J. Stock

发表

Benzimidazole- and indole-substituted 1,3'-bipyrrolidine benzamides as histamine H3 receptor antagonists.

T. Comery, A. Robichaud, J. Ellingboe, 2010, Bioorganic & medicinal chemistry letters.

Acylguanidines as small-molecule beta-secretase inhibitors.

M. Malamas, K. Fan, B. Harrison, 2006, Journal of medicinal chemistry.

Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1' substrate binding pocket.

M. Malamas, K. Fan, B. Harrison, 2008, Bioorganic & medicinal chemistry letters.

Discovery of a novel series of Notch-sparing gamma-secretase inhibitors.

B. Harrison, D. Huryn, J. Ellingboe, 2008, Bioorganic & medicinal chemistry letters.

Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism

S. C. K. Sukuru, F. Loganzo, C. J. O’Donnell, 2016, ACS medicinal chemistry letters.

Acylguanidines as Small-Molecule β-Secretase Inhibitors

Rajiv Chopra, Yun Hu, Eric S. Manas, 2006 .

N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists.

J. Ellingboe, Guoming Zhang, H. Mazandarani, 2005, Bioorganic & medicinal chemistry letters.

Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist.

K. Marquis, C. Beyer, J. Ellingboe, 2007, Journal of medicinal chemistry.

Modification of the swern oxidation: use of a recyclable, polystyrene bound sulfoxide.

D. Cole, J. Stock, J. Kappel, 2002, Bioorganic & medicinal chemistry letters.

IMPROVED SYNTHESIS OF bis(2,2,2-TRIFLUOROETHYL) PHOSPHOROCHLORIDATE

J. Stock, J. A. Jackson, R. Bowman, 1999 .

Improved Synthesis of Bis(2,2,2-trifluoroethyl)phosphorochloridate.

J. Stock, J. A. Jackson, R. Bowman, 1999 .

Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.

T. Comery, K. Fan, B. Harrison, 2008, Journal of medicinal chemistry.

A fluorescent assay suitable for inhibitor screening and vanin tissue quantification.

B. Ruan, Paul W. Wu, L. Fitz, 2010, Analytical biochemistry.

(S)-N-(5-Chlorothiophene-2-sulfonyl)-beta,beta-diethylalaninol a Notch-1-sparing gamma-secretase inhibitor.

T. Comery, B. Harrison, Z. Wang, 2009, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads.

J. Pandit, S. C. K. Sukuru, K. Parris, 2016, ACS medicinal chemistry letters.

Conformationally constrained N1-arylsulfonyltryptamine derivatives as 5-HT6 receptor antagonists.

J. Ellingboe, G. Tawa, Guoming Zhang, 2005, Bioorganic & medicinal chemistry letters.

Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.

M. Malamas, K. Fan, A. Robichaud, 2010, Bioorganic & medicinal chemistry letters.

Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors.

D. Joseph-McCarthy, A. Wissner, J. Ellingboe, 2008, Journal of medicinal chemistry.

Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets

M. Malamas, K. Fan, B. Harrison, 2008 .