M. Giralt

发表

Different Responses to a High-Fat Diet in IL-6 Conditional Knockout Mice Driven by Constitutive GFAP-Cre and Synapsin 1-Cre Expression

J. Hidalgo, Olaya Fernandez-Gayol, Paula Sanchis, 2019, Neuroendocrinology.

Metallothionein-1+2 Protect the CNS after a Focal Brain Injury

N. Lago, J. Hidalgo, M. Penkowa, 2002, Experimental Neurology.

Impaired Inflammatory Response to Glial Cell Death in Genetically Metallothionein-I- and -II-Deficient Mice

Joaquı́n Hernández, J. Hidalgo, T. Moos, 1999, Experimental Neurology.

Differential role of tumor necrosis factor receptors in mouse brain inflammatory responses in cryolesion brain injury

S. Rojas, I. Campbell, A. Quintana, 2005, Journal of neuroscience research.

Astrocyte‐targeted expression of interleukin‐6 protects the central nervous system during neuroglial degeneration induced by 6‐aminonicotinamide

S. Rojas, I. Campbell, A. Quintana, 2003, Journal of neuroscience research.

Muscle-specific interleukin-6 deletion influences body weight and body fat in a sex-dependent manner

A. Quintana, J. Hidalgo, B. Ferrer, 2014, Brain, Behavior, and Immunity.

Exercise‐induced metallothionein expression in human skeletal muscle fibres

B. Pedersen, J. Hidalgo, M. Penkowa, 2005, Experimental physiology.

Metallothionein reduces central nervous system inflammation, neurodegeneration, and cell death following kainic acid‐induced epileptic seizures

A. Quintana, J. Hidalgo, M. Penkowa, 2005, Journal of neuroscience research.

Metallothionein‐I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte‐targeted interleukin‐6 expression

I. Campbell, Joaquı́n Hernández, J. Hidalgo, 2003, Glia.

Exercise normalises overexpression of TNF-α in knockout mice

B. Pedersen, J. Hidalgo, P. Keller, 2004 .

Metallothionein prevents neurodegeneration and central nervous system cell death after treatment with gliotoxin 6‐aminonicotinamide

A. Quintana, J. Hidalgo, M. Penkowa, 2004, Journal of neuroscience research.

Interleukin‐6 deletion in mice driven by aP2‐Cre‐ERT2 prevents against high‐fat diet‐induced gain weight and adiposity in female mice

B. Viollet, A. Quintana, J. Hidalgo, 2014, Acta physiologica.

Obesity and Metabolomics : Metallothioneins Protect Against High-Fat Diet-Induced Consequences in Metallothionein Knockout Mice

F. H. van der Westhuizen, Lorena Ramírez, P. J. Jansen van Rensburg, 2015 .

Role of muscle IL-6 in gender-specific metabolism in mice

J. Hidalgo, M. Vallejo, Olaya Fernandez-Gayol, 2017, PloS one.

Regulation of metallothionein concentrations in rat brain: effect of glucocorticoids, zinc, copper, and endotoxin.

J. Hidalgo, T. Gasull, M. Giralt, 1994, The American journal of physiology.

Interleukin‐6 receptor expression in contracting human skeletal muscle: regulating role of IL‐6

A. Steensberg, B. Pedersen, J. Hidalgo, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat

H. Pilegaard, J. Hidalgo, B. Ferrer, 2010, Brain, Behavior, and Immunity.

Effect of superoxide dismutase, allopurinol and glucocorticoids on liver and lung metallothionein induction by endotoxin in the rat

J. Hidalgo, M. Giralt, A. Blánquez, 2004, Biometals.

Effect of stress, adrenalectomy and changes in glutathione metabolism on rat kidney metallothionein content: comparison with liver metallothionein

Joaquı́n Hernández, J. Hidalgo, T. Gasull, 2004, Biometals.

Astrocyte-targeted expression of IL-6 protects the CNSagainst a focal brain injury

N. Lago, I. Campbell, Joaquı́n Hernández, 2003, Experimental Neurology.

Metallothionein-1+2 Deficiency Increases Brain Pathology in Transgenic Mice with Astrocyte-Targeted Expression of Interleukin 6

N. Lago, I. Campbell, Joaquı́n Hernández, 2002, Neurobiology of Disease.

Metallothionein 1+2 protect the CNS during neuroglial degeneration induced by 6‐aminonicotinamide

J. Hidalgo, M. Penkowa, M. Giralt, 2002, The Journal of comparative neurology.

Metallothionein expression and oxidative stress in the brain.

J. Hidalgo, M. Penkowa, A. Molinero, 2002, Methods in enzymology.

Astrocyte-Targeted Expression of Interleukin-3 and Interferon-α Causes Region-Specific Changes in Metallothionein Expression in the Brain

I. Campbell, J. Hidalgo, M. Penkowa, 2001, Experimental Neurology.

Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin‐6‐deficient mice

J. Hidalgo, M. Penkowa, M. Giralt, 2000, Glia.

Metallothioneins Are Upregulated in Symptomatic Mice with Astrocyte-Targeted Expression of Tumor Necrosis Factor-α

A. Stalder, I. Campbell, J. Hidalgo, 2000, Experimental Neurology.

CNS Wound Healing Is Severely Depressed in Metallothionein I- and II-Deficient Mice

J. Hidalgo, T. Moos, M. Penkowa, 1999, The Journal of Neuroscience.

Chronic stress reduces serum but not liver metallothionein response to acute stress.

A. Armario, J. Hidalgo, M. Giralt, 1993, Chemico-biological interactions.

PK and PK/PD of doxycycline in drinking water after therapeutic use in pigs.

M. Giralt, B. Pérez, C. Cristófol, 2005, Journal of veterinary pharmacology and therapeutics.

Sildenafil (Viagra) ameliorates clinical symptoms and neuropathology in a mouse model of multiple sclerosis

Agustina Garcı́a, D. Feinstein, J. Hidalgo, 2011, Acta Neuropathologica.

Interactions between metallothionein inducers in rat liver and primary cultures of rat hepatocytes.

J. Hidalgo, M. Giralt, B. Romero, 1996, Chemico-biological interactions.

Physiological role of glucocorticoids on rat serum and liver metallothionein in basal and stress conditions.

A. Armario, J. Hidalgo, M. Giralt, 1988, The American journal of physiology.

Exercise normalises overexpression of TNF-alpha in knockout mice.

B. Pedersen, J. Hidalgo, P. Keller, 2004, Biochemical and biophysical research communications.

Effects of chronic immobilization stress on GH and TSH secretion in the rat: Response to hypothalamic regulatory factors

A. Armario, T. Jolín, M. Giralt, 1993, Psychoneuroendocrinology.

Liver and brain metallothionein regulation in transgenic mice overexpressing interleukin-6 and in mice carrying a null mutation in the interleukin-6 gene

B. González, H. Bluethmann, I. Campbell, 1999 .

Metallothionein (MT)-III: generation of polyclonal antibodies, comparison with MT-I+II in the freeze lesioned rat brain and in a bioassay with astrocytes, and analysis of Alzheimer's disease brains.

J. Hidalgo, T. Moos, M. Penkowa, 1999, Journal of neurotrauma.

Specificity and divergence in the neurobiologic effects of different metallothioneins after brain injury

A. Quintana, J. Hidalgo, S. Atrian, 2006, Journal of neuroscience research.

Active Induction of Experimental Autoimmune Encephalomyelitis (EAE) with MOG35-55 in the Mouse.

J. Hidalgo, A. Molinero, M. Giralt, 2018, Methods in molecular biology.

Lack of microglial Interleukin-6 ameliorates the brain's response to traumatic brain injury

J. Hidalgo, M. Giralt, J. Vizueta, 2019, European Neuropsychopharmacology.

The comparison of mouse full metallothionein‐1 versus α and β domains and metallothionein‐1‐to‐3 mutation following traumatic brain injury reveals different biological motifs

J. Hidalgo, Y. Manso, P. González-Duarte, 2010, Journal of neuroscience research.

Absence of metallothionein-3 produces changes on MT-1/2 regulation in basal conditions and alters hypothalamic-pituitary–adrenal (HPA) axis

N. Lago, A. Quintana, J. Hidalgo, 2014, Neurochemistry International.

Effect of endotoxin on rat serum, lung and liver lipid peroxidation and on tissue metallothionein levels.

J. Hidalgo, T. Gasull, M. Giralt, 1993, Revista espanola de fisiologia.

Previous chronic ACTH administration does not protect against the effects of acute or chronic stress in male rats

A. Armario, M. Giralt, C. García-Marquez, 1987, Physiology & Behavior.

Mouse metallothionein-1 and metallothionein-2 are not biologically interchangeable in an animal model of multiple sclerosis, EAE.

J. Hidalgo, S. Atrian, M. Capdevila, 2019, Metallomics : integrated biometal science.

Effect of stress on mouse and rat brain metallothionein I and III mRNA levels.

P. Kille, J. Hidalgo, M. Giralt, 1996, Neuroendocrinology.

Effect of zinc, copper and glucocorticoids on metallothionein levels of cultured neurons and astrocytes from rat brain.

A. M. Oliva, A. García, Agustina Garcı́a, 1994, Chemico-biological interactions.

Evidence that the pituitary-adrenal axis does not cross-adapt to stressors: comparison to other physiological variables.

A. Armario, J. Hidalgo, M. Giralt, 1988, Neuroendocrinology.

Zinc or copper deficiency-induced impaired inflammatory response to brain trauma may be caused by the concomitant metallothionein changes.

J. Hidalgo, M. Penkowa, M. Giralt, 2001, Journal of neurotrauma.

Metal-saccharide chemistry and biology: saccharide complexes of zinc and their effect on metallothionein synthesis in mice.

C. Rao, J. Hidalgo, R. P. Bandwar, 1996, Carbohydrate research.

Transition-metal saccharide chemistry and biology: saccharide complexes of Cu(II) and their effect on in vivo metallothionein synthesis in mice.

G. U. Kulkarni, J. Hidalgo, R. P. Bandwar, 1997, Journal of inorganic biochemistry.

Role of metallothionein-III following central nervous system damage

R. Palmiter, I. Campbell, J. Hidalgo, 2003, Neurobiology of Disease.

A new mouse model to study restoration of interleukin-6 (IL-6) expression in a Cre-dependent manner: microglial IL-6 regulation of experimental autoimmune encephalomyelitis

R. Palmiter, J. Hidalgo, Olaya Fernandez-Gayol, 2020, Journal of neuroinflammation.

Novel roles for metallothionein‐I + II (MT‐I + II) in defense responses, neurogenesis, and tissue restoration after traumatic brain injury: Insights from global gene expression profiling in wild‐type and MT‐I + II knockout mice

M. Cáceres, F. Nielsen, A. Quintana, 2006, Journal of neuroscience research.

Targeted activation of CREB in reactive astrocytes is neuroprotective in focal acute cortical injury

Zhongming Zhao, P. Jia, E. Galea, 2016, Glia.

The effect of acute and chronic ACTH administration on pituitary-adrenal response to acute immobilization stress. Relationship to changes in corticosteroid-binding globulin.

R. W. Kuhn, A. Armario, J. Hidalgo, 1994, Endocrine research.

Astrocyte-specific deficiency of interleukin-6 and its receptor reveal specific roles in survival, body weight and behavior

A. Quintana, J. Hidalgo, B. Ferrer, 2013, Brain, Behavior, and Immunity.

The effect of cadmium exposure and stress on plasma cortisol, metallothionein levels and oxidative status in rainbow trout (Oncorhynchus mykiss) liver

L. Tort, J. Hidalgo, M. Giralt, 1996 .

Interleukin-6 Derived from the Central Nervous System May Influence the Pathogenesis of Experimental Autoimmune Encephalomyelitis in a Cell-Dependent Manner

R. Palmiter, J. Hidalgo, Olaya Fernandez-Gayol, 2020, Cells.

Astrocytic IL-6 Influences the Clinical Symptoms of EAE in Mice

J. Hidalgo, G. Comes, A. Molinero, 2016, Brain sciences.

Induction of atypical EAE mediated by transgenic production of IL‐6 in astrocytes in the absence of systemic IL‐6

Agustina Garcı́a, I. Campbell, A. Quintana, 2013, Glia.

Effect of dietary zinc deficiency on brain metallothionein-I and -III mRNA levels during stress and inflammation

J. Hidalgo, A. Molinero, M. Giralt, 2000, Neurochemistry International.

Interleukin-6 Regulation of AMP-Activated Protein Kinase

B. Pedersen, N. Ruderman, A. Saha, 2006, Diabetes.

Microglial cell‐derived interleukin‐6 influences behavior and inflammatory response in the brain following traumatic brain injury

J. Hidalgo, Olaya Fernandez-Gayol, G. Comes, 2019, Glia.

Inhibition of corticosteroid-binding globulin caused by a severe stressor is apparently mediated by the adrenal but not by glucocorticoid receptors

R. W. Kuhn, A. Armario, J. Hidalgo, 1997, Endocrine.

Expression of Metallothionein-I, -II, and -III in Alzheimer Disease and Animal Models of Neuroinflammation

C. Espejo, A. Quintana, J. Hidalgo, 2006, Experimental biology and medicine.

IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer’s Disease

S. Rose-John, J. Hidalgo, C. Becker-Pauly, 2020, Cells.

Effects of Interleukin-6 trans-signalling in a mouse model of Alzheimer's disease and high fat diet-induced obesity

F. LaFerla, J. Hidalgo, L. Giménez-Llort, 2019, European Neuropsychopharmacology.

IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer’s disease

S. Rose-John, J. Hidalgo, C. Becker-Pauly, 2019, Brain, Behavior, and Immunity.

AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise.

B. Pedersen, N. Ruderman, A. Saha, 2004, Biochemical and biophysical research communications.

Muscular interleukin-6 differentially regulates skeletal muscle adaptation to high-fat diet in a sex-dependent manner.

A. Serrano, J. Hidalgo, B. Ferrer, 2015, Cytokine.

Astrocytic IL-6 mediates locomotor activity, exploration, anxiety, learning and social behavior

J. Hidalgo, Olaya Fernandez-Gayol, M. Giralt, 2015, Hormones and Behavior.

Brain response to traumatic brain injury in wild‐type and interleukin‐6 knockout mice: a microarray analysis

M. Cáceres, F. Nielsen, A. Quintana, 2005, Journal of neurochemistry.

Metallothionein‐I Overexpression Decreases Brain Pathology in Transgenic Mice with Astrocyte‐Targeted Expression of Interleukin‐6

N. Lago, I. Campbell, J. Hidalgo, 2003, Journal of neuropathology and experimental neurology.

Phosphodiesterase 5 inhibition at disease onset prevents experimental autoimmune encephalomyelitis progression through immunoregulatory and neuroprotective actions

Agustina Garcı́a, J. Hidalgo, C. Roura-mir, 2014, Experimental Neurology.

Metallothionein induction by restraint stress: role of glucocorticoids and IL-6.

H. Bluethmann, G. Andrews, J. Hidalgo, 2000, Cytokine.

Interleukin‐6 Regulates the Expression of Hypothalamic Neuropeptides Involved in Body Weight in a Gender‐Dependent Way

J. Hidalgo, B. Ferrer, R. Señarís, 2011, Journal of neuroendocrinology.

Influence of Transgenic Metallothionein-1 on Gliosis, CA1 Neuronal Loss, and Brain Metal Levels of the Tg2576 Mouse Model of Alzheimer’s Disease

J. Hidalgo, Y. Manso, Olaya Fernandez-Gayol, 2017, International journal of molecular sciences.

Chronic stress induced changes in LH secretion: the contribution of anorexia associated to stress.

A. Armario, A. López-Calderón, M. Giralt, 1993, Life sciences.

Previous chronic chlorimipramine treatment did not modify some physiological responses to acute and chronic stress in rats

A. Armario, M. Giralt, C. García-Marquez, 2004, Psychopharmacology.

Sex and restraint stress differences in rat metallothionein and Zn levels.

A. Armario, J. Hidalgo, M. Giralt, 1987, Revista espanola de fisiologia.

Brain metallothionein in stress.

A. Armario, J. Hidalgo, T. Gasull, 1994, Biological signals.

Molecular aspects of metallothioneins in dementias

J. Hidalgo, Y. Manso, Olaya Fernandez-Gayol, 2020 .

Altered Central Nervous System Cytokine-Growth Factor Expression Profiles and Angiogenesis in Metallothionein-I+II Deficient Mice

I. Campbell, J. Hidalgo, M. Penkowa, 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Long-lasting effects of chronic chlorimipramine treatment of rats on exploratory activity on a hole-board, and on immobility in the force swimming test

A. Armario, M. Giralt, C. García-Marquez, 1987 .

Metallothioneins I/II are involved in the neuroprotective effect of sildenafil in focal brain injury

Agustina Garcı́a, J. Hidalgo, M. Giralt, 2013, Neurochemistry International.

Regulation of metallothionein‐I+II levels in specific brain areas and liver in the rat: Role of catecholamines

Agustina Garcı́a, J. Hidalgo, T. Gasull, 1994, Glia.

Diverging mechanisms for TNF‐α receptors in normal mouse brains and in functional recovery after injury: From gene to behavior

F. Nielsen, I. Campbell, A. Quintana, 2007, Journal of neuroscience research.

Overexpression of Metallothionein-1 Modulates the Phenotype of the Tg2576 Mouse Model of Alzheimer's Disease.

J. Delgado-García, A. Bush, P. Adlard, 2016, Journal of Alzheimer's disease : JAD.

Individual housing does not influence the adaptation of the pituitary-adrenal axis and other physiological variables to chronic stress in adult male rats

A. Armario, M. Giralt, 1989, Physiology & Behavior.

Catecholaminergic and cholinergic systems of mouse brain are modulated by LMN diet, rich in theobromine, polyphenols and polyunsaturated fatty acids.

Irene Bolea, P. Sun, G. Esteban, 2015, Food & function.

Phosphodiesterase 5 inhibition at disease onset prevents experimental autoimmune encephalomyelitis progression through immunoregulatory and neuroprotective actions

Agustina Garcı́a, J. Hidalgo, C. Roura-mir, 2014, Experimental Neurology.

Obesity and metabolomics: metallothioneins protect against high-fat diet-induced consequences in metallothionein knockout mice.

F. H. van der Westhuizen, P. J. Jansen van Rensburg, R. Louw, 2015, Omics : a journal of integrative biology.

Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury

Agustina Garcı́a, J. Hidalgo, A. Molinero, 2010, Journal of neurochemistry.

Absence of metallothionein-3 produces changes on MT-1/2 regulation in basal conditions and alters hypothalamic-pituitary–adrenal (HPA) axis

N. Lago, J. Hidalgo, A. Molinero, 2014, Neurochemistry International.

Metallothionein (MT)-III: generation of polyclonal antibodies, comparison with MT-I+II in the freeze lesioned rat brain and in a bioassay with astrocytes, and analysis of Alzheimer's disease brains.

J. Hidalgo, T. Moos, M. Penkowa, 1999, Journal of neurotrauma.

Analysis of the Cerebral Transcriptome in Mice Subjected to Traumatic Brain Injury: Importance of IL-6

I. Campbell, J. Hidalgo, M. Penkowa, 2007, Neuroimmunomodulation.