A. Bedini

发表

Synthesis and Characterization of New Bivalent Agents as Melatonin- and Histamine H3-Ligands

M. Mor, F. Scaglione, V. Lucini, 2014, International journal of molecular sciences.

Melatonin MT1 and MT2 Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle

Seung Hyun Min, D. De Gregorio, L. Posa, 2019, International journal of molecular sciences.

Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats

E. Macchi, A. Sgoifo, M. Mor, 2015, European Neuropsychopharmacology.

Antioxidant and cytoprotective activity of indole derivatives related to melatonin.

Claudia Silva, Marco Mor, Federica Vacondio, 2003, Advances in experimental medicine and biology.

2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists.

R. Nonno, A. Tontini, M. Mor, 1998, Journal of medicinal chemistry.

Towards the development of 5-HT₇ ligands combining serotonin-like and arylpiperazine moieties.

M. Mor, G. Tarzia, W. Cabri, 2014, European journal of medicinal chemistry.

PT628. First in class melatonin MT2 receptors agonists for neuropathic pain

G. Tarzia, M. López-Canúl, S. Comai, 2016, International Journal of Neuropsychopharmacology.

N‐(Anilinoethyl)amides: Design and Synthesis of Metabolically Stable, Selective Melatonin Receptor Ligands

M. Mor, G. Tarzia, G. Gobbi, 2009, ChemMedChem.

Plant-derived phenolic compounds prevent the DNA single-strand breakage and cytotoxicity induced by tert-butylhydroperoxide via an iron-chelating mechanism.

G. Tarzia, P. Sestili, O. Cantoni, 2002, The Biochemical journal.

Homology Models of Melatonin Receptors: Challenges and Recent Advances

A. Lodola, S. Rivara, G. Spadoni, 2013, International journal of molecular sciences.

Melatonin Receptor Agonists: New Options for Insomnia and Depression Treatment

M. Mor, S. Rivara, G. Spadoni, 2011, CNS neuroscience & therapeutics.

2-Arylmelatonin analogues: Probing the 2-phenyl binding pocket of melatonin MT1 and MT2 receptors.

M. Mor, K. Varani, F. Vincenzi, 2022, European journal of medicinal chemistry.

Pharmacokinetic and pharmacodynamic evaluation of ramelteon: an insomnia therapy

M. Mor, S. Rivara, G. Spadoni, 2015, Expert opinion on drug metabolism & toxicology.

Therapeutic uses of melatonin and melatonin derivatives: a patent review (2012 – 2014)

S. Rivara, G. Spadoni, D. Pala, 2015, Expert opinion on therapeutic patents.

Bivalent ligand approach on N-{2-[(3-methoxyphenyl)methylamino]ethyl}acetamide: synthesis, binding affinity and intrinsic activity for MT(1) and MT(2) melatonin receptors.

M. Mor, G. Tarzia, F. Scaglione, 2011, Bioorganic & medicinal chemistry.

Synthesis and biological activity of new melatonin dimeric derivatives.

G. Tarzia, F. Fraschini, V. Lucini, 2007, Bioorganic & medicinal chemistry.

Towards the Development of Mixed MT1‐Agonist/MT2‐Antagonist Melatonin Receptor Ligands

G. Tarzia, F. Fraschini, V. Lucini, 2006, ChemMedChem.

Synthesis and biological evaluation of 6-bromo-6-substituted penicillanic acid derivatives as β-lactamase inhibitors

A. Tontini, G. Tarzia, E. D. Modugno, 2002 .

Design, Synthesis, and Biological Activity of Hydrogen Peroxide Responsive Arylboronate Melatonin Hybrids.

R. Crinelli, A. Fraternale, L. Chiarantini, 2019, Chemical research in toxicology.

Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models.

M. Mor, G. Tarzia, S. Rivara, 2005, Journal of medicinal chemistry.

Radiosynthesis and In Vivo Evaluation of Four Positron Emission Tomography Tracer Candidates for Imaging of Melatonin Receptors.

Thomas A. Singleton, Allen F. Brooks, R. Koeppe, 2022, ACS chemical neuroscience.

In silico drug discovery of melatonin receptor ligands with therapeutic potential

A. Lodola, S. Rivara, L. Scalvini, 2022, Expert opinion on drug discovery.

Substituent effects on 1,3-dipolar cycloadditions to some 1,1-diphenyl-2-aza-1,3-butadiene derivatives.

A. Capelli, G. Spadoni, A. Bedini, 1994 .

Reactions of 3-carbomethoxy-2-aza-1,3-butadiene derivatives with dienophiles

G. Tarzia, R. Galarini, G. Spadoni, 1994 .

4,5‐Dihydroisoxazole and 4,5‐dihydro‐1,2,4‐oxadiazole derivatives from cycloaddition reactions of nitrile oxides to alkyl N‐(diphenylmethylene)‐α,β‐dehydroamino acids

G. Tarzia, M. Lanfranchi, M. Pellinghelli, 1992 .

The Christians and the Roman Empire

J. Bryant, A. Bedini, M. Sordi, 1988 .

Synthesis of tryptamine derivatives via a direct, one-pot reductive alkylation of indoles.

G. Piersanti, G. Spadoni, S. Bartolucci, 2012, The Journal of organic chemistry.

Synthesis, pharmacological characterization and QSAR studies on 2-substituted indole melatonin receptor ligands.

R. Nonno, M. Mor, G. Tarzia, 2001, Bioorganic & medicinal chemistry.

N‐(Anilinoethyl)amide Melatonergic Ligands with Improved Water Solubility and Metabolic Stability

M. Mor, G. Gobbi, S. Rivara, 2021, ChemMedChem.

AN IMPROVED ROUTE TO CYCLOALKA[b]PYRROLE 2-CARBOXYLATES

A. Tontini, G. Tarzia, A. Bedini, 1997 .

Synthesis of new C-6 alkyliden penicillin derivatives as β-lactamase inhibitors

A. Tontini, G. Tarzia, E. D. Modugno, 2002 .

N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands.

M. Mor, G. Tarzia, G. Gobbi, 2007, Journal of medicinal chemistry.

Iridium-catalyzed direct synthesis of tryptamine derivatives from indoles: exploiting n-protected β-amino alcohols as alkylating agents.

G. Piersanti, G. Spadoni, M. Mari, 2015, The Journal of organic chemistry.

1-Aminocylopropane-1-carboxylic acid derivatives as ligands at the glycine-binding site of the N-methyl-D-aspartate receptor.

A. Tontini, G. Tarzia, W. Balduini, 1998, Farmaco.

Short synthesis of tryptophane and β-carboline derivatives by reaction of indoles with N-(diphenylmethylene)-α,β-didehydroamino acid esters

A. Tontini, G. Spadoni, A. Bedini, 1992 .

Diastereo- and enantioselective hydrogenation of a challenging enamide derived from 4-phenyl-2-tetralone: an appealing shortcut towards enantiopure cis-2-aminotetraline derivatives.

G. Piersanti, G. Spadoni, A. Bedini, 2010, Chemistry, an Asian journal.

Differentiation between isomeric 1-aminocyclo-propane- 1 - carboxylic acid derivatives by means of chemical ionisation and mass selected collision induced dissociation

G. Tarzia, G. Spadoni, O. Curcuruto, 1993 .

Structural characterization of isomeric didehydro amino acids using chemical ionization

G. Gaviraghi, G. Tarzia, P. Traldi, 1991 .

Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines.

J. Boutin, M. Mor, P. Delagrange, 2015, Journal of medicinal chemistry.

An Improved Route to Cycloalka(b)pyrrole‐2‐carboxylates.

A. Tontini, G. Tarzia, A. Bedini, 1997 .

Synthesis, antioxidant activity and structure–activity relationships for a new series of 2‐(N‐acylaminoethyl)indoles with melatonin‐like cytoprotective activity

Claudia Silva, Marco Mor, Federica Vacondio, 2006, Journal of pineal research.

Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands.

S. Collina, M. Mor, P. Delagrange, 2018, Journal of medicinal chemistry.

Synthesis of New C‐6 Alkylidene Penicillin Derivatives as β‐Lactamase Inhibitors.

A. Tontini, G. Tarzia, E. D. Modugno, 2003 .

Toward the definition of stereochemical requirements for MT2-selective antagonists and partial agonists by studying 4-phenyl-2-propionamidotetralin derivatives.

M. Mor, G. Tarzia, F. Scaglione, 2011, Journal of medicinal chemistry.

Synthesis, Enantiomeric Resolution, and Structure–Activity Relationship Study of a Series of 10,11‐Dihydro‐5H‐Dibenzo[a,d]cycloheptene MT2 Receptor Antagonists

M. Mor, G. Tarzia, F. Fraschini, 2007, ChemMedChem.

Dysfunction of serotonergic activity and emotional responses across the light‐dark cycle in mice lacking melatonin MT2 receptors

D. De Gregorio, L. Posa, S. Comai, 2020, Journal of pineal research.

Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways

G. Tarzia, S. Comai, G. Gobbi, 2015, Pain.

Melatonin, selective and non-selective MT1/MT2 receptors agonists: Differential effects on the 24-h vigilance states

G. Tarzia, S. Comai, G. Gobbi, 2014, Neuroscience Letters.

Anxiolytic effects of the melatonin MT2 receptor partial agonist UCM765: Comparison with melatonin and diazepam

M. Mor, G. Tarzia, S. Comai, 2012, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Promotion of Non-Rapid Eye Movement Sleep and Activation of Reticular Thalamic Neurons by a Novel MT2 Melatonin Receptor Ligand

L. Descarries, M. Mor, G. Tarzia, 2011, The Journal of Neuroscience.

Synthesis and configuration determination of all enantiopure stereoisomers of the melatonin receptor ligand 4-phenyl-2-propionamidotetralin using an expedient optical resolution of 4-phenyl-2-tetralone.

G. Piersanti, G. Spadoni, S. Bartolucci, 2012, Organic & biomolecular chemistry.

Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes.

Lina Ghibelli, Sergio Ammendola, Giorgio Tarzia, 2009, Toxicology and applied pharmacology.

Design and synthesis of N-(3,3-diphenylpropenyl)alkanamides as a novel class of high-affinity MT2-selective melatonin receptor ligands.

M. Mor, G. Tarzia, F. Scaglione, 2006, Journal of Medicinal Chemistry.

MT2 selective melatonin receptor antagonists: design and structure-activity relationships

M. Mor, G. Tarzia, A. Lodola, 2006 .

Recent advances in the development of melatonin MT1 and MT2 receptor agonists

Daniele Pala, Silvia Rivara, Marco Mor, 2010, Expert opinion on therapeutic patents.

(E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives. A novel class of glycine site antagonists.

G. Tedesco, A. Reggiani, A. Tontini, 1998, Journal of Medicinal Chemistry.

3-(2-Carbamoylvinyl)-4,5-dimethylpyrrole-2-carboxylic acids as ligands at the NMDA glycine-binding site: a study on the 2-carbamoylvinyl chain modification.

A. Tontini, G. Tarzia, G. Spadoni, 1999, Farmaco.

Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit.

C. Supuran, E. Masini, M. Mor, 2018, Journal of medicinal chemistry.

Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation.

Claudia Silva, Silvia Rivara, Marco Mor, 2003, Journal of medicinal chemistry.

Combined targeting of fatty acid amide hydrolase and melatonin receptors promotes neuroprotection and stimulates inflammation resolution in rats

M. Mor, K. Varani, F. Vincenzi, 2022, British journal of pharmacology.

Synthetic Melatonin Receptor Ligands

M. Mor, S. Rivara, G. Spadoni, 2014 .

Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety

E. Macchi, A. Sgoifo, M. Mor, 2015, Scientific Reports.

Indole‐based analogs of melatonin: in vitro antioxidant and cytoprotective activities

M. Mor, G. Tarzia, M. Zusso, 2004, Journal of pineal research.

CORRELATION OF THE ANTIMETASTATIC PROPERTIES OF ARYLTRIAZENES WITH THEIR ELECTRON IMPACT IONIZATION MASS SPECTROMETRY

A. Tontini, G. Tarzia, P. Traldi, 1997 .

MT1‐Selective Melatonin Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Dynamics Investigation of N‐{[(3‐O‐Substituted)anilino]alkyl}amides

M. Mor, G. Tarzia, F. Scaglione, 2012, ChemMedChem.

Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders.

Silvia Rivara, Marco Mor, Giorgio Tarzia, 2008, Current topics in medicinal chemistry.

Tricyclic alkylamides as melatonin receptor ligands with antagonist or inverse agonist activity.

M. Mor, G. Tarzia, F. Fraschini, 2004, Journal of Medicinal Chemistry.

Direct, one-pot reductive alkylation of anilines with functionalized acetals mediated by triethylsilane and TFA. Straightforward route for unsymmetrically substituted ethylenediamine.

G. Piersanti, G. Spadoni, A. Bedini, 2011, The Journal of organic chemistry.

Application of 3D‐QSAR in the Rational Design of Receptor Ligands and Enzyme Inhibitors

A. Duranti, A. Tontini, M. Mor, 2005, Chemistry & biodiversity.

Antiproliferative and pro-apoptotic activity of melatonin analogues on melanoma and breast cancer cells

M. Mor, A. Calastretti, G. Canti, 2017, Oncotarget.

Chiral Recognition of Flexible Melatonin Receptor Ligands Induced by Conformational Equilibria

M. Mor, F. Scaglione, V. Lucini, 2020, Molecules.