J. Nalwalk

Shweta A. Mane, Dhruv Kool Rajamani, Zachary T. Olmsted, 2022, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Significance of cannabinoid CB1 receptors in improgan antinociception.

R. Razdan, B. Martin, M. Wentland, 2007, The journal of pain : official journal of the American Pain Society.

Cannabinoid-improgan cross-tolerance: Improgan is a cannabinomimetic analgesic lacking affinity at the cannabinoid CB1 receptor.

K. Svokos, J. Nalwalk, L. Hough, 2006, European journal of pharmacology.

Improgan-induced hypothermia: A role for cannabinoid receptors in improgan-induced changes in nociceptive threshold and body temperature

J. Nalwalk, L. Hough, C. Salussolia, 2007, Brain Research.

Antinociceptive activity of CC44, a biotinylated improgan congener.

Paul Hoerbelt, M. Wentland, J. Nalwalk, 2013, European journal of pharmacology.

Neuropharmacology and analgesia Antinociceptive activity of CC 44 , a biotinylated improgan congener

Paul Hoerbelt, M. Wentland, J. Nalwalk, 2013 .

Significance of neuronal cytochrome P450 activity in opioid-mediated stress-induced analgesia

Xinxin Ding, Weizhu Yang, J. Nalwalk, 2014, Brain Research.

Importance of histamine H2 receptors in restraint-morphine interactions.

J. Nalwalk, L. Hough, 1995, Life sciences.

Inhibition of brain [(3)H]cimetidine binding by improgan-like antinociceptive drugs.

I. D. de Esch, R. Stadel, Elwin Janssen, 2010, European journal of pharmacology.

Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic

O. Zuiderveld, R. Leurs, J. Bidlack, 2011, PAIN®.

A Third Life for Burimamide: Discovery and Characterization of a Novel Class of Non‐Opioid Analgesics Derived from Histamine Antagonists

R. Leurs, H. Timmerman, M. Wentland, 2000, Annals of the New York Academy of Sciences.

Antinociceptive activity of impentamine, a histamine congener, after CNS administration.

R. Leurs, H. Timmerman, W. Menge, 1998, Life Science.

Activation of brain stem nuclei by improgan, a non-opioid analgesic

R. Leurs, K. Svokos, H. Timmerman, 2004, Brain Research.

Improgan antinociception does not require neuronal histamine or histamine receptors

R. Leurs, H. Timmerman, K. Yanai, 2003, Brain Research.

Inhibition of Improgan Antinociception by the Cannabinoid (CB)1 AntagonistN-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A): Lack of Obligatory Role for Endocannabinoids Acting at CB1 Receptors

R. Leurs, S. Dey, H. Timmerman, 2002, Journal of Pharmacology and Experimental Therapeutics.

A role for spinal, but not supraspinal, α2 adrenergic receptors in the actions of improgan, a powerful, non-opioid analgesic

R. Leurs, K. Svokos, H. Timmerman, 2001, Brain Research.

Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice

R. Leurs, J. Pintar, H. Timmerman, 2000, Brain Research.

Novel qualitative structure-activity relationships for the antinociceptive actions of H2 antagonists, H3 antagonists and derivatives.

R. Leurs, H. Timmerman, C. Cioffi, 1997, The Journal of pharmacology and experimental therapeutics.

Effects of naltrexone and histamine antagonists on the antinociceptive activity of the cimetidine analog SKF92374 in rats

J. Nalwalk, L. Hough, B. Y. Li, 1997, Brain Research.

Characterization of the antinociceptive properties of cimetidine and a structural analog.

P. Cumming, M. Parsons, L. A. Barker, 1996, The Journal of pharmacology and experimental therapeutics.

Histamine-induced modulation of nociceptive responses

J. Nalwalk, L. Hough, S. Mischler, 1994, Pain.

Eight Flurothyl-Induced Generalized Seizures Lead to the Rapid Evolution of Spontaneous Seizures in Mice: A Model of Epileptogenesis with Seizure Remission

R. J. Ferland, D. Papandrea, Sridhar B Kadiyala, 2016, The Journal of Neuroscience.

Differential effects of morphine on histamine metabolism in brain and spinal cord of mice

J. Nalwalk, L. Hough, S. P. Licata, 1990, Brain Research.

Pain-facilitating medullary neurons contribute to opioid-induced respiratory depression.

Ryan S. Phillips, M. Heinricher, D. Cleary, 2012, Journal of neurophysiology.

Effects of external low intensity focused ultrasound on electrophysiological changes in vivo in a rodent model of common peroneal nerve injury

J. Pilitsis, Damian S Shin, G. Ghoshal, 2020, Neuroscience.

Neuronal cytochrome P450 activity and opioid analgesia: relevant sites and mechanisms

Xinxin Ding, Weizhu Yang, J. Nalwalk, 2015, Brain Research.

Absence of 5-HT3 and cholinergic mechanisms in improgan antinociception

R. Leurs, K. Svokos, J. Nalwalk, 2005, Pharmacology Biochemistry and Behavior.

Late adolescence mortality in mice with brain-specific deletion of the volume-regulated anion channel subunit LRRC8A

A. Scimemi, A. A. Mongin, R. J. Ferland, 2020, bioRxiv.

Conditional deletion of LRRC8A in the brain protects against stroke damage independently of effect on swelling-activated glutamate release

A. A. Mongin, R. Sah, Preeti Dohare, 2022, bioRxiv.

Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms

N. Scheer, Xinxin Ding, J. Nalwalk, 2015, Drug Metabolism and Disposition.

Expression of the EAAC1 Subtype of Glutamate Transporter through Activation of Platelet-derived Growth Factor Rapidly Increases Activity and Cell Surface

R. Leurs, H. Timmerman, C. Cioffi, 2007 .

High-Affinity Binding of [3H]Cimetidine to a Heme-Containing Protein in Rat Brain

R. Stadel, J. Nalwalk, L. Hough, 2008, Drug Metabolism and Disposition.

Physiological basis for inhibition of morphine and improgan antinociception by CC12, a P450 epoxygenase inhibitor.

M. Heinricher, J. Maire, J. Nalwalk, 2010, Journal of neurophysiology.

Opioids Activate Brain Analgesic Circuits Through Cytochrome P450/Epoxygenase Signaling

O. Zuiderveld, R. Leurs, J. Mazurkiewicz, 2010, Nature Neuroscience.

Pilot study on the effects of low intensity focused ultrasound in a swine model of neuropathic pain.

J. Pilitsis, Damian S Shin, Michael D. Staudt, 2021, Journal of neurosurgery.

Conditional deletion of LRRC8A in the brain reduces stroke damage independently of swelling-activated glutamate release

A. A. Mongin, R. Sah, Preeti Dohare, 2023, iScience.

The neuroprotective properties of the superoxide dismutase mimetic tempol correlate with its ability to reduce pathological glutamate release in a rodent model of stroke.

A. A. Mongin, Preeti Dohare, P. Feustel, 2014, Free radical biology & medicine.

Role of stress in histamine—morphine interactions

J. Nalwalk, L. Hough, 1995, Inflammation Research.

Modulation of morphine antinociception by the brain-penetrating H2 antagonist zolantidine: Detailed characterization in five nociceptive test systems

R. Bodnar, J. Nalwalk, L. Hough, 1995, Pharmacology Biochemistry and Behavior.

Development of a common peroneal nerve injury model in domestic swine for the study of translational neuropathic pain treatments.

J. Pilitsis, Michael D. Staudt, J. Nalwalk, 2021, Journal of neurosurgery.

alpha-Fluoromethylhistidine-induced inhibition of brain histidine decarboxylase. Implications for the CO2-trapping enzymatic method.

J. Nalwalk, L. Hough, K. Barke, 1994, Biochemical pharmacology.

Non-opioid antinociception produced by brain stem injections of improgan: Significance of local, but not cross-regional, cannabinoid mechanisms

K. Svokos, J. Nalwalk, L. Hough, 2009, Brain Research.

CC12, a P450/epoxygenase inhibitor, acts in the rat rostral, ventromedial medulla to attenuate morphine antinociception

J. Nalwalk, L. Hough, J. Phillips, 2013, Brain Research.

Extracellular histamine levels in the feline preoptic/anterior hypothalamic area during natural sleep–wakefulness and prolonged wakefulness: An in vivo microdialysis study

R. McCarley, R. Strecker, V. Ramesh, 2002, Neuroscience.

Actions of morphine on histamine dynamics in the mouse brain: a strain comparison.

J. Nalwalk, L. Hough, S. P. Licata, 1990, Biochemical pharmacology.

Low Intensity Focused Ultrasound Modulation of Vincristine Induced Neuropathy

J. Pilitsis, G. Ghoshal, J. Nalwalk, 2020, Neuroscience.

Predicting ablation zones with multislice volumetric 2-D magnetic resonance thermal imaging

E. Burdette, G. Fischer, J. Pilitsis, 2021, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Absence of antinociceptive tolerance to improgan, a cimetidine analog, in rats

R. Leurs, H. Timmerman, W. Menge, 1998, Brain Research.

Complex Region but not Via Direct Effects in the pre-Bötzinger Remifentanil Cause Bradypnea in Decerebrate Dogs

Ryan S. Phillips, M. Heinricher, K. Rice, 2015 .

Pain-relieving drugs and the brain histaminergic system: multiple analgesic mechanisms from histamine, improgan and cimetidine

R. Leurs, K. Svokos, J. Nalwalk, 2004, Inflammation Research.

Significance of GABAergic systems in the action of improgan, a non-opioid analgesic.

R. Leurs, H. Timmerman, W. Menge, 2001, Life sciences.

Efficacy of improgan, a non-opioid analgesic, in neuropathic pain

P. Albrecht, J. Nalwalk, L. Hough, 2011, Brain Research.

Antinociceptive, brain-penetrating derivatives related to improgan, a non-opioid analgesic.

K. Svokos, M. Wentland, Qun Lu, 2005, European journal of pharmacology.