S. Cotecchia

发表

The α1-Adrenergic Receptor as a Paradigm of Receptors Coupled to Guanine Nucleotide Binding Proteins

M. Caron, R. Lefkowitz, D. Schwinn, 1990 .

Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.

M. Caron, B. Kobilka, R. Lefkowitz, 1990, The Journal of biological chemistry.

Gain-of-function mutations of the V2 vasopressin receptor in nephrogenic syndrome of inappropriate antidiuresis (NSIAD): a cell-based assay to assess constitutive water reabsorption

Annarita Di Mise, G. Tamma, M. Ranieri, 2019, Pflügers Archiv - European Journal of Physiology.

G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.

M. Caron, R. Lefkowitz, L. F. Allen, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Constitutively active mutants of the alpha 2-adrenergic receptor.

R. Lefkowitz, H. Kurose, S. Cotecchia, 1993, The Journal of biological chemistry.

Decreased blood pressure response in mice deficient of the alpha1b-adrenergic receptor.

G. Lembo, C. Vecchione, T. Pedrazzini, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Agonist-induced beta-adrenergic receptor internalization on intact human mononuclear leukocytes: effect of temperature of mononuclear leukocyte separation.

M. Fratelli, A. de Blasi, S. Cotecchia, 1986, The Journal of laboratory and clinical medicine.

Abstracts, Poster Session

A. Zlotta, O. Rampin, J. Sullivan, 1999, European Urology.

A-Kinase-Anchoring Protein–Lbc Anchors IκB Kinase β To Support Interleukin-6-Mediated Cardiomyocyte Hypertrophy

D. Diviani, S. Cotecchia, C. D. del Vescovo, 2012, Molecular and Cellular Biology.

Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor.

R. Lefkowitz, G. Pei, T. Costa, 1994, Molecular pharmacology.

Expression and Secretion of the Atrial Natriuretic Peptide in Human Adipose Tissue and Preadipocytes

C. Darimont, R. Giorgino, V. Giusti, 2007, Obesity.

B2 kinin receptor-mediated internalization of bradykinin in DDT1 MF-2 smooth muscle cells is paralleled by sequestration of the occupied receptors.

L. M. Leeb-Lundberg, S. Cotecchia, C. M. Munoz, 1993, Archives of biochemistry and biophysics.

α1‐Adrenoceptors are required for normal male sexual function

G. Tsujimoto, A. Tanoue, A. Sanbe, 2007 .

RESEARCH PAPER a 1 -Adrenoceptors are required for normal male sexual function

G. Tsujimoto, A. Tanoue, A. Sanbe, 2007 .

Adrenergic receptors: recent insights into their mechanism of activation and desensitization.

M. Caron, R. Lefkowitz, James Inglese, 1993, Advances in second messenger and phosphoprotein research.

Impaired Glucose Homeostasis in Mice Lacking the α1b-Adrenergic Receptor Subtype*

M. Foretz, C. Perrin, R. Burcelin, 2004, Journal of Biological Chemistry.

Enhanced vascular contractility in alpha1-adrenergic receptor-deficient mice.

G. Tsujimoto, A. Tanoue, A. Sanbe, 2009, Life sciences.

The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse.

E. Foster, T. O’Connell, P. Simpson, 2003, The Journal of clinical investigation.

Neuroendocrine deregulation of food intake, adipose tissue and the gastrointestinal system in obesity and metabolic syndrome.

R. Giorgino, G. Garruti, F. Giorgino, 2008, Journal of gastrointestinal and liver diseases : JGLD.

Gene deletion of dopamine β-hydroxylase and α1-adrenoceptors demonstrates involvement of catecholamines in vascular remodeling

G. Tsujimoto, J. Faber, A. Tanoue, 2004 .

Altered catecholamine receptor affinity in rabbit aortic intimal hyperplasia.

P. Hagen, S. Cotecchia, M. K. O'malley, 1991, The Journal of surgical research.

The α1-adrenergic receptors: diversity of signaling networks and regulation

S. Cotecchia, 2010, Journal of receptor and signal transduction research.

Tissue transglutaminase (TG2) acting as G protein protects hepatocytes against Fas‐mediated cell death in mice

G. Melino, L. Fésüs, T. Németh, 2005, Hepatology.

Protein-Protein Interactions at the Adrenergic Receptors

D. Diviani, S. Cotecchia, L. Stanasila, 2012, Current drug targets.

The α -Adrenergic Receptors: New Subtypes, Pharmacology, and Coupling Mechanisms

J. Regan, S. Cotecchia, 1992 .

Adrenergic receptor homologies in vertebrate and invertebrate species examined by DNA hybridization.

M. Caron, J. Palacios, R. Lefkowitz, 1989, Life sciences.

Cardiovascular Influences of (cid:1) 1b -Adrenergic Receptor Defect in Mice

L. Fratta, E. Porteri, D. Rizzoni, 2002 .

The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates α1 adrenergic receptor-induced cardiomyocyte hypertrophy

T. Pedrazzini, A. Appert-Collin, D. Diviani, 2007, Proceedings of the National Academy of Sciences.

Critical Role for the &agr;-1B Adrenergic Receptor at the Sympathetic Neuroeffector Junction

A. Shoukas, J. Hare, L. Barouch, 2004, HYPERTENSION.

Murine alpha1-adrenoceptor subtypes. I. Radioligand binding studies.

M. Michel, S. Cotecchia, M. Yang, 1998, The Journal of pharmacology and experimental therapeutics.

Murine Alpha 1-Adrenoceptor Subtypes . I . Radioligand Binding Studies 1

Ming Yang, M. Michel, S. Cotecchia, 1998 .

Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features.

M. Caron, A. Scheer, S. Mhaouty-Kodja, 1999, Molecular pharmacology.

Truncation of the receptor carboxyl terminus impairs agonist-dependent phosphorylation and desensitization of the alpha 1B-adrenergic receptor.

D. Diviani, S. Cotecchia, A. Lattion, 1994, The Journal of biological chemistry.

Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein.

M. Caron, R. Lefkowitz, E. Lapetina, 1991, Cellular signalling.

Stress induced desensitization of lymphocyte β-adrenoceptors in young and aged rats

M. Fratelli, S. Cotecchia, A. Blasi, 1986, Pharmacology Biochemistry and Behavior.

Benzodiazepines: Relationship between pharmacological activity in the rat and in vivo receptor binding

S. Garattini, S. Caccia, T. Mennini, 1982, Pharmacology Biochemistry and Behavior.

Constitutively active mutants of the beta1-adrenergic receptor.

L. Abuin, S. Cotecchia, A. Lattion, 1999, FEBS letters.

Molecular mechanisms involved in the activation and regulation of the alpha 1-adrenergic receptor subtypes.

A. Scheer, F. Fanelli, P. D. De Benedetti, 1998, Farmaco.

Up-regulation of the levels of expression and function of a constitutively active mutant of the hamster alpha1B-adrenoceptor by ligands that act as inverse agonists.

G. Milligan, S. Cotecchia, T. Lee, 1997, The Biochemical journal.

(cid:1) 1 -Selective Agonist ( (cid:1) )-1-(3,4-Dimethoxyphenetylamino)-3-(3,4-dihydroxy)-2-propanol [( (cid:1) )-RO363] Differentially Interacts with Key Amino Acids Responsible for (cid:1) 1 -Selective Binding in Resting and Active States

G. Tsujimoto, T. Nagao, H. Kurose, 2002 .

A quantitative analysis of antagonism and inverse agonism at wild-type and constitutively active hamster α1B-adrenoceptors

M. Michel, P. Hein, M. Goepel, 2000, Naunyn-Schmiedeberg's Archives of Pharmacology.

Glucocorticoids increase β-adrenoceptors on human intact lymphocytes in vitro

S. Cotecchia, A. Blasi, 1984 .

Different Internalization Properties of the α1a- and α1b-Adrenergic Receptor Subtypes: The Potential Role of Receptor Interaction with β-Arrestins and AP50

L. Abuin, S. Cotecchia, L. Stanasila, 2008, Molecular Pharmacology.

Oligomerization of the alpha 1a- and alpha 1b-adrenergic receptor subtypes. Potential implications in receptor internalization.

H. Vogel, S. Cotecchia, Jean-Baptiste Perez, 2003, The Journal of biological chemistry.

Historical review: Negative efficacy and the constitutive activity of G-protein-coupled receptors.

T. Costa, S. Cotecchia, 2005, Trends in pharmacological sciences.

Characterization of the Phosphorylation Sites Involved in G Protein-coupled Receptor Kinase- and Protein Kinase C-mediated Desensitization of the α1B-Adrenergic Receptor*

D. Diviani, S. Cotecchia, A. Lattion, 1997, The Journal of Biological Chemistry.

The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity.

M. Caron, S. Liggett, R. Lefkowitz, 1991, Molecular pharmacology.

Phorbol ester effects on alpha 1-adrenoceptor binding and phosphatidylinositol metabolism in cultured vascular smooth muscle cells.

M. Caron, R. Lefkowitz, P. Hagen, 1985, Life sciences.

Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis.

M. Caron, R. Lefkowitz, J. Ostrowski, 1992, The Journal of biological chemistry.

Alpha1-adrenoceptor-dependent vascular hypertrophy and remodeling in murine hypoxic pulmonary hypertension.

G. Tsujimoto, J. Faber, A. Tanoue, 2007, American journal of physiology. Heart and circulatory physiology.

Constitutive activity and inverse agonism at the alpha1adrenoceptors.

S. Cotecchia, 2007, Biochemical pharmacology.

Ezrin directly interacts with AQP2 and promotes its endocytosis

Dennis Brown, Kenji Tsuji, William Jin, 2017, Journal of Cell Science.

Co- and posttranslational modification of the alpha(1B)-adrenergic receptor: effects on receptor expression and function.

L. Abuin, P. Greasley, S. Cotecchia, 2002, Biochemistry.

Complete hypogonadotropic hypogonadism associated with a novel inactivating mutation of the gonadotropin-releasing hormone receptor.

M. Aubert, L. Abuin, F. Pralong, 1999, The Journal of clinical endocrinology and metabolism.

Coupling of the expressed alpha 1B-adrenergic receptor to the phospholipase C pathway in Xenopus oocytes. The role of Go.

M. Caron, R. Blitzer, R. Lefkowitz, 1993, The Journal of biological chemistry.

The Vasopressin Receptor 2 Mutant R137L Linked to the Nephrogenic Syndrome of Inappropriate Antidiuresis (NSIAD) Signals through an Alternative Pathway that Increases AQP2 Membrane Targeting Independently of S256 Phosphorylation

G. Tamma, M. Ranieri, M. Centrone, 2020, Cells.

Selective changes of receptor binding in brain regions of aged rats.

A. de Blasi, T. Mennini, S. Cotecchia, 1982, Life sciences.

Molecular biology of α-adrenergic receptors: implications for receptor classification and for structure-function relationships

M. Caron, R. Lefkowitz, J. Lomasney, 1991 .

Molecular biology of alpha-adrenergic receptors: implications for receptor classification and for structure-function relationships.

M. Caron, R. Lefkowitz, J. Lomasney, 1991, Biochimica et Biophysica Acta.

Adrenoceptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

R. Graham, D. Bylund, K. Minneman, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

THE α1b-ADRENERGIC RECEPTOR SUBTYPE: MOLECULAR PROPERTIES AND PHYSIOLOGICAL IMPLICATIONS

F. Fanelli, O. Rossier, P. Greasley, 2002, Journal of receptor and signal transduction research.

Paired Activation of Two Components within Muscarinic M3 Receptor Dimers Is Required for Recruitment of β-Arrestin-1 to the Plasma Membrane*

F. Giorgi, G. Corsini, R. Maggio, 2005, Journal of Biological Chemistry.

Constitutively active mutants of the alpha 1B‐adrenergic receptor: role of highly conserved polar amino acids in receptor activation.

A. Scheer, F. Fanelli, P. D. De Benedetti, 1996, The EMBO journal.

Effect of Different G Protein-coupled Receptor Kinases on Phosphorylation and Desensitization of the -Adrenergic Receptor (*)

J. Benovic, P. Kunapuli, A. Pronin, 1996, The Journal of Biological Chemistry.

Phosphorylation of the Na,K-ATPase alpha-subunit by protein kinase A and C in vitro and in intact cells. Identification of a novel motif for PKC-mediated phosphorylation.

K. Geering, F. Jaisser, P. Mathews, 1994, The Journal of biological chemistry.

A Look at Receptor Efficacy. From the Signalling Network of the Cell to the Intramolecular Motion of the Receptor

A. Scheer, Alexander Scheer, T. Costa, 2000 .

Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.

M. Caron, R. Lefkowitz, J. Lomasney, 1985, Proceedings of the National Academy of Sciences of the United States of America.

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

R. Lefkowitz, T. Costa, S. Cotecchia, 1993, The Journal of biological chemistry.

α1b-Adrenergic Receptors Control Locomotor and Rewarding Effects of Psychostimulants and Opiates

J. Glowinski, J. Tassin, S. Cotecchia, 2002, The Journal of Neuroscience.

Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.

M. Caron, B. Kobilka, R. Lefkowitz, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5.

M. Caron, M. Brownstein, R. Lefkowitz, 1991, The Journal of biological chemistry.

Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells.

M. Caron, R. Lefkowitz, L. M. Leeb-Lundberg, 1987, The Journal of biological chemistry.

Anchoring of both PKA and 14‐3‐3 inhibits the Rho‐GEF activity of the AKAP‐Lbc signaling complex

L. Abuin, D. Diviani, S. Cotecchia, 2004, The EMBO journal.

Vasopressin receptor 2 mutations in the nephrogenic syndrome of inappropriate antidiuresis show different mechanisms of constitutive activation for G protein coupled receptors

P. Molinari, T. Costa, C. Ambrosio, 2020, Scientific Reports.

Effector coupling mechanisms of the cloned 5-HT1A receptor.

M. Caron, R. Lefkowitz, J. Regan, 1989, The Journal of biological chemistry.

Constitutive activity and inverse agonism at the alpha1adrenoceptors.

S. Cotecchia, 2007, Biochemical pharmacology.

Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.

M. Caron, R. Lefkowitz, J. Ostrowski, 1992, The Journal of biological chemistry.

Constitutively active G protein-coupled receptors: potential mechanisms of receptor activation.

A. Scheer, S. Cotecchia, Susanna Cotecchia, 1997, Journal of receptor and signal transduction research.

Constitutively active G protein-coupled receptor mutants: implications on receptor function and drug action.

F. Fanelli, T. Costa, S. Cotecchia, 2003, Assay and drug development technologies.

Mutagenesis and modelling of the alpha(1b)-adrenergic receptor highlight the role of the helix 3/helix 6 interface in receptor activation.

Francesca Fanelli, Olivier Rossier, F. Fanelli, 2002, Molecular pharmacology.

Mutations inducing divergent shifts of constitutive activity reveal different modes of binding among catecholamine analogues to the β2‐adrenergic receptor

A. IJzerman, T. Costa, C. Ambrosio, 2002, British journal of pharmacology.

Catechol-binding serines of beta(2)-adrenergic receptors control the equilibrium between active and inactive receptor states.

P. Molinari, T. Costa, C. Ambrosio, 2000, Molecular pharmacology.

Structure-Function Relationships of the α1b-Adrenergic Receptor

A. Scheer, F. Fanelli, P. D. De Benedetti, 1999, European Urology.

Constitutively active α1B-adrenergic receptor mutants: Potential mechanisms underlying receptor activation

A. Scheer, F. Fanelli, T. Costa, 1997 .

Cardiovascular Influences of &agr;1b-Adrenergic Receptor Defect in Mice

L. Fratta, E. Porteri, D. Rizzoni, 2002, Circulation.

Norepinephrine decreases EGF binding in primary rat hepatocyte cultures

G. Michalopoulos, S. Cotecchia, J. Cruise, 1986, Journal of cellular physiology.

Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype.

M. Caron, R. Lefkowitz, R. Fremeau, 1990, The Journal of biological chemistry.

The alpha1-adrenergic receptors in cardiac hypertrophy: signaling mechanisms and functional implications.

D. Diviani, M. Colella, S. Cotecchia, 2015, Cellular signalling.

Oligomerization of the α1a- and α1b-Adrenergic Receptor Subtypes

Horst Vogel, Jean-Baptiste Perez, H. Vogel, 2003, Journal of Biological Chemistry.

5‐HT2A and α1b‐adrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulants

J. Glowinski, J. Tassin, S. Cotecchia, 2004, The European journal of neuroscience.

d-Amphetamine Fails to Increase Extracellular Dopamine Levels in Mice Lacking α1b-Adrenergic Receptors: Relationship between Functional and Nonfunctional Dopamine Release

J. Glowinski, J. Tassin, S. Cotecchia, 2002, The Journal of Neuroscience.

Effects of m-chlorophenylpiperazine on receptor binding and brain metabolism of monoamines in rats

R. Samanin, T. Mennini, R. Invernizzi, 1981, Neurochemistry International.

Adrenergic, dopaminergic, and muscarinic receptor stimulation leads to PKA phosphorylation of Na-K-ATPase.

K. Geering, P. Béguin, S. Cotecchia, 1996, The American journal of physiology.

Ezrin Directly Interacts with the α1b-Adrenergic Receptor and Plays a Role in Receptor Recycling*

L. Abuin, D. Diviani, S. Cotecchia, 2006, Journal of Biological Chemistry.

Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors.

R. Lefkowitz, L. Luttrell, J. Ostrowski, 1993, Science.

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins.

R. Lefkowitz, T Costa, R J Lefkowitz, 1993, Trends in pharmacological sciences.

Role of brain α1B‐adrenoceptors in modafinil‐induced behavioral activity

D. Quartermain, S. Cotecchia, E. Stone, 2002, Synapse.

The activation process of the alpha1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate.

A. Scheer, F. Fanelli, P. D. De Benedetti, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Amino acids of the α 1B‐adrenergic receptor involved in agonist binding: differences in docking catecholamines to receptor subtypes

F. Fanelli, P. D. De Benedetti, A. Cavalli, 1996, FEBS letters.

Ab initio modeling and molecular dynamics simulation of the alpha 1b-adrenergic receptor activation.

A. Scheer, F. Fanelli, P. D. De Benedetti, 1998, Methods.

Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function.

M. Caron, R. Lefkowitz, S. Cotecchia, 1990, Proceedings of the National Academy of Sciences of the United States of America.

The effect of mutations in the DRY motif on the constitutive activity and structural instability of the histamine H(2) receptor.

R. Leurs, M. Smit, H. Timmerman, 2000, Molecular pharmacology.

Mutational analysis of the highly conserved arginine within the Glu/Asp-Arg-Tyr motif of the alpha(1b)-adrenergic receptor: effects on receptor isomerization and activation.

A. Scheer, S. Mhaouty-Kodja, F. Fanelli, 2000, Molecular pharmacology.

Erratum: Constitutively active mutants of the α2-adrenergic receptor (Journal of Biological Chemistry (1993) 268 (16483-16487))

R. Lefkowitz, H. Kurose, S. Cotecchia, 1994 .

Mammalian alpha 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit.

M. Caron, R. Lefkowitz, J. Regan, 1986, The Journal of biological chemistry.

α1-Adrenoceptor-dependent vascular hypertrophy and remodeling in murine hypoxic pulmonary hypertension

G. Tsujimoto, J. Faber, A. Tanoue, 2007 .

Expression of the alpha 1b-adrenergic receptor and G protein subunits in mammalian cell lines using the Semliki Forest virus expression system.

K. Lundstrom, A. Scheer, S. Cotecchia, 1999, Journal of receptor and signal transduction research.

Theoretical study of the electrostatically driven step of receptor‐G protein recognition

A. Scheer, F. Fanelli, P. D. De Benedetti, 1999, Proteins.

Theoretical study on receptor-G protein recognition: new insights into the mechanism of the α1b-adrenergic receptor activation

A. Scheer, F. Fanelli, P. Benedetti, 1999 .

Structural determinants involved in the activation and regulation of G protein‐coupled receptors: lessons from the alpha1‐adrenegic receptor subtypes

F. Fanelli, O. Rossier, D. Diviani, 2004 .

Structural determinants involved in the activation and regulation of G protein-coupled receptors: lessons from the alpha1-adrenegic receptor subtypes.

F. Fanelli, O. Rossier, D. Diviani, 2004, Biology of the cell.

The α1A/C- and α1B-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse

E. Foster, T. O’Connell, P. Simpson, 2003 .

Two α1-Adrenergic Receptor Subtypes Regulating the Vasopressor Response Have Differential Roles in Blood Pressure Regulation

G. Tsujimoto, C. Hosoda, T. Koshimizu, 2005, Molecular Pharmacology.

Correlation between vasoconstrictor roles and mRNA expression of α1‐adrenoceptor subtypes in blood vessels of genetically engineered mice

G. Tsujimoto, C. Hosoda, T. Koshimizu, 2005, British journal of pharmacology.

The α1a and α1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action

F. Fanelli, O. Rossier, A. Leonardi, 2000 .

Inverse agonism and neutral antagonism at alpha(1a)- and alpha(1b)-adrenergic receptor subtypes.

F. Fanelli, O. Rossier, L. Abuin, 1999, Molecular pharmacology.

Inverse Agonism and Neutral Antagonism at a 1 aand a 1 b-Adrenergic Receptor Subtypes

F. Fanelli, O. Rossier, L. Abuin, 1999 .

Two alpha1-adrenergic receptor subtypes regulating the vasopressor response have differential roles in blood pressure regulation.

G. Tsujimoto, C. Hosoda, T. Koshimizu, 2005, Molecular pharmacology.

Gene deletion of dopamine beta-hydroxylase and alpha1-adrenoceptors demonstrates involvement of catecholamines in vascular remodeling.

G. Tsujimoto, J. Faber, A. Tanoue, 2004, American journal of physiology. Heart and circulatory physiology.

Blockade of both α1A- and α1B-adrenergic receptor subtype signaling is required to inhibit neointimal formation in the mouse femoral artery

G. Tsujimoto, P. Simpson, C. Hosoda, 2007 .

Alpha1-adrenoceptors are required for normal male sexual function.

G. Tsujimoto, A. Tanoue, A. Sanbe, 2007, British Journal of Pharmacology.

Drugs: guide and caveats to explanatory and descriptive approaches--II. Drugs in psychiatric research.

G. Tognoni, A. de Blasi, S. Cotecchia, 1984, Journal of psychiatric research.

The alpha 1C-adrenergic receptor: a new member in the alpha 1-adrenergic receptor family.

M. Caron, R. Lefkowitz, D. Schwinn, 1990, Transactions of the Association of American Physicians.

Changes in serotonin, but not catecholamine, receptor binding in the brain of morphine-dependent rats.

R. Samanin, A. de Blasi, E. Poggesi, 1981, Molecular pharmacology.

Chromosomal organization of adrenergic receptor genes.

M. Caron, U. Francke, R. Lefkowitz, 1990, Proceedings of the National Academy of Sciences of the United States of America.

G-protein-coupled receptor genes as protooncogenes : Constitutively activating mutation of the a 1 B-adrenergic receptor enhances mitogenesis and tumorigenicity ( catecholam / tranformation / atherogenesis )

M. Caron, R. Lefkowitz, L. F. Allen, 2022 .

Constitutive activity and inverse agonism at the α(₁a) and α(₁b) adrenergic receptor subtypes.

S. Cotecchia, 2010, Methods in enzymology.

Mutational and computational analysis of the alpha(1b)-adrenergic receptor. Involvement of basic and hydrophobic residues in receptor activation and G protein coupling.

A. Scheer, F. Fanelli, L. Abuin, 2001, The Journal of biological chemistry.

AKAP-Lbc mediates protection against doxorubicin-induced cardiomyocyte toxicity.

M. Arambasic, D. Diviani, S. Cotecchia, 2017, Biochimica et biophysica acta. Molecular cell research.

Beta(1)-selective agonist (-)-1-(3,4-dimethoxyphenetylamino)-3-(3,4-dihydroxy)-2-propanol [(-)-RO363] differentially interacts with key amino acids responsible for beta(1)-selective binding in resting and active states.

G. Tsujimoto, T. Nagao, H. Kurose, 2002, The Journal of pharmacology and experimental therapeutics.

Agonist-dependent phosphorylation of the α2-adrenergic receptor by the β-adrenergic receptor kinase

M. Caron, R. Lefkowitz, J. Regan, 1987 .

Does ethyl‐β‐carboline‐3‐carboxylate interact with mouse brain benzodiazepine receptors in vivo?

S. Garattini, S. Caccia, T. Mennini, 1982, The Journal of pharmacy and pharmacology.

Sulphinpyrazone increases lymphocyte beta-adrenoceptors in man.

A. de Blasi, S. Cotecchia, 1984, British Journal of Clinical Pharmacology.

Constitutively active mutants of the β1‐adrenergic receptor

L. Abuin, S. Cotecchia, A. Lattion, 1999 .

The Adaptor Complex 2 Directly Interacts with the α1b-Adrenergic Receptor and Plays a Role in Receptor Endocytosis*

L. Abuin, D. Diviani, S. Cotecchia, 2003, Journal of Biological Chemistry.

Brain levels of tofizopam in the rat and relationship with benzodiazepine receptors

S. Garattini, S. Caccia, T. Mennini, 1982, Naunyn-Schmiedeberg's Archives of Pharmacology.

A Behavioral Study of Alpha-1b Adrenergic Receptor Knockout Mice: Increased Reaction to Novelty and Selectively Reduced Learning Capacities

F. Schenk, S. Cotecchia, M. Spreng, 2001, Neurobiology of Learning and Memory.

Ezrin directly interacts with AQP2 and promotes its endocytosis

Dennis Brown, Kenji Tsuji, William Jin, 2017, Journal of Cell Science.

Molecular biology of adrenergic receptors.

M. Caron, H. Dohlman, B. Kobilka, 1988, Cold Spring Harbor symposia on quantitative biology.

Regions of the a1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function (182-adrenergic receptor/guanine nucleotide-binding protein/phospholipase C/constitutive activity)

M. Caron, R. Lefkowitz, S. Cotecchia, 2016 .