H. Kimura

发表

Effects of ramelteon (TAK-375) on nocturnal sleep in freely moving monkeys

H. Nishikawa, M. Miyamoto, S. Ohkawa, 2004, Brain Research.

TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain.

T. Kawamoto, H. Kimura, Masayuki Ii, 2008, European journal of pharmacology.

Synthesis and Structure Activity Relationship Studies of Benzothieno[3,2- b ]furan Derivatives as a Novel Class of IKKβ Inhibitors

H. Oki, Toshimasa Tanaka, T. Kawamoto, 2007 .

Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.

Toshimasa Tanaka, Seiji Miwatashi, S. Asahi, 2005, Journal of medicinal chemistry.

Potent and selective inhibition of the human Na+/H+ exchanger isoform NHE1 by a novel aminoguanidine derivative T-162559.

T. Kawamoto, K. Kusumoto, H. Kimura, 2001, European journal of pharmacology.

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2).

Toshimasa Tanaka, T. Kawamoto, M. Yamaguchi, 2008, Bioorganic & medicinal chemistry.

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1).

Toshimasa Tanaka, T. Kawamoto, M. Yamaguchi, 2008, Bioorganic & medicinal chemistry.

Cloning and expression of the isopenicillin N synthase gene from Lysobacter lactamgenus YK90

Y. Sumino, H. Kimura, Masaru Suzuki, 1995 .

Cloning and Sequencing of the Putative Glyceraldehyde-3-Phosphate Dehydrogenase Gene from Cephalosporium acremonium and Its Application to Heterologous Gene Expression

Y. Sumino, H. Kimura, Masaru Suzuki, 1991 .

Physiology of α-amylase production by immobilized Bacillus amyloliquefaciens

H. Okada, A. Shinmyō, H. Kimura, 1982, European journal of applied microbiology and biotechnology.

Studies on non-thiazolidinedione antidiabetic agents. 2. Novel oxyiminoalkanoic acid derivatives as potent glucose and lipid lowering agents.

H. Imoto, Y. Momose, H. Kimura, 2003, Chemical & pharmaceutical bulletin.

Novel and potent calcium-sensing receptor antagonists: discovery of (5R)-N-[1-ethyl-1-(4-ethylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide monotosylate (TAK-075) as an orally active bone anabolic agent.

Y. Ikeda, T. Kawamoto, S. Morimoto, 2011, Bioorganic & medicinal chemistry.

Discovery of novel and potent orally active calcium-sensing receptor antagonists that stimulate pulselike parathyroid hormone secretion: synthesis and structure-activity relationships of tetrahydropyrazolopyrimidine derivatives.

Y. Ikeda, T. Kawamoto, A. Mori, 2011, Journal of medicinal chemistry.

Synthesis and structure-activity relationship of tetrahydropyrazolopyrimidine derivatives--a novel structural class of potent calcium-sensing receptor antagonists.

T. Kawamoto, M. Yamaguchi, A. Mori, 2010, Bioorganic & medicinal chemistry.

Organization and expression inPseudomonas putida of the gene cluster involved in cephalosporin biosynthesis fromLysobacter lactamgenus YK90

H. Miyashita, Y. Sumino, H. Kimura, 1996, Applied Microbiology and Biotechnology.

A novel oxyiminoalkanoic acid derivative, TAK-559, activates human peroxisome proliferator-activated receptor subtypes.

Hidekazu Sawada, Yu Momose, Hiroyuki Odaka, 2004, European journal of pharmacology.

Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone.

Y. Momose, H. Kimura, Y. Sugiyama, 2000, Biochemical and biophysical research communications.

Sequencing of the β-isopropylmalate dehydrogenase gene (LEU2) from Acremonium chrysogenum and its application to heterologous gene expression

Y. Sumino, H. Kimura, Masaru Suzuki, 1995 .

Molecular analysis of the gene cluster involved in cephalosporin biosynthesis from Lysobacter lactamgenus YK90

Y. Sumino, M. Izawa, H. Kimura, 2004, Applied Microbiology and Biotechnology.

Evolutionary adaptation of plasmid-encoded enzymes for degrading nylon oligomers

H. Okada, S. Negoro, H. Kimura, 1983, Nature.

Plasmid-determined enzymatic degradation of nylon oligomers

M. Kanaoka, H. Okada, S. Negoro, 1983, Journal of bacteriology.

Construction of hybrid genes of 6-aminohexanoic acid-oligomer hydrolase and its analogous enzyme. Estimation of the intramolecular regions important for the enzyme evolution.

H. Okada, K. Fujiyama, S. Negoro, 1984, The Journal of biological chemistry.

Biochemical characterization of a novel type-II VEGFR2 kinase inhibitor: comparison of binding to non-phosphorylated and phosphorylated VEGFR2.

M. Hixon, S. Imamura, H. Kimura, 2011, Bioorganic & medicinal chemistry.

Studies on non-thiazolidinedione antidiabetic agents. 1. Discovery of novel oxyiminoacetic acid derivatives.

H. Imoto, T. Sohda, Y. Momose, 2002, Chemical & pharmaceutical bulletin.

Biochemical characterization of TAK-593, a novel VEGFR/PDGFR inhibitor with a two-step slow binding mechanism.

M. Hixon, S. Imamura, Hidehisa Iwata, 2011, Biochemistry.

Cloning of the Bacillus Subtilis IMP Dehydrogenase Gene and its Application to Increased Production of Guanosine

M. Kikuchi, S. Akiyama, H. Kimura, 1986, Bio/Technology.

Activation of Human PPAR Subtypes by Pioglitazone

Y. Momose, H. Kimura, H. Ikeda, 2002 .

A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases.

H. Oki, J. Lawson, Terufumi Takagi, 2012, ACS medicinal chemistry letters.

Synthesis and Structure Activity Relationship Studies of Benzothieno[3,2‐b]furan Derivatives as a Novel Class of IKKβ Inhibitors.

H. Oki, Toshimasa Tanaka, T. Kawamoto, 2007 .

Organization and expression in Pseudomonas putida of the gene cluster involved in cephalosporin biosynthesis from Lysobacter lactamgenus YK90.

H. Miyashita, Y. Sumino, H. Kimura, 1996, Applied microbiology and biotechnology.

Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as p38 MAP kinase inhibitors.

T. Kawamoto, Seiji Miwatashi, S. Ohkawa, 2005, Chemical & pharmaceutical bulletin.

Synthesis and structure activity relationship studies of benzothieno[3,2-b]furan derivatives as a novel class of IKKbeta inhibitors.

H. Oki, Toshimasa Tanaka, T. Kawamoto, 2007, Chemical and pharmaceutical bulletin.

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2).

Toshimasa Tanaka, T. Kawamoto, M. Yamaguchi, 2008, Bioorganic & medicinal chemistry.