C. Egwuagu

发表

Identifying Mouse Autoimmune Uveitis from Fundus Photographs Using Deep Learning

Y. Badr, Siamak Yousefi, Jian Sun, 2020, Translational vision science & technology.

miR-204–containing exosomes ameliorate GVHD-associated dry eye disease

D. Pei, Xialin Liu, R. Ju, 2022, Science advances.

Extralenticular expression of the αA-crystallin promoter/gamma interferon transgene

A. B. Chepelinsky, C. Egwuagu, 1997 .

Analysis of Regulatory B Cells in Experimental Autoimmune Uveitis.

C. Egwuagu, J. K. Choi, 2021, Methods in molecular biology.

IL-27–producing B-1a cells suppress neuroinflammation and CNS autoimmune diseases

Y. Jittayasothorn, R. Caspi, Lijin Dong, 2021, Proceedings of the National Academy of Sciences.

Interleukin 35-Producing Exosomes Suppress Neuroinflammation and Autoimmune Uveitis

Y. Jittayasothorn, C. Egwuagu, J. K. Choi, 2020, Frontiers in Immunology.

Production of IL‐35 by Bregs is mediated through binding of BATF‐IRF‐4‐IRF‐8 complex to il12a and ebi3 promoter elements

C. Egwuagu, J. K. Choi, C. Yu, 2018, Journal of leukocyte biology.

IL-12p35 Inhibits Neuroinflammation and Ameliorates Autoimmune Encephalomyelitis

R. Caspi, M. Mattapallil, C. Egwuagu, 2017, Front. Immunol..

IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease

P. Wingfield, R. Wang, R. Caspi, 2017, Nature Communications.

Pre-existing CD19-independent GL7(-) Breg cells are expanded during inflammation and in mice with lupus-like disease.

Xiaoqian Wang, Yan Li, B. Shen, 2016, Molecular immunology.

A novel IL‐23p19/Ebi3 (IL‐39) cytokine mediates inflammation in Lupus‐like mice

Xiaoqian Wang, Yan Li, B. Shen, 2016, European journal of immunology.

Interferon-γ induces regression of epithelial cell carcinoma: critical roles of IRF-1 and ICSBP transcription factors

T. Nakamura, W. Li, C. Chan, 2006, Oncogene.

Novel IL27p28/IL12p40 Cytokine Suppressed Experimental Autoimmune Uveitis by Inhibiting Autoreactive Th1/Th17 Cells and Promoting Expansion of Regulatory T Cells*

R. Wang, C. Egwuagu, R. Mahdi, 2012, The Journal of Biological Chemistry.

TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1

R. Nussenblatt, I. Gery, Xuebin Liu, 2007, Nature Medicine.

Bone Marrow through STAT 3-Dependent That Mediate Chronic Uveitis Reside in the T Lymphocytes + Autoreactive Memory CD 4

H. Oh, Chi-Chao Chan, A. Maminishkis, 2011 .

Autoreactive Memory CD4+ T Lymphocytes That Mediate Chronic Uveitis Reside in the Bone Marrow through STAT3-Dependent Mechanisms

H. Oh, Chi-Chao Chan, A. Maminishkis, 2011, The Journal of Immunology.

Ectopic expression of gamma interferon in the eyes of transgenic mice induces ocular pathology and MHC class II gene expression.

R. Nussenblatt, C. Chan, A. B. Chepelinsky, 1994, Investigative ophthalmology & visual science.

Therapeutic Targeting of STAT3 (Signal Transducers and Activators of Transcription 3) Pathway Inhibits Experimental Autoimmune Uveitis

N. Surendran, Y. Lee, C. Egwuagu, 2012, PloS one.

T Cell Tolerance to a Neo-Self Antigen Expressed by Thymic Epithelial Cells: The Soluble Form Is More Effective Than the Membrane-Bound Form

E. Wawrousek, M. Gelderman, I. Gery, 2003, The Journal of Immunology.

Skewed Abrogation of Tolerance to a Neo Self-Antigen in Double-Transgenic Mice Coexpressing the Antigen with Interleukin-1β or Interferon-γ

E. Wawrousek, S. Whitcup, I. Gery, 2001 .

Thymic expression of autoantigens correlates with resistance to autoimmune disease.

P. Charukamnoetkanok, I. Gery, C. Egwuagu, 1997, Journal of immunology.

Central immunotolerance in transgenic mice expressing a foreign antigen under control of the rhodopsin promoter.

E. Wawrousek, I. Gery, Chi-Chao Chan, 2004, Investigative ophthalmology & visual science.

Inflammatory processes triggered by TCR engagement or by local cytokine expression: differences in profiles of gene expression and infiltrating cell populations

E. Wawrousek, S. Durum, I. Gery, 2006, Journal of leukocyte biology.

Constitutive and cytokine-induced GITR ligand expression on human retinal pigment epithelium and photoreceptors.

R. Nussenblatt, Chi-Chao Chan, R. Fariss, 2004, Investigative ophthalmology & visual science.

Membrane-Bound Form Soluble Form Is More Effective Than the Expressed by Thymic Epithelial Cells : The T Cell Tolerance to a Neo-Self Antigen Wawrousek and Igal Gery

E. Wawrousek, M. Gelderman, I. Gery, 2003 .

Malignant and nonmalignant brain tissues differ in their messenger RNA expression patterns for ERCC1 and ERCC2.

M. Berger, J. Silber, E. Reed, 1995, Cancer research.

and Expansion of Regulatory T Cells Inflammation via Upregulation of CTLA-4 Suppresses Development of Chronic Ocular SOCS3 Deletion in T Lymphocytes

C. Egwuagu, Sung-hye Kim, R. Mahdi, 2013 .

IL-4 synergistically enhances both IL-2– and IL-12–induced IFN-γ expression in murine NK cells

T. Aune, H. Young, M. Grusby, 2003 .

expression in murine NK cells γ induced IFN-− and IL-12 − IL-4 synergistically enhances both IL-2

Thomas, H. Young, M. Grusby, 2003 .

IL-4 synergistically enhances both IL-2- and IL-12-induced IFN-gamma expression in murine NK cells.

T. Aune, H. Young, M. Grusby, 2003, Blood.

Key role for IL-21 in experimental autoimmune uveitis

W. Telford, W. Leonard, Hyoung-Pyo Kim, 2011, Proceedings of the National Academy of Sciences.

Cell Proliferation and STAT6 Pathways Are Negatively Regulated in T Cells by STAT1 and Suppressors of Cytokine Signaling

S. Ebong, I. Gery, Yonghong Guo, 2004, The Journal of Immunology.

Induction of suppressors of cytokine signaling (SOCS) in the retina during experimental autoimmune uveitis (EAU): Potential neuroprotective role of SOCS proteins

I. Gery, X. Liu, H. Takase, 2005, Journal of Neuroimmunology.

SOCS5 mRNA levels in peripheral blood mononuclear cells (PBMC): a potential bio-marker for monitoring response of uveitis patients to Daclizumab therapy.

R. Nussenblatt, Zhuqing Li, C. Egwuagu, 2005, Journal of autoimmunity.

Expression of ocular autoantigens in the mouse thymus.

P. Charukamnoetkanok, S. Whitcup, I. Gery, 1998, Current eye research.

T cell receptor β-chain usage in experimental autoimmune uveoretinitis

C. Chow, R. Nussenblatt, E. Béraud, 1991 .

Persistence of IL‐2 expressing Th17 cells in healthy humans and experimental autoimmune uveitis

N. Golestaneh, H. Oh, C. Egwuagu, 2011, European journal of immunology.

Immunotolerance toward native alphaA-crystallin in knockout mice deficient in the functional protein.

P. Charukamnoetkanok, E. Wawrousek, S. Whitcup, 2003, Immunology letters.

Interferon Consensus Sequence-binding Protein Is Constitutively Expressed and Differentially Regulated in the Ocular Lens*

Wenmei Li, H. Ge, A. B. Chepelinsky, 1999, The Journal of Biological Chemistry.

SOCS1 Regulates CCR7 Expression and Migration of CD4+ T Cells into Peripheral Tissues1

T. Naka, T. Kishimoto, Xuebin Liu, 2008, The Journal of Immunology.

Tissues T Cells into Peripheral + Migration of CD 4 SOCS 1 Regulates CCR 7 Expression and

T. Naka, T. Kishimoto, Xuebin Liu, 2008 .

A pathogenic autoimmune process targeted at a surrogate epitope

J. Berzofsky, I. Gery, A. Kozhich, 1994, The Journal of experimental medicine.

STAT3 deficiency in B cells exacerbates uveitis by promoting expansion of pathogenic lymphocytes and suppressing regulatory B cells (Bregs) and Tregs

C. Egwuagu, J. K. Choi, C. Yu, 2020, Scientific Reports.

Evidence for selective accumulation of V beta 8+ T lymphocytes in experimental autoimmune uveoretinitis induced with two different retinal antigens.

I. Gery, R. Caspi, R. Nussenblatt, 1993, Journal of immunology.

Interferon Regulator Factor 8 (IRF8) Limits Ocular Pathology during HSV-1 Infection by Restraining the Activation and Expansion of CD8+ T Cells

Hongsheng Wang, H. Morse, Chi-Chao Chan, 2016, PloS one.

Identification of Toxoplasma gondii in paraffin-embedded sections by the polymerase chain reaction.

R. Nussenblatt, R. Gazzinelli, A. Brézin, 1990, American journal of ophthalmology.

Immunopathology of ocular onchocerciasis 3. Th-2 helper T cells in the conjunctiva.

R. Nussenblatt, C. Chan, S. Whitcup, 1993, Ocular immunology and inflammation.

Commitment and Maintenance Cells: Implications for Th Cell Lineage Are Differentially Expressed in Th1 and Th2 Suppressors of Cytokine Signaling Proteins

I. Gery, Stephen J. Kim, Meifen Zhang, 2002 .

The level of thymic expression of RPE65 inversely correlates with its capacity to induce experimental autoimmune uveitis (EAU) in different rodent strains.

I. Gery, D. Ham, Shirley Yu, 2006, Experimental eye research.

Immunotolerance against a foreign antigen transgenically expressed in the lens.

P. Charukamnoetkanok, S. Smith‐Gill, E. Wawrousek, 1998, Investigative ophthalmology & visual science.

Photoreceptor Cells Constitutively Express IL-35 and Promote Ocular Immune Privilege

M. Yadav, Y. Jittayasothorn, Lijin Dong, 2022, International journal of molecular sciences.

CENTRAL TOLERANCE MECHANISMS IN CONTROL OF SUSCEPTIBILITY TO AUTOIMMUNE UVEITIC DISEASE

I. Gery, C. Egwuagu, 2002, International reviews of immunology.

Susceptibility to ocular autoimmune disease

P. Charukamnoetkanok, I. Gery, C. Egwuagu, 2000, The British journal of ophthalmology.

Synthesis and analysis of the enantiomers of calmidazolium, and a 1H NMR demonstration of a chiral interaction with calmodulin.

J. F. Young, A. Edwards, D. Reid, 1996, Chirality.

Interleukin 12 (IL-12) family cytokines: Role in immune pathogenesis and treatment of CNS autoimmune disease.

C. Egwuagu, Chang He, Lekha K Nair, 2015, Cytokine.

Miliary toxoplasmic retinitis in acquired immunodeficiency syndrome.

W. Freeman, C. Wiley, B. Berger, 1993, Archives of ophthalmology.

Interleukin-35 Induces Regulatory B Cells that Suppress CNS Autoimmune Disease

P. Wingfield, R. Wang, Paul T. Wingfield, 2014, Nature Medicine.

Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors.

J. Hooks, A. B. Chepelinsky, C. Egwuagu, 1999, Investigative ophthalmology & visual science.

Suppressors of Cytokine Signaling Proteins Are Differentially Expressed in Th1 and Th2 Cells: Implications for Th Cell Lineage Commitment and Maintenance

I. Gery, Stephen J. Kim, Meifen Zhang, 2002, The Journal of Immunology.

Dendritic Cell Maturation Requires STAT1 and Is under Feedback Regulation by Suppressors of Cytokine Signaling

S. Ebong, C. Egwuagu, S. H. Jackson, 2004, The Journal of Immunology.

STAT3 Protein Interacts with Class O Forkhead Transcription Factors in the Cytoplasm and Regulates Nuclear/Cytoplasmic Localization of FoxO1 and FoxO3a Proteins in CD4+ T Cells*

H. Oh, C. Egwuagu, I. Dambuza, 2012, The Journal of Biological Chemistry.

STAT3 in CD4+ T helper cell differentiation and inflammatory diseases.

C. Egwuagu, 2009, Cytokine.

Loss of STAT3 in CD4+ T Cells Prevents Development of Experimental Autoimmune Diseases

Xuebin Liu, Y. Lee, C. Egwuagu, 2008, The Journal of Immunology.

Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals

X. Liu, C. Egwuagu, A. Lohani, 2007, Oncogene.

ERCC1 and ERCC2 expression in malignant tissues from ovarian cancer patients.

V. Bohr, E. Reed, M. Dabholkar, 1992, Journal of the National Cancer Institute.

Pertussis Toxin Is Superior to TLR Ligands in Enhancing Pathogenic Autoimmunity, Targeted at a Neo-Self Antigen, by Triggering Robust Expansion of Th1 Cells and Their Cytokine Production1

E. Wawrousek, I. Gery, D. Klinman, 2006, The Journal of Immunology.

Expression of interferon-gamma in the lens exacerbates anterior uveitis and induces retinal degenerative changes in transgenic Lewis rats.

C. Chan, J. A. Smith, A. B. Chepelinsky, 1999, Clinical immunology.

Dual Function of the IRF8 Transcription Factor in Autoimmune Uveitis: Loss of IRF8 in T Cells Exacerbates Uveitis, Whereas Irf8 Deletion in the Retina Confers Protection

Lin Sun, Hongsheng Wang, H. Morse, 2015, The Journal of Immunology.

Interleukin 35: Critical regulator of immunity and lymphocyte-mediated diseases.

Lin Sun, R. Wang, C. Egwuagu, 2015, Cytokine & growth factor reviews.

SOCS3 Deletion in T Lymphocytes Suppresses Development of Chronic Ocular Inflammation via Upregulation of CTLA-4 and Expansion of Regulatory T Cells

C. Egwuagu, Sung-hye Kim, R. Mahdi, 2013, The Journal of Immunology.

This information is current as and Expansion of Regulatory T Cells Inflammation via Upregulation of CTLA-4 Suppresses Development of Chronic Ocular SOCS 3 Deletion in T Lymphocytes

C. Egwuagu, Sung-hye Kim, R. Mahdi, 2013 .

Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin‐27 and interleukin‐10

Y. Lee, C. Egwuagu, A. Amadi-Obi, 2011, Immunology.

Interleukin 35 Regulatory B Cells.

C. Egwuagu, J. K. Choi, 2020, Journal of molecular biology.

Cytokine Production Robust Expansion of Th 1 Cells and Their Targeted at a Neo-Self Antigen , by Triggering in Enhancing Pathogenic Autoimmunity , Pertussis Toxin Is Superior to TLR Ligands

E. Wawrousek, C. Yu, I. Gery, 2006 .

IFN-gamma increases the severity and accelerates the onset of experimental autoimmune uveitis in transgenic rats.

P. Charukamnoetkanok, J. Smith, Janine A. Smith, 1999, Journal of immunology.

Uveitis

Janine A. Smith, C. Egwuagu, 2000 .

Suppressors of Cytokine Signaling and Is under Feedback Regulation by Dendritic Cell Maturation Requires STAT 1

C. Yu, S. Ebong, C. Egwuagu, 2004 .

Suppressor of Cytokine Signaling 1 (SOCS1) Mitigates Anterior Uveitis and Confers Protection Against Ocular HSV-1 Infection

K. Hayashi, D. Shen, Y. Lee, 2015, Inflammation.

Interleukin 35-Producing B Cells (i35-Breg): A New Mediator of Regulatory B-Cell Functions in CNS Autoimmune Diseases.

C. Egwuagu, C. Yu, 2015, Critical reviews in immunology.

Predominant usage of V beta 8.3 T cell receptor in a T cell line that induces experimental autoimmune uveoretinitis (EAU).

R. Nussenblatt, I. Gery, R. Caspi, 1992, Clinical immunology and immunopathology.

Thymic expression of peripheral tissue antigens in humans: a remarkable variability among individuals.

F. Midgley, D. Douek, I. Gery, 2005, International immunology.

Expression of excision repair genes in non-malignant bone marrow from cancer patients.

V. Bohr, E. Reed, M. Dabholkar, 1993, Mutation research.

SOCS1 Mimetic Peptide Suppresses Chronic Intraocular Inflammatory Disease (Uveitis)

Lin Sun, M. Mattapallil, C. Egwuagu, 2016, Mediators of inflammation.

STAT3 Regulates Proliferation and Survival of CD8+ T Cells: Enhances Effector Responses to HSV-1 Infection, and Inhibits IL-10+ Regulatory CD8+ T Cells in Autoimmune Uveitis

Gregory M. Frank, C. Egwuagu, I. Dambuza, 2013, Mediators of inflammation.

Suppressor of Cytokine Signaling 1 (SOCS1) Mitigates Anterior Uveitis and Confers Protection Against Ocular HSV-1 Infection

D. Shen, Y. Lee, C. Egwuagu, 2014, Inflammation.

STAT3 Protein Promotes T-cell Survival and Inhibits Interleukin-2 Production through Up-regulation of Class O Forkhead Transcription Factors*

N. Golestaneh, H. Oh, Y. Lee, 2011, The Journal of Biological Chemistry.

Interleukin 27 Induces the Expression of Complement Factor H (CFH) in the Retina

C. Egwuagu, I. Dambuza, Sung-hye Kim, 2012, PloS one.

African trypanosomes contain calmodulin which is distinct from host calmodulin.

C. Egwuagu, L. Ruben, C. Patton, 1983, Biochimica et biophysica acta.

Therapeutic targeting of STAT pathways in CNS autoimmune diseases

C. Egwuagu, Joseph Larkin Iii, 2013, JAK-STAT.

Activation of STAT signaling pathways and induction of suppressors of cytokine signaling (SOCS) proteins in mammalian lens by growth factors.

S. Ebong, A. B. Chepelinsky, C. Egwuagu, 2004, Investigative ophthalmology & visual science.

Suppressor of Cytokine Signaling 3 Regulates Proliferation and Activation of T-helper Cells*

S. Ebong, I. Gery, C. Egwuagu, 2003, Journal of Biological Chemistry.

Suppressor of cytokine signaling-1 (SOCS1) inhibits lymphocyte recruitment into the retina and protects SOCS1 transgenic rats and mice from ocular inflammation.

G. Levy-Clarke, H. Oh, C. Egwuagu, 2011, Investigative ophthalmology & visual science.

Detection of Toxoplasma Gondii DNA in Primary Intraocular B-Cell Lymphoma

R. Buggage, N. Tuaillon, D. Shen, 2001, Modern Pathology.

Uveitis: Molecular Pathogenesis and Emerging Therapies

C. Egwuagu, E. Mbanefo, S. Alhakeem, 2021, Frontiers in Immunology.

STAT3-Specific Single Domain Nanobody Inhibits Expansion of Pathogenic Th17 Responses and Suppresses Uveitis in Mice

Ming Yan, Y. Jittayasothorn, Sunanda R Singh, 2021, Frontiers in Immunology.

Deletion in the Retina Confers Protection Irf8 in T Cells Exacerbates Uveitis, Whereas Factor in Autoimmune Uveitis: Loss of IRF8 Dual Function of the IRF8 Transcription

Lin Sun, Hongsheng Wang, H. Morse, 2015 .

IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease

P. Wingfield, R. Wang, R. Caspi, 2017, Nature Communications.

STAT3 activates miR-155 in Th17 cells and acts in concert to promote experimental autoimmune uveitis.

Thelma M. Escobar, S. Muljo, Stefan A. Muljo, 2013, Investigative ophthalmology & visual science.

IL-27-containing exosomes secreted by innate B-1a cells suppress and ameliorate uveitis

M. Yadav, C. Egwuagu, C. Yu, 2023, Frontiers in Immunology.

Deletion of Irf4 in T Cells Suppressed Autoimmune Uveitis and Dysregulated Transcriptional Programs Linked to CD4+ T Cell Differentiation and Metabolism

Hyun-Su Lee, C. Egwuagu, J. K. Choi, 2021, International journal of molecular sciences.

Persistent Activation of STAT3 Pathway in the Retina Induced Vision Impairment and Retinal Degenerative Changes in Ageing Mice.

Lin Sun, H. Oh, C. Egwuagu, 2019, Advances in experimental medicine and biology.

Immunoproteasome expression in a nonimmune tissue, the ocular lens.

Shaneen Singh, B. Wagner, N. Awasthi, 2002, Archives of biochemistry and biophysics.

Topical administration of a suppressor of cytokine signaling-1 (SOCS1) mimetic peptide inhibits ocular inflammation and mitigates ocular pathology during mouse uveitis.

Lin Sun, C. Egwuagu, J. Larkin, 2015, Journal of autoimmunity.

STAT-3–independent production of IL-17 by mouse innate-like αβ T cells controls ocular infection

A. Laurence, R. Caspi, R. Horai, 2018, The Journal of experimental medicine.

gamma Interferon expression disrupts lens and retinal differentiation in transgenic mice.

R. Nussenblatt, C. Chan, A. B. Chepelinsky, 1994, Developmental biology.

Characterization of the roles of STAT1 and STAT3 signal transduction pathways in mammalian lens development.

S. Ebong, M. Robinson, A. B. Chepelinsky, 2004, Molecular vision.

Congenital toxoplasmosis transmitted from an immunologically competent mother infected before conception.

R. McLeod, R. Dorfman, J. Remington, 1996, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

TH17 cells contribute to uveitis and scleritis and are inhibited by IL-27/STAT1 in the retina. (6) Retinal cell isolation

Xuebin Liu, Y. Lee, C. Egwuagu, 2007 .

STAT 3 Activates miR-155 in Th 17 Cells and Acts in Concert to Promote Experimental Autoimmune Uveitis

Thelma M. Escobar, S. Muljo, Stefan A. Muljo, 2013 .

Suppressors of Cytokine-Signaling Proteins Induce Insulin Resistance in the Retina and Promote Survival of Retinal Cells

Xuebin Liu, Y. Lee, C. Egwuagu, 2008, Diabetes.

Extralenticular expression of the alpha A-crystallin promoter/gamma interferon transgene.

A. B. Chepelinsky, C. Egwuagu, 1997, Experimental eye research.

Cutting Edge: IL-1 Receptor Signaling is Critical for the Development of Autoimmune Uveitis

W. Leonard, Chi-Keung Wan, C. Egwuagu, 2016, The Journal of Immunology.

This information is current as Uveitis Critical for the Development of Autoimmune Cutting Edge : IL-1 Receptor Signaling is and

W. Leonard, Chi-Keung Wan, C. Egwuagu, 2015 .

STAT3 Protein Promotes T-cell Survival and Inhibits Interleukin-2 Production through Up-regulation of Class O Forkhead Transcription Factors*

N. Golestaneh, H. Oh, Y. Lee, 2011, The Journal of Biological Chemistry.

Usage of TCR Vγ2(+) T Lymphocytes in Experimental Autoimmune Uveoretinitis.

A. Kozhich, Janine A. Smith, C. Egwuagu, 1996, Ocular immunology and inflammation.