Jun Zhang

发表

Discovery of prolyl hydroxylase 2 inhibitors with new chemical scaffolds as in vivo active erythropoietin inducers through a combined virtual screening strategy

Hui-peng Song, Xiaojin Zhang, Zhihong Li, 2020, Chemical biology & drug design.

Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis.

M. Krohn, M. Gurney, L. Stewart, 2010, Journal of medicinal chemistry.

Synthesis and antiviral evaluation of 6'-acylamido-6'-deoxy-α-D-mannoglycerolipids.

Chunxia Li, Huashi Guan, Wei Wang, 2013, Carbohydrate research.

Hepatic Flavin-Containing Monooxygenase Gene Regulation in Different Mouse Inflammation Models

T. A. Richardson, J. Cashman, M. Chaluvadi, 2009, Drug Metabolism and Disposition.

A structure‐based strategy toward the development of novel candidates for antimycobacterial activity: Synthesis, biological evaluation, and docking study

Zhao-yong Yang, Yu Lu, Mingliang Liu, 2018, Chemical biology & drug design.

Genome-wide identification and characterization of macrolide glycosyltransferases from a marine-derived Bacillus strain and their phylogenetic distribution.

L. Tian, Wenli Li, Huayue Li, 2016, Environmental microbiology.

Alternative processing events in human FMO genes.

J. Cashman, Jun Zhang, V. Lattard, 2004, Molecular pharmacology.

Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variation.

J. Cashman, Jun Zhang, 2002, Drug metabolism and disposition: the biological fate of chemicals.

First identification of xanthone sulfonamides as potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors.

Honggang Hu, Yan Zou, Hong-Li Liao, 2010, Bioorganic & medicinal chemistry letters.

Impact of cblB mutations on the function of ATP:cob(I)alamin adenosyltransferase in disorders of vitamin B12 metabolism.

D. Rosenblatt, J. Lerner-Ellis, R. Gravel, 2006, Molecular genetics and metabolism.

3-Acrylamide-4-aryloxyindoles: synthesis, biological evaluation and metabolic stability of potent and selective EP3 receptor antagonists.

M. Gurney, A. Kiselyov, Jasbir Singh, 2009, Bioorganic & medicinal chemistry letters.

3,4-Disubstituted indole acylsulfonamides: a novel series of potent and selective human EP3 receptor antagonists.

M. Krohn, M. Gurney, A. Kiselyov, 2009, Bioorganic & medicinal chemistry letters.

Flavin-containing monooxygenase 3 and human disease

J. Cashman, Jun Zhang, M. Motika, 2007, Expert opinion on drug metabolism & toxicology.

Two new polymorphisms of the FMO3 gene in Caucasian and African-American populations: comparative genetic and functional studies.

J. Cashman, D. Schlenk, B. Furnes, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Characterization of Human Flavin-Containing Monooxygenase (FMO) 3 and FMO5 Expressed as Maltose-Binding Protein Fusions

J. Cashman, Jun Zhang, R. Reddy, 2010, Drug Metabolism and Disposition.

Characterization of human FMO3 and FMO5 expressed as maltose binding protein fusions

J. Cashman, Jun Zhang, R. Reddy, 2010 .

Novel Human Butyrylcholinesterase Variants: Toward Organophosphonate Detoxication

Emily M. Smith, M. Dwyer, J. Cashman, 2014, Biochemistry.

Design and synthesis of novel triazole antifungal derivatives based on the active site of fungal lanosterol 14a-demethylase (CYP51)

Honggang Hu, Qingyan Sun, Qiu-ye Wu, 2009 .

Stop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population.

M. Shimizu, H. Yamazaki, J. Cashman, 2007, Molecular genetics and metabolism.

Structure-activity relationship studies leading to the identification of (2E)-3-[l-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methyl-lH-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide (DG-041), a potent and selective prostanoid EP3 receptor antagonist, as a novel antiplatelet agent that

M. Gurney, D. Zembower, A. Kiselyov, 2010, Journal of medicinal chemistry.

Uncommon nornardosinane, seconeolemnane and related sesquiterpenoids from Xisha soft coral Litophyton nigrum.

Yanhua Lu, Yue‐Wei Guo, Lin-Fu Liang, 2020, Bioorganic chemistry.

Design, synthesis and molecular docking studies of novel triazole as antifungal agent.

Yan Zou, Yuan-Ying Jiang, Yongbing Cao, 2011, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase.

Honggang Hu, Yuan-Ying Jiang, Qingyan Sun, 2009, European journal of medicinal chemistry.

Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH.

M. Cushman, Wei-Ke Lv, Jianpeng Liang, 2019, European journal of medicinal chemistry.

5-Bromo-3-(3-hydroxyprop-1-ynyl)-2H-pyran-2-one targets prostate cancer cells by down-regulating inflammation-related genes

Jun Zhang, R. Fan, J. Niu, 2016 .

Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols.

Honggang Hu, Yan Zou, Da-Zhi Zhang, 2009, Bioorganic & medicinal chemistry letters.

Downregulating the expression of heparanase inhibits the invasion, angiogenesis and metastasis of human hepatocellular carcinoma.

Feng Shen, Li Li, Jun Zhang, 2007, Biochemical and biophysical research communications.

Synthesis and Antitumor Activity of 5-Bromo-7-azaindolin-2-one Derivatives Containing a 2,4-Dimethyl-1H-pyrrole-3-carboxamide Moiety

Mingliang Liu, Yun Chai, Kai Lv, 2016, Molecules.

Synthesis and biological activity of organotin 4-methyl-1,2,3-thiadiazole-5-carboxylates and benzo[1,2,3]thiadiazole-7-carboxylates.

Zhi-Jin Fan, Jun Zhang, Zhi-Hong Wang, 2010, Journal of agricultural and food chemistry.

Synthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents.

Yan Zou, Yuan-Ying Jiang, Yongbing Cao, 2011, Bioorganic & medicinal chemistry letters.

Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives.

Yan Zou, Yuan-Ying Jiang, Yongbing Cao, 2011, European journal of medicinal chemistry.

Design, synthesis and antifungal evaluation of 1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-1H-1,2,4-triazol-5(4H)-one.

Honggang Hu, Yan Zou, Yuan-Ying Jiang, 2011, European journal of medicinal chemistry.

Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (CYP51).

Yuan-Ying Jiang, Wannian Zhang, Qingyan Sun, 2007, European journal of medicinal chemistry.

Synthesis, antimycobacterial and antibacterial activity of 1-(6-amino-3,5-difluoropyridin-2-yl)fluoroquinolone derivatives containing an oxime functional moiety.

Bin Wang, Minghua Wang, Yu Lu, 2016, Bioorganic & medicinal chemistry letters.

Triazole derivatives with improved in vitro antifungal activity over azole drugs

Yuan-Ying Jiang, Yongbing Cao, Qingyan Sun, 2014, Drug design, development and therapy.

Amidine-oximes: reactivators for organophosphate exposure.

J. Cashman, Jun Zhang, J. Kalisiak, 2011, Journal of medicinal chemistry.

1,7-Disubstituted oxyindoles are potent and selective EP(3) receptor antagonists.

M. Gurney, A. Kiselyov, James R. Burgeson, 2010, Bioorganic & medicinal chemistry letters.

Human flavin-containing monooxygenases.

J. Cashman, Jun Zhang, 2006, Annual review of pharmacology and toxicology.

New mathematic model for predicting chiral separation using molecular docking: mechanism of chiral recognition of triadimenol analogues.

Liang Zhao, Guoqing Zhang, Z. Hong, 2009, Journal of separation science.

Synthesis and structural assignment of two major metabolites of the LTA4H inhibitor DG-051.

D. Zembower, A. Kiselyov, Jasbir Singh, 2009, Bioorganic & medicinal chemistry letters.

QUANTITATIVE ANALYSIS OF FMO GENE mRNA LEVELS IN HUMAN TISSUES

Jun Zhang, John R. Cashman, J. Cashman, 2006, Drug Metabolism and Disposition.

His-tag truncated butyrylcholinesterase as a useful construct for in vitro characterization of wild-type and variant butyrylcholinesterases.

J. Cashman, Longkuan Xiang, Jun Zhang, 2011, Protein expression and purification.

Effect of Genetic Variants of the Human Flavin-Containing Monooxygenase 3 on N- and S-Oxygenation Activities

M. Shimizu, H. Yamazaki, J. Cashman, 2007, Drug Metabolism and Disposition.

Investigation of Structure and Function of a Catalytically Efficient Variant of the Human Flavin-Containing Monooxygenase Form 3

J. Cashman, I. Likó, Jun Zhang, 2006, Drug Metabolism and Disposition.

Effect of genetic variants of the human flavin-containing monooxygenase 3 ( FMO 3 ) on Nand S-oxygenation activities 1

M. Shimizu, H. Yamazaki, H. Yano, 2006 .

Functional activity of the mouse flavin‐containing monooxygenase forms 1, 3, and 5

J. Cashman, Jun Zhang, M. Cerny, 2007, Journal of biochemical and molecular toxicology.

Deleterious mutations in the flavin-containing monooxygenase 3 (FMO3) gene causing trimethylaminuria

J. Cashman, Jun Zhang, V. Lattard, 2003 .

Novel variants of the human flavin-containing monooxygenase 3 (FMO3) gene associated with trimethylaminuria.

J. Cashman, Kiersten L Riedler, Jun Zhang, 2009, Molecular genetics and metabolism.

Deleterious mutations in the flavin-containing monooxygenase 3 (FMO3) gene causing trimethylaminuria.

J. Cashman, Jun Zhang, V. Lattard, 2003, Pharmacogenetics.

Identification of Human Butyrylcholinesterase Organophosphate-Resistant Variants through a Novel Mammalian Enzyme Functional Screen

M. Dwyer, J. Cashman, Jun Zhang, 2012, Journal of Pharmacology and Experimental Therapeutics.

Microsoft Word-20628170-file00

M. Dwyer, J. Cashman, Jun Zhang, 2012 .

Butyrylcholinesterase and G116H, G116S, G117H, G117N, E197Q and G117H/E197Q mutants: a molecular dynamics study.

Shijing Xia, Shubham Vyas, J. Beck, 2010, Chemico-biological interactions.

Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase.

J. Cashman, O. Lockridge, L. Schopfer, 2009, Chemical research in toxicology.

Synthesis of Dichlorobenzamide Derivatives: Crystal Structures of 3,5-Dichloro-N-(2-chlorophenyl)benzamide and 3,5-Dichloro-N-(4-chlorophenyl)benzamide

Qian-Feng Zhang, Jun Zhang, A. Jia, 2020, Journal of Chemical Crystallography.

Chemical synthesis of two series of nerve agent model compounds and their stereoselective interaction with human acetylcholinesterase and human butyrylcholinesterase.

Nora H Barakat, J. Cashman, Shubham Vyas, 2009, Chemical research in toxicology.

Immunodetection of Serum Albumin Adducts as Biomarkers for Organophosphorus Exposure

J. Cashman, L. Lumley, Jun Zhang, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Uncovering a Glycosyltransferase Provides Insights into the Glycosylation Step during Macrolactin and Bacillaene Biosynthesis

L. Tian, Wenli Li, Huayue Li, 2014, Chembiochem : a European journal of chemical biology.

Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding.

K. Stefánsson, M. Gurney, O. Magnusson, 2009, ACS chemical biology.

An Effective Strategy for Identification of Highly Unstable Bacillaenes.

Q. Cui, Yingang Feng, Wenli Li, 2019, Journal of natural products.

Ligand-binding by catalytically inactive mutants of the cblB complementation group defective in human ATP:cob(I)alamin adenosyltransferase.

H. Schubert, R. Gravel, D. Padovani, 2009, Molecular genetics and metabolism.

Synthesis and antitumor activity of ATB-429 derivatives containing a nitric oxide-releasing moiety.

Guimin Xia, Juxian Wang, Mingliang Liu, 2016, Bioorganic & medicinal chemistry letters.

Mutation-sensitive molecular switch method to detect CES1A2 mutation in the Chinese Han and Yao populations.

L. Miao, Xiao-liang Ding, Jun Zhang, 2011, Genetic testing and molecular biomarkers.

Synthesis and Biological Evaluation of Triazole Derivatives as Potential Antifungal Agent

Yan Zou, Yongbing Cao, Qingyan Sun, 2012, Chemical biology & drug design.

pH dependence on functional activity of human and mouse flavin-containing monooxygenase 5.

M. Dwyer, J. Cashman, Jun Zhang, 2012, Biochemical pharmacology.

Direct detection of the hydrolysis of nerve agent model compounds using a fluorescent probe.

J. Cashman, Jun Zhang, Karl J. Okolotowicz, 2010, Chemico-biological interactions.

Ligand-binding by catalytically inactive mutants of the cblB complementation group defective in human ATP:cob(I)alamin adenosyltransferase.

H. Schubert, R. Gravel, D. Padovani, 2009, Molecular genetics and metabolism.