Hongyu Zhao

发表

A method for easily determining coupling constant values: an addendum to "A practical guide to first-order multiplet analysis in 1H NMR spectroscopy".

T. Hoye, Hongyu Zhao, 2002, The Journal of organic chemistry.

Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.

Chaohong Sun, E. Olejniczak, Eric F. Johnson, 2006, Journal of medicinal chemistry.

Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.

Eric F. Johnson, C. Abad-Zapatero, H. Sham, 2006, Journal of medicinal chemistry.

When analoging is not enough: scaffold discovery in medicinal chemistry

I. Akritopoulou‐Zanze, Hongyu Zhao, 2010, Expert opinion on drug discovery.

Synthesis of substituted fused pyridines, pyrazines and pyrimidines by sequential Ugi/inverse electron demand Diels-Alder transformations

I. Akritopoulou‐Zanze, S. Djurić, Ying Wang, 2009 .

The prospects of antagonizing the growth hormone secretagogue receptor to treat obesity

Bo Liu, Hongyu Zhao, Michael D. Serby, 2008 .

Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: targeting the gatekeeper residue and beyond.

H. Sham, R. Gum, D. Haasch, 2006, Bioorganic & medicinal chemistry letters.

Optimization of 2,4-diaminopyrimidines as GHS-R antagonists: side chain exploration.

H. Sham, C. Collins, Gang Liu, 2006, Bioorganic & medicinal chemistry letters.

Discovery of Novel Aminotetralines and Aminochromanes as Selective and Competitive Glycine Transporter 1 (GlyT1) Inhibitors.

Justin D Dietrich, A. Vasudevan, J. Sydor, 2018, Journal of medicinal chemistry.

Hemodynamic effects of potent and selective JNK inhibitors in anesthetized rats: implication for targeting protein kinases in metabolic diseases.

H. Sham, D. Beno, J. Trevillyan, 2007, Bioorganic & medicinal chemistry letters.

Discovery and pharmacological evaluation of growth hormone secretagogue receptor antagonists.

E. Bush, H. Sham, D. Beno, 2006, Journal of medicinal chemistry.

2,4-diaminopyrimidine derivatives as potent growth hormone secretagogue receptor antagonists.

E. Bush, H. Sham, D. Beno, 2006, Journal of medicinal chemistry.

Synthesis and Structure—Activity Relationships of Isoxazole Carboxamides as Growth Hormone Secretagogue Receptor Antagonists.

H. Sham, Gang Liu, W. Kaszubska, 2005 .

Structure-activity relationship studies on tetralin carboxamide growth hormone secretagogue receptor antagonists.

Jyoti R. Patel, H. Sham, C. Collins, 2005, Bioorganic & medicinal chemistry letters.

Discovery of tetralin carboxamide growth hormone secretagogue receptor antagonists via scaffold manipulation.

H. Sham, C. Collins, Gang Liu, 2004, Journal of medicinal chemistry.

Novel isoxazole carboxamides as growth hormone secretagogue receptor (GHS-R) antagonists.

H. Sham, C. Collins, Gang Liu, 2004, Bioorganic & medicinal chemistry letters.

Growth hormone secretagogue receptor antagonists as anti-obesity therapies? Still an open question.

Hongyu Zhao, Gang Liu, 2006, Current opinion in drug discovery & development.

De Novo Design, Synthesis, and Biological Evaluation of 3,4-Disubstituted Pyrrolidine Sulfonamides as Potent and Selective Glycine Transporter 1 Competitive Inhibitors.

Justin D Dietrich, A. Vasudevan, J. Sydor, 2018, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists.

H. Sham, Gang Liu, W. Kaszubska, 2005, Bioorganic & medicinal chemistry letters.

Relay ring-closing metathesis (RRCM): a strategy for directing metal movement throughout olefin metathesis sequences.

T. Hoye, Jizhou Wang, C. Jeffrey, 2004, Journal of the American Chemical Society.

Discovery of 1-(4-phenoxypiperidin-1-yl)-2-arylaminoethanone stearoyl-CoA desaturase 1 inhibitors.

H. Sham, T. Surowy, C. Collins, 2007, Bioorganic & medicinal chemistry letters.

Synthesis of Substituted Fused Pyridines, Pyrazines and Pyrimidines by Sequential Ugi/Inverse Electron Demand Diels—Alder Transformations.

I. Akritopoulou‐Zanze, S. Djurić, Ying Wang, 2010 .

Privileged scaffolds in lead generation

Hongyu Zhao, Justin Dietrich, Justin D Dietrich, 2015, Expert opinion on drug discovery.

Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors.

H. Sham, T. Surowy, C. Collins, 2008, Bioorganic & medicinal chemistry letters.

Dual macrolactonization/pyran-hemiketal formation via acylketenes: applications to the synthesis of (-)-callipeltoside A and a lyngbyaloside B model system.

T. Hoye, Michael E. Danielson, Hongyu Zhao, 2008, Angewandte Chemie.

Synthesis of a C1—C14-Containing Fragment of Callipeltoside A.

T. Hoye, Hongyu Zhao, 1999 .

Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors.

Bo Liu, Gang Liu, Hongyu Zhao, 2007, Journal of medicinal chemistry.

Synergistic effect of naphthalenediimide and squaraine ligand targeting G-quadruplex DNA in cancer cells.

Rizhe Jin, C. Kang, Hongyu Zhao, 2022, Chemico-biological interactions.

The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy.

Ryan A McClure, K. Longenecker, Chaohong Sun, 2022, ACS chemical biology.

Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.

Gang Liu, Hongyu Zhao, Cristina M Rondinone, 2003, Journal of medicinal chemistry.

Phytochemicals targeting lncRNAs: A novel direction for neuroprotection in neurological disorders.

H. Zhao, Hongyu Zhao, Lijuan Zhang, 2023, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Total synthesis of (-)-callipeltoside A.

T. Hoye, Michael E. Danielson, Hongyu Zhao, 2010, The Journal of organic chemistry.

Growth hormone secretagogue receptor antagonists as potential therapeutic agents for obesity

Hongyu Zhao, 2005 .

Lead optimization in the nondrug-like space.

Hongyu Zhao, 2011, Drug discovery today.

Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors.

P. Hajduk, C. Abad-Zapatero, C. Rondinone, 2004, Bioorganic & medicinal chemistry letters.

Drug-likeness : what does it mean ?

Hongyu Zhao, Hongyu Zhao, 2011 .

Scaffold selection and scaffold hopping in lead generation: a medicinal chemistry perspective.

Hongyu Zhao, Hongyu Zhao, 2007, Drug discovery today.

Some allylic substituent effects in ring-closing metathesis reactions: allylic alcohol activation.

T. Hoye, Hongyu Zhao, H. Zhao, 1999, Organic letters.

SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.

Hongyu Zhao, Ying Wang, Zhiqin Ji, 2017, Bioorganic & medicinal chemistry letters.

Medicinal chemistry strategies in follow-on drug discovery.

Hongyu Zhao, Zongru Guo, Zongru Guo, 2009, Drug discovery today.

SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.

Mikkel A. Algire, Justin D Dietrich, P. Richardson, 2017, Bioorganic & medicinal chemistry letters.

When analoging is not enough: scaffold discovery in medicinal chemistry

I. Akritopoulou‐Zanze, Hongyu Zhao, 2010, Expert opinion on drug discovery.