S. Degrado

发表

Discovery of a potent thiadiazole class of histamine h3 receptor antagonist for the treatment of diabetes.

M. Senior, A. Palani, B. Mckittrick, 2012, ACS medicinal chemistry letters.

Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia.

W. Greenlee, M. Senior, Xiaohong Zhu, 2012, ACS medicinal chemistry letters.

Discovery of a novel series of potent MK2 non-ATP competitive inhibitors using 1,2-substituted azoles as cis-amide isosteres.

Xiaohong Zhu, A. Palani, J. Fossetta, 2014, Bioorganic & medicinal chemistry letters.

A three-step protocol for lead optimization: quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitors.

Xiaohong Zhu, A. Palani, Wei Zhou, 2012, Bioorganic & medicinal chemistry letters.

SAR studies of C2 ethers of 2H-pyrano[2,3-d]pyrimidine-2,4,7(1H,3H)-triones as nicotinic acid receptor (NAR) agonist.

Xiaohong Zhu, A. Palani, W. Zhou, 2012, Bioorganic & medicinal chemistry letters.

Modular peptide-based phosphine ligands in asymmetric catalysis: efficient and enantioselective Cu-catalyzed conjugate additions to five-, six-, and seven-membered cyclic enones.

H. Mizutani, A. Hoveyda, S. Degrado, 2001, Journal of the American Chemical Society.

Combinatorial synthesis of CCR5 antagonists.

D. Hazuda, W. Schleif, E. Emini, 2001, Bioorganic & medicinal chemistry letters.

Discovery of a potent nicotinic Acid receptor agonist for the treatment of dyslipidemia.

Xiaohong Zhu, A. Palani, C. Farley, 2011, ACS medicinal chemistry letters.

Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.

R G Smith, A. Patchett, J. Schaeffer, 1998, Science.

Efficient cu-catalyzed asymmetric conjugate additions of alkylzincs to trisubstituted cyclic enones.

H. Mizutani, A. Hoveyda, S. Degrado, 2002, Journal of the American Chemical Society.

Cu-catalyzed asymmetric conjugate additions of alkylzinc reagents to acyclic aliphatic enones.

H. Mizutani, A. Hoveyda, S. Degrado, 2002, Journal of the American Chemical Society.

Highly enantioselective Cu-catalyzed conjugate additions of dialkylzinc reagents to unsaturated furanones and pyranones: preparation of air-stable and catalytically active Cu-peptide complexes.

A. Hoveyda, M. K. Brown, S. Degrado, 2005, Angewandte Chemie.

Zr-catalyzed diastereo- and enantioselective diene cyclizations. An unexpected synthesis of chiral aldehydes

A. Hoveyda, S. Degrado, Jeffrey A. Adams, 2003 .

Design and Synthesis of Isoquinolidinobenzodiazepine Dimers, a Novel Class of Antibody-Drug Conjugate Payload.

Nareshkumar Jain, J. R. Junutula, S. Smith, 2018, ACS medicinal chemistry letters.

Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature.

D. Dimitrov, S. Seaman, C. Szot, 2017, Cancer cell.

Anti-CD 276-drug conjugates display potent anti-tumor and anti-metastatic activity d Pyrrolobenzodiazepine dimers are optimal warheads for targeting tumor

D. Dimitrov, S. Seaman, C. Szot, 2022 .

A combinatorial approach toward the discovery of non-peptide, subtype-selective somatostatin receptor ligands.

D. Underwood, J. Schaeffer, K. Chapman, 1999, Journal of combinatorial chemistry.

Site-specific antibody conjugations using bacterial transglutaminase and the Diels-Alder cycloaddition reaction

C. Kyratsous, S. Degrado, H. S. Afsari, 2023, Cell Reports Physical Science.