyl combination substituent effects with C3 amide groups.

E. Garvey, S. Foster, T. Fujiwara, 2013, Bioorganic & medicinal chemistry letters.

The Naphthyridinone GSK364735 Is a Novel, Potent Human Immunodeficiency Virus Type 1 Integrase Inhibitor and Antiretroviral

E. Garvey, S. Foster, T. Fujiwara, 2007, Antimicrobial Agents and Chemotherapy.

Neuromuscular blocking activity and therapeutic potential of mixed-tetrahydroisoquinolinium halofumarates and halosuccinates in rhesus monkeys.

Sanjay S. Patel, J. A. Ray, R. Mook, 2003, Journal of medicinal chemistry.

Novel 4,4-disubstituted piperidine-based C-C chemokine receptor-5 inhibitors with high potency against human immunodeficiency virus-1 and an improved human ether-a-go-go related gene (hERG) profile.

Brian A. Chauder, W. Kazmierski, B. Chauder, 2011, Journal of medicinal chemistry.

[2-(4-Phenyl-4-piperidinyl)ethyl]amine based CCR5 antagonists: derivatizations at the N-terminal of the piperidine ring.

T. Kenakin, W. Kazmierski, R. Ferris, 2009, Bioorganic & medicinal chemistry letters.

Synthesis of 4‐Substituted Piperidines via a Mild and Scalable Two‐Step Cu2O‐Mediated Decarboxylation of Cyanoesters

W. Kazmierski, B. Chauder, C. Koble, 2006 .

Synthesis of 4-Substituted Piperidines via a Mild and Scalable Two-Step Cu2O-Mediated Decarboxylation of Cyanoesters.

W. Kazmierski, B. Chauder, C. Koble, 2006 .

1‐(Fluorobenzyl)‐4‐amino‐1H‐1,2,3‐triazolo(4,5‐c)pyridines: Synthesis and Anticonvulsant Activity.

B. Cooper, C. Koble, F. Soroko, 1996 .