K. England

发表

Recent Progress in Histone Demethylase Inhibitors.

Akane Kawamura, Christopher J Schofield, Paul E Brennan, 2016, Journal of medicinal chemistry.

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

G. F. Ruda, O. Fedorov, C. Bountra, 2016, Journal of medicinal chemistry.

Acidic triazoles as soluble guanylate cyclase stimulators.

P. A. Bradley, M. Bunnage, Y. M. Fobian, 2011, Bioorganic & medicinal chemistry letters.

Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.

Yogesh Sabnis, J. Chrencik, G. Whitlock, 2017, Journal of medicinal chemistry.

Subtle overlapping deletions in the terminal region of chromosome 6q24.2-q26: three cases studied using FISH.

R. Fick, K. S. Reddy, S. Wang, 1999, American journal of medical genetics.

Targeting histone lysine demethylases — Progress, challenges, and the future

C. Schofield, R. Chowdhury, A. Kawamura, 2014, Biochimica et biophysica acta.

Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides

A. Turnbull, B. Kessler, Adán Pinto-Fernández, 2022, bioRxiv.

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

Akane Kawamura, Christopher J. Schofield, Faith Davies, 2017, Cell chemical biology.

C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays

G. F. Ruda, O. Fedorov, O. Rossanese, 2019, European journal of medicinal chemistry.

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor†

F. von Delft, P. Brennan, N. Burgess-Brown, 2014, MedChemComm.

USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation

D. Komander, M. Trost, H. Mortiboys, 2020, Life Science Alliance.

A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation

D. Komander, M. Trost, H. Mortiboys, 2020, bioRxiv.

An improved synthesis of a novel α1A partial agonist including a new two-step synthesis of 4-fluoropyrazole

Lee R. Roberts, Rachel Osborne, K. England, 2010 .

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor

F. von Delft, P. Brennan, N. Burgess-Brown, 2014, MedChemComm.

Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides

A. Turnbull, I. Vendrell, B. Kessler, 2023, Molecular & cellular proteomics : MCP.