Andrew C Flick

发表

Synthetic Approaches to the New Drugs Approved During 2017.

Emma McInturff, Carolyn A Leverett, Christopher J Helal, 2019, Journal of medicinal chemistry.

Synthetic approaches to the 2009 new drugs.

Jin Li, Kevin K-C Liu, K. Liu, 2011, Bioorganic & medicinal chemistry.

Synthetic approaches to the 2010 new drugs.

Kevin K-C Liu, K. Liu, S. Sakya, 2012, Bioorganic & medicinal chemistry.

Synthetic approaches to the 2012 new drugs.

Kevin K-C Liu, Carolyn A Leverett, K. Liu, 2014, Bioorganic & medicinal chemistry.

Direct photocapture of bromodomains using tropolone chemical probes

R. Denny, M. Pletcher, E. Hett, 2015 .

Synthesis of ( R )- and ( S )-α-trifluoromethyl propanoic acids via asymmetric hydrogenation followed by salt resolution

N. Sach, O. Fadeyi, R. Unwalla, 2016 .

Synthetic Approaches to the New Drugs Approved During 2020.

C. J. O’Donnell, C. Leverett, S. Berritt, 2022, Journal of medicinal chemistry.

Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities.

Kevin Lee, R. Denny, M. Pletcher, 2015, Chemistry & biology.

Practical Kilogram Synthesis of (S)-1-Benzyl-4-Bromo-3-Methyl-1,2,3,6-Tetrahydropyridine

N. Sach, Ming Z. Chen, Vince M. Lombardo, 2021, Organic Process Research & Development.

A tandem hetero Diels–Alder/Mannich approach for the synthesis of a versatile hexahydro-2H-pyrano[3,2-c]pyridin-4(3H)-one core

R. Robinson, A. Casimiro-Garcia, Andrew C Flick, 2013 .

Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1.

J. D. Clark, M. Hegen, Betsy S. Pierce, 2020, Bioorganic & medicinal chemistry.

Synthetic approaches to the 2013 new drugs.

K. Liu, C. J. O’Donnell, C. Leverett, 2015, Bioorganic & medicinal chemistry.

Access to Highly Substituted 7-Azaindoles from 2-Fluoropyridines via 7-Azaindoline Intermediates.

J. Mousseau, Alpay Dermenci, C. Allais, 2015, Organic letters.

A new route to heterocyclic compounds by the mercuric acetate oxidation of N-alkyl substituted 4-piperidones

A. Padwa, Andrew C Flick, 2008 .

Synthetic approaches to the 2014 new drugs.

K. Liu, C. J. O’Donnell, C. Leverett, 2016, Bioorganic & medicinal chemistry.

Synthesis of pyrazoles from 1,3-diols via hydrogen transfer catalysis.

Daniel C. Schmitt, Alexandria P. Taylor, Andrew C Flick, 2015, Organic letters.

Syntheses of the opioid substructures 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine and 2,3,4,5-te

J. Coe, P. Brooks, Michael G. Vetelino, 2011 .

Synthetic approaches to the 2011 new drugs.

K. Liu, S. Sakya, C. J. O’Donnell, 2013, Bioorganic & medicinal chemistry.

2,3-Bis(phenylsulfonyl)-1,3-butadiene-mediated syntheses of piperidone derivatives

A. Padwa, Andrew C Flick, 2013 .

A New Route to Heterocyclic Compounds by the Mercuric Acetate Oxidation of N-Alkyl Substituted 4-Piperidones.

A. Padwa, Andrew C Flick, 2009 .

Utilization of a Michael addition: dipolar cycloaddition cascade for the synthesis of (+/-)-cylindricine C.

A. Padwa, Andrew C Flick, M. Caballero, 2008, Organic letters.

Rhodium(II)-catalyzed aziridination of allyl-substituted sulfonamides and carbamates.

Andrew C. Flick, A. Padwa, C. Leverett, 2004, The Journal of organic chemistry.

Synthetic Approaches to the New Drugs Approved During 2018.

C. J. O’Donnell, C. Leverett, Hong X. Ding, 2020, Journal of medicinal chemistry.

Intramolecular Diels–Alder Cycloaddition of Furans (IMDAF) for Natural Product Synthesis

Andrew C. Flick, A. Padwa, Andrew C Flick, 2013 .

Use of 2,3-bis(phenylsulfonyl)-1,3-butadiene as a reagent for the synthesis of azapolycyclic ring systems

A. Padwa, Andrew C Flick, 2013 .

Synthesis of 4-azepanones and heteroaromatic-fused azepines

S. Sakya, David L. Gray, Kees Pouwer, 2012 .

A conjugate addition/dipolar-cycloaddition cascade sequence for the synthesis of ()-cylindricine C

Andrew C. Flick, A. Padwa, Maria José Arevalo Caballero, 2010 .

2,3-Bis(phenylsulfonyl)-1,3-butadiene as a reagent for the synthesis of the azatricyclic core of (+/-)-halichlorine.

A. Padwa, Andrew C Flick, H. I. Lee, 2010, The Journal of organic chemistry.

Application of cross-conjugated heteroaromatic betaines to the synthesis of the schizozygane alkaloid (+/-)-strempeliopine.

A. Padwa, Andrew C Flick, Drew R. Bobeck, 2009, The Journal of organic chemistry.

An approach to the isoschizozygane alkaloid core using a 1,4-dipolar cycloaddition of a cross-conjugated heteroaromatic betaine.

A. Padwa, Andrew C Flick, H. I. Lee, 2005, Organic letters.

Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1.

Stephen J. Wright, Hong Wang, K. Parris, 2021, Journal of medicinal chemistry.

Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists.

F. Vajdos, M. Schnute, M. Vazquez, 2023, ACS medicinal chemistry letters.

Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.

David C. Wood, K. Fennell, R. Kurumbail, 2018, Journal of medicinal chemistry.

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).

Li Xing, Eddine Saiah, David Lin, 2018, Journal of medicinal chemistry.

Efforts towards Rh(II)-catalyzed N-alkoxyazomethine ylide generation: Disparate reactivities of O-tethered α-diazo keto and -β-ketoester oximes

S. Wright, Andrew C Flick, Doris C. Chen, 2020, Tetrahedron.

Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain.

R. Denny, P. Brennan, M. Pletcher, 2017, Journal of medicinal chemistry.

Synthetic Approaches to the New Drugs Approved During 2015.

K. Liu, C. J. O’Donnell, Andrew C. Flick, 2017, Journal of medicinal chemistry.

Synthetic Approaches to the New Drugs Approved during 2019.

C. J. O’Donnell, C. Leverett, S. Berritt, 2021, Journal of medicinal chemistry.

Synthetic Approaches to New Drugs Approved During 2016.

C. J. O’Donnell, C. Leverett, Andrew C Flick, 2018, Journal of medicinal chemistry.

Synthetic Approaches to the New Drugs Approved During 2021.

C. J. O’Donnell, C. Leverett, S. Berritt, 2023, Journal of medicinal chemistry.

Synthetic Approaches to the New Drugs Approved During 2015.

K. Liu, C. J. O’Donnell, C. Leverett, 2017, Journal of medicinal chemistry.

Synthetic Approaches to the New Drugs Approved During 2022.

C. Leverett, S. Berritt, Andrew C Flick, 2024, Journal of medicinal chemistry.