J. Pratt

发表

D‐Amino Acid Homopiperazine Amides: Discovery of A‐320436, a Potent and Selective Non‐Imidazole Histamine H3‐Receptor Antagonist

G. Fox, A. Hancock, T. Pagano, 2004 .

Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole α1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia

M. Wendt, M. Brune, M. Meyer, 2000 .

Identification of halosalicylamide derivatives as a novel class of allosteric inhibitors of HCV NS5B polymerase.

L. Traphagen, U. Warrior, A. Molla, 2008, Bioorganic & medicinal chemistry letters.

Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies.

L. Lam, Xin Lu, S. Rosenberg, 2017, Cancer research.

Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides.

A. C. Krueger, A. Molla, D. Kempf, 2006, Bioorganic & medicinal chemistry letters.

Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines.

A. Molla, D. Kempf, H. Mo, 2005, Bioorganic & medicinal chemistry letters.

Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer

L. Lam, Chaohong Sun, S. Rosenberg, 2020, Nature.

Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.

Chaohong Sun, L. Hasvold, Chang H. Park, 2017, Journal of Medicinal Chemistry.

Discovery of N-ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET bromodomain inhibitor with selectivity for the second bromodomain.

K. Longenecker, P. Kovar, L. Hasvold, 2020, Journal of medicinal chemistry.

Des-A-ring benzothiadiazines: inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase.

A. Molla, D. Kempf, W. Kati, 2008, Bioorganic & medicinal chemistry letters.

Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A.

A. C. Krueger, A. Molla, T. Pilot‐Matias, 2014, Journal of medicinal chemistry.

Mechanistic study of HCV polymerase inhibitors at individual steps of the polymerization reaction.

S. Vasavanonda, W. Kati, Wen W. Jiang, 2006, Biochemistry.

Inhibitors of hepatitis C virus polymerase: synthesis and biological characterization of unsymmetrical dialkyl-hydroxynaphthalenoyl-benzothiadiazines.

A. C. Krueger, A. Molla, D. Kempf, 2009, Journal of medicinal chemistry.

A new class of potent non-imidazole H(3) antagonists: 2-aminoethylbenzofurans.

A. Hancock, A. Stewart, T. Esbenshade, 2004, Bioorganic & medicinal chemistry letters.

Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.

S. Elmore, M. Nakane, J. Miner, 2003, Journal of medicinal chemistry.

Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators.

David D. Anderson, M. Nakane, S. Elmore, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists.

I. Akritopoulou‐Zanze, Jyoti R. Patel, P. Kym, 2004, Bioorganic & medicinal chemistry letters.

5-Membered ring heterocyclic carboxylic acids as angiotensin II antagonists

D. Kerkman, S. Rosenberg, M. Winn, 1994 .

Pyridopyrimidine analogues as novel adenosine kinase inhibitors.

A. Gomtsyan, S. Muchmore, M. Jarvis, 2001, Bioorganic & medicinal chemistry letters.

Nonsteroidal selective glucocorticoid modulators: the effect of C-5 alkyl substitution on the transcriptional activation/repression profile of 2,5-dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.

S. Elmore, D. Anderson, B. Green, 2001, Journal of medicinal chemistry.

Dipeptide isosteres. 2. Synthesis of hydroxyethylene dipeptide isostere diastereomers from a common γ-lactone intermediate. Preparation of renin and HIV-1 protease inhibitor transition state mimics.☆

J. Pratt, W. Baker, 1993 .

Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.

A. Petros, Chaohong Sun, P. Kovar, 2017, Journal of medicinal chemistry.

Mutations Conferring Resistance to a Hepatitis C Virus (HCV) RNA-Dependent RNA Polymerase Inhibitor Alone or in Combination with an HCV Serine Protease Inhibitor In Vitro

Kent D. Stewart, Teresa Ng, Rubina Mondal, 2005, Antimicrobial Agents and Chemotherapy.

Adenosine kinase inhibitors: polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivity.

Chih-Hung Lee, Changcheng Zhu, M. Jarvis, 2003, Bioorganic & medicinal chemistry letters.

Discovery of pyrido[2,3-d]pyrimidine-based inhibitors of HCV NS5A.

A. Molla, D. Kempf, T. Pilot‐Matias, 2013, Bioorganic & medicinal chemistry letters.

A New Method for Hydrolyzing 2-Aryl-4,4-dimethyl-2-oxazolines to Aryl Carboxylic Acids.

J. Pratt, D. Phillion, 1992 .

Highlights of the Structure-Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530).

A. C. Krueger, T. Pilot‐Matias, J. Randolph, 2018, Journal of medicinal chemistry.

Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring.

A. Molla, D. Kempf, D. Beno, 2006, Bioorganic & medicinal chemistry letters.

Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole alpha1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia.

M. Wendt, M. Brune, M. Meyer, 2001, Journal of medicinal chemistry.

Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability.

K. Longenecker, A. C. Krueger, A. Molla, 2018, Journal of medicinal chemistry.

Methylpyrrole inhibitors of BET bromodomains.

A. Petros, Chaohong Sun, N. Soni, 2017, Bioorganic & medicinal chemistry letters.

In vitro optimization of structure activity relationships of analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists.

E. Bush, A. Hancock, P. Jacobson, 2004, Basic & clinical pharmacology & toxicology.

Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.

A. Petros, P. Kovar, Chang H. Park, 2017, Journal of medicinal chemistry.

Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors.

Ana L. Aguirre, A. Bogdan, Justin D Dietrich, 2018, Bioorganic & medicinal chemistry letters.

Methylpyrrole inhibitors of BET bromodomains.

A. Petros, N. Soni, P. Kovar, 2017, Bioorganic & medicinal chemistry letters.

Chang H. Park, D. Albert, Emily J. Faivre, 2017, Journal of medicinal chemistry.