S. Noel

发表

Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del‐CFTR by a CDK‐independent mechanism

L. Meijer, H. Galons, N. Oumata, 2014, British journal of pharmacology.

A cystic fibrosis respiratory epithelial cell chronically treated by miglustat acquires a non-cystic fibrosis-like phenotype.

C. Norez, C. Vandebrouck, F. Antigny, 2009, American journal of respiratory cell and molecular biology.

Azithromycin Attenuates Pseudomonas-Induced Lung Inflammation by Targeting Bacterial Proteins Secreted in the Cultured Medium

P. Melotti, P. Mauri, F. Huaux, 2016, Front. Immunol..

Inflammation biomarkers in sputum for clinical trials in cystic fibrosis: current understanding and gaps in knowledge.

P. Burgel, L. Dupont, I. Sermet-Gaudelus, 2021, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Lung immunoglobulin A immunity dysregulation in cystic fibrosis

S. Verleden, P. Burgel, C. Bouzin, 2020, EBioMedicine.

Dysregulated Proinflammatory and Fibrogenic Phenotype of Fibroblasts in Cystic Fibrosis

P. Lebecque, D. Lison, E. Marbaix, 2013, PloS one.

Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis

L. Touqui, J. Sallenave, X. Nassif, 2019, Scientific Reports.

Vardenafil reduces macrophage pro-inflammatory overresponses in cystic fibrosis through PDE5- and CFTR-dependent mechanisms.

F. Huaux, Nadtha Panin, S. Noel, 2017, Clinical science.

Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 Through 11 Years of Age with Cystic Fibrosis Heterozygous for F508del and a Minimal Function Mutation: A Phase 3b, Randomized, Placebo-controlled Study

D. Prais, P. Reix, H. Selvadurai, 2022, American journal of respiratory and critical care medicine.

Rescue of functional delF508‐CFTR channels in cystic fibrosis epithelial cells by the α‐glucosidase inhibitor miglustat

M. Wilke, C. Norez, F. Becq, 2006, FEBS letters.

Cystic fibrosis: insight into CFTR pathophysiology and pharmacotherapy.

S. Noel, T. Leal, B. Lubamba, 2012, Clinical biochemistry.

Discovery of α-Aminoazaheterocycle-Methylglyoxal Adducts as a New Class of High-Affinity Inhibitors of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels

J. Décout, F. Bossard, C. Gauthier, 2007, Journal of Pharmacology and Experimental Therapeutics.

In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities

Anna Forsby, Thomas Hartung, András Dinnyés, 2016, Archives of Toxicology.

PDE5 Inhibitors as Potential Tools in the Treatment of Cystic Fibrosis

S. Noel, T. Leal, B. Dhooghe, 2012, Front. Pharmacol..

Stereospecificity of the Siderophore Pyochelin Outer Membrane Transporters in Fluorescent Pseudomonads*

D. Rognan, C. Reimmann, I. Schalk, 2009, Journal of Biological Chemistry.

Vardenafil increases intracellular accumulation of the most prevalent mutant cystic fibrosis transmembrane conductance regulator (CTFR) in human bronchial epithelial cells

A. Mottais, C. Bouzin, E. Hermans, 2020, Biology Open.

Resveratrol increases F508del-CFTR dependent salivary secretion in cystic fibrosis mice

A. Capron, P. Wallemacq, S. Noel, 2015, Biology Open.

Discovery of Pyrrolo[2,3-b]pyrazines Derivatives as Submicromolar Affinity Activators of Wild Type, G551D, and F508del Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels

C. Norez, F. Becq, Y. Mettey, 2006, Journal of Pharmacology and Experimental Therapeutics.

Discovery of pyrrolo[2,3- b ]pyrazines derivatives as submicromolar affinity activators of wild-type, G551D and F508del CFTR chloride channels

C. Norez, Y. Mettey, S. Noel, 2006 .

Correlating genotype with phenotype using CFTR‐mediated whole‐cell Cl− currents in human nasal epithelial cells

I. Sermet-Gaudelus, N. Servel, D. Sheppard, 2021, The Journal of physiology.

A Phase 3 Open-Label Study of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 through 11 Years of Age with Cystic Fibrosis and at Least One F508del Allele

R. Gibson, S. McColley, D. Waltz, 2021, American journal of respiratory and critical care medicine.

Cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectives

S. Noel, T. Leal, Jérémy Haaf, 2016, Clinical pharmacology : advances and applications.

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.

John R Yates, Gerard Manning, Yoshihiro Matsumura, 2010, Nature chemical biology.

Strategies in early clinical development for the treatment of basic defects of cystic fibrosis

S. Noel, T. Leal, B. Dhooghe, 2016, Expert opinion on investigational drugs.

BIO010967 929..936

A. Capron, P. Wallemacq, S. Noel, 2015 .

Evaluation of eluforsen, a novel RNA oligonucleotide for restoration of CFTR function in in vitro and murine models of p.Phe508del cystic fibrosis

T. Ritsema, W. Beumer, Patricia Biasutto, 2019, PloS one.

Vardenafil increases intracellular accumulation of the most prevalent mutant CFTR in human bronchial epithelial cells.

A. Mottais, C. Bouzin, E. Hermans, 2020, Biology Open.

In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities

L. Smirnova, T. Hartung, M. Leist, 2016, Archives of Toxicology.

Dysregulated Proinflammatory and Fibrogenic Phenotype of Fibroblasts in Cystic Fibrosis

P. Lebecque, D. Lison, E. Marbaix, 2013, PloS one.