Y. Guindon

发表

Diastereoselective hydrogen-transfer reactions: an experimental and DFT study.

S. Gorelsky, Francois Godin, M. Prévost, 2013, Chemistry.

Regiocontrolled opening of cyclic ethers using dimethylboron bromide

C. Yoakim, Y. Girard, Y. Guindon, 1987 .

Diastereoselective and regioselective synthesis of adenosine thionucleoside analogues using an acyclic approach

M. Prévost, Y. Guindon, Starr Dostie, 2020, Canadian Journal of Chemistry.

Diastereoselective Radical Hydrogen Transfer Reactions using N-Heterocyclic Carbene Boranes.

Y. Guindon, Guillaume Tambutet, 2016, The Journal of organic chemistry.

Stereocontrolled synthesis of propionate motifs from l -lactic and l -alanine aldehydes. A DFT study of the hydrogen transfer under endocyclic control

M. Duplessis, Y. Guindon, J. Rodrigue, 2014 .

L-648,051, sodium 4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)- propylsulfonyl]-gamma-oxo-benzenebutanoate: a leukotriene D4 receptor antagonist.

R. Young, D. Denis, D. Éthier, 1986, Canadian journal of physiology and pharmacology.

Synthetic leukotriene B4 is a potent chemotaxin but a weak secretagogue for human PMN.

R. Zamboni, J. Rokach, B. Zanolari, 1983, Prostaglandins.

Pharmacological evidence for a role of lipoxygenase products in platelet-activating factor (PAF)-induced hyperalgesia.

A. Dallob, Y. Guindon, M. M. Goldenberg, 1987, Biochemical pharmacology.

Synthesis of the Leukotrienes

R. Young, J. Rokach, Julian Adams, 2007 .

L-648,051: an aerosol active leukotriene D4 receptor antagonist.

D. Denis, D. Éthier, A. Ford-hutchinson, 1987, Advances in prostaglandin, thromboxane, and leukotriene research.

L-649,923, Sodium (βS*, γR*)-4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propylthio)-γ-hydroxy-β-methylbenzenebutanoate, a selective, orally active leukotriene receptor antagonist

R. Young, D. Denis, A. Ford-hutchinson, 1986 .

Therapeutic potential of 5-lipoxygenase inhibitors: the discovery and development of MK-886, a novel-mechanism leukotriene inhibitor

R. Dixon, C. Yoakim, C. Rouzer, 1992 .

The stereospecific synthesis of leukotriene A4 (LTA4), 5-epi-LTA4, 6-epi-LTA4 and 5-epi,6-epi-LTA4

R. Zamboni, J. Rokach, Y. Guindon, 1981 .

A study of exocyclic radical reductions of polysubstituted tetrahydropyrans.

S. Gorelsky, M. Prévost, Philippe Mochirian, 2013, The Journal of organic chemistry.

L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3- methyl-5-propyl-4-benzofuranol): a novel, selective, orally active 5-lipoxygenase inhibitor.

A. Ford-hutchinson, A. Maycock, C. Mcfarlane, 1987, Canadian journal of physiology and pharmacology.

Stereospecific synthesis of leukotriene B4 (LTB4)

R. Zamboni, J. Rokach, Y. Guindon, 1982 .

Pharmacology of L-655,240 (3-[1-(4-chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]2,2-dimethylpro pan oic acid); a potent, selective thromboxane/prostaglandin endoperoxide antagonist.

D. Éthier, J. Evans, A. Ford-hutchinson, 1987, European journal of pharmacology.

Synthesis of Sialyl LewisX Glycomimetics Bearing a Bicyclic 3- O,4- C-Fused Galactopyranoside Scaffold.

P. Colarusso, M. Nemer, K. Patel, 2019, The Journal of organic chemistry.

Diastereoselective Synthesis of C2'-Fluorinated Nucleoside Analogues Using an Acyclic Approach.

M. Prévost, Philippe Mochirian, Y. Guindon, 2016, The Journal of organic chemistry.

Dual-face nucleoside scaffold featuring a stereogenic all-carbon quaternary center. Intramolecular silicon tethered group-transfer reaction.

M. Prévost, Philippe Mochirian, Y. Guindon, 2014, Organic letters.

Nucleotide Analogues Bearing a C2′ or C3′-Stereogenic All-Carbon Quaternary Center as SARS-CoV-2 RdRp Inhibitors

G. Wang, M. Nemer, Adrian Oo, 2022, Molecules.

Investigation of diastereoselective acyclic α-alkoxydithioacetal substitutions involving thiacarbenium intermediates.

M. Prévost, Y. Guindon, Starr Dostie, 2014, The Journal of organic chemistry.

Exceptionally mild and stereospecific ring fragmentations promoted by dimethylboron bromide

J. Gauthier, Y. Guindon, 1987 .

Synthesis of β-Trimethylsilyloxythioethers and β-Hydroxythioethers by the Reaction of Epoxides with Aryl- and Alkylthiotrimethylsilanes

R. Young, R. Frenette, Y. Guindon, 1981 .

Photoredox Catalyzed Stereoselective Radical Reactions to Synthesize Nucleoside Analogues with a C2'-Stereogenic All-Carbon Quaternary Center.

M. Prévost, Y. Guindon, Starr Dostie, 2019, The Journal of organic chemistry.

Diastereoselective synthesis of 2,3-disubstituted tetrahydrofuran synthons via the iodoetherification reaction. A transition state model based rationalization of the allylic asymmetric induction

M. Labelle, Y. Guindon, 1989 .

Homoallylic chiral induction in the synthesis of 2,4-disubstituted tetrahydrofurans by iodoetherification. Synthetic scope and chiral induction mechanism

J. Springer, M. Labelle, Y. Guindon, 1988 .

Chemistry of the glycosidic linkage. Direct conversion of glycosides into 1-thioglycosides by use of [alkyl(or aryl)thio]trimethylsilanes

S. Hanessian, Y. Guindon, 1980 .

Synthesis of polypropionate motifs containing the anti–anti unit

B. Guérin, M. Prévost, Philippe Mochirian, 2002 .

Assembly of the carbon skeletal framework of erythronolide A

S. Hanessian, Y. Guindon, G. Rancourt, 1978 .

Facile access to ethyl 2-C-β-D-ribofuranosylacetates

S. Hanessian, Y. Guindon, T. Ogawa, 1974 .

Intramolecular Aminyl and Iminyl Radical Additions to α,β-Unsaturated Esters. Diastereoselective Tandem Cyclofunctionalization and Hydrogen Transfer Reactions

B. Guérin, S. Landry, Y. Guindon, 2001 .

PRACTICAL, STEREOSELECTIVE SYNTHESIS OF PALINAVIR, A POTENT HIV PROTEASE INHIBITOR

C. Yoakim, P. Anderson, J. Gillard, 1997 .

Large scale preparation of (2S,3S)-N-Boc-3-amino-1,2-epoxy-4-phenylbutane: A key building block for HIV-protease inhibitors

P. Beaulieu, D. Wernic, Y. Guindon, 1995 .

Synthesis of 2,3-anti-3,4-anti and 2,3-anti-3,4-syn propionate motifs: a diastereoselective tandem sequence of Mukaiyama and free-radical-based hydrogen transfer reactions.

B. Guérin, M. Prévost, Philippe Mochirian, 2002, Organic letters.

Synthesis of tertiary and quaternary stereogenic centers: a diastereoselective tandem reaction sequence combining Mukaiyama and free radical-based allylation.

B. Guérin, Y. Guindon, B. Cardinal-David, 2005, The Journal of organic chemistry.

Stereoselective Hydrogen Transfer Reactions Involving Acyclic Radicals. Tandem Substituted Tetrahydrofuran Formation and Stereoselective Reduction: Synthesis of the C17-C22 Subunit of Ionomycin

C. Yoakim, D. Delorme, A. Slassi, 1994 .

2.16 Selected Diastereoselective Reactions: Free Radical Additions and Cyclizations

M. Prévost, Philippe Mochirian, Y. Guindon, 2012 .

A bidirectional approach to the synthesis of polypropionates: synthesis of C1-C13 fragment of zincophorin and related isomers.

Philippe Mochirian, Y. Guindon, Jean-François Brazeau, 2011, The Journal of organic chemistry.

Total synthesis of zincophorin methyl ester. Stereocontrol of 1,2-induction using sterically hindered enoxysilanes

Philippe Mochirian, Y. Guindon, Gabrielle St-Pierre, 2015 .

tert-Butylmethoxyphenylsilyl ether-a new selective, stable alcohol protecting group with remarkable lability to fluoride

C. Yoakim, J. Gillard, Y. Guindon, 1984 .

Diastereoselective synthesis of 2,3,5-trisubstituted tetrahydrofurans via cyclofunctionalization reactions. Evidence of stereoelectronic effects.

C. Yoakim, L. Plamondon, F. Soucy, 2001, The Journal of organic chemistry.

Stereoselective rardical-mediated reduction and alkylation of α-halo esters

C. Yoakim, C. Chabot, B. Simoneau, 1991 .

Stereocontrol in radical processes through the exocyclic effect: dual role of triethylboron as radical initiator and in situ derivatization agent.

B. Guérin, Y. Guindon, G. Jung, 2001, Organic letters.

Cleavage of carbonoxygen bonds. Dimethylboron bromide. A new reagent for ether cleavage

C. Yoakim, Y. Guindon, H. Morton, 1983 .

Direct synthesis of thio ethers from thiols and alcohols

J. Rokach, R. Frenette, Y. Guindon, 1983 .

Stereoselective silver triflate-mediated iodocyclization of carbamates

A. Slassi, G. Bantle, Y. Guindon, 1992 .

Study of the endocyclic versus exocyclic C-O bond cleavage pathways of α- and β-methyl furanosides.

M. Prévost, Y. Guindon, Olivier St-Jean, 2013, The Journal of organic chemistry.

Cyclofunctionalization and free-radical-based hydrogen-transfer reactions. An iterative reaction sequence applied to the synthesis of the C(7)-C(16) subunit of zincophorin.

B. Guérin, A. Faucher, S. Landry, 2001, The Journal of organic chemistry.

STEREOSELECTIVE RADICAL CARBON-CARBON BOND FORMING REACTIONS OF BETA -ALKOXY ESTERS : ATOM AND GROUP TRANSFER ALLYLATIONS UNDER BIDENTATE CHELATION CO NTROLLED CONDITIONS

C. Chabot, B. Guérin, Y. Guindon, 1996 .

Intramolecular oxygen radical additions to α,β-unsaturated esters. Diastereoselective tandem cyclofunctionalization and hydrogen transfer reactions

R. Denis, Y. Guindon, 1998 .

Synthesis of postulated molecular probes: stereoselective free-radical-mediated C-glycosylation in tandem with hydrogen transfer.

Y. Guindon, A. Bouzide, M. Bencheqroun, 2005, Journal of the American Chemical Society.

The effect of polar substituents on the conformation and stereochemistry of enolate radicals

B. Giese, J. Rancourt, F. Wetterich, 1993 .

Stereoselective hydrogen-transfer reactions involving acyclic radicals. A study of radical conformations using semiempirical calculations

Kathleen A. Durkin, J. Rancourt, D. Liotta, 1992 .

Stereoelectronic effects in the ring cleavage of methyl glycopyranosides using dimethylboron bromide

Y. Guindon, P. C. Anderson, 1987 .

Free radicals and Lewis acid. Chelation-controlled radical allylations of substituted α-halo- or α-phenylseleno-β-alkoxy esters. The endocyclic effect.

C. Chabot, B. Guérin, Y. Guindon, 2000 .

Dialkyl and diaryl boron halides: reductive opening of benzylidene acetals

C. Yoakim, Y. Girard, S. Berthiaume, 1990 .

A stereoselective approach to β-L-arabino nucleoside analogues: synthesis and cyclization of acyclic 1',2'-syn N,O-acetals.

M. Prévost, Y. Guindon, Starr Dostie, 2012, The Journal of organic chemistry.

Stereoselective opening of acetals derived from dimethyl tartrate

Y. Guindon, W. Ogilvie, B. Simoneaua, 1991 .

Synthetic utility of chiral tetrahydrofurans: Preparation of (1R, 3R, 5S)-1, 3-dimethyl-2, 9-dioxabicyclo[3.3.1]nonane

Y. Guindon, H. Morton, S. Daigneault, 1986 .

A C-glycoside route to leukotrienes

R. Zamboni, J. Rokach, Y. Guindon, 1981 .

Utilization of functionalized polymers in synthesis: immobilization of carbohydrates as acetals, and some chemical transformations

R. Roy, S. Hanessian, Y. Guindon, 1974 .

Total synthesis of 11-oxaprostaglandin F2α and F2β

S. Hanessian, P. Lavallée, Y. Guindon, 1985 .

Cleavage of methyl and benzyl ethers with thiotrimethylsilanes

S. Hanessian, Y. Guindon, 1980 .

Dimethylboron bromide--interconversion of protecting groups: preparation of MTM [(methylthio)methyl] ethers, O,S-acetals, and cyanomethyl ethers

Y. Guindon, H. Morton, 1985 .

Stereopentads derived from a sequence of Mukaiyama aldolization and free radical reduction on alpha-methyl-beta-alkoxy aldehydes: a general strategy for efficient polypropionate synthesis.

M. Prévost, Philippe Mochirian, Y. Guindon, 2009, The Journal of organic chemistry.

Diastereoselective mukaiyama and free radical processes for the synthesis of polypropionate units.

Y. Guindon, Jean-François Brazeau, 2004, Organic letters.

Dimethylboron bromide and diphenylboron bromide: cleavage of acetals and ketals

C. Yoakim, Y. Guindon, H. Morton, 1984 .

Synthesis of propionate motifs: diastereoselective tandem reactions involving anionic and free radical based processes.

B. Guérin, S. Landry, B. Daoust, 2001, Journal of the American Chemical Society.

Hydrogen and Allylation Transfer Reactions in Acyclic Free Radicals

B. Guérin, Y. Guindon, W. Ogilvie, 1998 .

The Exocyclic Effect: Protecting Group Strategy to Enhance Stereoselectivity in Hydrogen Transfer Reactions of Acyclic Free Radicals

A. Faucher, S. Landry, Y. Guindon, 1997 .

The Exo-Cyclic Effect: Strategy Employing in Situ Derivatization or Lewis Acid Complexation to Enhance Stereoselectivity in Hydrogen Transfer Reactions

Ziping Liu, Y. Guindon, G. Jung, 1997 .

The preparation of octahydro leukotrienes C, D, and E via a stereoselective sulfenyllactonization reaction

R. Young, D. Éthier, J. Rokach, 1981 .

Lewis acids in diastereoselective processes involving acyclic radicals

C. Chabot, J. Rancourt, B. Guérin, 1996 .

Symmetrical alkoxysilyl ethers. A new class of alcohol-protecting groups. Preparation of tert-butoxydiphenylsilyl ethers

C. Yoakim, J. Gillard, Y. Guindon, 1988 .

Synthesis of 1',2'-cis-nucleoside analogues: evidence of stereoelectronic control for SN2 reactions at the anomeric center of furanosides.

M. Prévost, Y. Guindon, Olivier St-Jean, 2010, Journal of the American Chemical Society.

A new approach to explore the binding space of polysaccharide-based ligands: selectin antagonists.

M. Vaillancourt, Y. Guindon, B. Wilkes, 2012, ACS medicinal chemistry letters.

Ring cleavage of THP and THF ethers using dimethylboron bromide

M. Bernstein, Y. Guindon, P. C. Anderson, 1987 .

Preparation of ethyl 5(s),6-epoxy-3(r)-(methoxymethoxy)hexanoate: a key chiral intermediate for mevinolin and compactin.

C. Yoakim, M. Bernstein, Y. Guindon, 1985 .

Ring Cleavage of THP and THF Ethers Using Dimethylboron Bromide.

M. Bernstein, Y. Guindon, P. C. Anderson, 1987 .

Role of .sigma.-Donation in the Stereocontrol of Hydrogen-Transfer Reactions Involving Acyclic Radicals

J. Rancourt, A. Slassi, G. Bantle, 1995 .

New synthetic applications of dialkylboron halide reagents

C. Yoakim, Y. Girard, S. Berthiaume, 1988 .

Synthesis of N-glycosides. An alternative approach based on diastereoselective base coupling and S(N)2 cyclization.

B. Guérin, M. Gagnon, Y. Guindon, 2002, Organic Letters.

Influence of N-substituted lactams on acyclic free radical based hydrogen transfer

Y. Guindon, M. Bencheqroun, 2001 .

The Use of Lewis Acids in Radical Chemistry. Chelation-Controlled Radical Reductions of Substituted α-Bromo-β-alkoxy Esters and Chelation-Controlled Radical Addition Reactions

J. Rancourt, Y. Guindon, 1998 .

Stereoselective reduction of acyclic α-bromo esters

C. Yoakim, D. Delorme, Y. Guindon, 1990 .

Practical, Stereoselective Synthesis of Palinavir, a Potent HIV Protease Inhibitor.

C. Yoakim, P. Anderson, J. Gillard, 2010 .

Diastereoselective Synthesis of Arabino- and Ribo-like Nucleoside Analogues Bearing a Stereogenic C3' All-Carbon Quaternary Center.

M. Prévost, Philippe Mochirian, Y. Guindon, 2019, The Journal of organic chemistry.

A stereoselective approach to nucleosides and 4'-thioanalogues from acyclic precursors.

M. Gagnon, M. Prévost, Y. Guindon, 2009, Journal of the American Chemical Society.

Synthesis of N-Glycosides. An Alternative Approach Based on Diastereoselective Base Coupling and SN2 Cyclization.

B. Guérin, M. Gagnon, Y. Guindon, 2002 .

Exceptionally Mild and Stereospecific Ring Fragmentations Promoted by Dimethylboron Bromide.

J. Gauthier, Y. Guindon, 1988 .

Stereoselective Radical Allylation of α-Iodo-β-Alkoxy Esters: Reversal of Facial Selectivity by Lewis Acid Complexation

C. Chabot, B. Guérin, Y. Guindon, 1995 .

Direct synthesis of thio ethers from thiols and alcohols

J. Rokach, R. Frenette, Y. Guindon, 1983 .

Acyclic tethers mimicking subunits of polysaccharide ligands: selectin antagonists.

J. Gratton, M. Vaillancourt, M. Prévost, 2014, ACS medicinal chemistry letters.

Stereoselective chelation-controlled reduction of .alpha.-iodo-.beta.-alkoxy esters under radical conditions

J. Rancourt, Y. Guindon, J. Lavallée, 1991 .

A potent peptidomimetic inhibitor of HSV ribonucleotide reductase with antiviral activity in vivo

M. Garneau, P. Beaulieu, J. Chafouleas, 1994, Nature.

L-651,392: a novel, potent and selective 5-lipoxygenase inhibitor.

R. Egan, A. Ford-hutchinson, Y. Girard, 1987, Advances in prostaglandin, thromboxane, and leukotriene research.

Total synthesis of LTB4 and analogs

R. Zamboni, D. Delorme, Y. Guindon, 1988 .

Photoaffinity labelling of the human platelet thromboxane A2/prostaglandin H2 receptor.

C. Yoakim, J. Rokach, J. Gillard, 1989, Biochimica et biophysica acta.

Identification of a C3'-nitrile nucleoside analogue inhibitor of pancreatic cancer cell line growth.

M. Nemer, M. Prévost, Y. Guindon, 2020, Bioorganic & medicinal chemistry letters.

Design and synthesis of a new sialyl Lewis X mimetic: how selective are the selectin receptors?

N. Goudreau, D. Gravel, M. Vaillancourt, 2001, Bioorganic & medicinal chemistry letters.

Stereoselective quaternary center construction via atom-transfer radical cyclization using silicon tethers on acyclic precursors.

M. Duplessis, Y. Guindon, B. Cardinal-David, 2009, Organic letters.

Stereoselective Quaternary Center Construction via Atom‐Transfer Radical Cyclization Using Silicon Tethers on Acyclic Precursors.

M. Duplessis, Y. Guindon, B. Cardinal-David, 2009 .

The synthesis of a leukotriene with SRS-like activity

P. Masson, Robert N. Young, Yves Girard, 1980 .

Sialyl LewisX glycomimetics bearing an extended anionic chain targeting E- and P- selectin binding sites

M. Prévost, Y. Guindon, Wael M Maharsy, 2023, Bioorganic & Medicinal Chemistry.

Identification of a C2′-fluorinated SAH analogue

Fengling Li, V. Santhakumar, Y. Guindon, 2020 .