J. Montgomery

发表

Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes

Stephen Brown, R. Horst, Yilin Meng, 2020, Nature Chemical Biology.

Toward the assembly and characterization of an encoded library hit confirmation platform: Bead-Assisted Ligand Isolation Mass Spectrometry (BALI-MS).

Timothy L. Foley, K. Farley, L. Byrnes, 2021, Bioorganic & Medicinal Chemistry.

A Solution Phase Platform to Characterize Chemical Reaction Compatibility with DNA-Encoded Chemical Library Synthesis.

Timothy L. Foley, B. Paegel, Justin D. Smith, 2019, ACS combinatorial science.

Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms

M. Dowty, A. Thorarensen, C. Banfield, 2017, Drug Metabolism and Disposition.

Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition.

J. Bauman, J. D. Clark, M. Hegen, 2016, ACS chemical biology.

Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family.

T. Rolph, M. Hayward, D. Erion, 2016, Journal of medicinal chemistry.

Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.

Timothy L. Foley, J. Pandit, J. Cianfrogna, 2018, Journal of medicinal chemistry.

Discovery and characterization of a novel class of pyrazolopyrimidinedione tRNA synthesis inhibitors

C. Limberakis, M. Lescoe, James F. Smith, 2014, The Journal of Antibiotics.

Synthesis of cis,cis,cis,cis-[5.5.5.4]-1-azafenestrane with discovery of an unexpected dyotropic rearrangement.

S. Denmark, J. Montgomery, 2005, Angewandte Chemie.

Synthesis of cis,cis,cis,cis-[5.5.5.5]-1-azafenestrane.

S. Denmark, J. Montgomery, Laurenz A Kramps, 2002, Angewandte Chemie.

Synthesis, X-ray crystallography, and computational analysis of 1-azafenestranes.

S. Denmark, J. Montgomery, Laurenz A Kramps, 2006, Journal of the American Chemical Society.

One-pot (1-ethoxycarbonylcyclopropyl)triphenylphosphonium tetrafluoroborate ring-opening and Wittig reaction.

Laura A McAllister, Robert M. Oliver, Seungwon Chung, 2011, Organic letters.

Inhibition of LpxC Protects Mice from Resistant Acinetobacter baumannii by Modulating Inflammation and Enhancing Phagocytosis

M. Adams, R. Bonomo, K. Hujer, 2012, mBio.

Enhancing Phagocytosis by Modulating Inflammation and Acinetobacter baumannii Inhibition of LpxC Protects Mice from Resistant 2012

M. Adams, R. Bonomo, K. Hujer, 2012 .

LpxC Inhibitors as New Antibacterial Agents and Tools for Studying Regulation of Lipid A Biosynthesis in Gram-Negative Pathogens

M. Kuhn, Tess M. Eidem, Alita A. Miller, 2014, mBio.

Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections.

V. Shanmugasundaram, K. Leach, M. Huband, 2012, Journal of medicinal chemistry.

Potent inhibitors of LpxC for the treatment of Gram-negative infections.

V. Shanmugasundaram, J. Warmus, K. Leach, 2012, Journal of medicinal chemistry.

Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase.

J. Warmus, P. Toogood, Y. Smith, 2009, Bioorganic & medicinal chemistry letters.

A general synthesis of N-vinyl nitrones.

S. Denmark, J. Montgomery, 2006, The Journal of organic chemistry.

Delineating the role of cooperativity in the design of potent PROTACs for BTK

Graham M. West, James Smith, V. Shanmugasundaram, 2018, Proceedings of the National Academy of Sciences.

Selecting Approaches for Hit Identification and Increasing Options by Building the Efficient Discovery of Actionable Chemical Matter from DNA-Encoded Libraries

Timothy L. Foley, B. Kapinos, M. Flanagan, 2021, SLAS discovery : advancing life sciences R & D.

Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.

M. Hegen, J. Telliez, J. Chrencik, 2017, Journal of medicinal chemistry.

Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents.

Mark J. Mitton-Fry, V. Shanmugasundaram, Ye Che, 2012, Bioorganic & medicinal chemistry letters.

The synthesis of C-13 functionalized pleuromutilins via C–H amidation and subsequent novel rearrangement product

A. Stepan, K. Farley, J. Chen, 2011 .

Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors.

G. S. Walker, V. Shanmugasundaram, R. Obach, 2014, Journal of medicinal chemistry.

Understanding Data Noise and Uncertainty through Analysis of Replicate Samples in DNA-Encoded Library Selection

Timothy L. Foley, R. Stanton, J. Montgomery, 2021, J. Chem. Inf. Model..

A chemical probe to modulate human GID4 Pro/N-degron interactions

S. Knapp, J. Min, C. Arrowsmith, 2023, bioRxiv.

Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors.

G. S. Walker, V. Shanmugasundaram, M. Hayward, 2014, Journal of medicinal chemistry.