A. Pearce

发表

GPVI and integrin αIIbβ3 signaling in platelets

O. McCarty, S. Watson, J. Auger, 2005, Journal of thrombosis and haemostasis : JTH.

The C-type Lectin Receptors CLEC-2 and Dectin-1, but Not DC-SIGN, Signal via a Novel YXXL-dependent Signaling Cascade*

Gemma L. J. Fuller, S. Watson, M. Tomlinson, 2007, Journal of Biological Chemistry.

Renal cells activate the platelet receptor CLEC-2 through podoplanin.

S. Watson, D. Jackson, A. R. Mistry, 2008, The Biochemical journal.

Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C.

E. Vigorito, M. Turner, S. Watson, 2002, Blood.

DC-SIGN and CLEC-2 Mediate Human Immunodeficiency Virus Type 1 Capture by Platelets

Gemma L. J. Fuller, J. Hoxie, S. Watson, 2006, Journal of Virology.

Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3.

E. Vigorito, M. Turner, O. McCarty, 2007, The Biochemical journal.

Chronic Obstructive Pulmonary Disease (COPD)

I. Konstantinova, A. Pearce, 2014 .

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

Gemma L. J. Fuller, S. Watson, Ángel García, 2006, Blood.

The molecular species responsible for α1‐antitrypsin deficiency are suppressed by a small molecule chaperone

J. Irving, D. Lomas, A. Fra, 2020, The FEBS journal.

Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome.

A. Hovnanian, J. Liddle, Kathrine J. Smith, 2019, Acta crystallographica. Section F, Structural biology communications.

Extensive analysis of the human platelet proteome by two‐dimensional gel electrophoresis and mass spectrometry

R. Dwek, S. Watson, Ángel García, 2004, Proteomics.

Towards complete analysis of the platelet proteome

R. Dwek, E. O’Neill, S. Watson, 2002, Proteomics.

A major role for Scar/WAVE‐1 downstream of GPVI in platelets

O. McCarty, R. Insall, L. Machesky, 2007, Journal of thrombosis and haemostasis : JTH.

A critical role for phospholipase Cgamma2 in alphaIIbbeta3-mediated platelet spreading.

S. Watson, D. Vaux, P. Wonerow, 2003, The Journal of biological chemistry.

A Critical Role for Phospholipase Cγ2 in αIIbβ3-mediated Platelet Spreading*

S. Watson, D. Vaux, P. Wonerow, 2003, Journal of Biological Chemistry.

Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II.

D. Budd, A. Holmes, L. Ciuclan, 2011, Blood.

Impaired bone morphogenetic protein receptor II signaling in a transforming growth factor-β-dependent mouse model of pulmonary hypertension and in systemic sclerosis.

C. Denton, A. Holmes, A. Gilbane, 2015, American journal of respiratory and critical care medicine.

An inhibitor of NADPH oxidase-4 attenuates established pulmonary fibrosis in a rodent disease model.

Benjamin R Bellenie, C. Cope, N. Press, 2013, American journal of respiratory cell and molecular biology.

The development of highly potent and selective small molecule correctors of Z α1-antitrypsin misfolding.

J. Irving, Zhengrong Zhu, D. Lomas, 2021, Bioorganic & medicinal chemistry letters.

The heptapeptide LSARLAF mediates platelet activation through phospholipase Cgamma2 independently of glycoprotein IIb-IIIa.

S. Watson, J. Frampton, P. Wonerow, 2004, The Biochemical journal.

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2

S. Watson, C. Hughes, J. Auger, 2008, Journal of thrombosis and haemostasis : JTH.

A role for adhesion and degranulation‐promoting adapter protein in collagen‐induced platelet activation mediated via integrin α2β1

S. Watson, C. Rudd, C. Hughes, 2012, Journal of thrombosis and haemostasis : JTH.

Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors.

A. Hovnanian, J. Liddle, P. Thomas, 2019, Bioorganic & medicinal chemistry letters.

murine megakaryopoiesis is critical for p21 SCL-mediated regulation of the cell-cycle regulator

P. Vyas, D. Ferguson, S. Watson, 2012 .

SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis.

P. Vyas, D. Ferguson, S. Watson, 2011, Blood.

A functional analysis of Wnt inducible signalling pathway protein −1 (WISP-1/CCN4)

I. Konstantinova, G. Jarai, A. Pearce, 2015, Journal of Cell Communication and Signaling.

A potent and selective Kallikrein-5 inhibitor delivers high pharmacological activity in Netherton Syndrome patient skin.

M. Lennon, A. Hovnanian, D. Grillot, 2021, The Journal of investigative dermatology.

The C-type Lectin Receptors CLEC-2 and Dectin-1, but Not DC-SIGN, Signal via a Novel YXXL-dependent

Gemma L. J. Fuller, S. Watson, M. Tomlinson, 2007 .

Role of the p110δ PI 3-kinase in integrin and ITAM receptor signalling in platelets

E. Vigorito, K. Okkenhaug, S. Watson, 2005, Platelets.

Vav family proteins are required for optimal regulation of PLCγ2 by integrin αIIbβ3

E. Vigorito, O. McCarty, S. Watson, 2007 .

Vav1 and Vav3 Have Critical but Redundant Roles in Mediating Platelet Activation by Collagen*

Elena Vigorito, Martin Turner, E. Vigorito, 2004, Journal of Biological Chemistry.

Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins.

R. Dwek, S. Watson, Ángel García, 2004, Blood.

G6b-B Inhibits Constitutive and Agonist-induced Signaling by Glycoprotein VI and CLEC-2*S⃞

S. Watson, M. Tomlinson, Y. Senis, 2008, Journal of Biological Chemistry.

Rac1 Is Essential for Platelet Lamellipodia Formation and Aggregate Stability under Flow*

N. Kalia, O. McCarty, S. Watson, 2005, Journal of Biological Chemistry.

Differential Roles of the PKC Novel Isoforms, PKCδ and PKCε, in Mouse and Human Platelets

S. Watson, C. Pears, C. Hughes, 2008, PloS one.

GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice

J. Schofield, M. Convery, Xiping Zhang, 2021, The Journal of biological chemistry.

Optimization of Platelet-Derived Growth Factor Receptor (PDGFR) Inhibitors for Duration of Action, as an Inhaled Therapy for Lung Remodeling in Pulmonary Arterial Hypertension.

P. Furet, I. Konstantinova, A. Saunders, 2016, Journal of medicinal chemistry.

Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression.

I. Clay, J. Westwick, D. Rowlands, 2013, American journal of respiratory and critical care medicine.

A functional analysis of Wnt inducible signalling pathway protein −1 (WISP-1/CCN4)

I. Konstantinova, G. Jarai, A. Pearce, 2015, Journal of Cell Communication and Signaling.

Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin

J. Irving, Zhengrong Zhu, D. Lomas, 2020, bioRxiv.

thrombin, but neither is required for regulation of phospholipase C

E. Vigorito, S. Watson, V. Tybulewicz, 2013 .

hypersensitivity in vivo Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type

A. Dietz, G. Knutson, E. Vigorito, 2004 .