J. Losman

发表

Spontaneous hemorrhage after external ventricular drain placement in the setting of low factor VII secondary to liver cirrhosis

S. Izzy, Alvin S. Das, M. M. J. Chua, 2020, Surgical neurology international.

Protein Phosphatase 2A Regulates the Stability of Pim Protein Kinases*

Bao Q. Vuong, S. Fay, P. Rothman, 2003, The Journal of Biological Chemistry.

The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies

Sven Christian, D. Scadden, A. Haegebarth, 2019, Leukemia.

Cancer therapy: The leukaemia epigenome targeted

J. Losman, 2017, Nature.

Haemophagocytic lymphohistiocytosis complicating pembrolizumab treatment for metastatic breast cancer in a patient with the PRF1A91V gene polymorphism

S. Nikiforow, S. Tolaney, H. Al‐Samkari, 2018, Journal of Medical Genetics.

A bleeding heart.

K. Cavanaugh, J. Losman, Jenna Goldberg, 2006, The American journal of medicine.

Antihistone antibodies in antinuclear antibody-positive juvenile arthritis.

L. Bohm, S. Albani, A. Martini, 1990, Arthritis and rheumatism.

Regulation of Cytokine Signaling

Alexander S. Banks, S. Fay, P. Rothman, 2005 .

IL-4 Signal Transduction Cutting Edge: SOCS-1 Is a Potent Inhibitor of

D. Hilton, P. Rothman, J. Losman, 1999 .

De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

R. Deberardinis, K. Ligon, D. Cahill, 2022, Cancer cell.

Secondary IDH1 resistance mutations and oncogenic IDH2 mutations cause acquired resistance to ivosidenib in cholangiocarcinoma

P. Wen, N. Bardeesy, B. Wolpin, 2022, npj Precision Oncology.

TRIM8/GERP RING Finger Protein Interacts with SOCS-1*

P. Rothman, V. Flati, J. Losman, 2002, The Journal of Biological Chemistry.

Enantiomer-Specific Transformation by 2HG Is Linked to Opposing Effects on α-Ketoglutarate-Dependent Dioxygenases

W. Kaelin, P. Koivunen, R. Looper, 2011 .

(asparagine-valine-threonine) in the framework 1 region of its iclight

Leung, G. Griffiths, D. Goldenberg, 2006 .

DDRE-29. DE NOVO PYRIMIDINE SYNTHESIS IS A TARGETABLE VULNERABILITY IN IDH-MUTANT GLIOMA

R. Deberardinis, K. Ligon, D. Cahill, 2021, bioRxiv.

Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1

John G Doench, C. Rudin, M. Tolstorukov, 2021, Nature Communications.

Cases from the Osler Medical Service at Johns Hopkins University. Diagnosis: P. carinii pneumonia and primary pulmonary sporotrichosis.

K. Cavanaugh, J. Losman, 2004, The American journal of medicine.

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer.

W. Kaelin, J. Losman, 2013, Genes & development.

Transformation by the R Enantiomer of 2-Hydroxyglutarate Linked to EglN Activation

R. Verhaak, K. Ligon, Hai Yan, 2012, Nature.

D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice

Travis J Cohoon, K. Ligon, Kwok-Kin Wong, 2014, Genes & development.

(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

Benjamin L. Ebert, David E. Root, Glenn S. Cowley, 2013, Science.

2-Oxoglutarate-dependent dioxygenases in cancer

W. Kaelin, P. Koivunen, J. Losman, 2020, Nature Reviews Cancer.

Direct Interaction of Jak1 and v-Abl Is Required for v-Abl-Induced Activation of STATs and Proliferation

S. Goff, N. Danial, Jean Y. J. Wang, 1998, Molecular and Cellular Biology.

Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation.

F. Al-Shahrour, R. Schneider, J. Perales-Patón, 2016, Cancer discovery.

Targeting Aberrant Signaling in Myeloid Malignancies: Promise Versus Reality.

J. Losman, R. Sellar, 2017, Hematology/oncology clinics of North America.

Pim serine/threonine kinases regulate the stability of Socs-1 protein

M. Nawijn, Bao Q. Vuong, S. Fay, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Cutting edge: SOCS-1 is a potent inhibitor of IL-4 signal transduction.

D. Hilton, P. Rothman, J. Losman, 1999, Journal of immunology.

IL-4 signaling is regulated through the recruitment of phosphatases, kinases, and SOCS proteins to the receptor complex.

M. Kashiwada, P. Rothman, C. Giallourakis, 1999, Cold Spring Harbor symposia on quantitative biology.

Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase

D. Neuberg, S. Signoretti, W. Kaelin, 2018, Proceedings of the National Academy of Sciences.

SOCS-1 Localizes to the Microtubule Organizing Complex-Associated 20S Proteasome

Alexander S. Banks, P. Rothman, Brian M. Showalter, 2004, Molecular and Cellular Biology.

SOCS proteins, regulators of intracellular signaling.

P. Rothman, J. Losman, X P Chen, 2000, Immunity.

Persistence of endothelial thrombomodulin in a patient with infectious purpura fulminans treated with protein C concentrate.

F. Duke, N. LeBoeuf, A. Bhatt, 2018, Blood advances.

Pathway-based Rare Variant Burden Analysis Identifies a Role for the Complement System in an Extreme Phenotype of Sepsis with Coagulopathy

S. Sunyaev, Á. Tóth-Petróczy, J. Krier, 2022, medRxiv.

Nucleosome-specific antibody from an autoimmune MRL/Mp-lpr/lpr mouse.

M. Monestier, M. Massa, K. Novick, 1993, Arthritis and rheumatism.

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer.

W. Kaelin, J. Losman, 2013, Genes & development.