L. Aluisio

发表

Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.

P. Bonaventure, Kiev S. Ly, T. Lovenberg, 2010, Bioorganic & medicinal chemistry letters.

Histamine H3 receptor antagonists: from target identification to drug leads.

P. Bonaventure, F. Kamme, T. Lovenberg, 2007, Biochemical pharmacology.

Acute wake‐promoting actions of JNJ‐5207852, a novel, diamine‐based H3 antagonist

Sandy J. Wilson, T. Lovenberg, N. Carruthers, 2004 .

Direct Imaging of Hippocampal Epileptiform Calcium Motifs Following Kainic Acid Administration in Freely Behaving Mice

Mark J. Schnitzer, E. Paxon Frady, Jonathan J. Nassi, 2016, Front. Neurosci..

Corrigendum to acute wake‐promoting actions of JNJ‐5207852, a novel, diamine‐based H3 antagonist

T. Lovenberg, X. Langlois, C. Berridge, 2005, British journal of pharmacology.

Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX(2)R) antagonists.

C. Dvorak, T. Lovenberg, N. Carruthers, 2004, Bioorganic & medicinal chemistry letters.

Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia

P. Bonaventure, T. Lovenberg, N. Carruthers, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement

P. Bonaventure, T. Lovenberg, N. Carruthers, 2011, Psychopharmacology.

JNJ-10181457, a selective non-imidazole histamine H3 receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition

P. Bonaventure, T. Lovenberg, R. Galici, 2009, Neuropharmacology.

Translational evaluation of JNJ-18038683, a 5-HT7 receptor antagonist, on REM sleep and in major depressive disorder

P. Bonaventure, C. Dvorak, T. Lovenberg, 2012 .

REM sleep and in major depressive disorder

P. Bonaventure, W. Chai, C. Dvorak, 2012 .

Managing Esketamine Treatment Frequency Toward Successful Outcomes: Analysis of Phase 3 Data

A. Dibernardo, F. Wiegand, Jaskaran Singh, 2019, European Neuropsychopharmacology.

Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia

M. Papp, T. Lovenberg, N. Carruthers, 2018, Neuropsychopharmacology.

4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate.

P. Bonaventure, C. Dvorak, T. Lovenberg, 2017, Journal of medicinal chemistry.

In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y2 receptor

P. Bonaventure, C. Dvorak, T. Lovenberg, 2010, Psychopharmacology.

JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats

E. Levin, P. Bonaventure, T. Lovenberg, 2011, Psychopharmacology.

Pharmacological characterization of JNJ-28583867, a histamine H(3) receptor antagonist and serotonin reuptake inhibitor.

P. Bonaventure, Sandy J. Wilson, T. Lovenberg, 2007, European journal of pharmacology.

Zolpidem Reduces Hippocampal Neuronal Activity in Freely Behaving Mice: A Large Scale Calcium Imaging Study with Miniaturized Fluorescence Microscope

Mark J. Schnitzer, Yaniv Ziv, Sujin Yun, 2014, PloS one.

Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H3 antagonist and serotonin transporter inhibitors.

Sandy J. Wilson, T. Lovenberg, N. Carruthers, 2007, Bioorganic & medicinal chemistry letters.

Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors.

Sandy J. Wilson, T. Lovenberg, N. Carruthers, 2007, Bioorganic & medicinal chemistry letters.

Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors.

Sandy J. Wilson, T. Lovenberg, N. Carruthers, 2007, Bioorganic & medicinal chemistry letters.

A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate.

C. Dvorak, N. Carruthers, A. Bhattacharya, 2018, Journal of medicinal chemistry.

Blockade of Orexin-1 Receptors Attenuates Orexin-2 Receptor Antagonism-Induced Sleep Promotion in the Rat

P. Bonaventure, C. Dvorak, T. Lovenberg, 2009, Journal of Pharmacology and Experimental Therapeutics.

Selective Blockade of 5-Hydroxytryptamine (5-HT)7 Receptors Enhances 5-HT Transmission, Antidepressant-Like Behavior, and Rapid Eye Movement Sleep Suppression Induced by Citalopram in Rodents

P. Bonaventure, T. Lovenberg, J. Atack, 2007, Journal of Pharmacology and Experimental Therapeutics.

Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ‐47965567

P. Bonaventure, T. Lovenberg, Hong Ao, 2013, British journal of pharmacology.

Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling.

T. Lovenberg, N. Carruthers, S. Bembenek, 2008, Bioorganic & medicinal chemistry.

Neuropeptide S stimulates dopaminergic neurotransmission in the medial prefrontal cortex

P. Bonaventure, R. Reinscheid, Naoe Okamura, 2010, Journal of neurochemistry.

Pharmacokinetics and pharmacodynamics of norfluoxetine in rats: Increasing extracellular serotonin level in the frontal cortex

T. Lovenberg, Y. Qu, J. Boggs, 2009, Pharmacology Biochemistry and Behavior.

Esketamine Nasal Spray Plus Oral Antidepressant in Patients With Treatment-Resistant Depression: Assessment of Long-Term Safety in a Phase 3, Open-Label Study (SUSTAIN-2).

A. Young, Cheng-Ta Li, W. Drevets, 2020, The Journal of clinical psychiatry.

Evaluating PK/PD Relationship of CNS Drug by Using Liquid Chromtography/ Tandem Mass Spectrometry Coupled to In Vivo Microdialysis

T. Lovenberg, Y. Qu, Christopher L King, 2012 .

142 Withdrawal Symptom Assessment in an Esketamine Safety Study in Patients with Treatment-resistant Depression

W. Drevets, A. Dibernardo, A. Krystal, 2020, CNS Spectrums.

P.327 Withdrawal symptom assessment in an esketamine safety study in patients with treatment-resistant depression

W. Drevets, A. Dibernardo, A. Krystal, 2019, European Neuropsychopharmacology.

Pharmacology of a Novel Central Nervous System–Penetrant P2X7 Antagonist JNJ-42253432

P. Bonaventure, T. Lovenberg, N. Carruthers, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Utilizing Miniature Fluorescence Microscopy to Image Hippocampal Place Cell Ensemble Function in Thy1.GCaMP6f Transgenic Mice

Tim Indersmitten, Tamara Berdyyeva, Leah Aluisio, 2018, Current protocols in pharmacology.

In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor.

Brian Lord, Leah Aluisio, Pascal Bonaventure, 2008, European journal of pharmacology.

Pharmacological Blockade of Serotonin 5-HT7 Receptor Reverses Working Memory Deficits in Rats by Normalizing Cortical Glutamate Neurotransmission

Brian Lord, Leah Aluisio, Pascal Bonaventure, 2011, PloS one.

Novel Substituted 4‐Phenyl‐[1,3]dioxanes: Potent and Selective Orexin Receptor 2 (OX2R) Antagonists.

C. Dvorak, T. Lovenberg, N. Carruthers, 2004 .

Neurochemical profile of orexin receptor antagonists : awakening the neurochemistry of sleep

P. Bonaventure, C. Dvorak, T. Lovenberg, 2008 .

Pharmacological or genetic orexin1 receptor inhibition attenuates MK-801 induced glutamate release in mouse cortex

P. Bonaventure, T. Lovenberg, Tamara Berdyyeva, 2014, Front. Neurosci..

Novel benzamide-based histamine h3 receptor antagonists: the identification of two candidates for clinical development.

P. Bonaventure, Kiev S. Ly, T. Lovenberg, 2015, ACS Medicinal Chemistry Letters.

Translational Evaluation of JNJ-18038683, a 5-Hydroxytryptamine Type 7 Receptor Antagonist, on Rapid Eye Movement Sleep and in Major Depressive Disorder

P. Bonaventure, C. Dvorak, T. Lovenberg, 2012, Journal of Pharmacology and Experimental Therapeutics.