J. Joseph

发表

Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis.

M. Reitman, D. Leroith, S. Yakar, 2003, Diabetes.

The loss of ARNT/HIF1β in male pancreatic β-cells is protective against high fat diet-induced diabetes.

S. Paglialunga, A. R. Tupling, E. Bombardier, 2019, Endocrinology.

Overcoming the spatial barriers of the stimulus secretion cascade in pancreatic β-cells

P. Huypens, J. Joseph, Mei Huang, 2012, Islets.

The Mitochondrial 2-Oxoglutarate Carrier Is Part of a Metabolic Pathway That Mediates Glucose- and Glutamine-stimulated Insulin Secretion*

M. Jensen, O. Ilkayeva, C. Newgard, 2010, The Journal of Biological Chemistry.

The dicarboxylate carrier plays a role in mitochondrial malate transport and in the regulation of glucose-stimulated insulin secretion from rat pancreatic beta cells

S. Ronnebaum, P. Huypens, S. Wettig, 2010, Diabetologia.

Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion.

M. Jensen, O. Ilkayeva, C. Newgard, 2006, The Journal of biological chemistry.

Nicotinamide Mononucleotide Prevents Free Fatty Acid-Induced Reduction in Glucose Tolerance by Decreasing Insulin Clearance

S. Najjar, S. Ghanem, A. Giacca, 2021, International journal of molecular sciences.

NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents

J. Scholey, A. Giacca, K. Koulajian, 2013, Diabetologia.

Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice.

O. Gavrilova, D. Leroith, Stephanie Pack, 2004, Endocrinology.

Inhibition of Kv2.1 Voltage-dependent K+Channels in Pancreatic β-Cells Enhances Glucose-dependent Insulin Secretion*

Catherine B. Chan, P. MacDonald, G. Sakellaropoulos, 2002, The Journal of Biological Chemistry.

Isoform-specific Roles of Prolyl Hydroxylases in the Regulation of Pancreatic β-Cell Function

S. Janssen, D. Hodson, G. Fong, 2021, Endocrinology.

Mitochondrial Glutathione Transport Is a Key Determinant of Neuronal Susceptibility to Oxidative and Nitrosative Stress*

D. Linseman, H. Wilkins, J. Joseph, 2013, The Journal of Biological Chemistry.

Chronic Suppression of Acetyl-CoA Carboxylase 1 in β-Cells Impairs Insulin Secretion via Inhibition of Glucose Rather Than Lipid Metabolism*

O. Ilkayeva, C. Newgard, S. Ronnebaum, 2008, Journal of Biological Chemistry.

Oral delivery of glucagon-like peptide-1 in a modified polymer preparation normalizes basal glycaemia in diabetic db/db mice

P. Brubaker, S. St.-Pierre, J. Joseph, 2000, Diabetologia.

Effect of N-acetyl-l-cysteine on insulin resistance caused by prolonged free fatty acid elevation.

A. Giacca, J. Joseph, S. Pereira, 2015, The Journal of endocrinology.

Role of prolyl hydroxylase domain proteins in the regulation of insulin secretion

S. Paglialunga, J. Joseph, M. Hoang, 2016, Physiological reports.

Normal Flux through ATP-Citrate Lyase or Fatty Acid Synthase Is Not Required for Glucose-stimulated Insulin Secretion*

C. Newgard, S. Ronnebaum, S. Burgess, 2007, Journal of Biological Chemistry.

Aryl Hydrocarbon Receptor Nuclear Translocator/Hypoxia-inducible Factor-1β Plays a Critical Role in Maintaining Glucose-stimulated Anaplerosis and Insulin Release from Pancreatic β-Cells*

P. Huypens, S. Wettig, J. Joseph, 2010, The Journal of Biological Chemistry.

The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and β-cell mass.

A. Bonen, M. Huising, S. Paglialunga, 2017, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

Gαz Negatively Regulates Insulin Secretion and Glucose Clearance*

P. Casey, C. Newgard, C. Bailey, 2008, Journal of Biological Chemistry.

Prevention of Lipotoxicity in Pancreatic Islets with Gammahydroxybutyrate

M. Wheeler, A. Giacca, M. Mamelak, 2022, Cells.

Mitochondrial Metabolism of Pyruvate Is Essential for Regulating Glucose-stimulated Insulin Secretion*

P. MacDonald, J. E. Manning Fox, J. Joseph, 2014, The Journal of Biological Chemistry.

Deletion of ARNT/HIF1β in pancreatic beta cells does not impair glucose homeostasis in mice, but is associated with defective glucose sensing ex vivo

F. Gonzalez, M. Wheeler, S. Paglialunga, 2015, Diabetologia.

Glucose-sensing mechanisms in pancreatic β-cells

Patrik Rorsman, P. MacDonald, P. Rorsman, 2005, Philosophical Transactions of the Royal Society B: Biological Sciences.

Epac-selective cAMP Analog 8-pCPT-2′-O-Me-cAMP as a Stimulus for Ca2+-induced Ca2+ Release and Exocytosis in Pancreatic β-Cells*

J. Bos, M. Wheeler, O. Chepurny, 2003, The Journal of Biological Chemistry.

A Pyruvate Cycling Pathway Involving Cytosolic NADP-dependent Isocitrate Dehydrogenase Regulates Glucose-stimulated Insulin Secretion*

M. Jensen, O. Ilkayeva, C. Newgard, 2006, Journal of Biological Chemistry.

Metabolic cycling in control of glucose-stimulated insulin secretion.

M. Jensen, C. Newgard, S. Ronnebaum, 2008, American journal of physiology. Endocrinology and metabolism.

Distinct Role for ARNT/HIF-1β in Pancreatic Beta-Cell Function, Insulin Secretion and Type 2 Diabetes

J. Joseph, R. Pillai, 2012 .

Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death.

J. Pawliszyn, M. Minden, A. Datti, 2015, Cancer research.

The role of α-ketoglutarate and the hypoxia sensing pathway in the regulation of pancreatic β-cell function

J. Joseph, M. Hoang, 2020, Islets.

The Mitochondrial Citrate/Isocitrate Carrier Plays a Regulatory Role in Glucose-stimulated Insulin Secretion*

M. Jensen, O. Ilkayeva, C. Newgard, 2006, Journal of Biological Chemistry.

Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet.

Catherine B. Chan, B. Lowell, V. Koshkin, 2002, Diabetes.

Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action.

P. Pennefather, C. Chan, M. Wheeler, 2001, Diabetes.

Prolyl-4-hydroxylase 3 maintains β cell glucose metabolism during fatty acid excess in mice

L. Hodson, D. Tennant, D. Hodson, 2021, JCI insight.

Prolyl-4-hydroxylase 3 maintains β-cell glucose metabolism during fatty acid 1 excess in mice 2 3

Leanne, Hodson, D. Tennant, 2021 .

Free Fatty Acid-induced β-Cell Defects Are Dependent on Uncoupling Protein 2 Expression*

Catherine B. Chan, B. Lowell, V. Koshkin, 2004, Journal of Biological Chemistry.

Assessment of the metabolic pathways associated with glucose-stimulated biphasic insulin secretion.

Mei Huang, Jamie W. Joseph, J. Joseph, 2014, Endocrinology.

Metabolomic analysis of pancreatic β-cell insulin release in response to glucose

Jamie W Joseph, Mei Huang, J. Joseph, 2012, Islets.

A method for mouse pancreatic islet isolation and intracellular cAMP determination.

M. Kimple, J. Joseph, Nathan A Truchan, 2014, Journal of visualized experiments : JoVE.

The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing

F. Dai, M. Wheeler, K. J. Prentice, 2013, Diabetologia.

Kinetic modelling of β-cell metabolism reveals control points in the insulin-regulating pyruvate cycling pathways

B. Ingalls, A. Stinchcombe, J. Joseph, 2021, bioRxiv.

Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased beta-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinase.

P. MacDonald, J. Diao, F. Dai, 2004, Endocrinology.

Oral delivery of glucagon-like peptide-1 using PLGA-COOH microspheres

J. Joseph, 1999 .

cAMP-mediated signaling normalizes glucose-stimulated insulin secretion in uncoupling protein-2 overexpressing beta-cells.

A. Gyulkhandanyan, C. Chan, M. Wheeler, 2006, The Journal of endocrinology.

A method for mouse pancreatic islet isolation and intracellular cAMP determination.

M. Kimple, J. Joseph, J. Neuman, 2014, Journal of visualized experiments : JoVE.