A. Wada

A. Naito, I. Kawamura, S. Tuzi, 2015, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

Alcohol dehydrogenase activity converts 3"-hydroxygeranylhydroquinone to an aldehyde intermediate for shikonin and benzoquinone derivatives in Lithospermum erythrorhizon.

K. Yazaki, A. Wada, Hirobumi Yamamoto, 2020, Plant & cell physiology.

Total synthesis of cucurbitaxanthin A, cycloviolaxanthin and capsanthin 3,6-epoxide by applying a regioselective ring opening of tetrasubstituted epoxides.

A. Wada, Masayoshi Ito, Y. Yamano, 2008, Organic & biomolecular chemistry.

Iodocyclization of hydroxylamine derivatives based on the control of oxidative aromatization leading to 2,5-dihydroisoxazoles and isoxazoles.

T. M. Potewar, Takashi Okitsu, A. Wada, 2011, The Journal of organic chemistry.

Iodocyclization of ethoxyethyl ethers to ynamides: an immediate construction to benzo[b]furans.

Takashi Okitsu, A. Wada, Kohei Nakata, 2014, The Journal of organic chemistry.

Iodocyclization of ethoxyethyl ethers to alkynes: a broadly applicable synthesis of 3-iodobenzo[b]furans.

Takashi Okitsu, A. Wada, Rie Taniguchi, 2008, Organic letters.

A Convenient Synthesis of Methyl (E)-β-Pyrimidinylacrylates

T. Hase, J. Yamamoto, A. Wada, 1986 .

Synthesis of 5‐substituted pyrimidines. ortho‐directed lithiation of pyrimidine derivatives

J. Yamamoto, A. Wada, S. Kanatomo, 1990 .

Synthesis of substituted 5-(3-oxobutyl)pyrimidines via palladium-catalyzed coupling reactions of iodopyrimidines with methyl vinyl ketone

A. Wada, S. Kanatomo, H. Yasuda, 1988 .

Substituent effect of bis(pyridines)iodonium complexes as iodinating reagents: control of the iodocyclization/oxidation process.

Takashi Okitsu, A. Wada, Y. In, 2013, Chemistry.

A dearomative ipso-iodocyclization/desymmetrization sequence leading to optically active tricyclic piperazine scaffolds.

Takashi Okitsu, A. Wada, N. Shimazawa, 2020, Organic & biomolecular chemistry.

3-Methylene-4-amido-1,2-diazetidine as a Formal 1,4-Dipole Precursor: Lewis Acid-Catalyzed Nucleophilic Addition with Silylated Nucleophiles.

Takashi Okitsu, A. Wada, Keiko Kobayashi, 2017, Organic letters.

Synthesis of γ-Hydroxybutenolides Applying Crossed Aldol Condensation in the Presence of a Bulky Lewis Acid and Their Anti-tumor Activity

K. Nakagawa, T. Okano, A. Wada, 2007 .

Silyl Group-Directed 6-exo-dig Iodocyclization of Homopropargylic Carbamates and Amides.

Takashi Okitsu, A. Wada, Y. In, 2018, Chemistry.

Reagent-controlled oxidative aromatization in iodocyclization: switchable access to dihydropyrazoles and pyrazoles.

Takashi Okitsu, A. Wada, Kana Sato, 2010, Organic letters.

Retinoids and related compounds. Part 19.1Syntheses of 9E- and 9Z-lockedretinoic acid analogues and their transcriptional activities as ligandsfor retinoic acid receptors and retinoid X receptors

A. Wada, Y. Aoyama, Y. Katsuta, 1997 .

Synthesis of 7-alkyl-2,4-dimethoxy-5-oxo-5H-pyrano[4,3-d]pyrimidines

A. Wada, S. Kanatomo, 1990 .

Synthesis of quinazoline derivatives through anionic cycloaddition reactions of methyl 2,4-dimethoxy-6-methyl-5-pyrimidinecarboxylate with acetylenes and olefins

A. Wada, Hiromi Yamamoto, S. Kanatomo, 1992 .

Iodocyclization of ethoxyethyl ethers to ynamides: an immediate construction to benzo[b]furans.

Takashi Okitsu, A. Wada, Kohei Nakata, 2014, The Journal of organic chemistry.

Anthracyclinone syntheses using strong base induced cycloaddition of homophthalic anhydrides and related compounds

Y. Kita, S. Akai, M. Sasho, 1984 .

A new general regiocontrolled synthesis of anthracyclinones using cycloaddition of homophthalic anhydrides to 2-chloro-6-oxo-5,6,7,8-tetrahydro-1,4-naphthoquinone 1,2-ethanediyl acetal

Y. Kita, K. Fukunaga, M. Sasho, 1982 .

Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase.

N. Ueda, K. Tsuboi, Xing-Hua Jin, 2012, Bioorganic & medicinal chemistry.

Retinoids and related compounds. Part 26. Synthesis of (11Z)-8,18-propano- and methano-retinals and conformational study of the rhodopsin chromophore

Y. Shichida, H. Imai, A. Wada, 2001 .

Determination of 6s-trans conformation of retinal chromophore in sensory rhodopsin I and phoborhodopsin.

A. Akai, T. Goshima, A. Wada, 1998, Bioorganic & medicinal chemistry letters.

Synthesis of 818-ethanoretinal and its interaction with apo-retinochrome

T. Kinumi, K. Tsujimoto, M. Sakai, 1993 .

Convergent Synthesis of Dronedarone, an Antiarrhythmic Agent.

Takashi Okitsu, A. Wada, Mizuki Ogasahara, 2016, Chemical & pharmaceutical bulletin.

Efficient synthesis and biological evaluation of demethyl geranylgeranoic acid derivatives.

K. Nakagawa, T. Okano, Y. Suhara, 2010, Bioorganic & medicinal chemistry.

Caesium fluoride-promoted Stille coupling reaction: an efficient synthesis of 9Z-retinoic acid and its analogues using a practical building block.

Takashi Okitsu, A. Wada, Kinya Iwatsuka, 2008, Chemical communications.

Synthesis and Photocyclization of 2-Aroyl-3-methylcyclohex-2-enones

Y. Kita, Y. Tamura, A. Wada, 1981 .

Synthesis of 5-substituted pyrimidines through ortho-directed lithiation reactions

J. Yamamoto, A. Wada, S. Kanatomo, 1987 .

ortho-Directed lithiation of (2-methoxy)ethoxy- and (2-dimethylamino)ethoxy-arenes

A. Wada, S. Nagai, S. Kanatomo, 1985 .

A NOVEL SYNTHESIS OF QUINAZOLINEQUINONE AND CARBAZOLEQUINONE THROUGH ANIONIC CYCLOADDITION : ITS APPLICATION TO A SYNTHESIS OF MURRAYAQUINONE A

M. Hanaoka, A. Wada, Syuichi Hirai, 1994 .

Stereocontrolled Synthesis of (11Z)-Retinal and Its Analogues.

R. Kawahama, O. Yonemitsu, J. Uenishi, 1998, Angewandte Chemie.

Title Pinopsin evolved as the ancestral dim-light visual opsin invertebrates

H. Ohuchi, Keita Sato, Keiichi Kojima, 2019 .

Pinopsin evolved as the ancestral dim-light visual opsin in vertebrates

H. Ohuchi, Keita Sato, Keiichi Kojima, 2018, Communications Biology.

Adaptation of cone pigments found in green rods for scotopic vision through a single amino acid mutation

Keiichi Kojima, Takahiro Yamashita, Keisuke Sakurai, 2017, Proceedings of the National Academy of Sciences.

Menadione (Vitamin K3) Is a Catabolic Product of Oral Phylloquinone (Vitamin K1) in the Intestine and a Circulating Precursor of Tissue Menaquinone-4 (Vitamin K2) in Rats*

K. Nakagawa, N. Tsugawa, Yuri Uchino, 2013, The Journal of Biological Chemistry.

Modulation of thermal noise and spectral sensitivity in Lake Baikal cottoid fish rhodopsins

M. Olivucci, J. M. Morrow, H. Luk, 2016, Scientific Reports.

High-performance liquid chromatographic separation and spectral identification of the photoreaction products of methyl 5,8-epoxyretinoate.

A. Wada, M. Matsuishi, M. Ito, 1992, Journal of nutritional science and vitaminology.

Identical Hydrogen-Bonding Strength of the Retinal Schiff Base between Primate Green- and Red-Sensitive Pigments: New Insight into Color Tuning Mechanism.

K. Katayama, H. Kandori, H. Imai, 2015, The journal of physical chemistry letters.

Assignment of the hydrogen-out-of-plane and -in-plane vibrations of the retinal chromophore in the K intermediate of pharaonis phoborhodopsin.

N. Kamo, H. Kandori, Y. Sudo, 2006, Biochemistry.

Evolutionary adaptation of visual pigments in geckos for their photic environment.

Keiichi Kojima, Y. Shichida, Masataka Yanagawa, 2021, Science advances.

Shift in Conformational Equilibrium Induces Constitutive Activity of G-Protein-Coupled Receptor, Rhodopsin.

Y. Sako, Ryo Maeda, Y. Shichida, 2018, The journal of physical chemistry. B.

- 1-Single-molecule observation of the ligand-induced population shift of rhodopsin , a G-protein coupled receptor

Y. Sako, Ryo Maeda, Y. Shichida, 2018 .

Origin of the low thermal isomerization rate of rhodopsin chromophore

K. Nakanishi, Y. Sako, Keiichi Kojima, 2015, Scientific Reports.

Single-molecule observation of the ligand-induced population shift of rhodopsin, a G-protein-coupled receptor.

Y. Sako, Ryo Maeda, Y. Shichida, 2014, Biophysical journal.

An improved synthesis of benzocycloalkanone derivatives.

N. Ono, A. Wada, Kyoko Sawada, 2004, Chemical & pharmaceutical bulletin.

Stereoselective synthesis of 11Z-9-demethyl-9-benzyl- and 9-phenyl-retinals and their interaction with bovine opsin.

Y. Shichida, H. Imai, A. Wada, 1998, Bioorganic & medicinal chemistry letters.

Evidence for the archaebacterial‐type conformation about the bond between the β‐ionone ring and the polyene chain of the chromophore retinal in chlamyrhodopsin

Tetsuo Takahashi, A. Wada, Masayoshi Ito, 1998, FEBS letters.

FTIR spectroscopy of the O photointermediate in pharaonis phoborhodopsin.

N. Kamo, M. Iwamoto, H. Kandori, 2004, Biochemistry.

Retinoids and Related Compounds; 18: A Convenient Synthesis of Retinoic Acid Analogs Having an Anthraquinone Ring

A. Wada, C. Tode, Masayoshi Ito, 1995 .

A convenient and stereoselective synthesis of 11Z-3,4-didehydroretinal by Horner-Emmons reaction using diphenyl phosphonate.

Fei Wang, A. Wada, Masayoshi Ito, 2008, Chemical & pharmaceutical bulletin.

Stereoselective synthesis of 11Z-retinal by use of tricarbonyliron complex

A. Wada, N. Fujioka, Masayoshi Ito, 1996 .

Red-Tuning of the Channelrhodopsin Spectrum Using Long Conjugated Retinal Analogues.

T. Ishizuka, H. Yawo, Y. Shichida, 2018, Biochemistry.

Visual adaptation of opsin genes to the aquatic environment in sea snakes

Y. Satta, T. Hariyama, Y. Terai, 2020, BMC evolutionary biology.

Substrate Specificity and Subcellular Localization of the Aldehyde-Alcohol Redox-coupling Reaction in Carp Cones*

Shinya Sato, A. Wada, S. Kawamura, 2013, The Journal of Biological Chemistry.

Drosophila melanogaster rhodopsin Rh7 is a UV-to-visible light sensor with an extraordinarily broad absorption spectrum

N. Iwabe, T. Yamashita, A. Wada, 2018 .

Drosophila melanogaster rhodopsin Rh7 is a UV-to-visible light sensor with an extraordinarily broad absorption spectrum

Y. Shichida, N. Iwabe, T. Yamashita, 2017, Scientific Reports.

Time-resolved FTIR study of light-driven sodium pump rhodopsins.

H. Kandori, A. Wada, Keiichi Inoue, 2018, Physical chemistry chemical physics : PCCP.

Assignment of the vibrational modes of the chromophores of iodopsin and bathoiodopsin: low-temperature fourier transform infrared spectroscopy of 13C- and 2H-labeled iodopsins.

H. Kandori, Y. Shichida, H. Imai, 2006, Biochemistry.

Steric constraint in the primary photoproduct of an archaeal rhodopsin from regiospecific perturbation of C-D stretching vibration of the retinyl chromophore.

N. Kamo, H. Kandori, Y. Sudo, 2005, Journal of the American Chemical Society.

Retinoids and Related Compounds. Part 27. An Improved Synthesis of Benzocycloalkanone Derivatives.

N. Ono, A. Wada, Kyoko Sawada, 2004 .

Synthesis of 11Z-8,18-propano- and methano-retinals and their interaction with bovine opsin.

Y. Shichida, H. Imai, A. Wada, 1995, Chemical & pharmaceutical bulletin.

Retinoids and Related Compounds. 17. Conformational Study of Retinochrome Chromophore: Synthesis of 8,18-Ethanoretinal and a New Retinochrome Analog

T. Kinumi, K. Tsujimoto, M. Yamauchi, 1994 .

Synthesis of 11Z‐9‐demethyl‐9‐((3‐indolyl)methyl)retinal

A. Wada, N. Fujioka, Masayoshi Ito, 2001 .

Total synthesis of lycopene-5,6-diol and γ-carotene-5′,6′-diol stereoisomers and their HPLC separation

T. Maoka, A. Wada, Yuya Nishiyama, 2017 .

Oxidative metabolites of lycopene and γ-carotene in gac (Momordica cochinchinensis).

T. Maoka, H. Nishino, H. Tokuda, 2015, Journal of agricultural and food chemistry.

Stereocontrolled first total syntheses of amarouciaxanthin A and B.

A. Wada, M. V. Chary, Y. Yamano, 2013, Organic letters.

Palladium‐catalyzed conjugate addition type reaction of 5‐iodopyrimidines with α,β‐unsaturated ketones

A. Wada, S. Kanatomo, S. Nagai, 1991 .

Analysis of the molecular interaction of the farnesyl moiety of transducin through the use of a photoreactive farnesyl analogue.

Y. Fukada, Y. Ohya, P. Casey, 2004, Biochemistry.

Identification of Paracentrone in Fucoxanthin-fed mice and Anti-inflammatory Effect Against Lipopolysaccharide-stimulated Macrophages and Adipocytes.

K. Miyashita, Fumiaki Beppu, M. Hosokawa, 2020, Molecular nutrition & food research.

Total synthesis of myxol and deoxymyxol stereoisomers and their application to determining the absolute configurations of the natural products

S. Takaichi, A. Wada, Y. Yamano, 2018 .

Stereoselective total synthesis of the acetylenic carotenoids alloxanthin and triophaxanthin.

A. Wada, M. V. Chary, Y. Yamano, 2012, Organic & biomolecular chemistry.

Total Synthesis of Loroxanthin

A. Wada, Y. Yamano, A. Shimada, 2022, Marine drugs.

Solid-state NMR spectroscopy structure determination of a lipid-embedded heptahelical membrane protein

L. Brown, K. Jung, V. Ladizhansky, 2013, Nature Methods.

Palladium-Catalyzed Conjugate Addition Type Reaction of 5- Iodopyrimidines with α,β-Unsaturated Ketones.

A. Wada, S. Kanatomo, S. Nagai, 1991 .

Ynamides enabled 6-, 7-, and 8-endo-dig iodocyclization of ethoxyethyl ethers: rapid construction of medium-sized oxacycles at room temperature

S. Kondo, Takashi Okitsu, A. Wada, 2020 .

Synthesis and biological evaluation of 9Z-retinoic acid analogs having 2-substituted benzo[b]furan.

K. Nakagawa, T. Okano, Takashi Okitsu, 2010, Chemical & pharmaceutical bulletin.

Visual adaptation in Lake Victoria cichlid fishes: depth-related variation of color and scotopic opsins in species from sand/mud bottoms

N. Okada, A. Sato, Y. Terai, 2017, BMC Evolutionary Biology.

UV-Sensitive Photoreceptor Protein OPN5 in Humans and Mice

Y. Fukada, D. Kojima, A. Wada, 2011, PloS one.

Carotenoid Profiling of a Red Seaweed Pyropia yezoensis: Insights into Biosynthetic Pathways in the Order Bangiales

T. Maoka, K. Miyashita, K. Mikami, 2018, Marine drugs.

Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity.

K. Nakagawa, T. Okano, N. Sawada, 2011, Bioorganic & medicinal chemistry.

Preparation and biological activity of 13-substituted retinoic acids.

K. Nakagawa, T. Okano, A. Wada, 2004, Bioorganic & medicinal chemistry.

Carotenoid synthesis: retrospect and recent progress.

A. Wada, C. Tode, Masayoshi Ito, 2009, Archives of biochemistry and biophysics.

Two isoforms of chicken melanopsins show blue light sensitivity

Y. Fukada, T. Okano, D. Kojima, 2007, FEBS letters.

Interacting Targets of the Farnesyl of Transducin γ-Subunit

Y. Fukada, P. Casey, M. Umeda, 2008, Biochemistry.

Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies.

Y. Nishida, H. Ueyama, Y. Shichida, 2002, Biochemical and biophysical research communications.

Solid-state NMR 13C and 15N resonance assignments of a seven-transmembrane helical protein Anabaena Sensory Rhodopsin

L. Brown, V. Ladizhansky, Shenlin Wang, 2013, Biomolecular NMR assignments.

Correlation between nuptial colors and visual sensitivities tuned by opsins leads to species richness in sympatric Lake Victoria cichlid fishes.

N. Okada, H. Tachida, T. Sugawara, 2012, Molecular biology and evolution.

Synthesis of all-E- and 9Z-Heteroaryl-retinoic Acid Applying Palladium Catalyzed Coupling Reaction of (Arylvinyl)tributyl Stannane with Vinyl Triflate

A. Wada, Masayoshi Ito, G. Babu, 2001 .

Stereocontrolled Synthesis of 13-Substituted Retinoic Acids by Palladium-Catalyzed Coupling Reaction of Alkenyl Stannane with Vinyl Triflate

A. Wada, Masayoshi Ito, Kouki Fukunaga, 2001 .

Trienylboronic acid, a versatile coupling tool for retinoid synthesis; stereospecific synthesis of 13-aryl substituted (11Z)-retinal

J. Uenishi, A. Wada, Katsuaki Matsui, 2003 .

A Novel Synthesis of 2-Substituted Indole Derivatives: A Palladium Catalyzed Cross-coupling Reaction of Enol Triflate Derived from N-Methyl- 2-Indolone with (Alkenyl)tributylstannane and Acetylene

J. Uenishi, A. Wada, Masayoshi Ito, 2006 .

Inhibition of lysine-specific demethylase 1 by the acyclic diterpenoid geranylgeranoic acid and its derivatives.

Y. Shidoji, Takashi Okitsu, A. Wada, 2014, Biochemical and biophysical research communications.

Elucidation of the mechanism producing menaquinone-4 in osteoblastic cells.

T. Okano, Y. Suhara, A. Wada, 2009, Bioorganic & medicinal chemistry letters.

Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells.

H. Tokiwa, K. Nakagawa, T. Okano, 2015, Journal of medicinal chemistry.

Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells.

A. Takeuchi, N. Osakabe, S. Kuwahara, 2017, Journal of medicinal chemistry.

Antitumoral activity of 13-demethyl or 13-substituted analogues of all-trans retinoic acid and 9-cis retinoic acid in the human myeloid leukemia cell line HL-60.

K. Nakagawa, T. Okano, A. Wada, 2006, Biological & pharmaceutical bulletin.

Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities.

M. Makishima, S. Kuwahara, Y. Suhara, 2017, Bioorganic & medicinal chemistry letters.

Structure around C6-C7 bond of the chromophore in bathorhodopsin: low-temperature spectroscopy of 6s-cis-locked bicyclic rhodopsin analogs.

Y. Shichida, A. Wada, M. Ito, 1996, Biochemistry.

Anti-Oxidative Activity of Mytiloxanthin, a Metabolite of Fucoxanthin in Shellfish and Tunicates

T. Maoka, H. Yasui, A. Wada, 2016, Marine drugs.

Targeting transglutaminase 2 mediated exostosin glycosyltransferase 1 signaling in liver cancer stem cells with acyclic retinoid

Harukazu Suzuki, M. Shirouzu, S. Kojima, 2023, Cell death & disease.

Production of a Light-Gated Proton Channel by Replacing the Retinal Chromophore with Its Synthetic Vinylene Derivative.

S. Tsunoda, M. Mizuno, Y. Mizutani, 2018, Journal of Physical Chemistry Letters.

Characterization of retinal chromophore and protonated Schiff base in Thermoplasmatales archaeon heliorhodopsin using solid-state NMR spectroscopy.

A. Naito, I. Kawamura, K. Katayama, 2023, Biophysical chemistry.

Protonation of Asp116 and distortion of the all-trans retinal chromophore in Krokinobacter eikastus rhodopsin 2 causes a redshift in absorption maximum upon dehydration

A. Wada, Y. Furutani, Sahoko Tomida, 2023, Photochemical & Photobiological Sciences.

Stereocontrolled Synthesis of 13-Substituted Retinoic Acids by Palladium-Catalyzed Coupling Reaction of Alkenyl Stannane with Vinyl Triflate

A. Wada, Masayoshi Ito, Kouki Fukunaga, 2001 .

Stereoselective synthesis of retinoid isomers using tricarbonyliron complex and its application

A. Wada, Masayoshi Ito, 1999 .

A Novel Method for a Stereoselective Synthesis of Trisubstituted Olefin Using Tricarbonyliron Complex: A Highly Stereoselective Synthesis of (all-E)- and (9Z)-Retinoic Acids.

A. Wada, N. Takamura, Masayoshi Ito, 1997, The Journal of organic chemistry.

STEREOSELECTIVE SYNTHESIS OF 7E, 9E- AND 7E, 9Z-β-IONYLIDENEACETALDEHYDES BY USE OF TRICARBONYL IRON COMPLEX

A. Wada, Masayoshi Ito, Saeko Hiraishi, 1994 .

Drosophila melanogaster rhodopsin Rh7 is a UV-to-visible light sensor with an extraordinarily broad absorption spectrum

Y. Shichida, N. Iwabe, T. Yamashita, 2017, Scientific Reports.

Synthesis of One Double Bond-Inserted Retinal Analogs and Their Binding Experiments with Opsins: Preparation of Novel Red-Shifted Channelrhodopsin Variants.

Yuka Kobayashi, Y. Shichida, T. Yamashita, 2020, Chemical & pharmaceutical bulletin.

Chromophore Structure in an Inactive State of a Novel Photosensor Protein Opn5L1: Resonance Raman Evidence for the Formation of a Deprotonated Adduct at the 11th Carbon Atom.

M. Mizuno, Y. Mizutani, Keita Sato, 2023, The journal of physical chemistry. B.

Correlation between nuptial colors and visual sensitivities tuned by opsins leads to species richness in sympatric Lake Victoria cichlid fishes.

N. Okada, H. Tachida, T. Sugawara, 2012, Molecular biology and evolution.

Convergent mechanism underlying the acquisition of vertebrate scotopic vision.

Keiichi Kojima, Y. Shichida, Masataka Yanagawa, 2024, The Journal of biological chemistry.

Alternative Formation of Red-Shifted Channelrhodopsins: Noncovalent Incorporation with Retinal-Based Enamine-Type Schiff Bases and Mutated Channelopsin.

T. Ishizuka, H. Yawo, Y. Shichida, 2017, Chemical & pharmaceutical bulletin.

Recent progress in carotenoid and retinoid synthesis

A. Wada, Masayoshi Ito, Y. Yamano, 1994 .

Structure-activity relationships in the conversion of vitamin K analogues into menaquinone-4. Substrates essential to the synthesis of menaquinone-4 in cultured human cell lines.

K. Nakagawa, T. Okano, Masato Watanabe, 2010, Bioorganic & medicinal chemistry.