Yingru Zhang

发表

Enantiomeric separation and determination of absolute stereochemistry of asymmetric molecules in drug discovery: building chiral technology toolboxes.

K. Fan, R. Williamson, V. Marathias, 2007, Chirality.

Microscale purification in support of high-throughput medicinal chemistry.

C. Cavallaro, E. Priestley, Andrew F Donnell, 2021, Chemical communications.

In-depth characterization of six cellulose tris-(3,5-dimethylphenylcarbamate) chiral stationary phases in supercritical fluid chromatography.

C. West, Yingru Zhang, S. Khater, 2013, Journal of chromatography. A.

Effects of column back pressure on supercritical fluid chromatography separations of enantiomers using binary mobile phases on 10 chiral stationary phases.

Yingru Zhang, Chunlei Wang, 2013, Journal of chromatography. A.

A Middle-Up Approach with Online Capillary Isoelectric Focusing/Mass Spectrometry for In-Depth Characterization of Cetuximab Charge Heterogeneity.

Yingru Zhang, Jun Dai, 2018, Analytical chemistry.

The role of chromatographic and chiroptical spectroscopic techniques and methodologies in support of drug discovery for atropisomeric drug inhibitors of Bruton's tyrosine kinase.

A. Tymiak, Yingru Zhang, M. Obermeier, 2017, Journal of chromatography. A.

Characterization and quantification of histidine degradation in therapeutic protein formulations by size exclusion-hydrophilic interaction two dimensional-liquid chromatography with stable-isotope labeling mass spectrometry.

A. Yamniuk, A. Tymiak, Yingru Zhang, 2015, Journal of chromatography. A.

Optimization and simulation of tandem column supercritical fluid chromatography separations using column back pressure as a unique parameter.

A. Tymiak, Yingru Zhang, Chunlei Wang, 2014, Analytical chemistry.

NMR CHARACTERIZATION OF AN S-LINKED GLUCURONIDE METABOLITE OF THE POTENT, NOVEL, NONSTEROIDAL PROGESTERONE AGONIST TANAPROGET

O. Mcconnell, K. Keating, Yingru Zhang, 2006, Drug Metabolism and Disposition.

Chromatography-based methods for determining molar extinction coefficients of cytotoxic payload drugs and drug antibody ratios of antibody drug conjugates.

Richard Y.-C. Huang, A. Tymiak, Yingru Zhang, 2016, Journal of chromatography. A.

Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design.

Vijay T. Ahuja, Derek J. Norris, J. Tokarski, 2021, Journal of medicinal chemistry.

Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer.

Shana L. Posy, J. Fargnoli, R. Talbott, 2015, ACS medicinal chemistry letters.

Capillary Isoelectric Focusing-Mass Spectrometry Method for the Separation and Online Characterization of Intact Monoclonal Antibody Charge Variants.

Qiangwei Xia, Yingru Zhang, Jared Lamp, 2018, Analytical chemistry.

Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177).

K. McIntyre, J. Barrish, A. Mathur, 2016, Journal of medicinal chemistry.

Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK.

Michael A. Galella, K. McIntyre, J. Barrish, 2020, ACS medicinal chemistry letters.

Rapid method development for chiral separation in drug discovery using multi-column parallel screening and circular dichroism signal pooling.

O. Mcconnell, L. Nogle, William L Watts, 2004, Journal of chromatography. A.

Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily.

J. Fargnoli, J. Tokarski, G. Trainor, 2009, Journal of medicinal chemistry.

Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors.

K. Burroughs, D. Deecher, P. Mahaney, 2010, Bioorganic & medicinal chemistry letters.

Insights into chiral recognition mechanism in supercritical fluid chromatography IV. Chlorinated polysaccharide stationary phases.

C. West, Yingru Zhang, S. Khater, 2014, Journal of chromatography. A.

Design of LFA-1 antagonists based on a 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold.

J. Barrish, S. Sheriff, M. Poss, 2007, Bioorganic & medicinal chemistry letters.

Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked

Michael A. Galella, K. McIntyre, J. Barrish, 2016, Journal of medicinal chemistry.

Enantioselective chromatography in drug discovery.

A. Tymiak, Adrienne A Tymiak, Yingru Zhang, 2005, Drug discovery today.

Insights into chiral recognition mechanisms in supercritical fluid chromatography. I. Non-enantiospecific interactions contributing to the retention on tris-(3,5-dimethylphenylcarbamate) amylose and cellulose stationary phases.

L. Morin-Allory, C. West, Yingru Zhang, 2011, Journal of chromatography. A.

Insights into chiral recognition mechanisms in supercritical fluid chromatography. II. Factors contributing to enantiomer separation on tris-(3,5-dimethylphenylcarbamate) of amylose and cellulose stationary phases.

L. Morin-Allory, C. West, Yingru Zhang, 2011, Journal of chromatography. A.

Insights into chiral recognition mechanism in supercritical fluid chromatography III. Non-halogenated polysaccharide stationary phases.

C. West, Yingru Zhang, S. Khater, 2014, Journal of chromatography. A.

Impact of CO2-solvent separators on the degradation of benzyl-2,3-dihydroxypiperidine-1-carboxylate during preparative supercritical fluid chromatographic (SFC) purification.

Pravin S. Shirude, Yingru Zhang, Dauh-Rurng Wu, 2017, Journal of chromatography. A.

BMS-871: a novel orally active pan-Notch inhibitor as an anticancer agent.

Derek J. Norris, D. Shen, G. Trainor, 2015, Bioorganic & medicinal chemistry letters.

Investigation of a Degradant in a Biologics Formulation Buffer Containing L-Histidine

Noah T. Ditto, A. Yamniuk, Yingru Zhang, 2015, Pharmaceutical Research.

Absolute configuration of C2-symmetric spiroselenurane: 3,3,3',3'-tetramethyl-1,1'-spirobi[3 H,2,1]benzoxaselenole.

Ana G. Petrovic, H. Duddeck, O. Mcconnell, 2005, Chemistry.

Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development.

P. Lam, W. Humphreys, A. Mathur, 2015, The Journal of organic chemistry.

Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols.

D. Deecher, P. Mahaney, E. Trybulski, 2009, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.

L. Leventhal, E. Koury, K. Burroughs, 2008, Journal of medicinal chemistry.

[2.2.1]-Bicyclic sultams as potent androgen receptor antagonists.

Michael A. Galella, G. Trainor, Weifang Shan, 2016, Bioorganic & medicinal chemistry letters.

Supercritical Fluid Chromatography

A. Tymiak, Yingru Zhang, Jun Dai, 2012 .

Pre-absorption physicochemical compatibility assessment of 8-drug metabolic cocktail.

Zhanbin Wang, M. Hageman, Ching Kim Tye, 2016, International journal of pharmaceutics.

Coproporphyrins I and III as Functional Markers of OATP1B Activity: In Vitro and In Vivo Evaluation in Preclinical Species

W. Humphreys, P. Marathe, Y. Lai, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Identification of 1- and 3-methylhistidine as biomarkers of skeletal muscle toxicity by nuclear magnetic resonance-based metabolic profiling.

Lois Lehman-McKeeman, N. Araníbar, M. Reily, 2011, Analytical biochemistry.

Preparative separation and identification of derivatized beta-methylphenylalanine enantiomers by chiral SFC, HPLC and NMR for development of new peptide ligand mimetics in drug discovery.

L. Nogle, William L Watts, Yingru Zhang, 2006, Journal of pharmaceutical and biomedical analysis.

Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors.

Derek J. Norris, D. Shen, G. Trainor, 2015, ACS medicinal chemistry letters.

Correction to "Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development".

P. Lam, W. Humphreys, A. Mathur, 2015, Journal of Organic Chemistry.

Development and implementation of a stereoselective normal-phase liquid chromatography-tandem mass spectrometry method for the determination of intrinsic metabolic clearance in human liver microsomes.

A. Tymiak, J. Santella, C. D’arienzo, 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

J. Fargnoli, J. Tokarski, G. Trainor, 2009, Journal of medicinal chemistry.

In-depth characterization of six cellulose tris-(3,5-dimethylphenylcarbamate) chiral stationary phases in supercritical fluid chromatography.

C. West, Yingru Zhang, S. Khater, 2013, Journal of chromatography. A.

Impact of CO2-solvent separators on the degradation of benzyl-2,3-dihydroxypiperidine-1-carboxylate during preparative supercritical fluid chromatographic (SFC) purification.

Pravin S. Shirude, Yingru Zhang, R. Sarabu, 2017, Journal of chromatography. A.

A Simple and Efficient Approach for Estimating Recovery of a Preparative Reversed Phase HPLC Purification

Yingru Zhang, Lakshmikant Bajpai, Kathiravan Asokan, 2016, Chromatographia.

Simulated moving columns technique for enantioselective supercritical fluid chromatography.

A. Tymiak, Yingru Zhang, Jun Dai, 2007, Chirality.