D. Beattie

发表

Baclofen antagonism by 2-hydroxy-saclofen in the cat spinal cord

D. R. Curtis, D. Kerr, R. Prager, 1988, Neuroscience Letters.

The involvement of calcitonin gene-related peptide (CGRP) and substance P in feline pial artery diameter responses evoked by capsaicin

S. Brain, D. Beattie, K. Escott, 1995, Neuropeptides.

Constitutive sensory transduction mutations in the Bordetella pertussis bvgS gene

S. Falkow, J. Mekalanos, J. Miller, 1992, Journal of bacteriology.

Live cholera vaccines: perspectives on their construction and safety

M. Waldor, J. Mekalanos, K. Killeen, 1995 .

Clinical trial: the efficacy and tolerability of velusetrag, a selective 5‐HT4 agonist with high intrinsic activity, in chronic idiopathic constipation – a 4‐week, randomized, double‐blind, placebo‐controlled, dose–response study

J. Johanson, M. Goldberg, O. Daniels, 2010, Alimentary pharmacology & therapeutics.

Production of a complement inhibitor possessing sialyl Lewis X moieties by in vitro glycosylation technology.

R. Bayer, D. Zopf, H. Marsh, 2004, Glycobiology.

A vir-repressed gene of Bordetella pertussis is required for virulence

J. Mekalanos, D. Beattie, R. Shahin, 1992, Infection and immunity.

Vaccine-Induced Antibodies Inhibit CETP Activity In Vivo and Reduce Aortic Lesions in a Rabbit Model of Atherosclerosis

A. Callow, U. Ryan, H. Marsh, 2000, Arteriosclerosis, thrombosis, and vascular biology.

A multivalent approach to the design and discovery of orally efficacious 5-HT4 receptor agonists.

S. D. Turner, J. Shaw, S. Choi, 2009, Journal of medicinal chemistry.

Functional Genomics of Enterococcus faecalis: Multiple Novel Genetic Determinants for Biofilm Formation in the Core Genome

G. Dunny, C. J. Kristich, S. Grindle, 2009, Journal of bacteriology.

The activity of GR205171, a potent non-peptide tachykinin NK1 receptor antagonist, in the trigeminovascular system

M. Perren, P. Ward, D. Beattie, 1997, Regulatory Peptides.

The modulation of the increase in rat facial skin blood flow observed after trigeminal ganglion stimulation.

S. Brain, D. Beattie, K. Escott, 1995, European journal of pharmacology.

Trigeminal ganglion stimulation increases facial skin blood flow in the rat: a major role for calcitonin gene-related peptide

S. Brain, D. Beattie, K. Escott, 1995, Brain Research.

Heterologous antigen expression in Vibrio cholerae vector strains

J. Mekalanos, K. Killeen, S. Calderwood, 1995, Infection and immunity.

Evidence that modulation requires sequences downstream of the promoters of two vir-repressed genes of Bordetella pertussis

S. Knapp, J. Mekalanos, D. Beattie, 1990, Journal of bacteriology.

Identification of novel staphylococcal virulence genes by in vivo expression technology

D. Beattie, R. Deresiewicz, A. M. Lowe, 1998, Molecular microbiology.

Discovery of TD-8954, a clinical stage 5-HT(4) receptor agonist with gastrointestinal prokinetic properties.

J. Shaw, R. Vickery, D. Long, 2013, Bioorganic & medicinal chemistry letters.

Discovery, oral pharmacokinetics and in vivo efficacy of a highly selective 5-HT4 receptor agonist: clinical compound TD-2749.

J. Shaw, S. Choi, R. Vickery, 2012, Bioorganic & medicinal chemistry letters.

The Pharmacology of TD-8954, a Potent and Selective 5-HT4 Receptor Agonist with Gastrointestinal Prokinetic Properties

O. Daniels, K. Kersey, R. Vickery, 2011, Front. Pharmacol..

The in vitro pharmacological profile of TD-1211, a neutral opioid receptor antagonist

R. Vickery, Pamela R. Tsuruda, D. Long, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

The in vitro pharmacological profile of TD-5108, a selective 5-HT4 receptor agonist with high intrinsic activity

J. Shaw, R. Vickery, J. A. Smith, 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexone

R. Vickery, D. Beattie, M. Cheruvu, 2007, Naunyn-Schmiedeberg's Archives of Pharmacology.

A comparison of the pharmacological properties of guinea‐pig and human recombinant 5‐HT4 receptors

R. Vickery, T. Pulido-Rios, J. A. Smith, 2007, British journal of pharmacology.

Neurokinin‐induced changes in pial artery diameter in the anaesthetized guinea‐pig

W. Feniuk, D. Beattie, H. Connor, 1993, British journal of pharmacology.

Development of Gut-Selective Pan-Janus Kinase Inhibitor TD-1473 for Ulcerative Colitis: A Translational Medicine Programme

J. Leighton, D. Boyle, W. Sandborn, 2020, Journal of Crohn's & colitis.

Repressor binding to a regulatory site in the DNA coding sequence is sufficient to confer transcriptional regulation of the vir-repressed genes (vrg genes) in Bordetella pertussis

J. Mekalanos, M. Mahan, D. Beattie, 1993, Journal of bacteriology.

The activity of 5-HT1D receptor ligands at cloned human 5-HT1Dα and 5-HT1Dβ receptors

D. Walsh, D. Beattie, H. Connor, 1995 .

The activity of 5-HT1D receptor ligands at cloned human 5-HT1D alpha and 5-HT1D beta receptors.

D. Walsh, D. Beattie, H. Connor, 1995, European journal of pharmacology.

An in vitro investigation of the cardiovascular effects of the 5-HT(4) receptor selective agonists, velusetrag and TD-8954.

Deborah L. Higgins, K. Kersey, R. Vickery, 2013, Vascular pharmacology.

The inability of tegaserod to affect platelet aggregation and coronary artery tone at supratherapeutic concentrations

Deborah L. Higgins, K. Kersey, D. Beattie, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Effects of calcium channel antagonists on action potential conduction and transmitter release in the guinea‐pig vas deferens

T. C. Muir, D. Beattie, T. Cunnane, 1986, British journal of pharmacology.

Safety and efficacy update: Alvimopan in postoperative ileus:

D. Beattie, 2009 .

Discovery of N-substituted-endo-3-(8-aza-bicyclo[3.2.1]oct-3-yl)-phenol and -phenyl carboxamide series of μ-opioid receptor antagonists.

R. Vickery, Lan Jiang, J. R. Jacobsen, 2017, Bioorganic & medicinal chemistry letters.

Discovery, oral pharmacokinetics and in vivo efficacy of velusetrag, a highly selective 5-HT(4) receptor agonist that has achieved proof-of-concept in patients with chronic idiopathic constipation.

S. D. Turner, J. Shaw, S. Choi, 2012, Bioorganic & medicinal chemistry letters.

NK1 and CGRP receptor-mediated dilatation of the carotid arterial bed of the anaesthetized rabbit

M. Perren, D. Beattie, H. Connor, 1996, Neuropeptides.

Recent developments in tachykinin NK1 receptor antagonists: prospects for the treatment of migraine headache.

R. Hagan, D. Beattie, H. Connor, 1995, Canadian journal of physiology and pharmacology.

The influence of neurokinins and calcitonin gene-related peptide on cerebral blood flow in anaesthetized guinea-pigs

D. Beattie, H. Connor, D. Mcneil, 1993, Neuropeptides.

High resolution electron microscopy and X-ray powder diffraction studies of Sr2Nb5O9

S. Wold, P. Krogsgaard‐Larsen, G. Svensson, 1990 .

The Crystal Structure of Chlorobis(diethyldithiocarbamato)-4-ethoxyphenyltellurium(IV) Hemidioxane Solvate, [TeCl(Et2NCS2)2(EtOPh)].0.5C4H8O2.

S. Wold, P. Krogsgaard‐Larsen, D. Beattie, 1990 .

GR205171: A novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity

Gavin Kilpatrick, J. Gale, P. Ward, 1996, Regulatory Peptides.

Novel class of amino acid antagonists at non-N-methyl-D-aspartic acid excitatory amino acid receptors. Synthesis, in vitro and in vivo pharmacology, and neuroprotection.

D. R. Curtis, P. Krogsgaard‐Larsen, N. Diemer, 1991, Journal of medicinal chemistry.

Serotonin pharmacology in the gastrointestinal tract: a review

J. A. Smith, D. Beattie, D. Beattie, 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

Novel Class of Amino Acid Antagonists at Non‐N‐methyl‐D‐aspartic Acid Excitatory Amino Acid Receptors. Synthesis, in vitro and in vivo Pharmacology, and Neuroprotection.

D. R. Curtis, P. Krogsgaard‐Larsen, N. Diemer, 1991 .

The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activity

R. Vickery, Pamela R. Tsuruda, Christina B. Campbell, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

AZD-3043: A Novel, Metabolically Labile Sedative–Hypnotic Agent with Rapid and Predictable Emergence from Hypnosis

T. Egan, S. Steffensen, D. R. Cook, 2012, Anesthesiology.

Critical Role for Uremic Neutrophils Acute Uremia but Not Renal Inflammation Attenuates Aseptic Acute Lung Injury: A

A. Zarbock, R. Quigg, R. Bayer, 2008 .

Intestinally-restricted Janus Kinase inhibition: a potential approach to maximize the therapeutic index in inflammatory bowel disease therapy

Pamela R. Tsuruda, P. Brassil, D. Beattie, 2017, Journal of Inflammation.

Safety, immunogenicity, and efficacy of live attenuated Vibrio cholerae 0139 vaccine prototype

M. Waldor, D. Spriggs, J. Mekalanos, 1995, The Lancet.

Peru-15, an improved live attenuated oral vaccine candidate for Vibrio cholerae O1.

D. Spriggs, J. Mekalanos, K. Killeen, 1995, The Journal of infectious diseases.

The 5‐HT4 receptor agonist, tegaserod, is a potent 5‐HT2B receptor antagonist in vitro and in vivo

R. Vickery, T. Pulido-Rios, J. A. Smith, 2004, British journal of pharmacology.

Discovery of Axelopran (TD-1211): A Peripherally Restricted μ-Opioid Receptor Antagonist.

P. Colson, R. Vickery, Pamela R. Tsuruda, 2019, ACS medicinal chemistry letters.

Measurement of 5-HT4 receptor-mediated esophageal responses by digital sonomicrometry in the anesthetized rat.

D. Beattie, S. Armstrong, J. L. McCullough, 2006, Journal of pharmacological and toxicological methods.

The 5-HT2B antagonist and 5-HT4 agonist activities of tegaserod in the anaesthetized rat.

D. Beattie, S. Hegde, S. Armstrong, 2006, Pharmacological research.

The inability of tegaserod to affect platelet aggregation and coronary artery tone at supratherapeutic concentrations

K. Kersey, D. Beattie, M. Ero, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Baclofen antagonism by 4-amino-3-(5-methoxybenzo[b]furan-2-yl) butanoic acid in the cat spinal cord

D. R. Curtis, C. Vaccher, P. Berthelot, 1989, Neuroscience Letters.

Use of genetic recombination as a reporter of gene expression.

J. Mekalanos, A. Camilli, D. Beattie, 1994, Proceedings of the National Academy of Sciences of the United States of America.

The pre- and postjunctional activity of CP-122,288, a conformationally restricted analogue of sumatriptan.

D. Beattie, H. Connor, 1995, European journal of pharmacology.

Development of a live, oral, attenuated vaccine against El Tor cholera.

J. Ezzell, J. Mekalanos, K. Killeen, 1994, The Journal of infectious diseases.

Naratriptan: biological profile in animal models relevant to migraine.

D. Saynor, W. Feniuk, D. Beattie, 1997, Cephalalgia : an international journal of headache.

Baclofen: reduction of presynaptic calcium influx in the cat spinal cord in vivo

D. R. Curtis, D. Beattie, B. D. Gynther, 1997, Experimental Brain Research.

5-HT4 receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment

Pamela R. Tsuruda, D. Beattie, R. Chang, 2011, Neuropharmacology.

Mutants de deletion utilises en tant que vaccins contre le cholera

K. Killeen, D. Beattie, Yichen Lu, 1993 .

The in vivo gastrointestinal activity of TD-5108, a selective 5-HT4 receptor agonist with high intrinsic activity

J. Taylor, J. Shaw, J. A. Smith, 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

Attenuation of Fos-like immunoreactivity in the trigeminal nucleus caudalis following trigeminovascular activation in the anaesthetised guinea-pig

D. Beattie, P. Gaskin, Joanne S Clayton, 1997, Brain Research.

The in vitro pharmacological profile of TD-1211, a neutral opioid receptor antagonist

R. Vickery, D. Long, D. Beattie, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

An in vivo electrophysiological investigation of group Ia afferent fibres and ventral horn terminations in the cat spinal cord

D. R. Curtis, D. Beattie, B. D. Gynther, 2004, Experimental Brain Research.

Intestinally-restricted Janus Kinase inhibition: a potential approach to maximize the therapeutic index in inflammatory bowel disease therapy

Pamela R. Tsuruda, P. Brassil, D. Beattie, 2017, Journal of Inflammation.

The Three-Dimensional Structure of the RGD (Arg-Gly-Asp) Adhesion Sequence of Fibronectin; NMR Studies of the Peptides RGDS and GRGDSP.

S. Wold, P. Krogsgaard‐Larsen, D. Beattie, 1990 .