C. Busacca

发表

Development of a 13C NMR Chemical Shift Prediction Procedure Using B3LYP/cc-pVDZ and Empirically Derived Systematic Error Correction Terms: A Computational Small Molecule Structure Elucidation Method.

C. Tautermann, C. Senanayake, K. Fandrick, 2017, The Journal of organic chemistry.

Synthesis of deleobuvir, a potent hepatitis C virus polymerase inhibitor, and its major metabolites labeled with carbon-13 and carbon-14.

C. Senanayake, Maxim V. Chevliakov, B. Latli, 2015, Journal of labelled compounds & radiopharmaceuticals.

Ambient temperature hydrophosphination of internal, unactivated alkynes and allenyl phosphineoxides with phosphine borane complexes.

C. Senanayake, Shengli Ma, Heewon Lee, 2009, Organic letters.

Enzyme-Transporter Interplay in the Formation and Clearance of Abundant Metabolites of Faldaprevir Found in Excreta but not in Circulation

D. Tweedie, Jun Xu, Yongmei Li, 2014, Drug Metabolism and Disposition.

Simple N‐Heterocyclic Carbenes as Ligands in Ullmann‐Type Ether and Thioether Formations

Jiang-Ping Wu, C. Senanayake, Heewon Lee, 2016 .

The reaction of Grignard reagents with Bunte salts: a thiol-free synthesis of sulfides.

C. Senanayake, Heewon Lee, Z. Han, 2014, Organic letters.

Practical Synthesis of Di-tert-Butyl-Phosphinoferrocene

C. Senanayake, B. Qu, N. Haddad, 2014 .

1,4-Dicarbofunctionalization of 4-Fluoroaryl Grignard and Lithium Reagents with Disubstituted Malononitriles.

C. Senanayake, A. Howell, Christian A. Malapit, 2017, The Journal of organic chemistry.

Application of the palladium-catalyzed N-arylation of hydrazones to deactivated heteroaryl halides in the synthesis of pyrazoles

N. Haddad, Annette Salvagno, C. Busacca, 2004 .

Transition Metal Catalysis in the Pharmaceutical Industry

Jinhua J. Song, C. Senanayake, Daniel R Fandrick, 2012 .

Sulfone Mediated SNAr Reaction as a Powerful Tool for the Synthesis of 4-Quinolinyl Ethers and more - Application to the Synthesis of HCV NS3/4a Protease Inhibitor BI 201420.

B. Narayanan, C. Senanayake, Xudong Wei, 2020, The Journal of organic chemistry.

A highly convergent and efficient synthesis of a macrocyclic hepatitis C virus protease inhibitor BI 201302.

C. Senanayake, Xudong Wei, N. Yee, 2013, Organic letters.

A Computational Investigation of the Ligand-Controlled Cu-Catalyzed Site-Selective Propargylation and Allenylation of Carbonyl Compounds

C. Senanayake, M. Kozlowski, K. Fandrick, 2017, Organic letters.

Development of an asymmetric synthesis of a chiral quaternary FLAP inhibitor.

Jinhua J. Song, C. Senanayake, P. Mahaney, 2015, The Journal of organic chemistry.

PAT Application in the Expedited Development of a Three-Step, One-Stage Synthesis of the Dipeptide Intermediate of HCV Protease Inhibitor Faldaprevir

C. Senanayake, Heewon Lee, B. Qu, 2015 .

A novel five-lipoxygenase activity protein inhibitor labeled with carbon-14 and deuterium.

C. Senanayake, Joe J. Gao, B. Latli, 2015, Journal of labelled compounds & radiopharmaceuticals.

Early Development Scale-Up of a Structurally-Challenging 5-Lipoxygenase Activating Protein (FLAP) Inhibitor

Jinhua J. Song, Jun Wang, C. Senanayake, 2017 .

Structure Elucidation of Poly-Faldaprevir: Polymer Backbone Solved Using Solid-State and Solution Nuclear Magnetic Resonance Spectroscopy.

Jiang-Ping Wu, A. Ding, Thomas J Offerdahl, 2016, Journal of pharmaceutical sciences.

Study and characterization of crystalline hydrate/polymorph forms of 5,11-dihydro-11-ethyl-5-methyl-8-(2-(1-oxido-4-quinolinyl)ethyl-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepin-6-one by solid-state NMR and solution NMR.

D. Norwood, J. Smoliga, C. Busacca, 2010, Journal of pharmaceutical and biomedical analysis.

31P Solid state NMR study of structure and chemical stability of dichlorotriphenylphosphorane

D. Norwood, Shengli Ma, N. Grinberg, 2009, Magnetic resonance in chemistry : MRC.

Process Development of the BACE Inhibitors BI 1147560 BS and BI 1181181 MZ

Jinhua J. Song, S. Venkatraman, C. Senanayake, 2022, Organic Process Research & Development.

Phenethylamines via Heck arylation of a new vinylamine equivalent

Robert E. Johnson, C. Busacca, John Swestock, 1993 .

Indoles from o-Haloanilines: Syntheses of Tryptamines and Tryptophols via Regioselective Hydroformylation of Functionalized Anilines

C. Busacca, Yong Dong, 1997 .

Development of an Efficient Asymmetric Synthesis of the Chiral Quaternary 5-Lipoxygenase Activating Protein Inhibitor

Jinhua J. Song, C. Senanayake, J. Mulder, 2016 .

Synthesis of novel tetrahydrobenzazepinones

Robert E. Johnson, C. Busacca, 1992 .

Cationic triazinium heterocycles by intramolecular NN bond formation

C. Senanayake, Heewon Lee, Z. Han, 2014 .

Rhodium-Catalyzed Addition of Aryl Boronic Acids to 2,2-Disubstituted Malononitriles.

C. Senanayake, A. Howell, Z. Han, 2017, Angewandte Chemie.

A General Method for Imine Formation Using B(OCH2CF3)3.

C. Senanayake, N. Grinberg, C. Busacca, 2015, Organic letters.

Development of an Enantioselective Hydrogenation Route to (S)-1-(2-(Methylsulfonyl)pyridin-4-yl)propan-1-amine

Jinhua J. Song, Bing-Shiou Yang, C. Senanayake, 2014 .

The Growing Impact of Catalysis in the Pharmaceutical Industry

Jinhua J. Song, Chris H. Senanayake, C. Senanayake, 2011 .

Chelation controlled reductive amination of cyclic ketones to trans-4-methoxycyclohexylamines: 9-BBN reduction mediated with FeCl3

C. Senanayake, Shengli Ma, Heewon Lee, 2012 .

One‐Pot Synthesis of 2,5‐Disubstituted Pyrimidines from Nitriles.

C. Senanayake, J. Mulder, Xudong Wei, 2013 .

One-pot synthesis of 2,5-disubstituted pyrimidines from nitriles.

C. Senanayake, J. Mulder, Xudong Wei, 2013, The Journal of organic chemistry.

A ONE STEP SYNTHESIS OF THIAZOLINES FROM ESTERS

C. Busacca, E. Spinelli, Yong Dong, 1996 .

Synthesis of highly potent lymphocyte function-associated antigen-1 antagonists labeled with carbon-14 and with stable isotopes, part 3.

C. Senanayake, J. Horan, B. Latli, 2018, Journal of labelled compounds & radiopharmaceuticals.

Process Development and Pilot-Plant Synthesis of (S)-tert-Butyl 1-Oxo-1-(1-(pyridin-2-yl)cyclopropylamino)propan-2-ylcarbamate: Studies on the Scale-Up of Kulinkovich–Szymoniak Cyclopropanation

C. Senanayake, Joe J. Gao, Shengli Ma, 2012 .

Asymmetric Diels–Alder reactions. A route to chiral carbocycles via bicyclic lactams

A. Meyers, C. Busacca, 1991 .

Potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 labeled with carbon-13 and carbon-14.

C. Senanayake, B. Latli, C. Busacca, 2017, Journal of labelled compounds & radiopharmaceuticals.

An asymmetric route to fused carbocyclic systems via Diels-Alder reactions on chiral α,β-unsaturated bicyclic lactams

A. Meyers, C. Busacca, 1989 .

Palladium-catalyzed aminocarbonylation of heteroaryl halides using di-tert-butylphosphinoferrocene

C. Senanayake, Heewon Lee, N. Grinberg, 2009 .

Rhodium-Catalyzed Transnitrilation of Aryl Boronic Acids with Dimethylmalononitrile.

C. Senanayake, A. Howell, Christian A. Malapit, 2016, Angewandte Chemie.

Transnitrilation from Dimethylmalononitrile to Aryl Grignard and Lithium Reagents: A Practical Method for Aryl Nitrile Synthesis.

C. Senanayake, K. Fandrick, Christian A. Malapit, 2015, Journal of the American Chemical Society.

The ambiphilic nature of N-acyliminium ion-enamide tautomers. Novel annulation to enantiomerically pure polycyclic frameworks

A. Meyers, C. Busacca, S. Bienz, 1989 .

Synthesis of pyridyl-dihydrobenzooxaphosphole ligands and their application in asymmetric hydrogenation of unfunctionalized alkenes.

Jinhua J. Song, C. Senanayake, Xudong Wei, 2014, The Journal of organic chemistry.

Tuning the Peri Effect for Enantioselectivity: Asymmetric Hydrogenation of Unfunctionalized Olefins with the BIPI Ligands

Dajun Chen, C. Senanayake, K. Fandrick, 2013 .

Synthesis of deuterium-, tritium-, and carbon-14- labeled BILN2061, a potent hepatitis C virus protease inhibitor

C. Senanayake, V. Gorys, B. Latli, 2005 .

Nickel- or Cobalt-Catalyzed Cross-Coupling of Arylsulfonic Acid Salts with Grignard Reagents

C. Senanayake, A. Howell, Christian A. Malapit, 2015 .

Probing electronic effects in the asymmetric Heck reaction with the BIPI ligands.

E. O'brien, R. So, C. Busacca, 2003, Organic letters.

Tandem Pd(II)-Catalyzed Vinyl Ether Exchange−Claisen Rearrangement as a Facile Approach to γ,δ-Unsaturated Aldehydes

C. Senanayake, Xudong Wei, N. Haddad, 2007 .

4-Trifloxy-9-SEM-β-Carboline: Preparation and Synthetic Utility

Magnus C. Eriksson, Anthony S. Prokopowicz, C. Busacca, 1999 .

Hydrophosphination of propargylic alcohols and amines with phosphine boranes.

P. Wipf, Jiang-Ping Wu, C. Senanayake, 2013, Organic letters.

4,5-Dihydro-3-(methanesulfonamidophenyl)-1-phenyl-1H-2,4-benzodiazepines: a novel class III antiarrhythmic agents.

G. M. Briggs, G M Briggs, R. E. Johnson, 1995, Journal of medicinal chemistry.

A One Step Synthesis of Thiazolines from Esters.

C. Busacca, E. Spinelli, Yong Dong, 1996 .

A General Method for Imine Formation Using B(OCH2CF3)3.

C. Senanayake, N. Grinberg, C. Busacca, 2015, Organic letters.

Application of the Palladium-Catalyzed N-Arylation of Hydrazones to Deactivated Heteroaryl Halides in the Synthesis of Pyrazoles.

N. Haddad, Annette Salvagno, C. Busacca, 2004 .

Discovery of 2-phenylamino-imidazo[4,5-h]isoquinolin-9-ones: a new class of inhibitors of lck kinase.

J. Peterson, N. Moss, S. Lukas, 2002, Journal of medicinal chemistry.

Copper-catalyst-controlled site-selective allenylation of ketones and aldehydes with propargyl boronates.

C. Senanayake, K. Fandrick, Daniel R Fandrick, 2013, Organic letters.

Reduction of tertiary phosphine oxides with DIBAL-H.

C. Senanayake, Heewon Lee, N. Grinberg, 2008, The Journal of organic chemistry.

A superior method for the reduction of secondary phosphine oxides.

Paul S. Sabila, C. Senanayake, Xudong Wei, 2005, Organic letters.

Reduction of Phosphinites,Phosphinates, and Related Species with DIBAL-H

C. Senanayake, Sreedhar Cheekoori, S. Kapadia, 2009 .

Reduction of Phosphinites, Phosphinates, and Related Species with DIBAL-H.

C. Senanayake, Sreedhar Cheekoori, S. Kapadia, 2009 .

[2,3]-Sigmatropic rearrangements of 2-phosphineborane 2-propen-1-ols: rapid access to enantioenriched diphosphine monoxide derivatives.

P. Wipf, Jiang-Ping Wu, C. Senanayake, 2013, Organic letters.

Asymmetric hydrogenation of unsaturated ureas with the BIPI ligands.

C. Senanayake, Heewon Lee, N. Grinberg, 2008, Organic letters.

Development of a Scalable, Chromatography-Free Synthesis of t-Bu-SMS-Phos and Application to the Synthesis of an Important Chiral CF3-Alcohol Derivative with High Enantioselectivity Using Rh-Catalyzed Asymmetric Hydrogenation.

Jinhua J. Song, B. Narayanan, C. Senanayake, 2018, The Journal of organic chemistry.

Synthesis of phosphaguanidines by hydrophosphination of carbodiimides with phosphine boranes.

P. Wipf, C. Senanayake, Heewon Lee, 2014, The Journal of organic chemistry.

1.9 The use of New Phosphines as Powerful Tools in Asymmetric Synthesis of Biologically Active Compounds

C. Senanayake, C. Busacca, 2012 .

Safety Assessment of Benzyne Generation from a Silyl Triflate Precursor.

N. Garg, C. Busacca, I. Volchkov, 2020, Organic letters.

Rational Design of New Dihydrobenzooxophosphole-Based Lewis Base Organocatalysts.

C. Senanayake, M. Kozlowski, Mac G. Schumer, 2020, Synlett : accounts and rapid communications in synthetic organic chemistry.

Carbamoyl Anion Addition to Azirines.

P. Wipf, C. Senanayake, Michael J Kerner, 2021, Organic letters.

Carbamoyl anion addition to nitrones.

C. Senanayake, Heewon Lee, C. Busacca, 2014, The Journal of organic chemistry.

Enantioselective Nickel-Catalyzed Mizoroki-Heck Cyclizations To Generate Quaternary Stereocenters.

Jinhua J. Song, C. Senanayake, M. Kozlowski, 2017, Organic letters.

Concise and Practical Asymmetric Synthesis of a Challenging Atropisomeric HIV Integrase Inhibitor.

Y. Tsantrizos, Jiang-Ping Wu, C. Senanayake, 2015, Angewandte Chemie.

Addressing the configuration stability of lithiated secondary benzylic carbamates for the development of a noncryogenic stereospecific boronate rearrangement.

Jinhua J. Song, C. Senanayake, J. Mulder, 2014, Organic letters.

Development of the BIPI ligands for asymmetric hydrogenation

C. Senanayake, Sreedhar Cheekoori, Heewon Lee, 2012 .

Acid mediated deprotection of N-isopropyl tertiary amides

C. Senanayake, C. Busacca, J. Reeves, 2015 .

Triisopropyl borate mediated N-sulfinyl imine formation

C. Senanayake, C. Busacca, I. Volchkov, 2016 .

Electronic control of chiral quaternary center creation in the intramolecular asymmetric heck reaction.

Robert E. Harris, Ji-Young Kim, E. O'brien, 2004, The Journal of organic chemistry.

A facile synthesis of 4-aryl-2,3-dihydropyrroles

C. Busacca, Yong Dong, 1996 .

Asymmetric Diels‐Alder Reactions. A Route to Chiral Carbocycles via Bicyclic Lactams.

A. Meyers, C. Busacca, 1992 .

Development of Multikilogram Continuous Flow Cyclopropanation of N-Benzylmaleimide through Kinetic Analysis

Bing-Shiou Yang, C. Senanayake, N. Yee, 2014 .

A potent IκB kinase-β inhibitor labeled with carbon-14 and deuterium.

C. Senanayake, Magnus C. Eriksson, B. Latli, 2016, Journal of labelled compounds & radiopharmaceuticals.

The Anomalous Stille Reactions of Methyl .alpha.-(Tributylstannyl)acrylate: Evidence for a Palladium Carbene Intermediate

Robert E. Johnson, C. Busacca, T. Bailey, 1994 .

Cross coupling of vinyl triflates and alkyl Grignard reagents catalyzed by nickel(0)-complexes

Magnus C. Eriksson, C. Busacca, R. Fiaschi, 1999 .

Directly probing the racemization of imidazolines by vibrational circular dichroism: kinetics and mechanism.

C. Senanayake, N. Yee, K. Fandrick, 2010, Organic Letters.

Part 2: Designation and Justification of API Starting Materials: Current Practices across Member Companies of the IQ Consortium

M. Faul, Frederick A. Hicks, J. Orr, 2014 .

RCM macrocyclization made practical: an efficient synthesis of HCV protease inhibitor BILN 2061.

Xudong Wei, Ming-Hong Hao, M. Hao, 2008, Organic letters.

1H and 13C NMR assignments of all three isomeric o‐fluoronaphthaldehydes and three o‐fluorophenanthrene aldehydes

C. Senanayake, C. Busacca, N. Gonnella, 2010, Magnetic resonance in chemistry : MRC.

Hydrophosphination of Bicyclo[1.1.0]butane-1-carbonitriles.

P. Wipf, C. Senanayake, C. Busacca, 2016, Organic letters.

Development of a Pilot-Plant Process for a Nevirapine Analogue HIV NNRT Inhibitor

P. Beaulieu, Ji-Young Kim, D. Norwood, 2008 .

Practical Large‐Scale Synthesis of the Hepatitis C Virus Protease Inhibitor BI 201335

C. Senanayake, Xudong Wei, J. Smoliga, 2012 .

Developing Palladium‐Catalyzed Arylations of Carbonyl‐Activated CH Bonds

C. Senanayake, C. Busacca, 2013 .

Phenethylamines via Heck Arylation of a New Vinylamine Equivalent.

Robert E. Johnson, C. Busacca, John Swestock, 1993 .

Carbon-13 and carbon-14 labeled dabigatran etexilate and tritium labeled dabigatran.

C. Senanayake, Maxim V. Chevliakov, B. Latli, 2016, Journal of labelled compounds & radiopharmaceuticals.

Indoles from o‐Haloanilines: Syntheses of Tryptamines and Tryptophols via Regioselective Hydroformylation of Functionalized Anilines.

C. Busacca, Yong Dong, 1998 .

Development of an Efficient Synthesis of (2-Aminopyrimidin-5-yl) Boronic Acid

Jinhua J. Song, C. Senanayake, J. Mulder, 2016 .

Buscopan labeled with carbon-14 and deuterium.

C. Senanayake, Heewon Lee, N. Grinberg, 2016, Journal of labelled compounds & radiopharmaceuticals.

Effective BI‐DIME Ligand for Suzuki–Miyaura Cross‐Coupling Reactions in Water with 500 ppm Palladium Loading and Triton X

C. Senanayake, N. Yee, K. Fandrick, 2017 .

Synthesis of 4-(p-Methoxyphenyl)-β-Carboline, A New Inhibitor of Cellular Calcium Influx

C. Busacca, Yong Dong, 2000 .

Synthesis of [14C]-and [13C6]-labeled potent HIV non-nucleoside reverse transcriptase inhibitor

C. Senanayake, B. Latli, C. Busacca, 2009 .

9.19 Synthesis of the Leading HCV Protease Inhibitors

Jinhua J. Song, C. Senanayake, N. Yee, 2012 .

A convenient synthesis of (1S)-tert-butyl-1,2-ethylenediamine

C. Busacca, E. Spinelli, D. Grossbach, 2000 .

Probing the cation binding modes of macrocyclic HCV protease inhibitor BILN 2061 by multinuclear NMR.

C. Senanayake, Paul-James Jones, C. Busacca, 2012, Journal of pharmaceutical and biomedical analysis.

Large-scale asymmetric synthesis of a cathepsin S inhibitor.

C. Senanayake, Xudong Wei, Heewon Lee, 2010, The Journal of organic chemistry.

Heart-Cutting Two-Dimensional Ultrahigh-Pressure Liquid Chromatography for Process Development: Asymmetric Reaction Monitoring

Jinhua J. Song, C. Senanayake, Shaun Mendonsa, 2013 .

Potent and selective CC chemokine receptor 1 antagonists labeled with carbon-13, carbon-14, and tritium.

C. Senanayake, B. Latli, C. Busacca, 2018, Journal of labelled compounds & radiopharmaceuticals.

Metabolic Switching of BILR 355 in the Presence of Ritonavir. I. Identifying an Unexpected Disproportionate Human Metabolite

D. Tweedie, Andrea Whitcher-Johnstone, Yongmei Li, 2012, Drug Metabolism and Disposition.

Atom-Economical Cross-Coupling of Internal and Terminal Alkynes to Access 1,3-Enynes.

Jinhua J. Song, C. Senanayake, K. Engle, 2020, Journal of the American Chemical Society.

The reaction of Grignard reagents with Bunte salts: a thiol-free synthesis of sulfides.

C. Senanayake, Heewon Lee, Z. Han, 2014, Organic letters.