K. Creech

发表

The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor.

L. Moore, T. Willson, B. Wisely, 2008, Molecular endocrinology.

Guggulsterone Activates Multiple Nuclear Receptors and Induces CYP3A Gene Expression through the Pregnane X Receptor

B. Goodwin, J. Staudinger, Xunshan Ding, 2004, Journal of Pharmacology and Experimental Therapeutics.

Discovery of selective small molecule type III phosphatidylinositol 4-kinase alpha (PI4KIIIα) inhibitors as anti hepatitis C (HCV) agents.

C. Moore, A. Mathis, J. Botyánszki, 2014, Journal of medicinal chemistry.

Discovery of novel urea-based hepatitis C protease inhibitors with high potency against protease-inhibitor-resistant mutants.

R. Hamatake, Suoming Zhang, S. Baker, 2012, Journal of medicinal chemistry.

Synthesis of new acylsulfamoyl benzoxaboroles as potent inhibitors of HCV NS3 protease.

Z. Ni, Suoming Zhang, S. Baker, 2010, Bioorganic & medicinal chemistry letters.

Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans.

T. Willson, Dalei Wu, D. Rajpal, 2017, The Journal of investigative dermatology.

Novel heterocyclic scaffolds of GW4064 as farnesoid X receptor agonists.

J. Caravella, D. Parks, Justin A. Caravella, 2015, Bioorganic & medicinal chemistry letters.

In Vitro Characterization of GSK2485852, a Novel Hepatitis C Virus Polymerase Inhibitor

R. Hamatake, Z. Hong, J. Vamathevan, 2013, Antimicrobial Agents and Chemotherapy.

Imidazo[1,2-a]pyridines That Directly Interact with Hepatitis C NS4B: Initial Preclinical Characterization.

D. J. Price, M. Thomson, R. Crosby, 2012, ACS medicinal chemistry letters.

Design of N-Benzoxaborole Benzofuran GSK8175—Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor

D. J. Price, John Miller, Shawn P. Williams, 2019, Journal of medicinal chemistry.

764 IN VITRO PROFILING OF GSK2336805, A POTENT AND SELECTIVE INHIBITOR OF HCV NS5A

R. Hamatake, J. Vamathevan, W. Kazmierski, 2011 .

Novel benzophenones as non-nucleoside reverse transcriptase inhibitors of HIV-1.

L. Boone, S. Short, K. Weaver, 2004, Journal of medicinal chemistry.

Hepatitis C replication inhibitors that target the viral NS4B protein.

D. J. Price, R. Hamatake, Z. Hong, 2014, Journal of medicinal chemistry.

Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses.

G. A. Freeman, K. Gudmundsson, K. Creech, 2006, Bioorganic & medicinal chemistry.

Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses.

G. A. Freeman, K. Gudmundsson, Zhicheng Wang, 2005, Bioorganic & medicinal chemistry.

Synthesis and SAR of acyclic HCV NS3 protease inhibitors with novel P4-benzoxaborole moieties.

Z. Ni, Suoming Zhang, S. Baker, 2011, Bioorganic & medicinal chemistry letters.

FXR agonist activity of conformationally constrained analogs of GW 4064.

Shawn P. Williams, D. Parks, K. Madauss, 2009, Bioorganic & medicinal chemistry letters.

Pyrazolopyridine antiherpetics: SAR of C2' and C7 amine substituents.

J. A. Ray, V. Samano, G. A. Freeman, 2005, Bioorganic & medicinal chemistry.

Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene.

Shawn P Williams, G. B. Wisely, Shawn P. Williams, 2011, Bioorganic & medicinal chemistry letters.

Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064.

Shawn P Williams, G. B. Wisely, Shawn P. Williams, 2009, Bioorganic & medicinal chemistry letters.

Identification of a chemical tool for the orphan nuclear receptor FXR.

L. Moore, T. Willson, K. Plunket, 2000, Journal of medicinal chemistry.

Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor

T. Willson, W. Zuercher, K. Creech, 2019, Scientific Reports.

Abstract 5554: Preclinical characterization of GSK532, a novel STING agonist with potent anti-tumor activity

J. Adams, Kishore K. Pasikanti, J. Smothers, 2018, Clinical Research (Excluding Clinical Trials).

595 Differential ligand binding distinguishes therapeutic from pathologic Aryl Hydrocarbon Receptor (AhR) modulating agents: Implications for inflammatory skin disease

Dalei Wu, F. Rastinejad, C. Jayawickreme, 2020 .

Design and synthesis of spirocyclic compounds as HCV replication inhibitors by targeting viral NS4B protein.

D. J. Price, J. Pouliot, A. Maynard, 2014, Bioorganic & medicinal chemistry letters.

Conformationally constrained farnesoid X receptor (FXR) agonists: alternative replacements of the stilbene.

G. B. Wisely, Shawn P. Williams, D. Parks, 2011, Bioorganic & medicinal chemistry letters.

Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064.

Shawn P Williams, G. B. Wisely, Shawn P. Williams, 2008, Bioorganic & medicinal chemistry letters.

2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1.

D I Stuart, R J Ott, D. Stuart, 2001, Journal of medicinal chemistry.