M. Toteva

发表

Acid catalyzed intramolecular attack of β‐phenylthioureido group on amide function. Parallel formation of thiodihydrouracil and 4‐iminothiodihydrouracil. Different pathways in the Edman degradation reaction in the formation of six‐ versus five‐membered cyclic intermediates

N. Vassilev, I. Pojarlieff, I. Blagoeva, 2008 .

Structure-Reactivity Relationships and Intrinsic Reaction Barriers for Nucleophile Additions to a Quinone Methide: A Strongly Resonance-Stabilized Carbocation

J. Richard, J. Crugeiras, M. Toteva, 2000 .

A Potent Class of GPR40 Full Agonists Engages the EnteroInsular Axis to Promote Glucose Control in Rodents

Sean P. Brown, S. Wong, B. Shan, 2012, PloS one.

Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infection

Xuping Xie, P. Shi, R. Mackman, 2022, Antiviral Research.

Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV.

R. Mackman, J. Bilello, T. Cihlar, 2021, Journal of medicinal chemistry.

Combinations of an acetyl CoA carboxylase inhibitor with hepatic lipid modulating agents do not augment antifibrotic efficacy in preclinical models of NASH and fibrosis

Saritha Kusam, J. Trevaskis, M. Toteva, 2022, Hepatology communications.

Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines.

R. Hungate, M. Rong, W. Zhong, 2010, Bioorganic & medicinal chemistry letters.

Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists.

R. Hungate, M. Rong, W. Zhong, 2010, Bioorganic & medicinal chemistry letters.

Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit.

R. Hungate, M. Rong, W. Zhong, 2011, Bioorganic & medicinal chemistry letters.

Substituent effects on carbocation stability: the pK(R) for p-quinone methide.

J. Richard, T. L. Amyes, M. Toteva, 2003, Journal of the American Chemical Society.

The Generation and Reactions of Quinone Methides.

J. Richard, M. Toteva, 2011, Advances in physical organic chemistry.

Hydrolysis of the quinone methide of butylated hydroxytoluene in aqueous solutions.

V. Stella, M. Toteva, M. Willcockson, 2013, Journal of pharmaceutical sciences.

Changes in the relative contribution of specific and general base catalysis in cationic micelles. The cyclization of substituted ethyl hydantoates.

I. Blagoeva, M. Toteva, M. Ruasse, 2001, The Journal of organic chemistry.

7 Reaction mechanisms. Part (i) Polar reactions

A. O’Donoghue, M. Toteva, 2001 .

Mechanism for Nucleophilic Substitution and Elimination Reactions at Tertiary Carbon in Largely Aqueous Solutions: Lifetime of a Simple Tertiary Carbocation

J. Richard, M. Toteva, 1996 .

9 Reaction mechanisms

A. O’Donoghue, M. Toteva, 2000 .

Formation and stability of carbocations and carbanions in water and intrinsic barriers to their reactions.

J. Richard, T. L. Amyes, M. Toteva, 2001, Accounts of chemical research.

Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.

Y. Wang, J. Canon, M. Peterson, 2014, Journal of medicinal chemistry.

Binding energy and catalysis by D-xylose isomerase: kinetic, product, and X-ray crystallographic analysis of enzyme-catalyzed isomerization of (R)-glyceraldehyde.

Karen N. Allen, N. Silvaggi, J. Richard, 2011, Biochemistry.

Mechanistic Imperatives for the Reaction Catalyzed by Isopentenyl Pyrophosphate Isomerase: Free Energy Profile for Stepwise Isomerization in Water through a Tertiary Carbocation Intermediate

J. Richard, M. Toteva, 1997 .

Ground-state, transition-state, and metal-cation effects of the 2-hydroxyl group on beta-D-galactopyranosyl transfer catalyzed by beta-galactosidase (Escherichia coli, lac Z).

J. Richard, M. Toteva, C. Heo, 2005, Biochemistry.

Dynamics for the reactions of ion pair intermediates of solvolysis

J. Richard, T. L. Amyes, M. Toteva, 2005 .

How does structure determine organic reactivity? Partitioning of carbocations between addition of nucleophiles and deprotonation

J. Richard, A. O’Donoghue, K. B. Williams, 2000 .

What is the stabilizing interaction with nucleophilic solvents in the transition state for solvolysis of tertiary derivatives: nucleophilic solvent participation or nucleophilic solvation?

J. Richard, T. L. Amyes, M. Toteva, 2001, Organic letters.

Assisted hydrolysis of cis-2-(3-phenylthioureido)cyclo pentane-carbonitrile in alkaline solution. Solvent dependent switch from hydrolysis to rearrangement of the iminothiooxopyrimidine intermediate

J. T. Edward, I. Pojarlieff, I. Blagoeva, 2000 .

Scrambling of oxygen-18 during the "borderline" solvolysis of 1-(3-nitrophenyl)ethyl tosylate.

J. Richard, T. L. Amyes, M. Toteva, 2004, Organic letters.

Deprotonation of the α-(N,N-dimethylcarbamoyl)-α-methyl-4-methoxybenzyl carbocation by alkanecarboxylate and halide ions

J. Richard, M. Toteva, 2001 .

Structure-based design of novel inhibitors of the MDM2-p53 interaction.

J. Canon, J. Oliner, Min Jiang, 2012, Journal of medicinal chemistry.

Dynamics of reaction of ion pairs in aqueous solution: racemization of the chiral ion pair intermediate of solvolysis of (S)-1-(4-methylphenyl)ethyl pentafluorobenzoate

J. Richard, M. Toteva, Y. Tsuji, 2003 .

Kinetics and mechanism of the hydrolytic degradation of indinavir: intramolecular catalysis.

R. Zanon, D. Ostovic, M. Toteva, 2008, Journal of pharmaceutical sciences.

Structure-Reactivity Relationships for β-Galactosidase (Escherichia coli, lac Z): A Second Derivative Effect on β(nuc) for Addition of Alkyl Alcohols to an Oxocarbenium Ion Reaction Intermediate.

J. Richard, M. Toteva, C. Heo, 2008, Journal of physical organic chemistry.

Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit.

R. Hungate, M. Rong, W. Zhong, 2011, Bioorganic & medicinal chemistry letters.