C. Largman

发表

Solid phase degradation of water insoluble peptides.

C. Largman, G. Mross, 1975, Analytical biochemistry.

Abnormalities of circulating immunoreactive pancreatic anionic trypsinogen in cystic fibrosis: an assay artifact due to cross-reacting serum antibodies.

P. Durie, S. Wong, D. Moore, 1986, Clinical biochemistry.

Serum immunoreactive cationic trypsinogen: a useful indicator of severe exocrine dysfunction in the paediatric patient without cystic fibrosis.

P. Durie, G. Cleghorn, S. Wong, 1986, Gut.

Elevated serum immunoreactive pancreatic cationic trypsinogen in acute malnutrition: evidence of pancreatic damage.

P. Durie, K. Gaskin, L. Ellis, 1985, The Journal of pediatrics.

Epithelial sodium channels are upregulated during epidermal differentiation.

P. Elias, Y. Oda, L. Kömüves, 1999, The Journal of investigative dermatology.

Alternatively spliced forms of the cGMP‐gated channel in human keratinocytes

T. Mauro, Y. Oda, D. Sauder, 1997, FEBS letters.

Cyclical pattern of blood alcohol levels during continuous intragastric ethanol infusion in rats.

H. Tsukamoto, S. French, R. Reidelberger, 1985, Alcoholism, clinical and experimental research.

Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet

H. Tsukamoto, S. French, E. Larkin, 1985, Hepatology.

Fluorescence polarization studies on the interaction of active site modified chymotrypsins with alpha1-protease inhibitor.

D. Drechsel, C. Glaser, C. Largman, 1982, Biochemistry.

The HOX Homeodomain Proteins Block CBP Histone Acetyltransferase Activity

A. Fishman, C. Largman, K. Krishnan, 2001 .

Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia

U. Thorsteinsdóttir, G. Sauvageau, M. R. Hough, 1997, Molecular and cellular biology.

Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds.

J. Arbeit, D. Cass, C. Largman, 1998, The Journal of investigative dermatology.

Plasma Immunoreactive Pancreatic Cationic Trypsinogen in Cystic Fibrosis: a Sensitive Indicator of Exocrine Pancreatic Dysfunction

P. Durie, K. Gaskin, C. Largman, 1981, Pediatric Research.

Radioimmunoassay determination of circulating pancreatic endopeptidases.

C. Largman, M. C. Geokas, J. W. Brodrick, 1981, Methods in enzymology.

Molecular forms of immunoreactive pancreatic cationic trypsin in pancreatitis patient sera.

J. H. Johnson, M. Fassett, C. Largman, 1979, The American journal of physiology.

Determination of human pancreatic cationic trypsinogen in serum by radioimmunoassay.

J. H. Johnson, C. Largman, M. C. Geokas, 1979, The American journal of physiology.

Demonstration of human pancreatic anionic trypsinogen in normal serum by radioimmunoassay.

J. H. Johnson, C. Largman, M. C. Geokas, 1978, Biochimica et biophysica acta.

Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA.

C. Largman, W. Shen, T. Fletcher, 1987, Biochemistry.

Isolation and characterization of a cDNA encoding rat cationic trypsinogen.

C. Craik, C. Largman, T. Fletcher, 1987, Biochemistry.

Expression of homeobox genes in human erythroleukemia cells.

F. M. Hack, C. Largman, W. Shen, 1989, Advances in experimental medicine and biology.

Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines.

F. M. Hack, C. Hauser, C. Largman, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Increased pancreatic acinar content and secretion of cationic trypsinogen following 30-day continuous ethanol intoxication in rats.

H. Tsukamoto, R. Reidelberger, C. Largman, 1986, Biochemical pharmacology.

MicroRNA-126 Regulates HOXA9 by Binding to the Homeobox

E. Passegué, C. Largman, L. Uttarwar, 2008, Molecular and Cellular Biology.

The stoichiometry of inhibition of human pancreatic elastase 2 by human alpha1-antitrypsin.

C. Largman, M. C. Geokas, J. W. Brodrick, 1977, Biochemical and biophysical research communications.

Bone Morphogenetic Protein‐2 Induces Scar Formation and Skin Maturation in the Second Trimester Fetus

M. Longaker, W. Hoffman, M. Harrison, 1998, Plastic and reconstructive surgery.

Purification and characterization of two human pancreatic elastases.

C. Largman, M. C. Geokas, J. W. Brodrick, 1976, Biochemistry.

Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation.

U. Thorsteinsdóttir, G. Sauvageau, M. R. Hough, 1997, Immunity.

Isolation and characterization of rat pancreatic elastase.

C. Largman, 1983, Biochemistry.

Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells.

G. Sauvageau, C. Eaves, P. Lansdorp, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Modulation of homeobox gene expression alters the phenotype of human hematopoietic cell lines.

F. M. Hack, D. Morgan, C. Largman, 1992, The EMBO journal.

Proinsulin conversion to desalanyl insulin by α2-macroglobin-bound trypsin

C. Largman, M. C. Geokas, J. W. Brodrick, 1977, Nature.

Radioimmunoassay ofActivePancreatic Enzymes inSerafromPatients with AcutePancreatitis. I. ActiveCarboxypeptidase B

C. Largman, A. Delk, Peter R. Dune, 1985 .

The HOX-MEIS connection in AML

C. Largman, H. Lawrence, 2005 .

Immunoreactive forms of cationic trypsin in plasma and ascitic fluid of dogs in experimental pancreatitis.

J. Vollmer, P. Durie, C. Largman, 1981, American Journal of Pathology.

Modulation of HOX2 gene expression following differentiation of neuronal cell lines.

E. Boncinelli, C. Largman, R. Safaei, 1992, Differentiation; research in biological diversity.

A sensitive new substrate for chymotrypsin.

E. G. Delmar, C. Largman, M. C. Geokas, 1979, Analytical biochemistry.

Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.

U. Thorsteinsdóttir, G. Sauvageau, C. Eaves, 1995, Genes & development.

Human pancreatic carboxypeptidase B. I. Isolation, purification, and characterization of fraction II.

C. Largman, M. C. Geokas, J. W. Brodrick, 1975, Biochimica et biophysica acta.

Immunoenzymometric determination of trypsin/alpha 1-protease inhibitor complex in plasma of rats with experimental pancreatitis.

H. Tsukamoto, C. Largman, T. Fletcher, 1986, Clinical chemistry.

Clearance of circulating anionic and cationic pancreatic trypsinogens in the rat.

C. Largman, M. C. Geokas, J. W. Brodrick, 1980, The American journal of physiology.

Plasma immunoreactive anionic pancreatic trypsin in cystic fibrosis.

P. Durie, K. Gaskin, C. Largman, 1982, Journal of pediatric gastroenterology and nutrition.

Studies on the ascites fluid of acute pancreatitis in man

C. Largman, M. C. Geokas, J. W. Brodrick, 1978, The American Journal of Digestive Diseases.

Redesigning trypsin: alteration of substrate specificity.

W. Rutter, R. Fletterick, C. Craik, 1985, Science.

DNA sequence of the yeast transketolase gene.

I. Kwee, B. Martin, C. Largman, 1992, Biochemistry.

Correlation of trypsin-plasma inhibitor complexes with mortality in experimental pancreatitis in rats

H. Tsukamoto, R. Reidelberger, C. Largman, 1986, Digestive Diseases and Sciences.

lmmunoenzymometric Determination ofTrypsin/a1 -Protease Inhibitor Complex in Plasmaof RatswithExperimental Pancreatitis

C. Largman, T. Fletcher, Hklekazu Taukamoto, 1986 .

The Role of Homeobox Genes in Erythropoiesis a

S. Perrine, C. Largman, Robert A. Johnson, 1994, Annals of the New York Academy of Sciences.

Erythroid-restricted expression of homeobox genes of the human HOX 2 locus.

E. Boncinelli, C. Largman, H. Lawrence, 1991, Blood.

The human homeobox genes MSX-1, MSX-2, and MOX-1 are differentially expressed in the dermis and epidermis in fetal and adult skin.

L. Kömüves, N. Adzick, C. Largman, 1997, Differentiation; research in biological diversity.

HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development

Y. Oda, L. Kömüves, C. Largman, 2003, Developmental dynamics : an official publication of the American Association of Anatomists.

HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development.

L. Kömüves, N. Adzick, C. Largman, 1998, The Journal of investigative dermatology.

The Role of HOX Homeobox Genes in Normal and Leukemic Hematopoiesis

Guy Sauvageau, G. Sauvageau, R. Humphries, 1996, Stem cells.

Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA.

G. Sauvageau, M. Cleary, R. Humphries, 1996, Nucleic acids research.

Expression of HOX C homeobox genes in lymphoid cells.

E. Boncinelli, E. Migliaccio, C. Largman, 1993, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Homeobox Genes in Normal Hematopoiesis and Leukemia

C. Largman, C Largman, H J Lawrence, 1992 .

Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia

U. Thorsteinsdóttir, G. Sauvageau, M. R. Hough, 1997, Molecular and cellular biology.

The catalytic role of the active site aspartic acid in serine proteases.

W. Rutter, C. Craik, S. Roczniak, 1987, Science.

HOXA9 Modulates Its Oncogenic Partner Meis1 To Influence Normal Hematopoiesis

Yu-Long Hu, Steve Fong, Christina Ferrell, 2009, Molecular and Cellular Biology.

HOXA9 Forms Triple Complexes with PBX2 and MEIS1 in Myeloid Cells

L. Kömüves, C. Largman, A. Kwong, 1999, Molecular and Cellular Biology.

Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins.

M. Cleary, C. Largman, W. Shen, 1995, Genes & development.

HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo.

M. L. Le Beau, D. Ginzinger, S. Kogan, 2005, Blood.

Protein Kinase C-Mediated Phosphorylation of the Leukemia-Associated HOXA9 Protein Impairs Its DNA Binding Ability and Induces Myeloid Differentiation

D. Stokoe, C. Brandts, C. Largman, 2004, Molecular and Cellular Biology.

The transcriptome of the leukemogenic homeoprotein HOXA9 in human hematopoietic cells.

M. Derynck, C. Haqq, D. Khodabakhsh, 2004, Blood.

HOXB4 homeodomain protein is expressed in developing epidermis and skin disorders and modulates keratinocyte proliferation

J. Arbeit, Qian-chun Yu, L. Kömüves, 2002, Developmental dynamics : an official publication of the American Association of Anatomists.

Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemias

L. Kömüves, K. Matsukuma, C. Largman, 1999, Leukemia.

Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells.

G. Sauvageau, K. Humphries, M. Link, 1995, Experimental hematology.

Loss of function of the homeobox gene Hoxa-9 perturbs early T-cell development and induces apoptosis in primitive thymocytes.

D. Izon, L. Kömüves, C. Largman, 1998, Blood.

Overexpression of HOXB4 enhances the hematopoietic potential of embryonic stem cells differentiated in vitro.

G. Sauvageau, R. Humphries, C. Helgason, 1996, Blood.

Substrate specificity of human pancreatic elastase 2.

M. Fassett, C. Largman, M. C. Geokas, 1980, Biochemistry.

Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus

L. Brocchieri, M. Cleary, C. Largman, 1996, Molecular and cellular biology.

Evidence that the Pim1 kinase gene is a direct target of HOXA9.

E. Passegué, C. Largman, Yu-Long Hu, 2007, Blood.

Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells.

I. Weissman, G. Sauvageau, R. Humphries, 2005, Blood.

Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation

C. Croce, S. Volinia, H. Alder, 2011, Proceedings of the National Academy of Sciences.

Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis.

G. Sauvageau, R. Humphries, C. Helgason, 1997, Blood.

Hepatic origin of triglycerides in fatty livers produced by the continuous intragastric infusion of an ethanol diet

H. Tsukamoto, E. Larkin, C. Largman, 1984, Lipids.

Serial Alterations in the Forms of Immunoreactive Pancreatic Cationic Trypsin in Plasma from Patients with Acute Pancreatitis

P. Durie, K. Gaskin, C. R. Smith, 1985, Journal of pediatric gastroenterology and nutrition.

Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion.

C. Largman, M. C. Geokas, J. W. Brodrick, 1976, Biochimica et biophysica acta.

Clearance and metabolism of circulating pancreatic proelastase in the rat.

C. Largman, M. C. Geokas, J. W. Brodrick, 1980, The American journal of physiology.

Proinsulin conversion to desalanyl insulin by alpha2-macroglobin-bound trypsin.

J. H. Johnson, C. Largman, M. C. Geokas, 1977, Nature.

embryonic stem cells differentiated in vitro Overexpression of HOXB4 enhances the hematopoietic potential of

G. Sauvageau, R. Humphries, C. Largman, 2011 .

HOXB6 Protein Is Bound to CREB-binding Protein and Represses Globin Expression in a DNA Binding-dependent, PBX Interaction-independent Process*

C. Largman, K. Krishnan, W. Shen, 2004, Journal of Biological Chemistry.

Expression of retinoic acid receptor alpha mRNA in human leukemia cells.

F. M. Hack, C. Largman, H. Lawrence, 1989, Blood.

Human cationic trypsinogen. Purification, characterization, and characteristics of autoactivation.

J. H. Johnson, C. Largman, M. C. Geokas, 1978, The Journal of biological chemistry.

AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins

J. Moskow, A. Buchberg, S. Rozenfeld, 1997, Molecular and cellular biology.

Deletion of the homeobox gene PRX-2 affects fetal but not adult fibroblast wound healing responses.

P. Stephens, C. Largman, E. Stelnicki, 2003, The Journal of investigative dermatology.

Changes in HOXB6 homeodomain protein structure and localization during human epidermal development and differentiation

Y. Oda, B. Lau, L. Kömüves, 2000, Developmental dynamics : an official publication of the American Association of Anatomists.

Expression of class I homeobox genes in fetal and adult murine skin.

C. Largman, H. Lawrence, K. Detmer, 1993, The Journal of investigative dermatology.

Effects of HOX homeobox genes in blood cell differentiation

M. Magli, Corey Largman, Maria Cristina Magli, 1997, Journal of cellular physiology.

Expression of the Hox 2.2 homeobox gene in murine embryonic epidermis.

C. Largman, H. Lawrence, K. Detmer, 1993, Differentiation; research in biological diversity.

Pancreatic elastase in human serum. Determination by radioimmunoassay.

J. H. Johnson, C. Largman, M. C. Geokas, 1977, The Journal of biological chemistry.

Primary structure of human pancreatic protease E determined by sequence analysis of the cloned mRNA.

C. Largman, W. Shen, T. Fletcher, 1987, Biochemistry.

The Abd-B-like Hox Homeodomain Proteins Can Be Subdivided by the Ability to Form Complexes with Pbx1a on a Novel DNA Target*

C. Largman, W. Shen, H. Lawrence, 1997, The Journal of Biological Chemistry.

Veterans Administration support for medical research: opinions of the endangered species of physician‐scientists1

R. McCarley, J. Crabbe, F. Finkelman, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Veterans Administration support for medical research: opinions of the endangered species of physicianâ•’scientists¹

R. McCarley, J. Crabbe, F. Finkelman, 2004 .

Activation of Stem‐Cell Specific Genes by HOXA9 and HOXA10 Homeodomain Proteins in CD34+ Human Cord Blood Cells

R. Humphries, M. Derynck, C. Haqq, 2005, Stem cells.

Long-term cannulation model for blood sampling and intragastric infusion in the rat.

H. Tsukamoto, R. Reidelberger, C. Largman, 1984, The American journal of physiology.

HOX genes: not just myeloid oncogenes any more

C. Largman, H. Lawrence, N. Fischbach, 2005, Leukemia.

Interaction of chymotrypsinogens with alpha 1-protease inhibitor.

H. Maeda, M. Fassett, C. Glaser, 1980, Biochemistry.

Effect of oxidation of methionine in a peptide substrate for human elastases: a model for inactivation of alpha 1-protease inhibitor.

C. Largman, M. C. Geokas, J. W. Brodrick, 1979, Biochemical and biophysical research communications.

HOXA9 regulates miR-155 in hematopoietic cells

C. Largman, W. Shen, S. Fong, 2010, Nucleic acids research.

Homeobox Gene Networks and the Regulation of Hematopoiesis

G. Sauvageau, R. Humphries, C. Largman, 2002 .

Cellular proliferation and transformation induced by HOXB4 and HOXB3 proteins involves cooperation with PBX1

J. Krosl, G. Sauvageau, G. Krosl, 1998, Oncogene.

A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells.

L. Deaven, M. Lebeau, C. Largman, 1991, Nucleic acids research.

Functional Cloning and Characterization of a Novel Nonhomeodomain Protein That Inhibits the Binding of PBX1-HOX Complexes to DNA*

R. Humphries, N. Pineault, S. Imren, 2000, The Journal of Biological Chemistry.

Evidence that the Pim 1 kinase gene is a direct target of HOXA 9

E. Passegué, C. Largman, H. Lawrence, 2007 .

Activation of Stem-Cell Specific Genes by HOXA9 and HOXA10 Homeodomain Proteins in CD34+ Human Cord Blood Cells.

R. Humphries, M. Derynck, C. Haqq, 2004 .

Hoxb13 knockout adult skin exhibits high levels of hyaluronan and enhanced wound healing

V. Hascall, E. Maytin, J. Mack, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues.

C. Largman, W. Shen, H. Lawrence, 1991, Nucleic acids research.

Radioimmunoassay of active pancreatic enzymes in sera from patients with acute pancreatitis. I. Active carboxypeptidase B.

P. Durie, C. Largman, A. Delk, 1985, Clinical chemistry.

The HOX Homeodomain Proteins Block CBP Histone Acetyltransferase Activity

C. Largman, K. Krishnan, W. Shen, 2001, Molecular and Cellular Biology.

Homeobox genes in normal hematopoiesis and leukemia.

C. Largman, H. Lawrence, 1992, Blood.

Human pancreatic proelastase 2. Sequence of the activation peptide.

C. Largman, M. C. Geokas, J. W. Brodrick, 1980, Biochimica et biophysica acta.

Proteolysis of Parathyroid Hormone in Vitro by Sera from Acute Pancreatitis Patients 1

C. Largman, M. C. Geokas, J. W. Brodrick, 1981, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Cholecystokinin-induced secretion and synthesis of amylase and cationic trypsinogen by pancreatic acini isolated from rats given an ethanol diet.

H. Tsukamoto, E. Larkin, C. Largman, 1985, Life sciences.