B. Lord

发表

Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.

P. Bonaventure, Kiev S. Ly, T. Lovenberg, 2010, Bioorganic & medicinal chemistry letters.

Indole- and benzothiophene-based histamine H3 antagonists.

Cheryl A. Grice, T. Lovenberg, N. Carruthers, 2010, Bioorganic & medicinal chemistry letters.

Novel imidazole-based histamine H3 antagonists.

J. A. Jablonowski, C. Dvorak, Kiev S. Ly, 2009, Bioorganic & medicinal chemistry letters.

Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists.

P. Bonaventure, Sandy J. Wilson, T. Lovenberg, 2009, European journal of medicinal chemistry.

2-Aryloxymethylmorpholine histamine H(3) antagonists.

P. Bonaventure, Kiev S. Ly, N. Carruthers, 2008, Bioorganic & medicinal chemistry letters.

Histamine H3 receptor antagonists: from target identification to drug leads.

P. Bonaventure, F. Kamme, T. Lovenberg, 2007, Biochemical pharmacology.

Acute wake‐promoting actions of JNJ‐5207852, a novel, diamine‐based H3 antagonist

Sandy J. Wilson, T. Lovenberg, N. Carruthers, 2004 .

Developing and Validating a Sham Acupuncture Needle

A. White, S. Richards, Elizabeth A Tough, 2009, Acupuncture in medicine : journal of the British Medical Acupuncture Society.

Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor.

P. Bonaventure, C. Dvorak, T. Lovenberg, 2015, ACS medicinal chemistry letters.

Corrigendum to acute wake‐promoting actions of JNJ‐5207852, a novel, diamine‐based H3 antagonist

T. Lovenberg, X. Langlois, C. Berridge, 2005, British journal of pharmacology.

Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor.

T. Lovenberg, N. Carruthers, Hong Ao, 2016, Journal of medicinal chemistry.

Pharmacology of JNJ‐28583113: A novel TRPM2 antagonist

C. Dvorak, T. Lovenberg, N. Carruthers, 2019, European journal of pharmacology.

Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors.

P. Bonaventure, J. A. Jablonowski, Kiev S. Ly, 2007, Bioorganic & medicinal chemistry letters.

Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors.

Kiev S. Ly, Sandy J. Wilson, T. Lovenberg, 2007, Bioorganic & medicinal chemistry letters.

Novel Octahydropyrrolo[3,4-c]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate.

P. Bonaventure, Kiev S. Ly, T. Lovenberg, 2015, Journal of medicinal chemistry.

Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia

P. Bonaventure, T. Lovenberg, N. Carruthers, 2015, The Journal of Pharmacology and Experimental Therapeutics.

JNJ-10181457, a selective non-imidazole histamine H3 receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition

P. Bonaventure, T. Lovenberg, R. Galici, 2009, Neuropharmacology.

Putative role of GPR139 on sleep modulation using pharmacological and genetic rodent models.

P. Bonaventure, C. Dvorak, T. Lovenberg, 2020, European journal of pharmacology.

Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists.

P. Bonaventure, N. Carruthers, Hong Ao, 2015, Bioorganic & medicinal chemistry letters.

Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists.

N. Carruthers, Hong Ao, A. Bhattacharya, 2015, ACS medicinal chemistry letters.

Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans

T. P. Lebold, P. Bonaventure, W. Drevets, 2020, Translational Psychiatry.

Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a Small Molecule Antagonist of the Neuropeptide Y Y2 Receptor

P. Bonaventure, J. A. Jablonowski, T. Lovenberg, 2004, Journal of Pharmacology and Experimental Therapeutics.

Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793.

P. Bonaventure, C. Dvorak, T. Lovenberg, 2020, ACS medicinal chemistry letters.

NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain.

D. Bredt, E. Siuda, A. Harrington, 2017, Cell reports.

Translational evaluation of JNJ-18038683, a 5-HT7 receptor antagonist, on REM sleep and in major depressive disorder

P. Bonaventure, C. Dvorak, T. Lovenberg, 2012 .

REM sleep and in major depressive disorder

P. Bonaventure, W. Chai, C. Dvorak, 2012 .

Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia

M. Papp, T. Lovenberg, N. Carruthers, 2018, Neuropsychopharmacology.

4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate.

P. Bonaventure, C. Dvorak, T. Lovenberg, 2017, Journal of medicinal chemistry.

Preclinical characterization of substituted 6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one P2X7 receptor antagonists.

N. Carruthers, Hong Ao, A. Bhattacharya, 2016, Bioorganic & medicinal chemistry letters.

A novel radioligand for the ATP-gated ion channel P2X7: [3H] JNJ-54232334.

P. Bonaventure, T. Lovenberg, N. Carruthers, 2015, European journal of pharmacology.

Neuropharmacology and analgesia A novel radioligand for the ATP-gated ion channel P 2 X 7 : [ 3 H ] JNJ-54232334

P. Bonaventure, T. Lovenberg, N. Carruthers, 2015 .

Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists.

P. Bonaventure, N. Carruthers, Hong Ao, 2013, ACS medicinal chemistry letters.

In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y2 receptor

P. Bonaventure, C. Dvorak, T. Lovenberg, 2010, Psychopharmacology.

Substituted 5,6-(Dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)-methanones as P2X7 Antagonists.

P. Bonaventure, T. Lovenberg, N. Carruthers, 2016, ACS chemical neuroscience.

dantly expressed NPY receptor subtypes in the brain

P. Bonaventure, J. A. Jablonowski, T. Lovenberg, 2004 .

Characterization of JNJ-5207787, a small molecule antagonist of the neuropeptide Y Y 2 receptor

P. Bonaventure, T. Lovenberg, N. Carruthers, 2003 .

Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models

D. Henshall, T. Engel, W. Fischer, 2016, PloS one.

JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats

E. Levin, P. Bonaventure, T. Lovenberg, 2011, Psychopharmacology.

Pharmacological characterization of JNJ-28583867, a histamine H(3) receptor antagonist and serotonin reuptake inhibitor.

P. Bonaventure, Sandy J. Wilson, T. Lovenberg, 2007, European journal of pharmacology.

Discovery and SAR Studies of 2-Alkyl-3-phenyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepines as 5-HT7/2 Inhibitors Leading to the Identification of a Clinical Candidate.

P. Bonaventure, C. Dvorak, T. Lovenberg, 2020, Bioorganic & medicinal chemistry letters.

Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H3 antagonist and serotonin transporter inhibitors.

Sandy J. Wilson, T. Lovenberg, N. Carruthers, 2007, Bioorganic & medicinal chemistry letters.

Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors.

Sandy J. Wilson, T. Lovenberg, N. Carruthers, 2007, Bioorganic & medicinal chemistry letters.

Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists.

P. Bonaventure, Sandy J. Wilson, T. Lovenberg, 2009, European journal of medicinal chemistry.

Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors.

Sandy J. Wilson, T. Lovenberg, N. Carruthers, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors.

P. Bonaventure, Kiev S. Ly, Sandy J. Wilson, 2008, Bioorganic & medicinal chemistry letters.

Diamine-based human histamine H3 receptor antagonists: (4-aminobutyn-1-yl)benzylamines.

P. Bonaventure, J. A. Jablonowski, C. Dvorak, 2009, European journal of medicinal chemistry.

Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor

P. Bonaventure, T. Lovenberg, P. Connolly, 2019, The Journal of Pharmacology and Experimental Therapeutics.

A Selective Orexin-1 Receptor Antagonist Attenuates Stress-Induced Hyperarousal without Hypnotic Effects

T. P. Lebold, P. Bonaventure, T. Lovenberg, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO

D. Bredt, S. Sutton, A. Harrington, 2016, Neuron.

P2X7 receptor antagonism reduces the severity of spontaneous seizures in a chronic model of temporal lobe epilepsy

S. Dedeurwaerdere, S. Kumar-Singh, S. Missault, 2016, Neuropharmacology.

A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate.

C. Dvorak, N. Carruthers, A. Bhattacharya, 2018, Journal of medicinal chemistry.

Blockade of Orexin-1 Receptors Attenuates Orexin-2 Receptor Antagonism-Induced Sleep Promotion in the Rat

P. Bonaventure, C. Dvorak, T. Lovenberg, 2009, Journal of Pharmacology and Experimental Therapeutics.

Selective Blockade of 5-Hydroxytryptamine (5-HT)7 Receptors Enhances 5-HT Transmission, Antidepressant-Like Behavior, and Rapid Eye Movement Sleep Suppression Induced by Citalopram in Rodents

P. Bonaventure, T. Lovenberg, J. Atack, 2007, Journal of Pharmacology and Experimental Therapeutics.

Discovery of Imidazo[1,2-a]pyrazines and Pyrazolo[1,5-c]pyrimidines as TARP γ-8 Selective AMPAR Negative Modulators.

T. Lovenberg, N. Carruthers, B. Savall, 2018, ACS medicinal chemistry letters.

Lead Optimization of 5-Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ-8.

T. Lovenberg, N. Carruthers, B. Savall, 2018, ACS medicinal chemistry letters.

Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8

T. Lovenberg, N. Carruthers, T. Steckler, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ‐47965567

P. Bonaventure, T. Lovenberg, Hong Ao, 2013, British journal of pharmacology.

Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.

N. Carruthers, A. Dubin, Sui-Po Zhang, 2005, Journal of medicinal chemistry.

Pharmacokinetics and pharmacodynamics of norfluoxetine in rats: Increasing extracellular serotonin level in the frontal cortex

T. Lovenberg, Y. Qu, J. Boggs, 2009, Pharmacology Biochemistry and Behavior.

In vivo Characterization of a Selective, Orally Available, and Brain Penetrant Small Molecule GPR139 Agonist

P. Bonaventure, T. Lovenberg, Changlu Liu, 2019, Front. Pharmacol..

Pharmacology of a Novel Central Nervous System–Penetrant P2X7 Antagonist JNJ-42253432

P. Bonaventure, T. Lovenberg, N. Carruthers, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation

P. Bonaventure, T. Lovenberg, A. Shekhar, 2017, Front. Pharmacol..

In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor.

Brian Lord, Leah Aluisio, Pascal Bonaventure, 2008, European journal of pharmacology.

Pharmacological Blockade of Serotonin 5-HT7 Receptor Reverses Working Memory Deficits in Rats by Normalizing Cortical Glutamate Neurotransmission

Brian Lord, Leah Aluisio, Pascal Bonaventure, 2011, PloS one.

Comparison of the ex vivo receptor occupancy profile of ketamine to several NMDA receptor antagonists in mouse hippocampus.

P. Bonaventure, T. Lovenberg, X. Langlois, 2013, European journal of pharmacology.

α6-Containing Nicotinic Acetylcholine Receptor Reconstitution Involves Mechanistically Distinct Accessory Components.

D. Bredt, B. Lord, S. Gu, 2019, Cell reports.

Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-g 8 s

T. Lovenberg, N. Carruthers, T. Steckler, 2016 .

Novel benzamide-based histamine h3 receptor antagonists: the identification of two candidates for clinical development.

P. Bonaventure, Kiev S. Ly, T. Lovenberg, 2015, ACS Medicinal Chemistry Letters.

Translational Evaluation of JNJ-18038683, a 5-Hydroxytryptamine Type 7 Receptor Antagonist, on Rapid Eye Movement Sleep and in Major Depressive Disorder

P. Bonaventure, C. Dvorak, T. Lovenberg, 2012, Journal of Pharmacology and Experimental Therapeutics.

Design, Synthesis and Preclinical Evaluation of 3-Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5-b]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders.

T. Koudriakova, K. Coe, Xiaohui Jiang, 2020, Journal of medicinal chemistry.

1H-Pyrrolo[3,2-b]pyridine GluN2B-Selective Negative Allosteric Modulators.

N. Carruthers, T. Koudriakova, K. Coe, 2019, ACS medicinal chemistry letters.

Discovery of a Series of Substituted 1H-((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators.

C. Dvorak, N. Carruthers, J. Alcázar, 2023, Journal of medicinal chemistry.

Developing and Validating a Sham Acupuncture Needle

S. Richards, B. Lord, John L. Campbell, 2009, Acupuncture in medicine : journal of the British Medical Acupuncture Society.