Jinyi Zhang

发表

The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse.

K. Siminovitch, K. Badour, Jinyi Zhang, 2003, Immunity.

Fyn and PTP-PEST–mediated Regulation of Wiskott-Aldrich Syndrome Protein (WASp) Tyrosine Phosphorylation Is Required for Coupling T Cell Antigen Receptor Engagement to WASp Effector Function and T Cell Activation

K. Siminovitch, Y. Leng, Michaela Collins, 2004, The Journal of experimental medicine.

Involvement of the Wiskott-Aldrich syndrome protein and other actin regulatory adaptors in T cell activation.

K. Siminovitch, K. Badour, Jinyi Zhang, 2004, Seminars in immunology.

CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1

Xuan Zheng, P. Love, Xiequn Chen, 2016, International journal of molecular medicine.

The mDial Formin Is Required for Neutrophil Polarization, Migration, and Activation of the LARG/RhoA/ROCK Signaling Axis during Chemotaxis1

K. Siminovitch, A. Alberts, M. Mullin, 2009, The Journal of Immunology.

Apoptotic Dendritic Cells Induce Tolerance in Mice through Suppression of Dendritic Cell Maturation and Induction of Antigen-Specific Regulatory T Cells1

K. Siminovitch, Jim Hu, Jinyi Zhang, 2009, The Journal of Immunology.

Uptake of apoptotic DC converts immature DC into tolerogenic DC that induce differentiation of Foxp3+ Treg

K. Siminovitch, Jim Hu, Jing Wu, 2010, European journal of immunology.

Interaction of the Wiskott–Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells

G. Mills, K. Siminovitch, M. Julius, 2007, Proceedings of the National Academy of Sciences.

The SH2 Domain Containing Tyrosine Phosphatase-1 Down-regulates Activation of Lyn and Lyn-induced Tyrosine Phosphorylation of the CD19 Receptor in B Cells*

K. Siminovitch, D. Branch, Jinyi Zhang, 2001, The Journal of Biological Chemistry.

Phosphatase in Regulation of T Cell Selection Involvement of the SHP-1 Tyrosine

K. Siminovitch, P. Love, D. Yuen, 1999 .

Peripheral T Cells Receptor-Induced Apoptosis of Activated Tyrosine Phosphatase-1 Inhibits Antigen The Src-Homology Domain 2-Bearing Protein

G. Mills, K. Siminovitch, Jinyi Zhang, 1999 .

Elucidation of the integrin LFA-1-mediated signaling pathway of actin polarization in natural killer cells.

K. Siminovitch, F. Takei, E. Mace, 2010, Blood.

Antigen-Specific Regulatory T Cells Cell Maturation and Induction of in Mice through Suppression of Dendritic Apoptotic Dendritic Cells Induce Tolerance

K. Siminovitch, Jim Hu, Jinyi Zhang, 2009 .

Biochemical and Genetic Evidence for a SAP-PKC-θ Interaction Contributing to IL-4 Regulation

K. Siminovitch, J. Cannons, P. Schwartzberg, 2010, The Journal of Immunology.

Regulation Interaction Contributing to IL-4 q C-Protein Kinase - Molecule-Associated Protein Signaling Lymphocytic Activation Biochemical and Genetic Evidence for a

K. Siminovitch, J. Cannons, P. Schwartzberg, 2010 .

WAVE2 suppresses mTOR activation to maintain T cell homeostasis and prevent autoimmunity

K. Siminovitch, Jimin Gao, Ming Liu, 2021, Science.

Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils.

K. Siminovitch, A. Alberts, Yongquan Shi, 2009, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Cutting Edge: Selective Requirement for the Wiskott-Aldrich Syndrome Protein in Cytokine, but Not Chemokine, Secretion by CD4+ T Cells1

K. Siminovitch, D. Fowell, V. Morales-Tirado, 2004, The Journal of Immunology.

N-WASp is required for Schwann cell cytoskeletal dynamics, normal myelin gene expression and peripheral nerve myelination

A. Bharioke, J. Roder, K. Siminovitch, 2011, Development.

An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs

Alexander E. Lopez, Aaron M. King, Andrew L Blumenfeld, 2021, Journal of hepatology.

Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis

P. Gregersen, Y. Kamatani, Y. Okada, 2022, Nature Genetics.

The Intersectin 2 Adaptor Links Wiskott Aldrich Syndrome Protein (WASp)-mediated Actin Polymerization to T Cell Antigen Receptor Endocytosis

K. Siminovitch, T. Kubiseski, Jinyi Zhang, 2001, The Journal of experimental medicine.

The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

K. Siminovitch, G. Xie, E. Keystone, 2011, Nature Genetics.

Trans-ancestry genome-wide association study identifies novel genetic mechanisms in rheumatoid arthritis

P. Gregersen, Y. Kamatani, Y. Okada, 2021, medRxiv.

Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation.

K. Siminovitch, Y. Leng, K. Badour, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function

C. McKerlie, K. Siminovitch, N. Bottini, 2005, The Journal of experimental medicine.

Lymphocyte microvilli are dynamic, actin-dependent structures that do not require Wiskott-Aldrich syndrome protein (WASp) for their morphology

Wilhelm Friedrich, K. Siminovitch, W. Friedrich, 2004 .

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Casey S. Greene, Marco Carbone, Andrew Fraser, 2015, Nature Communications.

Tyrosine Phosphorylation of p85 Relieves Its Inhibitory Activity on Phosphatidylinositol 3-Kinase*

G. Mills, K. Siminovitch, Yiling Lu, 2001, The Journal of Biological Chemistry.

Antigen Receptor–Induced Activation and Cytoskeletal Rearrangement Are Impaired in Wiskott-Aldrich Syndrome Protein–Deficient Lymphocytes

K. Siminovitch, S. Grinstein, A. Nagy, 1999, The Journal of experimental medicine.

Contributions of Wiskott–Aldrich syndrome family cytoskeletal regulatory adapters to immune regulation

K. Siminovitch, Jinyi Zhang, Baoxia Dong, 2009, Immunological reviews.

T Cell Responses in Mammalian Diaphanous-related Formin mDia1 Knock-out Mice*

K. Siminovitch, K. Eisenmann, S. Kitchen, 2007, Journal of Biological Chemistry.

The Wiskott–Aldrich syndrome protein: forging the link between actin and cell activation

K. Siminovitch, K. Badour, Jinyi Zhang, 2003, Immunological reviews.

WASp verprolin homology, cofilin homology, and acidic region domain-mediated actin polymerization is required for T cell development

K. Siminovitch, K. Badour, Jinyi Zhang, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis

Naoto Hirano, Christopher I. Amos, Xuemei Ji, 2017, Arthritis & rheumatology.

Src Family Protein-tyrosine Kinases Alter the Function of PTEN to Regulate Phosphatidylinositol 3-Kinase/AKT Cascades*

Yiling Lu, Gordon B. Mills, John S. McMurray, 2003, Journal of Biological Chemistry.

New variants at 10q26 and 15q21 are associated with aggressive prostate cancer in a genome-wide association study from a prostate biopsy screening cohort

M. Kattan, K. Siminovitch, J. Trachtenberg, 2011, Cancer biology & therapy.

Synergistic Efficacy of the Demethylation Agent Decitabine in Combination With the Protease Inhibitor Bortezomib for Treating Multiple Myeloma Through the Wnt/β-Catenin Pathway.

Juan Feng, Xiequn Chen, Jinyi Zhang, 2019, Oncology research.

Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis

P. Gregersen, K. Siminovitch, C. Amos, 2010, Nature Genetics.

Mammalian Diaphanous-Related Formin 1 Regulates GSK3β-Dependent Microtubule Dynamics Required for T Cell Migratory Polarization

K. Siminovitch, Wen Gao, A. Alberts, 2013, PloS one.

Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene.

Y. Okada, K. Siminovitch, C. Amos, 2015, Annals of the rheumatic diseases.

SHP-1 Regulates Lck-induced Phosphatidylinositol 3-Kinase Phosphorylation and Activity*

Yiling Lu, K. Siminovitch, Yiling Lu, 1999, The Journal of Biological Chemistry.

Abelson Interactor Protein-1 Positively Regulates Breast Cancer Cell Proliferation, Migration, and Invasion

Yan Leng, Ming-Sound Tsao, K. Siminovitch, 2007, Molecular Cancer Research.

T cell activation is reduced by the catalytically inactive form of protein tyrosine phosphatase SHP-2.

Xuan Zheng, Xiequn Chen, Jinyi Zhang, 2015, International journal of clinical and experimental medicine.

T rans-ancestry genome-wide association study identifies novel genetic mechanisms in rheumatoid 2 arthritis 3

P. Gregersen, Y. Kamatani, Y. Okada, 2021 .

Corrigendum to ‘An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs’ [J Hepatol 2021;75(3):572–581]

Alexander E. Lopez, Aaron M. King, Andrew L Blumenfeld, 2021, Journal of hepatology.

Characterization of apoptosis-resistant antigen-specific T cells in vivo

Li Zhang, R. Miller, J. Zhang, 1996, The Journal of experimental medicine.

Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling.

K. Siminovitch, J. Zhang, Jinyi Zhang, 2000, Seminars in immunology.

Uptake of apoptotic DC converts immature DC into tolerogenic DC that induce differentiation

Jing Wu, Jinyi Zhang, R. Kushwah, 2010 .

This information is current as Regulation Interaction Contributing to IL-4 θ SAP-PKC-Biochemical and Genetic Evidence for a

P. Schwartzberg, Jinyi Zhang, J. Gómez-Rodríguez, 2010 .

Lymphocyte microvilli are dynamic, actin-dependent structures that do not require Wiskott-Aldrich syndrome protein (WASp) for their morphology.

K. Siminovitch, H. Higgs, Stefan Linder, 2004, Blood.