I. Greiner

发表

Discovery of novel steroidal histamine H3 receptor antagonists/inverse agonists. Part 2. Versatile steroidal carboxamide derivatives.

G. Lévay, J. Éles, István Ledneczki, 2019, Bioorganic & medicinal chemistry letters.

Investigation of Selective Microwave Heating Phenomena in the Reactions of 2-Substituted Pyridines*

P. Bana, I. Greiner, Péter Bana, 2017 .

Comparison of Conventional and Microwave Heating for Evaluation of Microwave Effects

P. Bana, I. Greiner, Péter Bana, 2016 .

4-Aryl-3-arylsulfonyl-quinolines as negative allosteric modulators of metabotropic GluR5 receptors: From HTS hit to development candidate.

J. Galambos, G. Keserű, Z. Szakács, 2016, Bioorganic & medicinal chemistry letters.

Flow-oriented synthetic design in the continuous preparation of the aryl piperazine drug flibanserin

P. Bana, J. Éles, J. Kóti, 2019, Reaction Chemistry & Engineering.

Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors.

J. Galambos, A. Gere, É. Schmidt, 2012, Bioorganic & medicinal chemistry letters.

Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists.

J. Galambos, B. Kiss, L. Molnár, 2010, Bioorganic & medicinal chemistry letters.

Interpretation of the Effects of Microwaves

P. Bana, I. Greiner, Péter Bana, 2016 .

Novel solid-phase synthesis of 2,6-disubstituted 4(3H)-quinazolinones for combinatorial library generation

G. Szendrei, I. Greiner, A. Bielik, 2002 .

Solid-phase synthesis of 2,6- and 2,7-diamino-4(3H)-quinazolinones via palladium-catalyzed amination

G. Szendrei, I. Greiner, Á. Demeter, 2003 .

Controlling receptor function from the extracellular vestibule of G-protein coupled receptors.

G. Keserű, Gáspár Pándy-Szekeres, Dalma Kurkó, 2020, Chemical communications.

Synthesis and neuropharmacological evaluation of 2-aryl- and alkylapomorphines.

É. Schmidt, B. Kiss, I. Greiner, 2008, Bioorganic & medicinal chemistry.

Synthesis and circular dichroism of optically active 1,3-disubstituted isochromans of dopamine D4 antagonist activity

K. Kövér, T. Kurtán, S. Antus, 2010 .

Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluR5 NAMs.

B. Kiss, L. Molnár, G. Keserű, 2010, Bioorganic & medicinal chemistry letters.

Biomimetic Synthesis of Drug Metabolites in Batch and Continuous-Flow Reactors.

G. Balogh, Diána Weiser, Z. Béni, 2018, Chemistry.

Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs).

G. Keserű, Z. Orgován, G. Lévay, 2019, European journal of medicinal chemistry.

Synthesis of vinca alkaloids and related compounds. Part 110: A new synthetic method for the preparation of pandoline-type alkaloid-like molecules

C. Szántay, Á. Gömöry, J. Oláh, 2008 .

N-heterocyclic dronic acids: applications and synthesis.

G. Keglevich, S. W. Bligh, H. R. Hudson, 2012, Mini reviews in medicinal chemistry.

Discovery of novel steroidal histamine H3 receptor antagonists/inverse agonists.

É. Schmidt, G. Lévay, J. Éles, 2017, Bioorganic & medicinal chemistry letters.

Synthesis of α-hydroxy-methylenebisphos-phonates by the microwave-assisted reaction of α-oxophosphonates and dialkyl phosphites under solventless conditions

G. Keglevich, I. Molnár, I. Greiner, 2009 .

Phenyl‐, benzyl‐, and unsymmetrical hydroxy‐methylenebisphosphonates as dronic acid ester analogues from α‐oxophosphonates by microwave‐assisted syntheses

G. Keglevich, I. Molnár, I. Greiner, 2011 .

C-N Bond Formation by Consecutive Continuous-Flow Reductions towards A Medicinally Relevant Piperazine Derivative

J. Éles, I. Greiner, Zsolt Fülöp, 2021, Molecules.

Evolution of flow-oriented design strategies in the continuous preparation of pharmaceuticals

Zsolt Fülöp, Péter Szemesi, Péter Bana, 2020 .

Synthesis of Urea Derivatives in Two Sequential Continuous-Flow Reactors

Z. Béni, G. Túrós, J. Éles, 2017 .

A Novel, Domino Synthesis of Tricyclic Benzimidazole Derivatives Using Continuous Flow

J. Éles, F. Faigl, I. Greiner, 2019, Periodica Polytechnica Chemical Engineering.

Synthesis of cyclic aminomethylphosphonates and aminomethyl-arylphosphinic acids by an efficient microwave-mediated phospha-mannich approach

G. Keglevich, K. Ludányi, Anna Szekrényi, 2008 .

Efficient Synthesis of Phosphono‐ and Phosphinoxidomethylated N‐Heterocycles under Solvent‐Free Microwave Conditions

G. Keglevich, K. Ludányi, I. Greiner, 2007 .

A study on the michael addition of dialkylphosphites to methylvinylketone

G. Keglevich, Daniella Takács, I. Greiner, 2007 .

Environmentally Friendly Chemistry with Organophosphorus Syntheses in Focus

G. Keglevich, Péter Bagi, I. Greiner, 2015 .

Synthesis of vinca alkaloids and related compounds. part 109. An intramolecular [4+2] cycloaddition mediated biomimetic synthesis of (±)-iboxyphylline

C. Szántay, Á. Gömöry, Å. Szöllösy, 2008 .

The Synthesis of α-Hydroxy- and α-Chlorophosphonic Acid Derivatives Starting from Benzaldehydes and Phosphorous Acid or Dimethyl Phosphite

G. Keglevich, I. Greiner, A. Grün, 2019, Current Organic Chemistry.

Synthesis of α-Hydroxy-methylenebisphosphonates by the Microwave-Assisted Reaction of α-Oxophosphonates and Dialkyl Phosphites under Solventless Conditions.

I. Molnár, I. Greiner, G. Keglevich, 2010 .

Efficient Synthesis of Phosphono‐ and Phosphinoxidomethylated N‐Heterocycles under Solvent‐Free Microwave Conditions.

G. Keglevich, K. Ludányi, I. Greiner, 2007 .

Monitoring the Phosphorylation of Phenol Derivatives with Diethyl Chlorophosphate in Liquid–Liquid and Solid–Liquid Phase by In Situ Fourier Transform Infrared Spectroscopy, Part II

I. Csontos, G. Keglevich, I. Greiner, 2010 .

Heterogeneous Phase Alkylation of Phenols Making Use of Phase Transfer Catalysis and Microwave Irradiation

G. Keglevich, I. Greiner, A. Grün, 2009 .

Chemoselectivity in the microwave-assisted solvent-free solid-liquid phase benzylation of phenols: O- versus C-alkylation

G. Keglevich, I. Greiner, A. Grün, 2008 .

Microwave Irradiation as a Green Alternative to Phase Transfer Catalysis: Solid-Liquid Phase Alkylation of Active Methylene Containing Substrates Under Solvent-Free Conditions

G. Keglevich, K. Majrik, I. Greiner, 2008 .

A Study of the pH Dependence of the Two-Step Oximation of Acetone by in situ Fourier Transform Infrared Spectroscopy

I. Csontos, G. Keglevich, I. Greiner, 2008 .

Green chemical approaches and tools in the development of environmentally friendly synthetic methods

I. Csontos, G. Keglevich, I. Greiner, 2007 .

Microwave irradiation as an alternative to phase transfer catalysis in the liquid-solid phase, solvent-free C-alkylation of active methylene containing substrates

István Greiner, György Keglevich, G. Keglevich, 2006 .

BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS FACULTY OF CHEMICAL AND BIOENGINEERING GEORGE OLAH DOCTORAL SCHOOL THE SYNTHESIS OF PHOSPHINATES AND PHOSPHINIC AMIDES; ENVIRONMENTALLY FRIENDLY APPROACHES

G. Keglevich, I. Greiner, N. Kiss, 2014 .

Microwave-assisted esterification of phosphinic acids

G. Keglevich, I. Greiner, A. Grün, 2011 .

Solid–liquid two-phase alkylation of tetraethyl methylenebisphosphonate under microwave irradiation

G. Keglevich, K. Ludányi, I. Greiner, 2011 .

Solid–liquid phase alkylation of P=O–functionalized CH acidic compounds utilizing phase transfer catalysis and microwave irradiation

G. Keglevich, I. Greiner, A. Grün, 2011 .

Microwave Irradiation as a Green Alternative to Phase Transfer Catalysis: Solid-Liquid Phase Alkylation of Active Methylene Containing Substrates under Solvent-Free Conditions.

G. Keglevich, K. Majrik, I. Greiner, 2008 .

Synthesis of Vinca Alkaloids and Related Compounds. 90.1 New Results in the Synthesis of Alkaloids with the Aspidospermane Skeleton. First Total Synthesis of (±)-3-Oxominovincine

I. Juhász, C. Szántay, I. Greiner, 1997 .

The role of phase transfer catalysis in the microwave-assisted N-benzylation of amides, imides and N-heterocycles

G. Keglevich, I. Greiner, A. Grün, 2009 .

Synthesis of vinca alkaloids and related compounds. Part 108: Efficient convergent synthetic pathway to the ibophyllidine skeleton IV. First synthesis of (±)-18-hydroxy-20-epiibophyllidine

C. Szántay, Á. Gömöry, I. Greiner, 2007 .

Synthesis of vinca alkaloids and related compounds. Part 105: Efficient convergent synthetic pathway to the ibophyllidine skeleton and synthesis of (±)-19-hydroxy-ibophyllidine and (±)-19-hydroxy-20-epiibophyllidine

C. Szántay, Á. Gömöry, I. Greiner, 2006 .

Synthesis of vinca alkaloids and related compounds. Part 106. An efficient convergent synthetic pathway to build up the ibophyllidine skeleton II. Total synthesis of (±)-deethylibophyllidine and (±)-14-EPI-deethylibophyllidine

C. Szántay, Á. Gömöry, I. Greiner, 2006 .

Synthesis of vinca alkaloids and related compounds. 63. A new synthetic pathway for preparing alkaloids and related compounds with the aspidosperma skeleton. Total syntheses of (.+-.)-vincadifformine, (.+-.)-tabersonine, and (.+-.)-oxotabersonine

C. Szántay, I. Greiner, M. Kajtár-Peredy, 1993 .

Synthesis of 2‐phosphinoxidomethyl‐ and 2‐phosphonomethyl glutaric acid derivatives

G. Keglevich, I. Greiner, K. Harsányi, 2005 .

A useful acylation method using trichloroacetonitrile and triphenylphosphine for solid phase organic synthesis

I. Greiner, I. Vágó, 2002 .

Enantioselective Phase Transfer Catalytic Reactions. A Comparative Study on the Use of Cinchonidine Salts and Glucose-Based Lariat Ethers Including Phosphinoxidomethyl Derivatives

G. Keglevich, I. Greiner, T. Novák, 2008 .

The Meeting of Two Disciplines: Organophosphorus and Green Chemistry

G. Keglevich, I. Greiner, 2013 .

Green Chemical Synthesis of Bisphosphonic/Dronic Acid Derivatives

G. Keglevich, I. Greiner, A. Grün, 2015 .

“Greener” synthesis of bisphosphonic/dronic acid derivatives

G. Keglevich, I. Greiner, A. Grün, 2014 .

Environmentally Friendly Syntheses and Tools

G. Keglevich, I. Greiner, A. Grün, 2013 .

Optimized synthesis of N-heterocyclic dronic acids; closing a black-box era

G. Keglevich, Klára Aradi, I. Greiner, 2011 .

Phenyl-, Benzyl-, and Unsymmetrical Hydroxy-Methylenebisphosphonates as Dronic Acid Ester Analogues from α-Oxophosphonates by Microwave-Assisted Syntheses.

I. Molnár, I. Greiner, G. Keglevich, 2012 .

Synthesis of vinca alkaloids and related compounds. Part 102: Simple synthesis and ring transformation of (′)-minovincine. First synthesis of (′)-vincaminine

K. Vékey, C. Szántay, I. Greiner, 2003 .

Synthesis of vinca alkaloids and related compounds. 100. Stereoselective oxidation reactions of compounds with the aspidospermane and quebrachamine ring system. First synthesis of some alkaloids containing the epoxy ring.

G. Keserű, C. Szántay, J. Éles, 2002, The Journal of organic chemistry.

Continuous Synthesis and Purification by Coupling a Multistep Flow Reaction with Centrifugal Partition Chromatography

Z. Szakács, Róbert Örkényi, J. Éles, 2017, Angewandte Chemie.

Synthesis of metabolites of cis and trans apovincamine derivatives

A. Nemes, I. Greiner, C. Szantay, 2008 .

Kynurenic acid amides as novel NR2B selective NMDA receptor antagonists.

A. Gere, S. Kolok, I. Greiner, 2007, Bioorganic & medicinal chemistry letters.

Diastereoselective synthesis of cis-N-Boc-4-aminocyclohexanol with reductive ring opening method using continuous flow

J. Éles, F. Faigl, I. Greiner, 2019, Journal of Flow Chemistry.

Synthesis of some aspidosperma and related alkaloids

C. Szántay, I. Greiner, G. Kalaus, 1998 .

Synthesis of vinca alkaloids and related compounds. Part 101: A new convergent synthetic pathway to build up the aspidospermane skeleton. Simple synthesis of 3-oxovincadifformine and 3-oxominovincine. Attempts to produce 15β-hydroxyvincadifformine

C. Szántay, J. Éles, P. Szabó, 2002 .

Synthesis of vinca alkaloids and related compounds, 73. Synthesis and ring transformations of deethylaspidospermane derivatives. Synthesis of (±)‐20‐deethyl‐3‐oxotabersonine

I. Juhász, C. Szántay, I. Greiner, 1995 .

Synthesis of vinca alkaloids and related compounds part 94. Epimerization of compounds with aspidospermane and D‐secoaspidospermane skeleton

I. Juhász, C. Szántay, J. Éles, 2000 .

Synthesis of Vinca Alkaloids and Related Compounds, 76.1 Synthesis and Ring Transformations of Compounds with the Aspidospermane- and D-Noraspidospermane Skeleton. A Formal Synthesis Of (±)-12-Demethoxy-N(1)-Acetyl-Cylindrocarine

C. Szántay, I. Greiner, I. Vágó, 1995 .

Synthesis of Vinca Alkaloids and Related Compounds. Part 73. Synthesis and Ring Transformations of Deethylaspidospermane Derivatives. Synthesis of (.+-.)-20-Deethyl-3-oxotabersonine.

I. Juhász, C. Szántay, I. Greiner, 1995 .

Synthesis of vinca alkaloids and related compounds. 64. Total syntheses of (.+-.)-pseudovincadifformine and (.+-.)-20-epipseudovincadifformine

C. Szántay, I. Greiner, M. Kajtár-Peredy, 1993 .

Synthesis of Vinca Alkaloids and Related Compounds 95. Attempted Build-up of the Aspidospermidine Skelton by [4+2] Cycloaddition. Some Unexpected Reactions, and Formation of a New Ring System

C. Szántay, I. Greiner, I. Vágó, 2001 .

Synthesis of vinca alkaloids and related compounds, Part LXXXIX. Some unexpected reactions of compounds containing the D-seco-aspidospermane ring system

I. Juhász, C. Szántay, I. Greiner, 1998 .

Synthesis of 18‐Hydroxyvincamines and Epoxy‐1,14‐secovincamines: A New Proof for the Aspidospermane‐eburnane Rearrangement.

A. Nemes, I. Greiner, C. Szantay, 2008 .

Synthesis of 18-Hydroxyvincamines and Epoxy-1,14-secovincamines; a New Proof for the Aspidospermane-Eburnane Rearrangement

A. Nemes, I. Greiner, C. Szantay, 2007 .

[The significance of cumulation and elimination for the determination of Phenytoin (diphenylhydantoin)].

H. Remmer, I. Greiner, J. Hirschmann, 1969, Deutsche medizinische Wochenschrift.

Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach.

B. Lendvai, G. Lévay, Márton Vass, 2021, European journal of medicinal chemistry.

hERG optimization of MCHR1 antagonist benzofuro-pyridine and pyrazino-indole derivatives.

J. Éles, I. Greiner, K. Szalai, 2022, ChemMedChem.

Environment-Friendly Synthesis of Indoline Derivates Using Flow Chemistry Techniques

Z. Szakács, Róbert Örkényi, J. Éles, 2017 .

The Role of Phase Transfer Catalysis in the Microwave‐Assisted N‐Benzylation of Amides, Imides and N‐Heterocycles.

I. Greiner, G. Keglevich, F. D. Sypaseuth, 2010 .

Interaction of dissolved radionuclides with organic matter in prealpine freshwater lakes

M. Wunderer, I. Greiner, S. Kaminski, 1993 .

Selective NR1/2B N-methyl-D-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides.

B. Ágai, A. Gere, G. Keserü, 2007, Journal of medicinal chemistry.

New practical synthesis of Tamsulosin.

G. Egri, I. Greiner, Á. Demeter, 2008, Chirality.

A Study on the Synthesis of Risedronic Acid: The Role of an Ionic Liquid Additive

G. Keglevich, I. Greiner, A. Grün, 2019, Letters in Drug Design & Discovery.

Efficient syntheses of zoledronic acid as an active ingredient of a drug against osteoporosis

G. Keglevich, I. Greiner, A. Grün, 2018 .

6-aryl-quinazolines as novel GABAB receptor positive allosteric modulators.

J. Éles, I. Greiner, Gábor Hornyánszky, 2022, Bioorganic & medicinal chemistry letters.

Rational Synthesis of Dronic Acid Derivatives

G. Keglevich, I. Greiner, A. Grün, 2015 .

Solid-phase synthesis of 6-hydroxy-2,4-diaminoquinazolines

G. Keserű, G. Szendrei, I. Greiner, 2005 .

The route from problem to solution in multistep continuous flow synthesis of pharmaceutical compounds.

Ferenc Faigl, Péter Bana, János Éles, 2017, Bioorganic & medicinal chemistry.

Synthesis of Vinca Alkaloids and Related Compounds. Part 90. New Results in the Synthesis of Alkaloids with the Aspidospermane Skeleton. First Total Synthesis of (.+-.)-3-Oxominovincine.

I. Juhász, C. Szántay, I. Greiner, 2010 .

The Synthesis of Pamidronic Derivatives in Different Solvents: An Optimization and a Mechanistic Study

G. Keglevich, I. Greiner, O. Németh, 2014 .

A Mechanistic Study on the Formation of Dronic Acids

G. Keglevich, P. Ábrányi‐Balogh, I. Greiner, 2021, Molecules.

Investigation of the effect of medium in the preparation of alendronate: till now the best synthesis in the presence of an ionic liquid additive

G. Keglevich, I. Greiner, A. Grün, 2017 .

The synthesis of dronic acid derivatives in sulfolane or in the presence of ionic liquids as additives

I. Greiner, A. Grün, G. Keglevich, 2016 .

Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents

G. Keglevich, I. Greiner, A. Grün, 2016, Molecules.

The Rational Synthesis of Fenidronate

G. Keglevich, I. Greiner, A. Grün, 2014 .

Optimized Synthesis of Etidronate

G. Balogh, G. Keglevich, I. Greiner, 2013 .

Rational Synthesis of Ibandronate and Alendronate

G. Keglevich, I. Greiner, A. Grün, 2013 .

Heteroarylacetyl Chlorides and Mixed Anhydrides as Intermediates in the Synthesis of Heterocyclic Dronic Acids

G. Keglevich, L. Drahos, B. Szolnoki, 2012 .

Microwave-Assisted Alkylation of Phenols by Quaternary Onium Salts

G. Keglevich, I. Greiner, E. Bálint, 2011 .

An Interpretation of the Rate Enhancing Effect of Microwaves – Modelling the Distribution and Effect of Local Overheating – A Case Study

G. Keglevich, I. Greiner, Z. Mucsi, 2015 .

Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists.

József Nagy, Csilla Horváth, Csilla Kiss, 2006, Bioorganic & medicinal chemistry letters.

Efficient Synthesis of Ibandronate in the Presence of an Ionic Liquid

G. Keglevich, I. Greiner, A. Grün, 2017, Letters in Drug Design & Discovery.

The Role of Phosphorus Trichloride and Phosphorous Acid in the Formation of α-Hydroxymethylenebisphosphonic Acids from the Corresponding Carboxylic Acids – A Mechanistic Overview

G. Keglevich, I. Greiner, A. Grün, 2017 .

“Greener” Synthesis of Bisphosphonic/Dronic Acid Derivatives.

I. Greiner, G. Keglevich, Alajos Gruen, 2014 .

Discovery and Preclinical Characterization of 3-((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications.

J. Galambos, G. Balogh, G. Keserű, 2017, Journal of medicinal chemistry.

Solid-phase synthesis of an N-(phenylalkyl)cinnamide library via Horner-Wadsworth-Emmons reaction.

G. Keserű, G. Szendrei, I. Greiner, 2004, Bioorganic & medicinal chemistry letters.

Charting the chemical space around the (iso)indoline scaffold, a comprehensive approach towards multitarget directed ligands.

Z. Kovács, Ákos Tarcsay, Z. Némethy, 2016, Bioorganic & medicinal chemistry letters.

Discovery of 4-amino-3-arylsulfoquinolines, a novel non-acetylenic chemotype of metabotropic glutamate 5 (mGlu5) receptor negative allosteric modulators.

J. Galambos, B. Kiss, G. Keserű, 2017, European journal of medicinal chemistry.

Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560).

J. Éles, S. Kolok, A. Visegrády, 2023, Journal of medicinal chemistry.